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12 p, 9.6 MB |
Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling
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Estupiñán, Óscar (Instituto Universitario de Oncología del Principado de Asturias) ;
Rey, Verónica (Instituto Universitario de Oncología del Principado de Asturias) ;
Tornín, Juan (Instituto Universitario de Oncología del Principado de Asturias) ;
Murillo, Dzohara (Instituto Universitario de Oncología del Principado de Asturias) ;
Gallego, Borja (Instituto Universitario de Oncología del Principado de Asturias) ;
Huergo, Carmen (Instituto Universitario de Oncología del Principado de Asturias) ;
Blanco-Lorenzo, Verónica (Hospital Universitario Central de Asturias) ;
Victoria González, M. (Universidad de Oviedo) ;
Rodríguez, Aida (Instituto Universitario de Oncología del Principado de Asturias) ;
Moris, Francisco (EntreChem SL, Oviedo) ;
González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, Veronica (Universidad de Granada) ;
Ramos-Mejía, Verónica (Universidad de Granada) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto Universitario de Oncología del Principado de Asturias)
Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor cells, including cancer stem cell subpopulations (CSC), in sarcomas. [...]
2023 -  10.1016/j.biopha.2023.114627
Biomedicine & pharmacotherapy, Vol. 162 (june 2023)
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2.
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34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
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Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
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3.
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13 p, 3.5 MB |
Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations
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Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Osete, Jordi Requena (Oslo University Hospital (Oslo, Noruega)) ;
Edel, Michael J (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. [...]
2023 - 10.3390/cells12242800
Cells, Vol. 12 (december 2023)
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5.
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9 p, 1.9 MB |
Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation
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Guglieri-Lopez, Beatriz (Hospital Universitari Doctor Peset (València)) ;
Perez-Pitarch, Alejandro (Hospital Clínico Universitario de València) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Gimenez, Estela (Hospital Clínico Universitario de València) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Rabella, Núria (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínico Universitario de València) ;
Fox, Maria Laura (Hospital Universitari Vall d'Hebron) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Ferriols-Lisart, Rafael (Hospital Clínico Universitario de València) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Solano, Carlos (Universitat de València) ;
Navarro, David (Universitat de València) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Piñana, José Luis (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV)DNAemia necessitating preemptive antiviral therapy. A total of 167 consecutive recipients of reduced-intensity conditioning (RIC)allogeneic hematopoietic stem cell transplantation (allo-HSCT)who received sirolimus- and tacrolimus-based graft-versus-host disease (GVHD)prophylaxis and whose CMV serostatus was positive for donors and/or recipients were included in this multicenter retrospective study. [...]
2019 - 10.1016/j.bbmt.2019.01.012
Biology of blood and marrow transplantation, Vol. 25 Núm. 5 (may 2019) , p. 1022-1030
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6.
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17 p, 2.9 MB |
The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming
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Mendoza, Gracia (Instituto de Investigación Sanitaria de Aragón) ;
González-Pastor, Rebeca (Universidad UTE. Centro de Investigación Biomédica) ;
Sánchez, Juan Miguel (Imperial College London. National Heart and Lung Institute) ;
Arce Cerezo, Altamira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Quintanilla, Miguel (Universidad Autónoma de Madrid. Departamento de Bioquímica) ;
Moreno-Bueno, Gema (Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red) ;
Pujol i Altarriba, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Belmar-López, Carolina (Universidad Privada San Juan Bautista) ;
de Martino, Alba (Instituto de Investigación Sanitaria de Aragón) ;
Riu, Efrén (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rodriguez, Tristan A. (Imperial College London. National Heart and Lung Institute) ;
Martin-Duque, Pilar (Universidad de Zaragoza. Departamento de Cirugía)
The induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka's group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. [...]
2023 - 10.3390/cells12091338
Cells, Vol. 12 (may 2023)
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7.
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5 p, 470.9 KB |
Spanish Cell Therapy Network (TerCel) : 15 years of successful collaborative translational research
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Sánchez-Guijo, Fermín (Universidad de Salamanca) ;
García-Olmo, Damián (Universidad Autónoma de Madrid) ;
Prósper, Felipe (Universidad de Navarra) ;
Martínez, Salvador (Instituto de Neurociencias UMH-CSIC) ;
Zapata, Agustín (Universidad Complutense de Madrid) ;
Fernandez Aviles, Francesc (IiSGM-Hospital General Universitario Gregorio Marañón) ;
Toledo-Aral, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Torres, Miguel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fariñas, Isabel (Universitat de València) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Labandeira-García, José Luis (Universidade de Santiago de Compostela) ;
García-Sancho, Javier (Universidad de Valladolid) ;
Moraleda, José M. (Universidad de Murcia) ;
Universitat Autònoma de Barcelona
In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this important area. [...]
2020 - 10.1016/j.jcyt.2019.11.001
Cytotherapy, Vol. 22 Núm. 1 (january 2020) , p. 1-5
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13 p, 5.2 MB |
Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells
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Nieto-Nicolau, Núria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
de la Torre, Raquel M. (CellTec-UB. Universitat de Barcelona) ;
Fariñas-Balaguer, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
Savio, Andrés (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vilarrodona, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Casaroli-Marano, Ricardo Pedro (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Mesenchymal stem cells (MSC) are heterogeneous cells of complex nature that show different potentials while different culture conditions can modify their functionalities through interactions with the microenviroment. [...]
2020 - 10.1016/j.scr.2020.101899
Stem Cell Research, Vol. 47 (august 2020) , p. 101899
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9.
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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 - 10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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10.
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11 p, 2.5 MB |
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis
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Kandel, Prasanna (Department of Biochemistry and Molecular Biomedicine. Institute of Biomedicine. University of Barcelona) ;
Semerci, Fatih (Universitat de Barcelona. Institut de Biomedicina. Departament de Bioquímica i Biomedicina Molecular) ;
Mishra, Rachana (Jan and Dan Duncan Neurological Research Institute. Texas Children's Hospital) ;
Choi, Willian (Medical Scientist Training Program. Baylor College of Medicine) ;
Bajic, Aleksandar (Department of Molecular and Human Genetics. Baylor College of Medicine) ;
Baluya, Dodge (Department of Interventional Radiology. University of Texas MD Anderson Cancer Center) ;
Ma, Li Hua (NMR and Drug Metabolism Advanced Technology Cores. Baylor College of Medicine) ;
Chen, Kevin (Department of Biosciences. Rice University) ;
Cao, Austin C. (Department of Chemistry. Rice University) ;
Phongmekhin, Tipwarin (Department of Biosciences. Rice University) ;
Matinyan, Nick (Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Baylor College of Medicine) ;
Jimenez-Panizo, Alba (Universitat de Barcelona. Institut de Biomedicina. Departament de Bioquímica i Biomedicina Molecular) ;
Chamakuri, Srinivas (Department of Pathology and Immunology. Baylor College of Medicine) ;
Raji, Idris O. (Department of Pharmacology & Chemical Biology. Baylor College of Medicine) ;
Chang, Lyra (Department of Pharmacology & Chemical Biology. Baylor College of Medicine) ;
Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
MacKenzie, Kevin R. (Department of Molecular and Cellular Biology. Baylor College of Medicine) ;
Benn, Caroline L. (Pfizer Regenerative Medicine) ;
Estebanez-Perpiña, Eva (Department of Biochemistry and Molecular Biomedicine. Institute of Biomedicine. University of Barcelona) ;
Venken, Koen (Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Baylor College of Medicine) ;
Moore, David D. (Department of Molecular and Cellular Biology. Baylor College of Medicine) ;
Young, Damian W. (Center for Drug Discovery. Baylor College of Medicine) ;
Maletic-Savatic, Mirjana (Department of Neuroscience. Baylor College of Medicine)
Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, regulating the neural stem cell population precisely has remained elusive because we have lacked the specific targets to stimulate their proliferation and neurogenesis. [...]
2022 - 10.1073/pnas.2023784119
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119 Núm. 13 (March 2022) , p. e2023784119
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