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17 p, 1000.0 KB The Induction of heme oxygenase 1 decreases painful diabetic neuropathy and enhances the antinociceptive effects of morphine in diabetic mice / Castany, Sílvia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Carcolé, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if treatment with an heme oxygenase 1 (HO-1) inducer, cobalt protoporphyrin IX (CoPP), could modulate the allodynia and hyperalgesia induced by diabetes and enhanced the antinociceptive effects of morphine. [...]
2016 - 10.1371/journal.pone.0146427
PloS one, Vol. 11, Issue 1 (2016) , p. e0146427  
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