2019-01-16
11:28 |
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18 p, 288.5 KB |
Translational research opportunities regarding homologous recombination in ovarian cancer
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Romeo Marín, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pardo, J.C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solé, Francesc (Institut Germants Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 -  10.3390/ijms19103249
International Journal of Molecular Sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249
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2018-12-24
03:55 |
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10 p, 1.9 MB |
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
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Codony Servat, Jordi (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Cuatrecasas Freixas, Miriam (Hospital Clínic) ;
Asensio, Elena (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Montironi, Carla (Hospital Clínic) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Marín Aguilera, Mercedes (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Horndler, Carlos (Hospital Miguel Servet) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Rubini, Michele (Department of Experimental and Diagnostic Medicine, University of Ferrara) ;
Jares, Pedro (Hospital Clínic) ;
Reig, Oscar (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Victoria, Iván (Medical Oncology Department, Hospital Clínic, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, Universitat de Barcelona) ;
Gaba, Lydia (Medical Oncology Department, Hospital Clínic, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, Universitat de Barcelona) ;
Martín Richard, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso, Vicente (Hospital Miguel Servet) ;
Escudero, Pilar (Hospital Clínico Universitatio Lozano Blesa) ;
Fernández-Martos, Carlos (Instituto Valenciano de Oncología) ;
Feliu, Jaime (Hospital La Paz, CIBERONC) ;
Méndez, Jose Carlos (Centro Oncológico de Galicia) ;
Méndez, Miguel (Hospital de Móstoles) ;
Gallego, Javier (Hospital de Elche) ;
Salud, Antonieta (Hospital Arnau de Vilanova) ;
Rojo, Federico (Pathology Department, Fundación Jiménez Diaz University) ;
Castells, Antoni (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Prat, Aleix (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
García-Albéniz, Xabier (Harvard T.H. Chan School of Public Health) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Maurel, Joan (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and constitutes the main reason for treatment failure. Monoclonal antibodies against insulin-like growth factor-1 receptor (IGF-1R) have been tested in pre-treated mCRC patients, but results have been largely deceiving. [...]
2017 - 10.1038/bjc.2017.279
British Journal of Cancer, Vol. 117 (november 2017) , p. 1777-1786
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2018-11-01
22:41 |
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From exome analysis in idiopathic azoospermia to the identification of a high-risk subgroup for occult Fanconi anemia
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Krausz, Csilla (Institut d'Investigació Biomèdica Sant Pau) ;
Riera-Escamilla, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Chianese, Chiara (Institut d'Investigació Biomèdica Sant Pau) ;
Moreno-Mendoza, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Ars, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ;
Rajmil, Osvaldo (Institut d'Investigació Biomèdica Sant Pau) ;
Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Blanco, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Badell Serra, Isabel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública) ;
Ruiz-Castañé, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Purpose: in about 10% of patients affected by Fanconi anemia (FA) the diagnosis is delayed until adulthood, and the presenting symptom in these "occult" FA cases is often a solid cancer and cancer treatment-related toxicity. [...]
2019 - 10.1038/s41436-018-0037-1
Genetics in Medicine, Vol. 21, issue 1 (Jan. 2019) , p. 189-194
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2018-10-26
18:13 |
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9 p, 1.2 MB |
Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy
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Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Siles, Ana M (Institut d'Investigació Biomèdica Sant Pau) ;
Alba-Rovira, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
Jáuregui, Agustín (Fundación Favaloro, Buenos, Aires, Argentina) ;
Devaux, Jérôme (Aix-Marseille Université) ;
Faivre-Sarrailh, Catherine (Aix-Marseille Université) ;
Araque,Josefa (Institut d'Investigació Biomèdica Sant Pau) ;
Rojas Garcia,Ricard (Institut d'Investigació Biomèdica Sant Pau) ;
Diaz Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Cortés Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Nogales Gadea,Gisela (Institut Germans Trias i Pujol) ;
Navas Madroñal, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo Vigo, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous disease in which diverse autoantibodies have been described but systematic screening has never been performed. Detection of CIDP-specific antibodies may be clinically useful. [...]
2017 - 10.1038/s41598-017-14853-4
Sientific reports, Vol. 7 (october 2017) , p. 1-9
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2018-10-26
18:09 |
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12 p, 5.0 MB |
Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient
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Saxena, Abhishek (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Stevens, Jo (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Cetin,Hakan (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ;
Koneczny, Inga (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Webster, Richard (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ;
Lazaridis, Konstantinos (Hellenic Pasteur Institute) ;
Tzartos, Socrates (Hellenic Pasteur Institute) ;
Vrolix, Kathleen (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Nogales-Gadea, Gisela (Institut Germans Trias i Pujol. Recerca Neuromuscular i Neuropediàtrica) ;
Machiels, Barbie (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Molenaar, Peter C. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Damoiseaux, Jan (Central Diagnostic Laboratory, Maastricht University Medical Center) ;
De Baets, Marc H. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Simon-Keller, Katja (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ;
Marx, Alexander (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ;
Vincent, Angela (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ;
Mario Losen (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Pilar Martinez-Martinez (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
We report here the sequence and functional characterization of a recombinantly expressed.
autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the VHCDR2. [...]
2017 - 10.1038/s41598-017-14350-8
Sientific reports, Vol. 7 (october 2017) , p. 1-12
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2018-10-26
17:17 |
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11 p, 1.1 MB |
Immune-mediated inflammatory diseases differently affect IGRAs' accuracy for latent tuberculosis infection diagnosis in clinical practice
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Latorre,Irene (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Mínguez, Sonia (Institut Germans Trias i Pujol. Servei de Reumatologia) ;
Carrascosa, José-Manuel (Institut Germans Trias i Pujol. Servei de Dermatologia) ;
Naves, Juan (Institut Germans Trias i Pujol. Servei de Digestiu) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Muriel, Beatriz (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Prat, Cristina (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
García-García, Esther (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Casas, Irma (Institut Germans Trias i Pujol. Servei de Medicina Preventiva) ;
Domènech, Eugeni (Institut Germans Trias i Pujol. Servei de Digestiu) ;
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Servei de Dermatologia) ;
Mateo, Lourdes (Institut Germans Trias i Pujol. Servei de Reumatologia) ;
Domínguez, Jose (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Universitat Autònoma de Barcelona
Background. Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT. [...]
2017 - 10.1371/journal.pone.0189202
Plos one, Vol. 12 Núm. 12 (december 2017) , p. 1-11
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2018-10-26
17:11 |
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12 p, 2.7 MB |
High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke
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Puig, Josep (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Blasco, Gerard (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Daunis-i-Estadella, Pepus (Departament d'Informàtica, Matemàtica Aplicada i Estadística. Universitat de Girona) ;
Eendendburg, Cecile van (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Carrillo-García, María (Hospital General Universitario Morales Meseguer) ;
Aboud, Carlos (Hospital Universitari i Politècnic La Fe de València) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol) ;
Serena, Joaquín (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Biarnés, Carles (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Nael, Kambiz (ICAHN School of Medicine at Mount Sinai) ;
Liebeskind, David S. (Neurovascular Imaging Research Core and UCLA Stroke Center) ;
Thomalla, Götz (Department of Neurology, University Medical Centre Hamburg-Eppendorf) ;
Menon, Bijoy K. (Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary) ;
Demchuk, Andrew (Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary) ;
Wintermark, Max (Department of Radiology, Neuroradiology Division, Stanford University, Palo Alto, California) ;
Pedraza,Salvador (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Castellanos, Mar (Instituto de Investigación Biomédica de A Coruña)
Objective. Blood-brain barrier (BBB) permeability has been proposed as a predictor of hemorrhagic transformation (HT) after tissue plasminogen activator (tPA) administration; however, the reliability of perfusion computed tomography (PCT) permeability imaging for predicting HT is uncertain. [...]
2017 - 10.1371/journal.pone.0188238
Plos one, Vol. 12 Núm. 11 (november 2017) , p. 1-12
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2018-10-26
17:05 |
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17 p, 1.9 MB |
Genetic variation associated with cardiovascular risk in autoimmune diseases.
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Perrotti, Pedro P. (Vall d'Hebron Institut de Recerca) ;
Aterido, Adrià (Vall d'Hebron Institut de Recerca) ;
Fernández-Nebro, Antonio (Universidad de Málaga) ;
Cañete, Juan D. (Hospital Clínic de Barcelona) ;
Ferrándiz, Carlos (Institut Germans Trias i Pujol) ;
Tornero, Jesús (Hospital Universitario Guadalajara) ;
Gisbert,Javier P. (CIBERehd) ;
Domènech, Eugeni (Institut Germans Trias i Pujol) ;
Fernández-Gutiérrez, Benjamín (Hospital Clínico San Carlos) ;
Gomollón, Fernando (CIBERehd) ;
García-Planella, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, Emilia (Hospital Clínic de Barcelona) ;
Sanmartí, Raimon (Hospital Clínic de Barcelona) ;
Gratacós, Jordi (Hospital Parc Taulí) ;
Martínez-Taboada, Víctor Manuel (Hospital Universitario Marqués de Valdecilla) ;
Rodríguez-Rodríguez, Luís (Hospital Clínico San Carlos) ;
Palau, Núria (Vall d'Hebron Institut de Recerca) ;
Tortosa, Raúl (Vall d'Hebron Institut de Recerca) ;
Corbeto, Mireia L. (Vall d'Hebron Institut de Recerca) ;
Lasanta, María L. (Vall d'Hebron Institut de Recerca) ;
Marsal,Sara (Vall d'Hebron Institut de Recerca) ;
Julià, Antonio (Vall d'Hebron Institut de Recerca) ;
IMID Consortium
Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. [...]
2017
Plos one, Vol. 12 Núm. 10 (october 2017) , p. 1-17
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2018-10-26
16:52 |
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14 p, 1.7 MB |
Is systematic training in opioid overdose prevention effective?
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Espelt, Albert (Universitat Autònoma de Barcelona. Departament de Psicobiologia i Metodologia de les Ciències de la Salut) ;
Bosque-Prous, Marina (Agència de Salut Pública de Barcelona) ;
Folch Toda, Cinta (Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT)) ;
Sarasa-Renedo, Ana (Agència de Salut Pública de Barcelona) ;
Majó, Xavier (Departament de Salut de la Generalitat de Catalunya. Subdirecció General de Drogodependències) ;
Casabona, Jordi (Departament de Salut de la Generalitat de Catalunya. Subdirecció General de Drogodependències) ;
Brugal, M. Teresa (Agència de Salut Pública de Barcelona) ;
REDAN Group
The objectives were to analyze the knowledge about overdose prevention, the use of naloxone, and the number of fatal overdoses after the implementation of Systematic Training in Overdose Prevention (STOOP) program. [...]
2017
Plos one, Vol. 12 Núm. 10 (october 2017) , p. 1-14
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2018-10-10
16:06 |
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11 p, 899.4 KB |
H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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Lagerstedt,Linnéa (University of Geneva. Department of Human Protein Sciences) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío) ;
Bustamante, Alejandro (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío) ;
El Rahal, Amir (Geneva University Hospitals. Department of Clinical Neurosciences.) ;
Turck, Natacha (University of Geneva. Department of Human Protein Sciences) ;
Quintana, Manuel (Hospital Universitario La Paz) ;
García Armengol, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prica, Carmen Melinda (Hospital de Tortosa Verge de la Cinta) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (University Hospital Heidelberg. Department of Neurosurgery) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Sanchez, Jean-Charles (University of Geneva. Department of Human Protein Sciences) ;
Universitat Autònoma de Barcelona
The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%±8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient's risk of developing intracranial lesions. [...]
2017 - 10.1371/journal.pone.0175572
Plos one, Vol. 12 Núm. 4 (2017) , p. 1-11
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