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Safety profile of the adjuvanted recombinant zoster vaccine : Pooled analysis of two large randomised phase 3 trials / López Fauqued, Marta (GlaxoSmithKline (GSK)) ; Campora, Laura (GlaxoSmithKline (GSK)) ; Delannois, Frédérique (GlaxoSmithKline (GSK)) ; El Idrissi, Mohamed (GlaxoSmithKline (GSK)) ; Oostvogels, Lidia (GlaxoSmithKline (GSK)) ; De Looze, Ferdinandus (University of Queensland) ; Diez-Domingo, Javier (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (València)) ; Heineman, Thomas (GlaxoSmithKline (GSK)) ; Lal, Himal (GlaxoSmithKline (GSK)) ; McElhaney, Janet (Health Sciences North Research Institute) ; McNeil, Shelly (Dalhousie University) ; Yeo, Wilfred (University of Wollongong) ; Tavares-Da-Silva, Fernanda (GlaxoSmithKline (GSK)) ; Ahonen, Anitta (University of Tampere) ; Avelino-Silva, Thiago (University of São Paulo Medical School) ; Barba-Gomez, José Fernando (Instituto Dermatológico de Jalisco) ; Berglund, Johan (Blekinge Institute of Technology) ; Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ; Caso, Covadonga (Hospital Clínico San Carlos (Madrid)) ; Chlibek, Roman (University of Defence) ; Choi, Won Suk (Korea University College of Medicine) ; Cunningham, Anthony (University of Sydney) ; Desole, Maria Giuseppina (Servizio di Igiene Pubblica) ; Eizenberg, Peter (Doctors of Ivanhoe) ; Esen, Meral (University Clinic of Tübingen) ; Espié, Emmanuelle (GlaxoSmithKline (GSK)) ; Gervais, Pierre (Q&T Research Sherbrooke) ; Ghesquiere, Wayne (University of British Columbia) ; Godeaux, Olivier O. (GlaxoSmithKline (GSK)) ; Gorfinkel, Iris (York University) ; Hui, David Shu Cheong (Prince of Wales Hospital (Australia)) ; Hwang, Shinnjang (Taipei Veterans General Hospital and National Yang Ming University School of Medicine) ; Korhonen, Tiina (University of Tampere Medical School) ; Kovac, Martina (GlaxoSmithKline (GSK)) ; Ledent, Edouard Y. (GlaxoSmithKline (GSK)) ; Leung, Edward Man Fuk (Hong Kong Association of Gerontology) ; Levin, Myron (University of Colorado Anschutz Medical Campus) ; Perez, Silvia Narejos (CAP Centelles) ; de Andrade Neto, José Luiz (Instituto A. Z. de Pesquisa e Ensino) ; Pauksens, Karlis (Uppsala University Hospital) ; Poder, Airi (Kliiniliste Uuringute Keskus) ; Rodriguez de la Pinta, Maria Luisa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Rombo, Lars (Uppsala University) ; Schwarz, Tino Francis (Standort Juliusspital) ; Smetana, Jan (University of Defence) ; Staniscia, Tommaso (University G. d'Annunzio of Chieti-Pescara) ; Tinoco-Fávila, Juan Carlos (Hospital General de Durango) ; Toma, Azhar (Manna Research) ; Vastiau, Ilse (GlaxoSmithKline (GSK)) ; Vesikari, Timo H. (University of Tampere) ; Volpi, Antonio (A.O. Univesitaria Policlinico Tor Vergata) ; Watanabe, Daisuke (Kobe University Graduate School of Medicine) ; Weckx, Lily (Federal University of Sao Paulo) ; Zahaf, Toufik (GlaxoSmithKline (GSK)) ; Universitat Autònoma de Barcelona
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies. [...]
2019 - DOI (Digital Object Identifier)

10.1016/j.vaccine.2019.03.043
Vaccine, Vol. 37 Núm. 18 (24 2019) , p. 2482-2493

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