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1.
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9 p, 969.5 KB |
SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer (2018)
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Gómez-España, M.A. (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Gallego, J. (Hospital General Universitario de Elche) ;
González-Flores, E. (Hospital Universitario Virgen de las Nieves (Granada)) ;
Maurel, Joan (Hospital Clínic i Provincial de Barcelona) ;
Páez, David (Institut d'Investigació Biomèdica Sant Pau) ;
Sastre, J. (Hospital Clínico San Carlos (Madrid)) ;
Aparicio, J. (Hospital Universitari i Politècnic La Fe (València)) ;
Benavides Orgaz, Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Feliu, J. (Hospital Universitario La Paz (Madrid)) ;
Vera, R. (Complejo Hospitalario de Navarra) ;
Universitat Autònoma de Barcelona
Colorectal cancer (CRC) is the second cause of cancer death in Spain, the objective of this guide published by the Spanish Society of Medical Oncology is to develop a consensus for the diagnosis and management of metastatic disease. [...]
2019 -  10.1007/s12094-018-02002-w
Clinical & Translational Oncology, Vol. 21 Núm. 1 (25 2019) , p. 46-54
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2.
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6 p, 1.1 MB |
Human-driven global nutrient imbalances increase risks to health
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Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Human-induced inputs of nitrogen (N) and phosphorus (P) into the biosphere have reached unprecedented levels, particularly N, leading to an escalating global anthropogenic N:P ratio. This ratio has emerged as a significant driver of environmental change, impacting organisms, ecosystems, and global food security. [...]
2023 - 10.1016/j.eehl.2023.08.003
Eco-Environment & Health, Vol. 2, issue 4 (Dec. 2023) , p. 246-251
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3.
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9 p, 841.7 KB |
Addressing current challenges in optimization of lipid management following an ACS event : Outcomes of the ACS EuroPath III initiative
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Catapano, Alberico L. (University of Milan) ;
De Caterina, Raffaele (Città Sant'Angelo) ;
Jukema, J. Wouter (Netherlands Heart Institute) ;
Klempfner, Robert (Tel-Aviv University) ;
Landmesser, Ulf (Berlin Institute of Health (BIH)) ;
Schiele, François (University Hospital Jean Minjoz) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Low-density lipoprotein cholesterol (LDL-C) lowering is key to reduce atherosclerotic disease progression and recurrent events for patients after acute coronary syndrome (ACS). However, LDL-C management for post-ACS patients remains challenging in clinical practice. [...]
2023 - 10.1002/clc.23988
Clinical Cardiology, Vol. 46 (february 2023) , p. 407-415
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4.
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14 p, 533.6 KB |
Atherosclerosis, Cardiovascular Disease, and COVID-19 : A Narrative Review
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Vilaplana-Carnerero, Carles (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Giner-Soriano, Maria (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Domínguez, Ángela (Universitat de Barcelona) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Pericas, Carles (Universitat de Barcelona) ;
Álamo-Junquera, Dolores (Hospital Universitari Vall d'Hebron) ;
Toledo, Diana (Universitat de Barcelona) ;
Gallego, Carmen (Universitat de Barcelona) ;
Redondo, Ana (Hospital Universitari de Bellvitge) ;
Grau, Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Atherosclerosis is a chronic inflammatory and degenerative process that mainly occurs in large- and medium-sized arteries and is morphologically characterized by asymmetric focal thickenings of the innermost layer of the artery, the intima. [...]
2023 - 10.3390/biomedicines11041206
Biomedicines, Vol. 11 (april 2023)
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5.
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10 p, 2.2 MB |
Role of B Cell Profile for Predicting Secondary Autoimmunity in Patients Treated With Alemtuzumab
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Walo-Delgado, Paulette Esperanza (Hospital Universitario Ramón y Cajal (Madrid)) ;
Monreal, Enric (Hospital Universitario Ramón y Cajal (Madrid)) ;
Medina, Silvia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Quintana, Ester (Institut d'Investigació Biomèdica de Girona) ;
Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fernández-Velasco, José Ignacio (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lapuente, Paloma (Hospital Universitario Ramón y Cajal (Madrid)) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramió-Torrentà, Lluís (Institut d'Investigació Biomèdica de Girona) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villarrubia, Noelia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Carrasco-Sayalero, Angela (Hospital Universitario Ramón y Cajal (Madrid)) ;
Rodríguez-Martín, Eulalia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Roldán, Ernesto (Hospital Universitario Ramón y Cajal (Madrid)) ;
Meca-Lallana, José (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Alvarez-Lafuente, Roberto (Hospital Clínico San Carlos (Madrid)) ;
Masjuan, Jaime (Hospital Universitario Ramón y Cajal (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona
UDHEBRON.
To explore if baseline blood lymphocyte profile could identify relapsing remitting multiple sclerosis (RRMS) patients at higher risk of developing secondary autoimmune adverse events (AIAEs) after alemtuzumab treatment. [...]
2021 - 10.3389/fimmu.2021.760546
Frontiers in immunology, Vol. 12 (october 2021)
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6.
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17 p, 1.5 MB |
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
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Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
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7 p, 2.8 MB |
Direct observation of the chemical transformations in BiVO4 photoanodes upon prolonged light-aging treatments
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Arcas, Ramón (Universitat Jaume I. Institute of Advanced Materials) ;
Cardenas-Morcoso, Drialys (Luxembourg Institute of Science and Technology) ;
Spadaro, Maria Chiara (Institut Català de Nanociència i Nanotecnologia) ;
García-Tecedor, Miguel (Institutos Madrileño de Estudios Avanzados) ;
Mesa, Camilo A. (Universitat Jaume I. Institute of Advanced Materials) ;
Arbiol i Cobos, Jordi (Institut Català de Nanociència i Nanotecnologia) ;
Fabregat-Santiago, Francisco (Universitat Jaume I. Institute of Advanced Materials) ;
Giménez, Sixto (Universitat Jaume I. Institute of Advanced Materials) ;
Mas-Marzá, Elena (Universitat Jaume I. Institute of Advanced Materials)
Exposing BiVO photoanodes to light-aging treatments is known to produce a significant photocurrent enhancement. Until now, the interpretation given to this phenomenon is associated to the formation of oxygen vacancies and little is reported about chemical changes in the material. [...]
2022 - 10.1002/solr.202200132
Solar RRL, Vol. 6, issue 7 (July 2022) , art. 2200132
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19 p, 345.2 KB |
Fertility-Sparing Approaches in Atypical Endometrial Hyperplasia and Endometrial Cancer Patients : Current Evidence and Future Directions
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Contreras, Nayanar-Adela (Hospital El Pilar. Gynecology Department) ;
Sabadell, Jordi (Hospital Universitari Vall d'Hebron) ;
Verdaguer, Paula (Department of Gynaecology-ASSIR) ;
Julià, Carla (Hospital de Viladecans) ;
Fernández-Montolí, Maria-Eulalia (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona ;
Universitat de Barcelona ;
Institut d'Investigació Biomèdica de Bellvitge
Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. Although it is usually diagnosed in postmenopausal women, its incidence has increased in young women, as well in recent decades, with an estimated rate of 4% in those under 40 years of age. [...]
2022 - 10.3390/ijms23052531
International journal of molecular sciences, Vol. 23 núm 5 (february 2022)
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28 p, 2.4 MB |
Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases
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Di Giovanni, Giuseppe (University of Malta) ;
Svob Strac, Dubravka (Rudjer Boskovic Institute) ;
Sole, Montse (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Unzeta, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tipton, Keith F. (Trinity College Dublin) ;
Mück-Šeler, Dorotea (Rudjer Boskovic Institute Zagreb, Croatia) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Della Corte, Laura (University of Florence) ;
Nikolac Perkovic, Matea (Rudjer Boskovic Institute Zagreb, Croatia) ;
Pivac, Nela (Rudjer Boskovic Institute Zagreb, Croatia) ;
Smolders, Ilse J. (Vrije Universiteit Brussels, Belgium) ;
Stasiak, Anna (Medical University of Lodz, Poland) ;
Fogel, Wieslawa A. (Medical University of Lodz, Poland) ;
De Deurwaerdère, Philippe (Institut of Neurodegenerative Diseases Bordeaux Cedex, France)
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. [...]
2016 - 10.3389/fnins.2016.00541
Frontiers in Neuroscience, Vol. 10 (november 2016)
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10.
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8 p, 2.2 MB |
Surgical Options for Optic Disc Pit Maculopathy : Perspectives and Controversies
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Pastor-Idoate, Salvador (Red Temática de Investigación Cooperativa en Salud (RETICS), Oftared, Instituto de Salud Carlos III) ;
Garcia-Arumi, Claudia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Onrubia, Luis (Universidad de Valladolid) ;
Copete, Sergio (Complex University Hospital) ;
García Arumí, José (Universitat Autònoma de Barcelona)
Optic disc pit (ODP) is a rare congenital optic nerve head abnormality, which can be complicated by intraretinal and subretinal fluid at the macula (ODP-maculopathy) with progressive visual loss. The source of this fluid remains unclear and the most dominant hypotheses have pointed to vitreous cavity or cerebrospinal fluid. [...]
2020 - 10.2147/OPTH.S250921
Clinical Ophthalmology (Auckland, N.Z.), Vol. 14 (june 2020) , p. 1601-1608
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