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Resultats globals: 5 registres trobats en 0.02 segons.
Articles, 4 registres trobats
Documents de recerca, 1 registres trobats
Articles 4 registres trobats  
1.
10 p, 2.1 MB Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents / Bellver-Sanchis, Aina (Universitat de Barcelona) ; Singh Choudhary, Bhanwar (Ganpat University) ; Companys-Alemany, Júlia (Universitat de Barcelona) ; Sukanya, None (Central University of Rajasthan) ; Ávila-López, Pedro A. (Northwestern University) ; Martínez Rodríguez, Antón Leandro (Universidade de Santiago de Compostela) ; Brea Floriani, Jose Manuel (Universidade de Santiago de Compostela) ; Malik, Ruchi (Central University of Rajasthan) ; Pallàs, Mercè (Universitat de Barcelona) ; Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Griñán-Ferré, Christian (Universitat de Barcelona)
G9a is a lysine methyltransferase able to di-methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post-translational modifications and effectively treat neurodegenerative diseases, like Alzheimer's disease (AD). [...]
2022 - 10.1002/cmdc.202200002
ChemMedChem, Vol. 17 (may 2022)  
Registre complet - Creative Commons
2.
14 p, 12.6 MB Rational Design of Hydrogels for Cationic Antimicrobial Peptide Delivery : A Molecular Modeling Approach / Pereira, Alfredo (Universidad de Chile) ; Valdés-Muñoz, Elizabeth (Universidad Católica del Maule) ; Marican, Adolfo (Universidad de Talca) ; Cabrera-Barjas, Gustavo (Universidad de Concepción) ; Vijayakumar, Sekar (Shandong University) ; Valdés, Oscar (Universidad Católica del Maule) ; Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Abaca, Paulina (Universidad de Talca. Instituto Ciencias Biologicas) ; Bustos, Daniel (Universidad Católica del Maule) ; Durán-Lara, Esteban F. (Universidad de Talca) ; Universitat Autònoma de Barcelona
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. [...]
2023 - 10.3390/pharmaceutics15020474
Pharmaceutics, Vol. 15 (january 2023)  
Registre complet - Creative Commons
3.
14 p, 3.0 MB Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation / De Luca, Laura (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences) ; Vittorio, Serena (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences) ; Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pitasi, Giovanna (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences) ; Fornt Suñé, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bucolo, Federica (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gitto, Rosaria (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences)
α-Synuclein (α-Syn) aggregates are implicated in Parkinson's disease (PD), so inhibitors of α-Syn aggregation have been intensively explored. It has been demonstrated that small molecules might be able to reduce α-Syn aggregation in fibrils, thus exerting neuroprotective effects in models of PD. [...]
2022 - 10.3390/ijms232314844
International journal of molecular sciences, Vol. 23, Issue 23 (November 2022) , art. 14844  
Registre complet - Creative Commons
4.
22 p, 4.6 MB Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors / Llinas del Torrent, Claudia (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Pérez-Benito, Laura (Computational Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V., Belgium) ; Tresadern, Gary (Computational Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V., Belgium)
Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors. [...]
2019 - 10.3390/molecules24061098
Molecules, Vol. 24 (march 2019)  
Registre complet - Creative Commons

Documents de recerca 1 registres trobats  
1.
153 p, 2.7 MB A virtual screening procedure combining pharmacophore filtering and molecular docking with the LIE method / Tunca, Guzin ; Daura i Ribera, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Actualment, el cribratge virtual juga un paper central en el món del descobriment de fàrmacs. L'anàlisi in silico permet el cribatge de milions de molècules petites i la tria de les més prometedores per a les proves experimentals. [...]
Virtual screening plays a central role in the world of drug discovery today. In silico testing allows to screen millions of small molecules and to choose only the most promising ones for experimental testing. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014  
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