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9 p, 4.2 MB |
Unleashing inkjet-printed nanostructured electrodes and battery-free potentiostat for the DNA-based multiplexed detection of SARS-CoV-2 genes
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Rossetti, Marianna (Institut Català de Nanociència i Nanotecnologia) ;
Srisomwat, Chawin (Chulalongkorn University. Department of Chemistry) ;
Urban, Massimo (Universitat Autònoma de Barcelona) ;
Rosati, Giulio (Institut Català de Nanociència i Nanotecnologia) ;
Maroli, Gabriel (Institut Català de Nanociència i Nanotecnologia) ;
Yaman Akbay, Hatice Gödze (Institut Català de Nanociència i Nanotecnologia) ;
Chailapakul, Orawon (Chulalongkorn University. Department of Chemistry) ;
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)
Following the global COVID-19 pandemic triggered by SARS-CoV-2, the need for rapid, specific and cost-effective point-of-care diagnostic solutions remains paramount. Even though COVID-19 is no longer a public health emergency, the disease still poses a global threat leading to deaths, and it continues to change with the risk of new variants emerging causing a new surge in cases and deaths. [...]
2024 -  10.1016/j.bios.2024.116079
Biosensors & bioelectronics, Vol. 250 (April 2024) , art. 116079
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2.
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9 p, 525.7 KB |
Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254
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Spinner, Christoph D. (Technical University of Munich) ;
Felizarta, Franco (Office of Franco Felizarta) ;
Rizzardini, Giuliano (University of the Witwatersrand) ;
Philibert, Patrick (Hôpital Europen de Marseille) ;
Mitha, Essack (Newtown Clinical Research) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Stephan, Christoph J. (Universitätsklinikum Frankfurt) ;
Degrosky, Michelle (ViiV Healthcare) ;
Bainbridge, Veronica (GlaxoSmithKline) ;
Zhan, Joyce (GlaxoSmithKline) ;
Dumitrescu, Teodora Pene (GlaxoSmithKline) ;
Jeffrey, Jerry L. (ViiV Healthcare. Research Triangle Park) ;
Xu, Jianfeng (GlaxoSmithKline) ;
Halliday, Fiona (GlaxoSmithKline) ;
Gan, Jianjun (GlaxoSmithKline) ;
Johnson, Mark (ViiV Healthcare. Research Triangle Park) ;
Gartland, Martin (ViiV Healthcare. Research Triangle Park) ;
Joshi, Samit R. (ViiV Healthcare) ;
Lataillade, Max (ViiV Healthcare) ;
Universitat Autònoma de Barcelona
GSK3640254 (GSK'254) is a next-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor with pharmacokinetics (PK) supporting once-daily therapy. This phase IIa double-blind (sponsor-unblinded), randomized, placebo-controlled, adaptive study evaluated antiviral effect, safety, tolerability, and PK of once-daily GSK'254 monotherapy administered with food (moderate-fat meal) in HIV-1-positive, treatment-naive adults. [...]
2022 - 10.1093/cid/ciab1065
Clinical Infectious Diseases, Vol. 75 Núm. 5 (january 2022) , p. 786-794
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3.
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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - 10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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4.
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14 p, 7.4 MB |
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
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Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ;
Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ;
Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ;
Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ;
Matsuba, Chikako (University of Southern California, Los Angeles, USA) ;
Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ;
Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ;
Unzueta, Fernando (Universitat de Barcelona) ;
Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ;
Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ;
Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ;
Cortés, Javier (Universidad Europea de Madrid) ;
DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lupien, Mathieu (University of Toronto) ;
Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - 10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)
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5.
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18 p, 15.6 MB |
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
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Garrido-Trigo, Alba (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Corraliza, Ana Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Veny, Marisol (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dotti, Isabella (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Melón-Ardanaz, Elisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rill, Aina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crowell, Helena L. (Department of Molecular Life Sciences. University of Zurich. Switzerland. SIB Swiss Institute of Bioinformatics) ;
Corbí, Ángel (Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC)) ;
Gudiño, Victoria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Esteller, Miriam (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Álvarez-Teubel, Iris (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Aguilar, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Masamunt, M.Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Killingbeck, E. (NanoString Technologies) ;
Kim, Youngmi (NanoString Technologies) ;
Leon, Michael (NanoString Technologies) ;
Visvanathan, Sudha (Translational Medicine and Clinical Pharmacology. Boehringer-Ingelheim Pharmaceuticals Inc) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Caratù, Ginevra (Centre de Regulació Genòmica) ;
Martin Cardona, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Esteve, Maria (Department of Gastroenterology. Hospital Universitari Mútua Terrassa. Universitat de Barcelona) ;
Panés, Julian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Ricart, Elena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Salas, Azucena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. [...]
2023 - 10.1038/s41467-023-40156-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 4506
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6.
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36 p, 4.7 MB |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
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García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ;
Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ;
Dietmann, Sabine (Washington University School of Medicine in St. Lou) ;
López, Judith (Instituto de Investigación Biomédica de Salamanca) ;
Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ;
D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ;
Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Paniagua, Alejandro (Universidad de Salamanca) ;
Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ;
Marchand, Virginie (Université de Lorraine, France) ;
Alonso-López, Diego (Universidad de Salamanca) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Tuñón, Ignacio (Universidad de Salamanca) ;
Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ;
Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ;
Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ;
Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ;
Sánchez-Martín, Manuel A. (Universidad de Salamanca) ;
De Las Rivas, Javier (Universidad de Salamanca) ;
Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Motorin, Yuri (Université de Lorrain) ;
Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ;
Pandolfi, Pier Paolo (University of Turin, Italy) ;
Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ;
Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 - 10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)
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17 p, 2.6 MB |
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
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García-Hernández, Violeta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lobo-Jarne, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Maqueda, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gekas, Christos (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Arnau (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Sentís, Inés (Centre de Regulació Genòmica) ;
Trincado Alonso, Juan Luis, 1987- (Centre de Regulació Genòmica) ;
Márquez-López, Ian (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the evolution of T-cell Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. [...]
2023 - 10.15252/emmm.202216554
EMBO Molecular Medicine, Vol. 15 Núm. 2 (february 2023)
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7 p, 663.7 KB |
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort
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Verheijen, Jan (University of Antwerp) ;
van der Zee, Julie (University of Antwerp) ;
Gijselinck, Ilse (University of Antwerp) ;
Van den Bossche, Tobi (University Hospital Antwerp (Bèlgica)) ;
Dillen, Lubina (University of Antwerp) ;
Heeman, Bavo (University of Antwerp) ;
Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ;
Lladó, Albert (Hospital Clínic i Provincial de Barcelona) ;
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pastor, Maria A. (Clínica Universidad de Navarra) ;
Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
de Mendonça, Alexandre (University of Lisbon) ;
Gelpi, Ellen (Hospital Clínic i Provincial de Barcelona) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Diehl-Schmid, Janine (Technische Universität München) ;
Nacmias, Benedetta (University of Florence) ;
Almeida, Maria Rosário (University of Coimbra) ;
Borroni, Barbara (University of Brescia) ;
Matej, Radoslav (Thomayer Hospital in Prague) ;
Ruiz, Agustín (Fundació ACE) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
De Deyn, Peter P. (University Hospital Antwerp (Bèlgica)) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Sleegers, Kristel (University of Antwerp) ;
Goeman, Johan ;
Nuytten, Dirk ;
Vandenbulcke, Mathieu ;
Santens, Patrick 700 1_ ;
Sieben, Anne ;
Dermaut, Bart ;
Versijpt, Jan ;
Michotte, Alex ;
Deryck, Olivier ;
Bergmans, Bruno ;
Willems, Christiana ;
Ivanoiu, Adrian ;
Salmon, Eric ;
Alexopoulos, Panagiotis (Technische Universität München) ;
Sorbi, Sandro ;
Bessi, Valentina ;
Bagnoli, Silvia ;
Santana, Isabel ;
Simões do Couto, Frederico ;
Martins, Madalena ;
Thonberg, Häkan ;
Fratiglioni, Laura ;
Padovani, Alessandro ;
Rohan, Zdenek ;
Razquin, Cristina ;
Lorenzo, Elena ;
Iglesias, Elena ;
Seijo-Martínez, Manuel ;
Rene, Ramon ;
Gascon, Jordi ;
Campdelacreu, Jaume ;
Koutroumani, Maria ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), often combined with memory deficits early in the disease course. [...]
2018 - 10.1016/j.neurobiolaging.2017.10.012
Neurobiology of Aging, Vol. 62 (february 2018) , p. 245.e1-245.e7
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