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40 p, 6.4 MB |
Roadmap on nanomedicine for the central nervous system
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Ciofani, Gianni (Italian Institute of Technology) ;
Campisi, Marco (Polytechnic University of Turin) ;
Mattu, Clara (Polytechnic University of Turin) ;
Kamm, Roger D. (Massachusetts Institute of Technology) ;
Chiono, Valeria (Polytechnic University of Turin) ;
Raynold, Aji Alex Moothedathu (University of Coimbra) ;
Freitas, João S. (University of Coimbra) ;
Redolfi Riva, Eugenio (Scuola Superiore Sant'Anna) ;
Micera, Silvestro (Scuola Superiore Sant'Anna) ;
Pucci, Carlotta (Italian Institute of Technology) ;
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Sierri, Giulia (University of Milano-Bicocca) ;
Re, Francesca (University of Milano-Bicocca) ;
Wunderlich, Hannah (Technical University of Munich) ;
Kumari, Prachi (Technical University of Munich) ;
Kozielski, Kristen L. (Technical University of Munich) ;
Chami, Mounia (Institut de Pharmacologie Moléculaire et Cellulaire) ;
Marino, Attilio (Italian Institute of Technology) ;
Ferreira, Lino (University of Coimbra) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. [...]
2023 -  10.1088/2515-7639/acab88
JPhys materials, Vol. 6, Issue 2 (April 2023) , art. 22501
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16 p, 1.8 MB |
Development of Fortified Breads Enriched with Plant-Based Bioactive Peptides Derived from the Chia (Salvia hispanica L.) Expeller
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Ozón, Brenda (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Geier, Florencia R. (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Kise, M. Paula (Universidad Nacional de Luján. Departamento de Ciencias Básicas) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parisi, Mónica G. (Universidad Nacional de Luján. Departamento de Ciencias Básicas) ;
Obregón, W. David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
By-products from the industrialization of oilseeds, particularly chia, can be sustainably used for the development of new functional products. In this work, wheat breads supplemented with up to 10 mg of chia expeller hydrolysate/g of flour were prepared, obtaining fortified breads with acceptability for consumption, according to a preliminary consumer research study based on an affective test employing a five-point hedonic scale of global acceptance. [...]
2023 - 10.3390/foods12183382
Foods, Vol. 12, Issue 18 (September 2023) , art. 3382
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23 p, 5.3 MB |
Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum
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Roca, Carlota (Universitat de Barcelona) ;
Avalos-Padilla, Yunuen (Universitat de Barcelona) ;
Prieto-Simón, Beatriz (Institució Catalana de Recerca i Estudis Avançats) ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ramírez, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Imperial, Santiago (Universitat de Barcelona) ;
Fernàndez-Busquets, Xavier (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for malaria parasites and also for several human pathogenic bacteria, thus representing an interesting target for future antimalarials and antibiotics and for diagnostic strategies. [...]
2022 - 10.3390/pharmaceutics14112515
Pharmaceutics, Vol. 14, Num. 11 (November 2022) , art. 2515
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37 p, 16.6 MB |
Marine Invertebrates : A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families
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Pascual Alonso, Isel (University of Havana. Center for Protein Studies) ;
Almeida García, Fabiola (University of Havana. Center for Protein Studies) ;
Valdés Tresanco, Mario Ernesto (University of Calgary. Department of Biological Sciences) ;
Arrebola Sánchez, Yarini (University of Havana. Center for Protein Studies) ;
Ojeda del Sol, Daniel (University of Havana. Center for Protein Studies) ;
Sánchez Ramírez, Belinda (Centro de Inmunología Molecular) ;
Florent, Isabelle (Muséum National d'Histoire Naturelle) ;
Schmitt, Marjorie (Université de Strasbourg) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes. [...]
2023 - 10.3390/md21050279
Marine drugs, Vol. 21, Issue 5 (April 2023) , art. 279
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13 p, 2.0 MB |
A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds : Uncovering Its Dual Antifungal and Hypoglycemic Properties
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Cotabarren, Juliana (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Ozón, Brenda (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Claver, Santiago (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Geier, Florencia (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Rossotti, Martina (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. [...]
2023 - 10.3390/pharmaceutics15030781
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 781
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14 p, 13.3 MB |
Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1 : Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
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García Viloca, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P3) independent manner. [...]
2022 - 10.1021/acsomega.2c02020
ACS omega, Vol. 7, Issue 29 (July 2022) , p. 25186-25199
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27 p, 943.8 KB |
Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages
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Morales, Kevin (Universitat Autònoma de Barcelona. Departament de Química) ;
Samper, Katia G. (Universitat Autònoma de Barcelona. Departament de Química) ;
Peña, Quim (Universitat Autònoma de Barcelona. Departament de Química) ;
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez-Diéguez, Antonio (Universidad de Granada. Departamento de Química Inorgánica) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayón, Joan Carles (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. [...]
2018 - 10.1021/acs.inorgchem.8b02854
Inorganic chemistry, Vol. 57, Issue 24 (December 2018) , p. 15517-15525
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302 p, 19.7 MB |
Nuevos mecanismos de control en la homeostasis de dNTPs mitocondriales : Papel de la proteína NDUFA10 en la disponibilidad de dGTP
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Molina Granada, David ;
Cámara Navarro, Yolanda, dir. ;
Martí Seves, Ramon, dir. ;
Meseguer Navarro, Anna, dir. ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Els mitocondris necessiten mantenir un contingut en dNTPs adequat per a garantir els processos de replicació i reparació del mtDNA. Per tal d'assegurar la disponibilitat d'aquests dNTPs, les cèl·lules eucariotes disposen de dues vies anabòliques diferenciades: la síntesi de novo i la ruta de salvament. [...]
Las mitocondrias necesitan mantener un contenido en dNTPs adecuado para garantizar los procesos de replicación y reparación del DNA mitocondrial (mtDNA). Para asegurar la disponibilidad de estos dNTPs, las células eucariotas disponen de dos vías anabólicas diferenciadas: la síntesis de novo y la ruta de salvamento de dNTPs. [...]
For the mitochondria it is essential to maintain a dNTP pool that is in an adequate quantity and proportion to guarantee mitochondrial DNA (mtDNA) replication and repair processes. In order to ensure the availability of these dNTPs, eukaryotic cells have two differentiated anabolic pathways: the de novo synthesis and the salvage pathway, both of which are tightly regulated. [...]
2021
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12 p, 1.5 MB |
Purification and identification of novel antioxidant peptides isolated from geoffroea decorticans seeds with anticoagulant activity
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Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Ozón, Brenda (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Claver, Santiago (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Geoffroea decorticans is a xerophilous deciduous tree present in most arid forests of southern South America, which is commonly used in traditional medicine. The seeds of this tree have been previously investigated for their singular chemical composition, but their protein content has been poorly investigated. [...]
2021 - 10.3390/pharmaceutics13081153
Pharmaceutics, Vol. 13, Issue 8 (August 2021) , art. 1153
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