Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)

The Institut Germans Trias i Pujol (IGTP) is a CERCA centre, a public research centre devoted to the improvement of people’s health through the generation of scientific knowledge and its transfer. Recognised as an excellence centre by the Instituto de Salud Carlos III, it conveys the research activity of the Germans Trias I Pujol hospital (HUGTP). IGTP is located at the Can Ruti Campus in Badalona, where it is strongly connected with the other research institutions composing the campus: Institut Català d’Oncologia (ICO), Institut de Recerca de la Sida IrsiCaixa, Universitat Autònoma de Barcelona (UAB), Institut Guttmann, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Fundació Lluita contra la Sida (FLS), Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Banc de Sang i Teixits (BST) and Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT).

The research activity at IGTP covers 8 areas, producing around 500 publication per year on renowned scientific journals. The areas are: Behavioural sciences and drug abuse; Immunology and inflammation; Heart, vascular and respiratory diseases; Infectious diseases; Endocrine-metabolic, bone and renal diseases; Liver and digestive system; Cancer; Neurosciences. Moreover the institute has several technological facilities providing essential support to the researchers.

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2020-05-15
13:00
13 p, 1.5 MB Impaired Phagocytosis in Dendritic Cells From Pediatric Patients With Type 1 Diabetes Does Not Hamper Their Tolerogenic Potential / Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Murillo, Marta (Hospital Universitari Germans Trias i Pujol) ; Villalba Felipe, Adrián (Hospital Universitari Germans Trias i Pujol) ; Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bel, Joan (Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance to self-antigens, but they can also prompt an immunogenic response against them, leading to autoimmunity. [...]
2019 - 10.3389/fimmu.2019.02811
Frontiers in immunology, Vol. 10 (November 2019) , art. 2811  
2020-05-08
18:36
2 p, 41.7 KB Use of antiviral drugs to reduce COVID-19 transmission / Mitjà, Oriol (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
2020 - 10.1016/S2214-109X(20)30114-5
The Lancet Global Health, Vol. 8 Núm. 5 (may 2020) , p. e639-e640  
2020-05-06
11:04
9 p, 240.3 KB Review : Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19) / Pastick, Katelyn A. (Department of Medicine. University of Minnesota) ; Okafor, Elizabeth C. (Department of Medicine. University of Minnesota) ; Wang, Fan (Department of Experimental and Clinical Pharmacology. University of Minnesota) ; Lofgren, Sarah M. (Department of Medicine. University of Minnesota) ; Skipper, Caleb P. (Department of Medicine. University of Minnesota) ; Nicol, Melanie R. (Department of Experimental and Clinical Pharmacology. University of Minnesota) ; Pullen, Matthew F. (Department of Medicine. University of Minnesota) ; Rajasingham, Radha (Department of Medicine. University of Minnesota) ; McDonald, Emily G. (Clinical Practice Assessment Unit. Department of Medicine. McGill University Health Centre) ; Lee, Todd C. (Clinical Practice Assessment Unit. Department of Medicine. McGill University Health Centre) ; Schwartz, Ilan S. (Division of Infectious Diseases. Department of Medicine. Faculty of Medicine and Dentistry. University of Alberta) ; Kelly, Lauren E. (Department of Pediatrics and Child Health. Department of Pharmacology. University of Manitoba) ; Lother, Sylvain A. (Department of Medicine. Sections of Critical Care and Infectious Diseases. University of Manitoba) ; Mitjà, Oriol (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Letang, Emili (ISGlobal. Barcelona Institute for Global Health. Universitat de Barcelona) ; Abassi, Mahsa (Department of Medicine. University of Minnesota) ; Boulware, David R. (Department of Medicine. University of Minnesota)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. [...]
2020 - 10.1093/ofid/ofaa130
Open Forum Infectious Diseases, Vol. 7 Núm. 4 (16 2020) , p. ofaa130  
2020-04-15
12:14
19 p, 2.6 MB Pharmacological modulation of SAMHD1 activity by CDK4/6 inhibitors improves anticancer therapy / Castellví, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ezeonwumelu, Ifeanyi Jude (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Garcia-Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Clotet, Bonaventura (Health Research Institute Germans Trias i Pujol (IGTP). Hospital Germans Trias i Pujol. Universitat Autònoma de Barcelona) ; Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase involved in the regulation of the intracellular dNTP pool, linked to viral restriction, cancer development and autoimmune disorders. [...]
2020 - 10.3390/cancers12030713
Cancers, Vol. 12 Núm. 3 (march 2020) , p. 713  
2019-10-07
04:01
9 p, 1.7 MB Switching From a Protease Inhibitor-based Regimen to a Dolutegravir-based Regimen : A Randomized Clinical Trial to Determine the Effect on Peripheral Blood and Ileum Biopsies From Antiretroviral Therapy-suppressed Human Immunodeficiency Virus-infected Individuals / Morón-López, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Navarro, Jordi (Institut de Recerca Vall d'Hebron) ; Jimenez, Montse (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rutsaert, Sofie (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Torrella, Ariadna (Hospital Universitari Vall d'Hebron) ; De Clercq, Laura (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ; Ribas, Bibiana Planas (,Hospital Universitari Vall d'Hebron) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Vandekerckhove, Linos (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ; Blanco, Julià (University of Vic-Central University of Catalonia) ; Crespo, Manel (Infectious Diseases Unit, Internal Medicine Department, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Sanitaria Galicia Sur) ; Martinez-Picado, Javier (Catalan Institution for Research and Advanced Studies) ; Universitat Autònoma de Barcelona
Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted protease inhibitor (PI/r)-based therapy to dolutegravir (DTG)-based therapy. [...]
2018 - 10.1093/cid/ciy1095
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Vol. 69 (december 2018) , p. 1320-1328  
2019-10-07
04:01
25 p, 2.8 MB Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages / Bejarano, David Alejandro (Department of Infectious Diseases, Virology. University of Heidelberg. Heidelberg, Germany) ; Puertas, Maria C. (Universitat Autònoma de Barcelona. Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Börner, Kathleen (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany) ; Martinez-Picado, Javier (Catalan Institution for Research and Advanced Studies (ICREA). Barcelona, Spain) ; Müller, Barbara (Department of Infectious Diseases, Virology, University of Heidelberg. Heidelberg, Germany) ; Kräusslich, Hans-Georg (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany)
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. [...]
2018 - 10.3390/v10110620
Viruses, Vol. 10 (november 2018)  
2019-08-19
04:01
15 p, 955.9 KB SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018) / Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Juan, O. (Hospital Universitari i Politècnic La Fe) ; Insa, A. (Hospital Clínico Universitario de Valencia) ; Reguart, N. (Universitat de Barcelona. Hospital Clínic) ; Trigo, J. M. (Hospital Universitario Virgen de la Victoria) ; Carcereny, E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García-Campelo, R. (Complexo Hospitalario Universitario A Coruña) ; García, Y. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Guirado, M. (Hospital General Universitario de Elche. Medical Oncology Department) ; Provencio, M. (Universidad Autónoma de Madrid.Hospital Universitario Puerta de Hierro)
Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular knowledge; so, more options can be offered to patients with driver mutations. [...]
2018 - 10.1007/s12094-018-1978-1
Clinical & Translational Oncology, Vol. 21 (november 2018) , p. 3-17  
2019-08-12
04:03
15 p, 676.0 KB Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers / Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fernández, Marco A. (Institut Germans Trias i Pujol) ; Cobarsi, Patricia (Institut Germans Trias i Pujol) ; Crespo, Manel (Complexo Hospitalario Universitario de Vigo) ; Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford,) ; del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ; Alcami, José (Instituto de Salud Carlos III, Madrid) ; Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)  
2019-08-12
04:03
12 p, 710.3 KB Pazopanib : Evidence review and clinical practice in the management of advanced renal cell carcinoma / Méndez-Vidal, María José (Hospital Reina Sofía, Córdoba) ; Molina, Áurea (Complejo Hospitalario Universitario A Coruña) ; Anido, Urbano (Complejo Hospitalario Universitario de Santiago) ; Chirivella, Isabel (Hospital Clínico Universitario de Valencia) ; Etxaniz, Olatz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fernández-Parra, Eva (Hospital Nuestra Señora del Valme) ; Guix, Marta (Hospital del Mar) ; Hernández, Carolina (Hospital Universitario Nuestra Señora de Candelaria) ; Lambea, Julio (Hospital Clínico Universitario Lozano Blesa) ; Montesa, Álvaro (Hospital Regional de Málaga) ; Pinto, Álvaro (Hospital la Paz) ; Ros, Silverio (Hospital Universitario Virgen de la Arrixaca) ; Gallardo, Enrique (Parc Taulí Hospital Universitari) ; Universitat Autònoma de Barcelona
Pazopanib is indicated in the first-line treatment of metastatic renal cell cancer (mRCC). The aim of this study was to review the efficacy, safety, and pharmacokinetics of pazopanib and see how these aspects are linked to clinical practice. [...]
2018 - 10.1186/s40360-018-0264-8
BMC Pharmacology & Toxicology, Vol. 19 (november 2018)  
2019-08-12
04:03
5 p, 173.0 KB Circulating levels of 423-5p are associated with 90 day mortality in cardiogenic shock / Jäntti, Toni (Department of Internal Medicine, University of Helsinki and Helsinki University Hospital) ; Segersvärd, Heli (Minerva Foundation Institute for Medical Research and University of Helsinki) ; Tolppanen, Heli (Department of Cardiology, University of Helsinki and Heart and Lung Center, Helsinki University Hospital) ; Tarvasmäki, Tuukka (Department of Cardiology, University of Helsinki and Heart and Lung Center, Helsinki University Hospital) ; Lassus, Johan (Department of Cardiology, University of Helsinki and Heart and Lung Center, Helsinki University Hospital) ; Devaux, Yvan (Luxembourg Institute of Health) ; Vausort, Mélanie (Luxembourg Institute of Health) ; Pulkki, Kari (Department of Clinical Chemistry, University of Eastern Finland and Eastern Finland Laboratory Centre (ISLAB)) ; Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ; Bayes-Genis, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Tikkanen, Ilkka (Division of Nephrology, University of Helsinki and Abdominal Center, Division of Nephrology, Helsinki University Hospital) ; Lakkisto, Päivi (Department of Clinical Chemistry, University of Helsinki and Department of Clinical Chemistry, Helsinki University Hospital) ; Harjola, Veli-Pekka (Division of Emergency Medicine, University of Helsinki and Department of Emergency Medicine and Services, Helsinki University Hospital) ; Universitat Autònoma de Barcelona. Departament de Medicina
The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. [...]
2018 - 10.1002/ehf2.12377
ESC Heart Failure, Vol. 6 (november 2018) , p. 98-102