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10 p, 596.5 KB |
PeSV-fisher : identification of somatic and non-somatic structural variants using next generation sequencing data
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Escaramís, Georgina (Centre de Regulació Genòmica) ;
Tornador, Cristian (Centre de Regulació Genòmica) ;
Bassaganyas, Laia (Centre de Regulació Genòmica) ;
Rabionet, Raquel (Centre de Regulació Genòmica) ;
Tubio, Jose M. C. (Centre de Regulació Genòmica) ;
Martínez-Fundichely, Alexander (Centre de Regulació Genòmica) ;
Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gut, Marta (Centre Nacional d'Anàlisi Genòmica) ;
Ossowski, Stephan (Centre de Regulació Genòmica) ;
Estivill, Xavier (Centre de Regulació Genòmica)
Next-generation sequencing technologies expedited research to develop efficient computational tools for the identification of structural variants (SVs) and their use to study human diseases. As deeper data is obtained, the existence of higher complexity SVs in some genomes becomes more evident, but the detection and definition of most of these complex rearrangements is still in its infancy. [...]
2013 -  10.1371/journal.pone.0063377
PloS one, Vol. 8 issue 5 (2013) , art. e63377
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10 p, 3.8 MB |
An atypical RNA silencing suppression strategy provides a snapshot of the evolution of sweet potato-infecting potyviruses
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Rodamilans, Bernardo (Centro Nacional de Biotecnología (Espanya)) ;
Valli, Adrián A. (Centro Nacional de Biotecnología (Espanya)) ;
Mingot, Ares (Centre de Recerca en Agrigenòmica) ;
San León, David (Centro Nacional de Biotecnología (Espanya)) ;
Lopez-Moya, Juan Jose (Centre de Recerca en Agrigenòmica) ;
García, Juan Antonio (Centro Nacional de Biotecnología (Espanya))
Plant viruses usually encode proteins with RNA silencing suppression (RSS) activity to counteract plant defenses. In Potyvirus, the largest genus in the family Potyviridae, this role is taken over by the multifunctional HCPro, also involved in aphid transmission, polyprotein processing and virion formation. [...]
2018 - 10.1038/s41598-018-34358-y
Scientific reports, Vol. 8 (October 2018) , art. 15937
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10 p, 1.2 MB |
Redefining the PF06864 Pfam Family Based on Burkholderia pseudomallei PilO2Bp S-SAD Crystal Structure
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Lassaux, Patricia (Università di Milano. Department of Biosciences) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Manjasetty, Babu A. (Grenoble Outstation. European Molecular Biology Laboratory) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Perletti, Lucia (Università di Milano. Department of Biosciences) ;
Belrhali, Hassan (Grenoble Outstation. European Molecular Biology Laboratory) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gourlay, Louise J. (Università di Milano. Department of Biosciences) ;
Bolognesi, Martino (Università di Milano. Department of Biosciences)
Type IV pili are surface-exposed filaments and bacterial virulence factors, represented by the Tfpa and Tfpb types, which assemble via specific machineries. The Tfpb group is further divided into seven variants, linked to heterogeneity in the assembly machineries. [...]
2014 - 10.1371/journal.pone.0094981
PloS one, Vol. 9 Issue 4 (April 2014) , p. e94981
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13 p, 590.3 KB |
miRNA Expression Profile Analysis in Kidney of Different Porcine Breeds
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Timoneda i Heredia, Oriol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Balcells Ortega, Ingrid (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Núñez, J. Ignacio (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Egea, Raquel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vera Rodríguez, Gonzalo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Tomas, Anna ;
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
MicroRNAs (miRNAs) are important post-transcriptional regulators in eukaryotes that target mRNAs repressing their expression. The uncertain process of pig domestication, with different origin focuses, and the selection process that commercial breeds suffered, have generated a wide spectrum of breeds with clear genetic and phenotypic variability. [...]
2013 - 10.1371/journal.pone.0055402
PloS one, Vol. 8 Issue 1 (January 2013) , p. e55402
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12 p, 764.1 KB |
Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma penetrans
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Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Planell Cerezo, Raquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Benach, Jordi (ALBA Laboratori de Llum de Sincrotró) ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez-Pons, Josep A.. (Josep Antoni) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The metabolism of arginine towards ATP synthesis has been considered a major source of energy for microorganisms such as Mycoplasma penetrans in anaerobic conditions. Additionally, this pathway has also been implicated in pathogenic and virulence mechanism of certain microorganisms, i. [...]
2012 - 10.1371/journal.pone.0047886
PloS one, Vol. 7 Issue 10 (October 2012) , p. e47886
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8 p, 356.0 KB |
Design and Characterization of a 52K SNP Chip for Goats
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Tosser-Klopp, Gwenola (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Bardou, Philippe (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Bouchez, Olivier (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Cabau, Cédric (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Crooijmans, Richard (Wageningen University. Animal Breeding and Genomics Centre) ;
Dong, Yang (Chinese Academy of Sciences. Kunming Institute of Zoology) ;
Donnadieu-Tonon, Cécile (Institut national de la recherche agronomique (França). GeT-PlaGe) ;
Eggen, André (Illumina Inc. (Hayward, Calif., Estats Units d'Amèrica)) ;
Heuven, Henri C. M. (Utrecht University. Faculty of Veterinary Medicine) ;
Jamli, Saadiah (Malaysian Agricultural Research and Development Institute) ;
Johari Jiken, Abdullah (Malaysian Agricultural Research and Development Institute) ;
Klopp, Christophe (Institut National de la Recherche Agronomique (França)) ;
Lawley, Cynthia T. (Illumina Inc. (Hayward, Calif., Estats Units d'Amèrica)) ;
McEwan, John (Invermay Agricultural Center (Mosgiel, Nova Zelanda)) ;
Martin, Patrice (Institut national de la recherche agronomique (França). Génétique Animale et Biologie Intégrative) ;
Moreno, Carole R. (Institut national de la recherche agronomique (França). Station d'Amélioration Génétique des Animaux) ;
Mulsant, Philippe (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Nabihoudine, Ibouniyamine (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Pailhoux, Eric (Institut national de la recherche agronomique (França). Biologie du Développement et Reproduction) ;
Palhière, Isabelle (Institut national de la recherche agronomique (França). Station d'Amélioration Génétique des Animaux) ;
Rupp, Rachel (Institut national de la recherche agronomique (França). Station d'Amélioration Génétique des Animaux) ;
Sarry, Julien (Institut national de la recherche agronomique (França). Laboratoire de Génétique Cellulaire) ;
Sayre, Brian L. (Virginia State University, Department of Biology) ;
Tircazes, Aurélie (Institut national de la recherche agronomique (França). Station d'Amélioration Génétique des Animaux) ;
Wang, Jun (Bejing Genome Institute) ;
Wang, Wen (Bejing Genome Institute) ;
Zhang, Wenguang (Chinese Academy of Sciences. Kunming Institute of Zoology) ;
Amills i Eras, Marcel, col. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
International Goat Genome Consortium
The success of Genome Wide Association Studies in the discovery of sequence variation linked to complex traits in humans has increased interest in high throughput SNP genotyping assays in livestock species. [...]
2014 - 10.1371/journal.pone.0086227
PloS one, Vol. 9 Issue 1 (January 2014) , p. e86227
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11 p, 7.8 MB |
Understanding the molecular determinants driving the immunological specificity of the protective pilus 2a backbone protein of Group B Streptococcus
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Nuccitelli, Annalisa (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Rinaudo, C. Daniela (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Brogioni, Barbara (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Cozzi, Roberta (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Telford, John L. (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Grandi, Guido (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Zacharias, Martin (Technical University Munich. Physics Department) ;
Maione, Domenico (Novartis Vaccines and Diagnostics (Siena, Itàlia))
The pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main immunologically distinct allelic variants, each inducing variant-specific protection. [...]
2013 - 10.1371/journal.pcbi.1003115
PLOS Computational Biology, Vol. 9, Issue 6 (June 2013) , p. e1003115
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