Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)

The Institut Germans Trias i Pujol (IGTP) is a CERCA centre, a public research centre devoted to the improvement of people’s health through the generation of scientific knowledge and its transfer. Recognised as an excellence centre by the Instituto de Salud Carlos III, it conveys the research activity of the Germans Trias I Pujol hospital (HUGTP). IGTP is located at the Can Ruti Campus in Badalona, where it is strongly connected with the other research institutions composing the campus: Institut Català d’Oncologia (ICO), Institut de Recerca de la Sida IrsiCaixa, Universitat Autònoma de Barcelona (UAB), Institut Guttmann, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Fundació Lluita contra la Sida (FLS), Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Banc de Sang i Teixits (BST) and Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT).

The research activity at IGTP covers 8 areas, producing around 500 publication per year on renowned scientific journals. The areas are: Behavioural sciences and drug abuse; Immunology and inflammation; Heart, vascular and respiratory diseases; Infectious diseases; Endocrine-metabolic, bone and renal diseases; Liver and digestive system; Cancer; Neurosciences. Moreover the institute has several technological facilities providing essential support to the researchers.

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2024-03-07
17:25
Corticosteroid tapering is a safe approach in patients with relapsed or refractory multiple myeloma receiving subcutaneous daratumumab : part 3 of the open-label, multicenter, phase 1b PAVO study / Nahi, Hareth (Karolinska Institute. Department of Medicine) ; Usmani, Saad Z. (Memorial Sloan Kettering Cancer Center) ; Mateos, Maria Victoria (University Hospital of Salamanca) ; van de Donk, Niels W C J (Department of Hematology. Vrije Universiteit Amsterdam) ; Oriol, Albert. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Plesner, Torben (Vejle Hospital and University of Southern Denmark) ; Bandyopadhyay, Nibedita (Janssen Research & Development. LLC) ; Hellemans, Peter (Janssen Research & Development) ; Tromp, Brenda (Janssen Research & Development. LLC) ; Nnane, Ivo (Janssen Research & Development. LLC) ; Zemlickis, Donna (Janssen Research & Development. LLC) ; Chari, Ajai (Icahn School of Medicine at Mount Sinai) ; Moreau, Philippe (Hematology Department. University Hospital Hôtel-Dieu)
2023 - 10.1080/10428194.2022.2148221
Leukemia and Lymphoma, Vol. 64 Núm. 2 (2023) , p. 468-472  
2024-03-07
17:25
18 p, 1.8 MB Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection / Gallardo-Gómez, María (Universidade de Vigo) ; Costas-Ríos, Lara (Universidade de Vigo) ; Garcia-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Rodríguez, Lara (Universidade de Vigo) ; Bujanda, Luis (Universidad del País Vasco (UPV/EHU)) ; Barrero, Maialen (Hospital Universitario Donostia) ; Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ; Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ; Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ; González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ; Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ; De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 - 10.1002/1878-0261.13573
Molecular Oncology, 2023  
2024-03-07
17:25
16 p, 3.7 MB An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma / Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lovell, Claudia D. (New York University School of Medicine, USA) ; Von Itter, Richard (New York University School of Medicine, USA) ; Dolgalev, Igor (New York University Grossman School of Medicine, USA) ; Agrawal, Praveen (New York University Grossman School of Medicine, USA) ; Baptiste, Gillian (New York University Grossman School of Medicine, USA) ; Kahler, David J. (New York University Grossman School of Medicine, USA) ; Sokolova, Elena (New York University Grossman School of Medicine, USA) ; Moran, Sebastian (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Piqué, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vega-Saenz de Miera, Eleazar (New York University School of Medicine, USA) ; Fontanals-Cirera, Barbara (New York University School of Medicine, USA) ; Karz, Alcida (New York University School of Medicine, USA) ; Tsirigos, Aristotelis (New York University Grossman School of Medicine, USA) ; Yun, Chi (New York University Grossman School of Medicine, USA) ; Darvishian, Farbod (New York University Grossman School of Medicine, USA) ; Etchevers, Heather C. (Aix-Marseille University, Marseille, France) ; Osman, Iman (New York University Grossman School of Medicine, USA) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Schober, Markus (New York University School of Medicine, USA) ; Hernando, Eva (New York University Grossman School of Medicine, USA)
Metastatic melanoma develops once transformed melanocytic cells begin to de-differentiate into migratory and invasive melanoma cells with neural crest cell (NCC)-like and epithelial-to-mesenchymal transition (EMT)-like features. [...]
2023 - 10.1038/s41467-023-36967-2
Nature communications, Vol. 14 Núm. 1 (april 2023)  
2024-03-07
17:25
11 p, 618.2 KB Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities : Laboratory tools for an early and differential diagnosis / Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ; Fernández, Sara (Hospital Clínic i Provincial de Barcelona) ; Ventosa, Helena (Hospital Clínic i Provincial de Barcelona) ; Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ; Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ramos, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ; Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ; Fernández De Larrea, Carlos (Hospital Clínic i Provincial de Barcelona) ; Urbano-Ispizua, Alvaro (Hospital Clínic i Provincial de Barcelona) ; Penack, Olaf (Charité Universitätsmedizin Berlin, Germany) ; Nicolás, J.M. (Hospital Clínic i Provincial de Barcelona) ; Téllez, Adrian (Hospital Clínic i Provincial de Barcelona) ; Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ; Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Avilés, Francesc (Hospital Clínic i Provincial de Barcelona) ; Castro Rebollo, Pedro (Hospital Clínic i Provincial de Barcelona) ; Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Background Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated neurotoxicity syndromes are life-threatening toxicities in which the endothelium could be a pathophysiological substrate. [...]
2023 - 10.1136/jitc-2022-006365
Journal for immunotherapy of cancer, Vol. 11 Núm. 4 (april 2023)  
2024-03-07
17:25
33 p, 20.4 MB Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells / Zhang, Yu Wei (University of Freiburg, Germany) ; Mess, Julian (University of Freiburg, Germany) ; Aizarani, Nadim (University of Freiburg, Germany) ; Mishra, Pankaj (University of Freiburg, Germany) ; Johnson, Carys (University of Cambridge, UK) ; Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ; Rettkowski, Jasmin (University of Freiburg, Germany) ; Schönberger, Katharina (University of Freiburg, Germany) ; Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Woessner, Nadine M. (University of Freiburg, Germany) ; Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Velasco-Hernandez, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Wäsch, Ralph (University of Freiburg, Germany) ; Lehnertz, Bernhard (University of Montreal, Canada) ; Sauvageau, Guy (University of Montreal, Canada) ; Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Menendez, Pablo (Catalan Institution for Research and Advanced Studies (ICREA)) ; Walter, Sebastian Gottfried (University Hospital of Cologne, Germany) ; Minguet, Susana (University of Freiburg, Germany) ; Laurenti, Elisa (University of Cambridge, UK) ; Günther, Stefan (University of Freiburg, Germany) ; Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 - 10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048  
2024-03-07
17:25
16 p, 3.3 MB The stem region of group A transferase is crucial for its specificity, and its alteration promotes heterologous Forssman synthase activity / Cid, Emili (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Miyako (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Barrero, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Some stem region mutants of human blood group A transferase (hAT) possess Forssman synthase (FS) activity, but very little is known about the mechanisms responsible for this enzymatic crosstalk. We performed confocal microscopy and image analysis to determine whether different intra-Golgi localization was accountable for this acquired activity. [...]
2023 - 10.1038/s41598-023-40900-4
Scientific reports, Vol. 13 Núm. 1 (december 2023) , p. 13996  
2024-03-07
17:25
12 p, 1.6 MB Antithrombotic and prohemorrhagic actions of different concentrations of apixaban in patients exposed to single and dual antiplatelet regimens / Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Castrillo, Leticia (Hospital Clínic i Provincial de Barcelona) ; Jerez, Didac (Hospital Clínic i Provincial de Barcelona) ; Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ; Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ; Mendieta, Guiomar (Hospital Clínic i Provincial de Barcelona) ; Zafar, M.Urooj (Icahn School of Medicine at Mount Sinai, New York, USA.) ; Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ; Sanchez, Pablo (Institut de Ciències del Mar, Spanish National Research Council, Barcelona) ; Badimon, Juan Jose (Icahn School of Medicine at Mount Sinai, New York, USA) ; Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona) ; Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ; Roqué, Mercè (Hospital Clínic i Provincial de Barcelona)
We evaluated modifications in the hemostatic balance of different concentrations of apixaban (APIX) in 25 healthy donors and 53 patients treated with aspirin (ASA, n = 21), ASA and clopidogrel (ASA + CLOPI, n = 11), or ASA and ticagrelor (ASA + TICA, n = 21). [...]
2023 - 10.1038/s41598-023-50347-2
Scientific reports, Vol. 13 Núm. 1 (december 2023)  
2024-03-07
17:25
15 p, 3.7 MB Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance / Botta, Cirino (Clinica Universidad de Navarra) ; Perez, Cristina (Clinica Universidad de Navarra) ; Larrayoz, Marta (Clinica Universidad de Navarra) ; Puig, Noemí (Hospital Universitario de Salamanca) ; Cedena, María Teresa (Hospital Universitario 12 de Octubre) ; Termini, Rosalinda (Clinica Universidad de Navarra) ; Goicoechea, Ibai (Clinica Universidad de Navarra) ; Rodriguez, Sara (Clinica Universidad de Navarra) ; Zabaleta, Aintzane (Clinica Universidad de Navarra) ; Lopez, Aitziber (Clinica Universidad de Navarra) ; Sarvide, Sarai (Clinica Universidad de Navarra) ; Blanco, Laura (Clinica Universidad de Navarra) ; Papetti, Daniele Marco (Department of Informatics. University of Milano-Bicocca) ; Nobile, M.S. (Biostatistics and Bioimaging Centre-B4) ; Besozzi, Daniela (Biostatistics and Bioimaging Centre-B4) ; Gentile, Massimo (Department of Oncohematology. "Annunziata" Hospital) ; Correale, Pierpaolo (Great Metropolitan Hospital "Riuniti" of Reggio Calabria) ; Siragusa, Sergio (Department of Health Promotion. University of Palermo) ; Oriol, Albert (Institut Català d'Oncologia i Institut Josep Carreras) ; González-Garcia, Maria Esther (Hospital de Cabueñes) ; Sureda, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; de Arriba, Felipe (Instituto Murciano de Investigación Biosanitaria) ; Ríos-Tamayo, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Moraleda, José María (Instituto Murciano de Investigación Biosanitaria) ; Gironella, Mercedes (Hospital Universitari Vall d'Hebron) ; Hernández, Miguel T. (Hospital Universitario de Canarias (Illes Canàries)) ; Bargay, Joan (Hospital Universitari Son Llàtzer (Illes Balears)) ; Palomera, Luís (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Pérez-Montaña, Albert (Hospital Universitari Son Espases (Illes Balears)) ; Goldschmidt, Hartmut (Department of Internal Medicine V. University of Heidelberg) ; Avet-Loiseau, Hervé (IUC-T Oncopole) ; Roccaro, Aldo (Department of Hematology. ASST Spedali Civili di Brescia) ; Orfao, Alberto (Department of Medicine. University of Salamanca) ; Martinez-Lopez, Joaquín (Hospital Universitario 12 de Octubre) ; Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lahuerta, J. J (Hospital Universitario 12 de Octubre) ; Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mateos, M. V (Hospital Universitario de SalamancaBiomedica de Salamanca (IBSAL). Centro de Investigación del Cancer (IBMCC-USAL. CSIC)) ; San-Miguel, J (Clinica Universidad de Navarra) ; Martinez Climent, Juan-José (Clinica Universidad de Navarra) ; Paiva, Bruno (Clinica Universidad de Navarra)
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). [...]
2023 - 10.1038/s41467-023-41562-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 5825  
2024-03-07
17:25
17 p, 2.3 MB Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity : Potential Involvement of Germ-Line microRNAs / Ribas-Aulinas, Francesc (Institut de Recerca Sant Joan de Déu) ; Ribo, Sílvia (Institut de Recerca Sant Joan de Déu) ; Casas Masnou, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mourin-Fernandez, Marta (Institut de Recerca Sant Joan de Déu) ; Ramon-Krauel, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Diaz, Ruben (Institut de Recerca Sant Joan de Déu) ; Lerin, Carles (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Kalko, Susana G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vavouri, Tanya (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Jimenez-Chillaron, Josep C. (School of Medicine. University of Barcelona)
Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. [...]
2023 - 10.3390/nu15051241
Nutrients, Vol. 15 Núm. 5 (march 2023) , p. 1241  
2024-03-07
17:25
13 p, 1.3 MB Effects of a Mediterranean Diet Intervention on Maternal Stress, Well-Being, and Sleep Quality throughout Gestation-The IMPACT-BCN Trial / Casas, Irene (University of Barcelona) ; Nakaki, Ayako (Institut de Recerca August Pi Sunyer) ; Pascal, Rosalia (Institut de Recerca Sant Joan de Deu) ; Castro-Barquero, Sara (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Youssef, Lina (Josep Carreras Leukaemia Research Institute. Hospital Clínic) ; Genero, Mariona (University of Barcelona) ; Benitez, Leticia. (Institut de Recerca August Pi Sunyer) ; Larroya, Marta (Institut de Recerca August Pi Sunyer) ; Boutet, Maria Laura (University of Barcelona) ; Casu, Giulia (University of Barcelona) ; Gomez-Gomez, A (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pozo, Oscar J (Institut Hospital del Mar d'Investigacions Mèdiques) ; Morilla Figueras, Ivette (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martínez-Àran, Anabel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Vieta, Eduard (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gómez-Roig, María Dolores (Institut de Recerca Sant Joan de Deu) ; Casas, Rosa (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Estruch, Ramon (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Gratacos, Eduard (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Crispi, Fàtima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Crovetto, Francesca (Institut de Recerca Sant Joan de Deu)
Stress and anxiety are frequent occurrences among pregnant women. We aimed to evaluate the effects of a Mediterranean diet intervention during pregnancy on maternal stress, well-being, and sleep quality throughout gestation. [...]
2023 - 10.3390/nu15102362
Nutrients, Vol. 15 Núm. 10 (may 2023) , p. 2362  
Focus on:
Josep Carreras Leukaemia Research Institute  (582)