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Resultats globals: 97 registres trobats en 0.04 segons.
Articles, 86 registres trobats
Contribucions a jornades i congressos, 1 registres trobats
Documents de recerca, 10 registres trobats
Articles 86 registres trobats  1 - 10següentfinal  anar al registre:
1.
14 p, 2.1 MB A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions / Eraña, Hasier (ATLAS Molecular Pharma S. L) ; Sampedro-Torres-Quevedo, Cristina (Basque Research and Technology Alliance) ; Charco, Jorge M. (ATLAS Molecular Pharma S. L) ; Díaz-Domínguez, Carlos M. (Instituto de Salut Carlos III. Centro de Investigación Biomédica en Red de Enfermedades infecciosas) ; Peccati, Francesca (Basque Research and Technology Alliance) ; San-Juan-Ansoleaga, Maitena (Basque Research and Technology Alliance) ; Vidal Barba, Enric (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ; Gonçalves-Anjo, Nuno (Basque Research and Technology Alliance) ; Pérez-Castro, Miguel A. (Basque Research and Technology Alliance) ; González-Miranda, Ezequiel (Basque Research and Technology Alliance) ; Piñeiro, Patricia (Basque Research and Technology Alliance) ; Fernández-Veiga, Leire (Basque Research and Technology Alliance) ; Galarza-Ahumada, Josu (Basque Research and Technology Alliance) ; Fernández-Muñoz, Eva (Basque Research and Technology Alliance) ; Pérez de Nanclares, Guiomar (Hospital Universitario de Araba Molecular (Epi)Genetics Laboratory) ; Telling, Glenn (Colorado State University. Prion Research Center) ; Geijo, Maria V (NEIKER-Basque Institute for Agricultural Research and Development) ; Jiménez-Osés, Gonzalo (Basque Foundation for Science) ; Castilla, Joaquín (Basque Foundation for Science)
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrP C) into a pathogenic form (PrP Sc). This process, despite being the central event underlying these disorders, remains largely unknown at a molecular level, precluding the prediction of new potential outbreaks or interspecies transmission incidents. [...]
2024 - 10.1038/s41467-024-46360-2
Nature communications, Vol. 15 (march 2024)  
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2.
11 p, 2.1 MB A glimpse into the structural properties of α-synuclein oligomers / Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
α-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson's disease is the most prevalent. [...]
2023 - 10.1002/biof.2021
BioFactors, (December 2023) , p. 1-11  
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3.
20 p, 3.7 MB A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation / Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bárcenas, Oriol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bartolomé-Nafría, Andrea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fornt Suñé, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona
The presence of insoluble protein deposits in tissues and organs is a hallmark of many human pathologies. In addition, the formation of protein aggregates is considered one of the main bottlenecks to producing protein-based therapeutics. [...]
2023 - 10.3390/biophysica3010001
Biophysica, Vol. 3 Núm. 1 (January 2023)  
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4.
11 p, 1.4 MB APOE ϵ4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease / Konijnenberg, Elles (Alzheimer Center Amsterdam) ; Tijms, Betty M. (Alzheimer Center Amsterdam) ; Gobom, Johan (University of Gothenburg) ; Dobricic, Valerija (University of Lübeck) ; Bos, Isabelle (Maastricht University) ; Vos, Stephanie (Maastricht University) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, Frans (Maastricht University) ; Popp, Julius (Lausanne University Hospital) ; Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Frölich, Lutz (University of Heidelberg) ; Lovestone, Simon (Janssen RandD) ; Streffer, Johannes (Janssen RandD) ; Bertram, Lars (University of Oslo) ; Blennow, Kaj (University of Gothenburg) ; Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ; Veerhuis, Robert (Vrije Universiteit Amsterdam) ; Smit, August B. (Vrije Universiteit Amsterdam) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Zetterberg, Henrik (UK Dementia Research Institute) ; Visser, Pieter Jelle (Karolinska Instutet) ; Universitat Autònoma de Barcelona
Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer's disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ϵ4 genotype plays a major role. [...]
2020 - 10.1186/s13195-020-00628-z
Alzheimer's research & therapy, Vol. 12 Núm. 1 (27 2020) , p. 65  
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5.
10 p, 1.9 MB A3DyDB : exploring structural aggregation propensities in the yeast proteome / Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Badaczewska-Dawid, Aleksandra E. (Iowa State University) ; Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Kuriata, Aleksander (University of Warsaw) ; Kmiecik, Sebastian (University of Warsaw) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes. [...]
2023 - 10.1186/s12934-023-02182-3
Microbial cell factories, Vol. 22, Issue 1 (September 2023) , art. 186  
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6.
10 p, 2.8 MB Functional consequences of Genetics variant in TMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing loss / Mutery, Abdullah (University of Sharjah. Department of Applied Biology) ; Mohamed, Kamal Eldin Walaa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mahfood, Mona (University of Sharjah. Department of Applied Biology) ; Chouchen, Jihen (University of Sharjah) ; Tlili, Abdelaziz (University of Sharjah. Research Institute of Sciences & Engineering)
Hearing loss (HL) is the most prevalent sensory disorder whose etiology comes from environmental and/or genetic factors. Approximately 60 % of HL cases are due to mutations in genes responsible for maintaining a normal hearing function. [...]
2023 - 10.1016/j.sjbs.2022.103520
Saudi Journal of Biological Sciences, Vol. 30, Issue 2 (February 2023) , art. 103520  
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7.
34 p, 4.0 MB Development of Small Molecules Targeting α-Synuclein Aggregation : A Promising Strategy to Treat Parkinson's Disease / Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Parkinson's disease, the second most common neurodegenerative disorder worldwide, is characterized by the accumulation of protein deposits in the dopaminergic neurons. These deposits are primarily composed of aggregated forms of α-Synuclein (α-Syn). [...]
2023 - 10.3390/pharmaceutics15030839
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 839  
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8.
15 p, 764.0 KB Can Electronegative LDL Act as a Multienzymatic Complex? / Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ; Puig Grifol, Núria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rives, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Solé, Arnau (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sanchez-Quesada, Jose Luis (Instituto de Salud Carlos III)
Electronegative LDL (LDL(−)) is a minor form of LDL present in blood for which proportions are increased in pathologies with increased cardiovascular risk. In vitro studies have shown that LDL(−) presents pro-atherogenic properties, including a high susceptibility to aggregation, the ability to induce inflammation and apoptosis, and increased binding to arterial proteoglycans; however, it also shows some anti-atherogenic properties, which suggest a role in controlling the atherosclerotic process. [...]
2023 - 10.3390/ijms24087074
International journal of molecular sciences, Vol. 24, Num. 8 (April 2023) , art. 7074  
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9.
35 p, 2.0 MB Optimal Decision Rules for the Discursive Dilemma / Alabert, Aureli (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Farré, Mercè (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Montes, Rubén (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
We consider the classical problem in truth-tracking judgment aggregation of a conjunctive agenda with two premisses and one conclusion. We study this problem from the point of view of finding the best decision rule according to a quantitative criterion, under very mild restrictions on the set of admissible rules. [...]
2023 - 10.1007/s10726-023-09828-y
Group Decision and Negotiation, Vol. 32, Issue 4 (August 2023) , p. 889-923  
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10.
13 p, 4.6 MB Aβ40 Aggregation under Changeable Conditions / Curto, Jofre Seira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Benseny Cases, Núria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Homeostasis is crucial for cell function, and disturbances in homeostasis can lead to health disorders. Under normal conditions, intracellular pH is maintained between 7. 35 and 7. 45. Altered endosomal and lysosomal pH together with a general drop in brain pH are associated with the aggregation of amyloid-β-peptide (Aβ) and the development of Alzheimer's disease. [...]
2023 - 10.3390/ijms24098408
International journal of molecular sciences, Vol. 24, Issue 9 (May 2023) , art. 8408  
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Articles : 86 registres trobats   1 - 10següentfinal  anar al registre:
Contribucions a jornades i congressos 1 registres trobats  
1.
51 p, 394.4 KB On the measurement of multidimensional poverty in multiple domain contexts / Permanyer, Iñaki
We develop the measurement of multidimensional poverty for the case in which the different dimensions taken into account are partitioned in several domains-an issue with crucial implications for the identification and aggregation of the poor which has been neglected in the literature. [...]
2016
Meeting of the Society for Social Choice and Welfare. Lund (Suècia), 13è : 2016  
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Documents de recerca 10 registres trobats  
1.
19.9 MB Structural biology of α-synuclein toxic oligomers : Design of peptide ligands and architecture elucidation / Santos, Jaime ; Pallarès i Goitiz, Irantzu, dir. ; Ventura Zamora, Salvador, dir.
L'agregació de l'alfa-sinucleïna (αS) és la principal característica neurològica d'un grup de trastorns neurodegeneratius debilitants, coneguts col·lectivament com a sinucleinopaties, dels quals la malaltia de Parkinson és la més freqüent. [...]
La agregación de la alfa-sinucleína (αS) es la principal característica neurológica de un grupo de trastornos neurodegenerativos debilitantes, conocidos colectivamente como sinucleinopatías, de los cuales la enfermedad de Parkinson es la más frecuente. [...]
α-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson's disease is the most prevalent. [...]
2023  
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2.
28 p, 242.1 KB Opinion aggregation : borda and condorcet revisited / Barberà, Salvador 1946- (Universitat Autònoma de Barcelona.) ; Bossert, Walter (University of Montreal)
In a world admitting a fixed finite set of alternatives, an opinion is an ordered pair of alternatives. Such a pair expresses the idea that one alternative is superior to another in some sense, and an opinion aggregator assigns an aggregate relation on the set of alternatives to every possible state of opinion. [...]
Barcelona Barcelona School of Economics, 2022 (BSE working paper ; 1262)
BSE Barcelona School of Economics Working Papers, 2022  
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3.
360 p, 15.4 MB Development of New Fluorophore-Tethered ortho-Carborane Systems : An Approach for Unique Photophysics and Applications / Sinha, Sohini ; Nuñez Aguilera, Maria Rosario, dir.
El treball que es presenta en aquest manuscrit segueix línies de recerca iniciades al Grup de Catàlisi i Síntesi Inorgànica (LMI) de l'Institut de Ciències de Materials de Barcelona (ICMAB-CSIC), basades en la síntesi, caracterització i estudi de nous derivats de clústers de bor amb propietats fotoluminiscents. [...]
El trabajo que se presenta en este manuscrito sigue líneas de investigación iniciadas en el Grupo de Catálisis y Síntesis Inorgánica (LMI) del Instituto de Ciencias de Materiales de Barcelona (ICMAB-CSIC), basadas en la síntesis, caracterización y estudio de nuevos derivados de clústeres de boro con propiedades fotoluminiscentes. [...]
The work presented in this manuscript follows with research lines initiated in the Catalysis and Inorganic Synthesis Group (LMI) at Institute of Material Sciences of Barcelona (ICMAB-CSIC), based on the synthesis, characterization and study of new boron cluster derivatives with photoluminescent properties and their potential applications. [...]
2022  
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4.
194 p, 7.0 MB Bioinformatic analysis on the determinants of protein aggregation and conformational conversion / Iglesias Mas, Valentín ; Ventura Zamora, Salvador, dir.
L'agregació de proteïnes ha passat de ser gairebé una curiositat biofísica sense major interès a un dels camps més actius de la recerca, especialment des que es va esbrinar que podia ser la causa de diverses malalties en humans. [...]
La agregación de proteínas ha pasado de ser prácticamente una curiosidad biofísica sin mayor interés a uno de los campos más activos de la investigación, especialmente desde que se dilucidó como el causante de diversas enfermedades en humanos. [...]
Protein aggregation has moved from being an almost neglected biophysical curiosity to a central research field mostly due to aggregating proteins causing debilitating conditions in humans. The aggregation propensity of polypeptidic sequences is primarily dictated by their amino acid sequence, which delimits the possible interactions between amino acids. [...]
2021  
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5.
1 p, 2.4 MB The amyloid state, an unexploited resource / Fornt Suñé, Marc ; Universitat Autònoma de Barcelona. Facultat de Biociències
2020
Grau en Bioquímica [814]  
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6.
1 p, 10.8 MB Deciphering hIAPP : a novel way to cure diabetes / Ruiz López, Iñigo ; Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Human islet amyloid polypeptide (hIAPP) is produced by pancreatic β-cells and is involved in type-II diabetes mellitus (T2DM) pathogenesis. In T2DM, the loss of pancreatic β-cell mass is accompanied by the accumulation of amyloid deposits of hIAPP. [...]
2019-05-29
Grau en Biotecnologia [815]  
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7.
1 p, 410.9 KB DJ-1, a possible therapeutic target against Parkinson's disease / Oliva Vilarnau, Núria ; Yuste Mateos, Víctor J. (Víctor José), , dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Biotecnologia [815]  
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8.
171 p, 3.7 MB Analysis of different evolutionary strategies to prevent protein aggregation / Graña Montes, Ricardo ; Ventura, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
En els darrers 15 anys, l'estudi de l'agregació de proteïnes ha evolucionat de ser una part de la química de proteïnes que tradicionalment generava poc interès, a convertir-se en una àrea d'investigació dinàmica que ha ampliat el seu abast a diferents camps de recerca incloenthi la bioquímica, la biotecnologia, la nanotecnologia y la biomedicina. [...]
In the last 15 years, the study of protein aggregation has evolved from a mostly neglected topic of protein chemistry to a highly dynamic research area which has expanded its implications through different fields including biochemistry, biotechnology, nanotechnology and biomedicine. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014  
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9.
199 p, 6.0 MB Characterization of intracellular protein aggregates / Villar i Piqué, Anna ; Ventura, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Durant les últimes dècades, l'agregació de proteïnes ha esdevingut un tema d'investigació molt dinàmic que s'estén transversalment per diferents camps de recerca, incloent la bioquímica, la biotecnologia, la biomedicina i la nanotecnologia. [...]
During the last decades, protein aggregation has become a dynamic research topic extending across distinct investigation fields, including biochemistry, biotechnology, biomedicine and nanotechnology. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2013  
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10.
39 p, 341.1 KB Heterogeneous dynamics, aggregation and the persistence of economic shocks / Mayoral, Laura ; Universitat Autònoma de Barcelona. Unitat de Fonaments de l'Anàlisi Econòmica ; Institut d'Anàlisi Econòmica
It has been recently emphasized that, if individuals have heterogeneous dynamics, estimates of shock persistence based on aggregate data are significatively higher than those derived from its disaggregate counterpart. [...]
2009 (Working papers ; 786.09)  
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