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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, Manel (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 -  10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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18 p, 1011.1 KB |
Publicaciones sobre los aspectos éticos, legales y sociales de los biobancos entre 2011-2018 : una revisión panorámica
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Argudo-Portal, Violeta (Departamento de Psicología Social) ;
Domènech i Argemí, Miquel (Universitat Autònoma de Barcelona. Departament de Psicologia Social)
Fundamentos: Los biobancos, con muestras de origen humano, han sido definidos como agentes intermedios entre los donantes/participantes, la comunidad científica, el sistema sanitario y los pacientes. [...]
BACKGROUND: Human-based biobanks have been presented as intermediary agents between donors/participants, the scientific community, the healthcare system, and patients. The objective of this systematic review was to contribute with an updated thematic synthesis in Spanish of the international literature (2011-2018) regarding ethical, legal, and social issues on contemporary biobanks. [...]
2020
Revista Espanola de Salud Publica, Vol. 94 (2020) , p. e202006031
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19 p, 2.0 MB |
Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
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Sandoval, Viviana (Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària) ;
Femenias, Antoni (Universitat de Lleida. Departament de Tecnologia d'Aliments) ;
Martínez-Garza, Úrsula (Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària) ;
Sanz-Lamora, Hèctor (Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària) ;
Castagnini, Juan Manuel (Universidad Nacional de Entre Ríos. Facultad de Ciencias de la Alimentación) ;
Quifer-Rada, Paola (Institut d'Investigació Biomèdica Sant Pau) ;
Lamuela-Raventós, Rosa M (CIBER Physiopathology of Obesity and Nutrition (CIBER-OBN). Instituto de Salud Carlos III) ;
Marrero, Pedro F. (Universitat de Barcelona. Institut de Biomedicina) ;
Haro, Diego (Universitat de Barcelona. Institut de Biomedicina) ;
Relat, Joana (CIBER Physiopathology of Obesity and Nutrition (CIBER-OBN). Instituto de Salud Carlos III)
Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. [...]
2019 - 10.3390/antiox8090360
Antioxidants, Vol. 8 Núm. 9 (september 2019) , p. 360
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6 p, 681.8 KB |
A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe
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Delgadillo Duarte, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kerkelä, Erja (Finnish Red Cross Blood Service (Finland)) ;
Waters, Allison (Irish Blood Transfusion Service. National Blood Centre (Ireland)) ;
van den Akker, Emile (University of Amsterdam) ;
Lechanteur, Chantal (Université de Liège) ;
Baudoux, Etienne (Université de Liège) ;
Gardiner, Nicola (St. James's Hospital (Dublín, Irlanda)) ;
De Vos, John (Hôpital Saint-Eloi (França)) ;
Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Blood, tissue and cell establishments (BTCs) stand out in the management of donor selection, procurement and processing of all types of substances of human origin (SoHO). In the last decades, the framework created around BTCs, including hospitals and national health system networks, and their links to research, development and innovation organizations and agencies have spurred their involvement in the study of groundbreaking advanced therapy medicinal products (ATMP). [...]
2023 - 10.1016/j.jcyt.2023.08.001
Cytotherapy, Vol. 25 Núm. 12 (december 2023) , p. 1259-1264
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15 p, 1.4 MB |
Systematic review and meta-analysis of surgical outcomes comparing mechanical valve replacement and bioprosthetic valve replacement in infective endocarditis
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Flynn, Campbell D. (St George Hospital) ;
Curran, Neil P. (St George Hospital) ;
Chan, Stephanie (St George Hospital) ;
Zegrí-Reiriz, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Taurón, Manel (Institut d'Investigació Biomèdica Sant Pau) ;
Tian, David H. (Macquarie University) ;
Pettersson, Gosta B. (Cleveland Clinic) ;
Coselli, Joseph S. (Texas Heart Institute) ;
Misfeld, Martin (University Department for Cardiac Surgery) ;
Antunes, Manuel J. (University of Coimbra Medical School) ;
Mestres, Carlos A. (The University of the Free State) ;
Quintana, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Infective endocarditis (IE) is an infection involving either native or prosthetic heart valves, the endocardial surface of the heart or any implanted intracardiac devices. IE is a rare condition affecting 3-15 patients per 100,000 population. [...]
2019 - 10.21037/acs.2019.10.03
Annals of Cardiothoracic Surgery, Vol. 8 Núm. 6 (2019) , p. 587-599
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9 p, 8.0 MB |
Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse
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Rapöhn, Inka (University of Leipzig) ;
Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Weiner, Juliane (University of Leipzig Medical Center) ;
Pujol, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kehr, Stephanie (Leipzig University) ;
Chadt, Alexandra (German Center for Diabetes Research) ;
Al-Hasani, Hadi (German Center for Diabetes Research) ;
Burkhardt, Ralph (University Hospital Regensburg) ;
Klöting, Nora (University of Leipzig) ;
Stumvoll, Michael (University of Leipzig) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kovacs, Peter (German Center for Diabetes Research) ;
Heiker, John T. (University of Leipzig Medical Center) ;
Breitfeld, Jana (Leipzig Medical Center)
Adipose tissue inflammation and insulin resistance are hallmarks in the development of metabolic diseases resulting from overweight and obesity, such as type 2 diabetes and non-alcoholic fatty liver disease. [...]
2023 - 10.3389/fendo.2023.1146454
Frontiers in Endocrinology, Vol. 14 (April 2023) , art. 1146454
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15 p, 2.6 MB |
Evidence mapping based on systematic reviews of therapeutic interventions for soft tissue sarcomas
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Ballesteros Silva, Mónica Patricia (C/Sant Antoni Maria Claret) ;
Montero, N. (Universidad Tecnológica Equinoccial) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Rada, Gabriel (Pontificia Universidad Católica de Chile) ;
Pardo-Hernandez, Hector (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bonfill, X. (Xavier) (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Soft tissue sarcomas are a heterogeneous group of rare tumours of mesenchymal origin. Evidence mapping is one of the most didactic and friendly approaches to organise and summarise the range of research activity in broad topic fields. [...]
2019 - 10.1007/s12094-019-02069-z
Clinical & Translational Oncology, Vol. 21 Núm. 10 (january 2019) , p. 1398-1412
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11 p, 1.5 MB |
Management of progressive pulmonary fibrosis associated with connective tissue disease
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Molina-Molina, María (Institut d'Investigació Biomèdica de Bellvitge) ;
Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Valenzuela, Claudia (Hospital La Princesa. Servicio de Neumología) ;
Ramirez, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez Portal, José Antonio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Franquet, Tomás (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Narváez, Javier (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona
Introduction: Fibrotic interstitial lung disease (ILD) is a frequent and severe complication of connective tissue disease (CTD). Areas covered: In this narrative review, we update the most relevant differential characteristics of fibrotic ILD associated with CTD (CTD-ILD) and propose a diagnostic and therapeutic approach based on a review of the articles published between 2002 and 2022 through PubMed. [...]
2022 - 10.1080/17476348.2022.2107508
Expert Review of Respiratory Medicine, Vol. 16 Núm. 7 (2022) , p. 765-774
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9 p, 3.8 MB |
Correlative radioimaging and mass spectrometry imaging : a powerful combination to study 14C-graphene oxide in vivo biodistribution
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Cazier, Hélène (Université Paris Saclay) ;
Malgorn, Carole (Université Paris Saclay) ;
Georgin, Dominique (Université Paris Saclay) ;
Fresneau, Nathalie (Université Paris Saclay) ;
Beau, Fabrice (Université Paris Saclay) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester) ;
Campidelli, Stéphane (Université Paris Saclay) ;
Pinault, Mathieu (Université Paris-Saclay) ;
Mayne-L'Hermite, Martine (Université Paris-Saclay) ;
Taran, Frédéric (Université Paris Saclay) ;
Junot, Christophe (Université Paris Saclay) ;
Fenaille, François (Université Paris Saclay) ;
Sallustrau, Antoine (Université Paris Saclay) ;
Colsch, Benoit (Université Paris Saclay)
Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the development of more efficient imaging techniques to track the fate of these materials. [...]
2023 - 10.1039/d2nr06753f
Nanoscale, Vol. 15, Issue 11 (March 2023) , p. 5510-5518
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