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15 p, 1.9 MB |
GC-MS/MS Determination of Synthetic Cathinones : 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study
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Nuñez-Montero, Melani (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lombroni, Claudia (Univesità degli Studi di Torino) ;
Maida, Nunzia La (Istituto Superiore di Sanità) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marchei, Emilia (Istituto Superiore di Sanità) ;
Universitat Autònoma de Barcelona
This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. [...]
2023 -  10.3390/ijms24119387
International journal of molecular sciences, Vol. 24 (may 2023)
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22 p, 444.8 KB |
Inhibition equivalency factors for microcystin variants in recombinant and wild-type protein phosphatase 1 and 2A assays
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Garibo, Diana (Institut de Recerca i Tecnologia Agroalimentàries) ;
Flores, Cintia (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Cetó Alsedà, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Prieto-Simón, Beatriz (Universitat Autònoma de Barcelona. Departament de Química) ;
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química) ;
Caixach, Josep (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Diogène, Jorge (Institut de Recerca i Tecnologia Agroalimentàries) ;
Campàs i Homs, Mònica (Institut de Recerca i Tecnologia Agroalimentàries)
In this work, protein phosphatase inhibition assays (PPIAs) have been used to evaluate the performance of recombinant PP1 and recombinant and wild-type PP2As. The enzymes have been compared using microcystins-LR (MC-LR) as a model cyanotoxin. [...]
2014 - 10.1007/s11356-014-3065-7
Environmental Science and Pollution Research International, Vol. 21, Issue 18 (September 2014) , p. 10652-10660
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13 p, 2.3 MB |
Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics
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Youssef, Lina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Miranda, Jezid (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Blasco Pelicano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Paules, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Crovetto, Francesca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torramade Moix, Sergi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García Calderó, Héctor (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Tura Ceide, Olga (Institut d'Investigació Biomèdica de Girona) ;
Dantas, A. P (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernandez Gea, Virginia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Herrero, Pol (Universitat Rovira i Virgili) ;
Canela, Núria (Universitat Rovira i Virgili) ;
Campistol Plana, Josep M (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Garcia Pagan, Joan Carles (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gratacos, Eduard (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Universitat Autònoma de Barcelona
Preeclampsia is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal morbidity and mortality. The exact pathogenesis of this multifactorial disease remains poorly defined. [...]
2021 - 10.1038/s41598-021-82733-z
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3048
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12 p, 3.8 MB |
Modular Evolution and Population Variability of Oikopleura dioica Metallothioneins
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Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Cañestro, Cristian (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Chordate Oikopleura dioica probably is the fastest evolving metazoan reported so far, and thereby, a suitable system in which to explore the limits of evolutionary processes. For this reason, and in order to gain new insights on the evolution of protein modularity, we have investigated the organization, function and evolution of multi-modular metallothionein (MT) proteins in O. [...]
2021 - 10.3389/fcell.2021.702688
Frontiers in Cell and Developmental Biology, Vol. 9 (July 2021) , art. 702688
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10 p, 1.1 MB |
Reference Intervals of Thyroid Function Tests Assessed by Immunoassay and Mass Spectrometry in Healthy Pregnant Women Living in Catalonia
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Hernández, José María (Institut Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velasco, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Moreno-Flores, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Montes de Oca, Alejandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santillán, Cecilia (Hospital Doctor Arturo Oñativia) ;
Muñoz, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballesta Purroy, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Canal Girol, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Granada, Maria Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background: Recent guidelines recommend establishing a local reference interval (RI) for thyroid function. We aimed to establish trimester-specific RIs for thyrotropin (TSH) and free thyroxine (FT4) in a cohort of healthy pregnant women in Catalonia (Spain). [...]
2021 - 10.3390/jcm10112444
Journal of clinical medicine, Vol. 10 (may 2021)
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19 p, 2.6 MB |
Coteaching in CLIL in Catalonia
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Escobar Urmeneta, Cristina (Universitat Autònoma de Barcelona. Departament de Didàctica de la Llengua i la Literatura i de les Ciències Socials)
This article addresses the issue of coteaching in Content and Language Integrated Learning (CLIL) contexts. It does so by retrieving and reviewing data from previous studies on CLIL projects carried out in school-university partnership with three secondary schools based in Barcelona and its metropolitan area, in Catalonia (Spain), in which coteaching was adopted as a strategy for inclusive CLIL. [...]
Aquest article aborda la qüestió de la co-docència en contextos d'Aprenentatge Integrat de Continguts i Llengua (AICLE). Amb aquesta finalitat, recupera i revisa dades d'estudis previs sobre projectes AICLE realitzats en partenariat escola-universitat amb tres centres d'educació secundària amb seu a Barcelona i la seva àrea metropolitana, a Catalunya (Espanya), en els quals es va adoptar la co-docència com a estratègia per a un AICLE inclusiu. [...]
Este artículo aborda la cuestión de la co-docencia en contextos de Aprendizaje Integrado de Contenidos y Lenguas (AICLE). Para ello, recupera y revisa datos de estudios previos sobre proyectos AICLE realizados en partenariado escuela-universidad con tres centros de educación secundaria con sede en Barcelona y su área metropolitana, en Cataluña (España), en los que se adoptó la co-docencia como estrategia para un AICLE inclusivo. [...]
2020 - 10.5565/rev/clil.54
CLIL : Journal of Innovation and Research in Plurilingual and Pluricultural Education, Vol. 3 Núm. 2 (2020) , p. 37-55 (Investigació i qüestions teòriques)
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17 p, 1.2 MB |
Multilayered Hematite Nanowires with Thin-Film Silicon Photovoltaics in an All-Earth-Abundant Hybrid Tandem Device for Solar Water Splitting
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Urbain, Félix (Institut de Recerca en Energia de Catalunya) ;
Tang, PengYi (Institut Català de Nanociència i Nanotecnologia) ;
Smirnov, Vladimir (Forschungszentrum Jülich) ;
Welter, Katharina (Forschungszentrum Jülich) ;
Andreu, Teresa (Institut de Recerca en Energia de Catalunya) ;
Finger, Friedhelm (Forschungszentrum Jülich) ;
Arbiol i Cobos, Jordi (Institut Català de Nanociència i Nanotecnologia) ;
Morante, Joan Ramon (Institut de Recerca en Energia de Catalunya)
The concept of hybrid tandem device structures that combine metal oxides with thin-film semiconducting photoabsorbers holds great promise for large-scale, robust, and cost-effective bias-free photoelectrochemical water splitting (PEC-WS). [...]
2019 - 10.1002/cssc.201802845
ChemSusChem, Vol. 12, Issue 7 (April 2019) , p. 1428-1436
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18 p, 3.1 MB |
Structural lesions of proteins connected to lipid membrane damages caused by radical stress : assessment by biomimetic systems and raman spectroscopy
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Torreggiani, Armida (CNR-Istituto per la Sintesi Organica e la Fotoreattività) ;
Tinti, Anna (Università di Bologna. Dipartimento di Scienze Biomediche e Neuromotorie) ;
Jurasekova, Zuzana (P.J. Šafárik University. Department of Biophysics) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Saracino, Michela (CNR-Istituto per la Sintesi Organica e la Fotoreattività) ;
Di Foggia, Michele (Università di Bologna. Dipartimento di Scienze Biomediche e Neuromotorie)
Model systems constituted by proteins and unsaturated lipid vesicles were used to gain more insight into the effects of the propagation of an initial radical damage on protein to the lipid compartment. [...]
2019 - 10.3390/biom9120794
Biomolecules, Vol. 9, issue 12 (Dec. 2019) , art. 794
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17 p, 2.6 MB |
Succination is increased on select proteins in the brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome
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Piroli, G. G. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Manuel, A. M. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Clapper, A. C. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Walla, M. D. (Mass Spectrometry Center. Department of Chemistry and Biochemistry. University of South Carolina) ;
Baatz, J. E. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Palmiter, Richard D (Howard Hughes Medical Institute and Department of Biochemistry. University of Washington) ;
Quintana Puebla, Alberto (Seattle Children's Research Institute) ;
Frizzell, N. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina)
Elevated fumarate concentrations as a result of Krebs cycle inhibition lead to increases in protein succination, an irreversible post-Translational modification that occurs when fumarate reacts with cysteine residues to generate S-(2-succino)cysteine (2SC). [...]
2016 - 10.1074/mcp.M115.051516
Molecular and Cellular Proteomics, Vol. 15 Núm. 2 (february 2016) , p. 445-461
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