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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 -  10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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11 p, 897.0 KB |
Insights into the light-driven hydrogen evolution reaction of mesoporous graphitic carbon nitride decorated with Pt or Ru nanoparticles
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Álvarez Prada, Luis Ignacio (Universitat Autònoma de Barcelona. Departament de Química) ;
Nguyen, Anh Dung (Technische Universität Berlin. Department of Chemistry) ;
Romero Fernández, Nuria (Universitat Autònoma de Barcelona. Departament de Química) ;
Hou, Heting (Universitat Autònoma de Barcelona. Departament de Química) ;
Benazzi, Elisabetta (Università degli Studi di Ferrara. Dipartimento di Scienze Chimiche, Farmaceutiche ed Agrarie) ;
Escriche Martínez, Lluís (Universitat Autònoma de Barcelona. Departament de Química) ;
Acharjya, Amitava (Technische Universität Berlin. Institut of Chemistry) ;
Thomas, Arne (Technische Universität Berlin. Institut of Chemistry) ;
Schwarze, Michael (Technische Universität Berlin. Department of Chemistry) ;
Schomäcker, Reinhard (Technische Universität Berlin. Department of Chemistry) ;
Sala Román, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Natali, Mirco (Università degli Studi di Ferrara. Dipartimento di Scienze Chimiche, Farmaceutiche ed Agrarie) ;
García-Antón, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Tasbihi, Minoo (Technische Universität Berlin. Department of Chemistry)
Ru or Pt nanoparticles have been prepared following the organometallic approach and deposited onto the surface of mesoporous graphitic carbon nitride (mpg-CN). Three different Ru-based samples have also been compared to investigate the effect of 4-phenylpyridine as a stabilizing agent. [...]
2022 - 10.1039/d1dt03006j
Dalton transactions, Vol. 51, issue 2 (January 2022) , p. 731-740
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13 p, 1.1 MB |
IgG4 Valency Modulates the Pathogenicity of Anti-Neurofascin-155 IgG4 in Autoimmune Nodopathy
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Jentzer, Alexandre (Department of Immunology. CHU Montpellier) ;
Attal, Arthur (Department of Neurology. CHU Montpellier. Hôpital Gui de Chauliac) ;
Roué, Clémence (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Raymond, Julie (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ;
Illa, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Taieb, Guillaume (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Devaux, Jérôme (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Universitat Autònoma de Barcelona
Background and Objective s : IgG4 autoantibodies to neurofascin-155 (Nfasc155) are associated with a subgroup of patients with chronic inflammatory demyelinating polyneuropathy (CIDP), currently named autoimmune nodopathy. [...]
2022 - 10.1212/NXI.0000000000200014
Neurology® neuroimmunology & neuroinflammation, Vol. 9 Núm. 5 (october 2022) , p. e200014
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12 p, 120.4 KB |
Žižek and the Kantian gesture : Parallax and beyond
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Harman, Graham (Southern California Institute of Architecture)
Early in his 1993 book Tarrying with the Negative, Slavoj Žižek asks contemporary philosophy to "repeat the Kantian gesture. " The implication is that (much like Plato did with the Sophists) Kant accepted the critique of metaphysics made by David Hume, affirming it in an unexpected positive sense. [...]
A principis del seu llibre de 1993 Tarrying with the negative, Slavoj Žižek demana a la filosofia contemporània que «repeteixi el gest kantià». La implicació és que Kant (com va fer Plató amb els sofistes) va acceptar la crítica de la metafísica feta per David Hume afirmant-la en un sentit positiu inesperat. [...]
Al principio de su libro de 1993 Tarrying with the negative, Slavoj Žižek pide a la filosofía contemporánea que «repita el gesto kantiano». La implicación es que Kant (como hizo Platón con los sofistas) aceptó la crítica de la metafísica hecha por David Hume al afirmarla en un sentido positivo inesperado. [...]
2023 - 10.5565/rev/enrahonar.1423
Enrahonar, Vol. 70 (2023) , p. 119-130 (Articles)
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27 p, 3.4 MB |
T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells
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Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oliver-Caldés, Aina (Hospital Clínic i Provincial de Barcelona) ;
Suárez Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Lozano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Bosch i Crespo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez Cibrián, Núria (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Moreno, David F. (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández de Larrea, Carlos (Universitat de Barcelona)
Autologous cell immunotherapy using B cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells is an effective novel treatment for multiple myeloma (MM). This therapy has only been used for relapsed and refractory patients, at which stage the endogenous T cells used to produce the CAR-T cells are affected by the immunosuppressive nature of advanced MM and/or side effects of previous therapies. [...]
2022 - 10.1016/j.omtm.2022.06.010
Molecular Therapy. Methods & Clinical Development, Vol. 26 (august 2022) , p. 207-223
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Mapping the Interface of a GPCR Dimer : A Structural Model of the A Adenosine and D Dopamine Receptor Heteromer
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Borroto-Escuela, Dasiel O. (Karolinska Institutet (Estocolm, Suècia) ;
Rodriguez, David (Science for Life Laboratory, Stockholm University) ;
Romero-Fernandez, Wilber (Uppsala University) ;
Kapla, Jon (Uppsala University) ;
Jaiteh, Mariama (Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University) ;
Ranganathan, Anirudh (Stockholm University) ;
Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fuxe, Kjell (Karolinska Institutet (Estocolm, Suècia)) ;
Carlsson, Jens (Uppsala University)
The A adenosine (AR) and D dopamine (DR) receptors form oligomers in the cell membrane and allosteric interactions across the AR-DR heteromer represent a target for development of drugs against central nervous system disorders. [...]
2018 - 10.3389/fphar.2018.00829
Frontiers in Pharmacology, Vol. 9 (august 2018)
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