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52 p, 705.6 KB |
Role of Amyloid-β and Tau Proteins in Alzheimer's Disease : Confuting the Amyloid Cascade
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Gulisano, W. (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Maugeri, Daniele (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fà, Mauro (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University) ;
Amato, Arianna (Department of Anaesthesiology. Università Cattolica Del Sacro Cuore) ;
Palmeri, Agostino (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
D'Adamio, Luciano (Department of Pharmacology. Physiology and Neuroscience. Rutgers University) ;
Grassi, Claudio (Institute of Human Physiology. Università Cattolica Del Sacro Cuore) ;
Devanand, D.P. (Department of Psychiatry. Columbia University. College of Phys. and Surg.) ;
Honig, Lawrence S. (Department of Neurology. Columbia University. College of Phys. and Surg.) ;
Puzzo, Daniela (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Arancio, Ottavio (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University)
The "Amyloid Cascade Hypothesis" has dominated the Alzheimer's disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers tau pathology followed by neuronal death and eventually, the disease. [...]
2018 -  10.3233/JAD-179935
Journal of Alzheimer's disease, Vol. 64 Núm. s1 (2018) , p. S611-S631
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11 p, 3.9 MB |
Analysis of the different subpeptidomes presented by the HLA class I molecules of the B7 supertype
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Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Guasp, Pablo (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ;
Pastor-Moreno, Alba (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Area Navarro, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
MHC-I molecules of the HLA-B7 supertype preferentially bind peptides with proline at position 2. HLA-B*51:01 and B*51:08 present two predominant subpeptidomes, one with Pro2 and hydrophobic residues at P1, and another with Ala2 and Asp enriched at position 1. [...]
2023 - 10.1016/j.cellimm.2023.104707
Cellular Immunology, Vol. 387 (2023)
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14 p, 1.7 MB |
Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation
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Serna, Naroa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Aceituno Abarzúa, Patricia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rojas-Peña, Mauricio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martínez-Torró, Carlos (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sanchez, Julieta M (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Di Somma, Angela (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Carratalá, José Vicente (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Livieri, Andrea L. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Both nanostructure and multivalency enhance the biological activities of antimicrobial peptides (AMPs), whose mechanism of action is cooperative. In addition, the efficacy of a particular AMP should benefit from a steady concentration at the local place of action and, therefore, from a slow release after a dynamic repository. [...]
2023 - 10.3390/pharmaceutics15112632
Pharmaceutics, Vol. 15, Num. 11 (November 2023) , art. 2632
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Antimicrobial peptides in the global microbiome : biosynthetic genes and resistance determinants
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Chen, Bingfeng (Zhejiang University of Technology. College of Environment) ;
Zhang, Zhenyan (Zhejiang University of Technology. College of Environment) ;
Zhang, Qi (Zhejiang University of Technology. College of Environment) ;
Xu, Nuohan Xu (Zhejiang University of Technology. College of Environment) ;
Lu, Tao (Zhejiang University of Technology. College of Environment) ;
Wang, Tingzhang (Key Laboratory of Microbial Technology and Bioinformatics (Zhejiang, Xina)) ;
Hong, Wenjie (Key Laboratory of Microbial Technology and Bioinformatics (Zhejiang, Xina)) ;
Fu, Zhengwei (Zhejiang University of Technology. College of Biotechnology and Bioengineering) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Antimicrobial peptides are a promising new class of antimicrobials that could address the antibiotic resistance crisis, which poses a major threat to human health. These peptides are present in all kingdoms of life, but especially in microorganisms, having multiple origins in diverse taxa. [...]
2023 - 10.1021/acs.est.3c01664
Environmental Science & Technology, Vol. 57, issue 20 (2023) , p.7698-7708
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13 p, 2.0 MB |
A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds : Uncovering Its Dual Antifungal and Hypoglycemic Properties
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Cotabarren, Juliana (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Ozón, Brenda (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Claver, Santiago (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Geier, Florencia (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Rossotti, Martina (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. [...]
2023 - 10.3390/pharmaceutics15030781
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 781
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13 p, 1.1 MB |
Cord Blood Cardiovascular Biomarkers in Left-Sided Congenital Heart Disease
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Soveral, Iris (Hospital Clínic i Provincial de Barcelona) ;
Guirado, Laura (Hospital Clínic i Provincial de Barcelona) ;
Escobar-Diaz, Maria C. (Sant Joan de Déu Hospital) ;
Alcaide, María José (Hospital Universitario La Paz (Madrid)) ;
Martínez, Josep Maria (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Sureda, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Bijnens, Bart (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Antolin, Eugenia (Hospital Universitario La Paz (Madrid)) ;
Llurba, E (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bartha, José Luis (Hospital Universitario La Paz (Madrid)) ;
Gómez, Olga (Hospital Clínic i Provincial de Barcelona) ;
Crispi, Fatima (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Fetal echocardiography has limited prognostic ability in the evaluation of left-sided congenital heart defects (left heart defects). Cord blood cardiovascular biomarkers could improve the prognostic evaluation of left heart defects. [...]
2022 - 10.3390/jcm11237119
Journal of clinical medicine, Vol. 11 (november 2022)
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13 p, 4.6 MB |
Aβ40 Aggregation under Changeable Conditions
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Curto, Jofre Seira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Benseny Cases, Núria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Homeostasis is crucial for cell function, and disturbances in homeostasis can lead to health disorders. Under normal conditions, intracellular pH is maintained between 7. 35 and 7. 45. Altered endosomal and lysosomal pH together with a general drop in brain pH are associated with the aggregation of amyloid-β-peptide (Aβ) and the development of Alzheimer's disease. [...]
2023 - 10.3390/ijms24098408
International journal of molecular sciences, Vol. 24, Issue 9 (May 2023) , art. 8408
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11 p, 1.0 MB |
Impact of angiogenic and cardiovascular biomarkers for pre-diction of placental dysfunction in the first trimester of pregnancy
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Nan, Madalina Nicoleta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
García Osuna, Álvaro (Institut d'Investigació Biomèdica Sant Pau) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
Trilla Solà, Cristina Carmen (Institut d'Investigació Biomèdica Sant Pau) ;
Antonijuan, Assumpta (Institut d'Investigació Biomèdica Sant Pau) ;
Orantes, Vanesa (Institut d'Investigació Biomèdica Sant Pau) ;
Cruz-Lemini, Monica (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco Vaca, Francisco (Institut d'Investigació Biomèdica Sant Pau) ;
Llurba, E (Institut d'Investigació Biomèdica Sant Pau)
Algorithms for first-trimester prediction of pre-eclampsia usually include maternal risk factors, blood pressure, placental growth factor (PlGF), and uterine artery Doppler pulsatility index. However, these models lack sensitivity for the prediction of late-onset pre-eclampsia and other placental complications of pregnancy, such as small for gestational age infants or preterm birth. [...]
2023 - 10.3390/biomedicines11051327
Biomedicines, Vol. 11 Num. 5 (April 2023)
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8 p, 1.1 MB |
Accelerated long-term forgetting over three months in asymptomatic APOE ɛ4 carriers
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Tort-Merino, Adrià (Institute of Neurosciences. University of Barcelona) ;
Laine, Matti J. (Department of Psychology. Åbo Akademi University) ;
Valech, Natalia (Hospital Clínic i Provincial de Barcelona) ;
Olives, Jaume (Institute of Neurosciences. University of Barcelona) ;
León, María (Hospital Clínic i Provincial de Barcelona) ;
Ecay-Torres, Mirian (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Estanga, Ainara (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Martinez-Lage, Pablo (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez-Fornells, Antoni (Institució Catalana de Recerca i Estudis Avançats)
Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. [...]
2021 - 10.1002/acn3.51245
Annals of Clinical and Translational Neurology, Vol. 8 Núm. 2 (february 2021) , p. 477-484
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21 p, 861.0 KB |
Array of peptide-modified electrodes for the simultaneous determination of Pb(II), Cd(II) and Zn(II)
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Serrano i Plana, Núria (Universitat de Barcelona. Departament de Química Analítica) ;
Prieto-Simón, Beatriz (Universitat Autònoma de Barcelona. Departament de Química) ;
Cetó Alsedà, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)
This paper reports the development of three peptide modified sensors in which glutathione (GSH) and its fragments Cys-Gly and γ-Glu-Cys were immobilized respectively through aryl diazonium electrochemical grafting onto the surface of graphite-epoxy composite electrodes (GEC), and used for the simultaneous determination of Cd(II), Pb(II) and Zn(II). [...]
2014 - 10.1016/j.talanta.2014.02.052
Talanta, Vol. 125 (Jul. 2014) , p. 159-166
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