2026-02-25
18:12 |
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11 p, 8.1 MB |
Subcutaneous administration of an endocrine-mimetic platform allows for prolonged tumor uptake of a tumor targeting protein
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Álamo, Patricia (Institut de Recerca Sant Pau) ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
de Pinho Favaro, Marianna T. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gallardo, Alberto (Institut de Recerca Sant Pau) ;
Alba Castellón, Lorena (Institut de Recerca Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut de Recerca Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Endocrine-like dynamic protein depots can be fabricated in vitro through the coordination of divalent zinc ions (Zn) with solvent-exposed histidine residues on functional proteins, leading to their controlled aggregation. [...]
2026 -  10.1016/j.ijpharm.2026.126585
International journal of pharmaceutics, Vol. 690 (February 2026) , art. 126585
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2026-02-19
20:12 |
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43 p, 940.3 KB |
Baseline PD-L1 expression on circulating immune cells as a predictor of survival and immune-related adverse events in extensive-stage small-cell lung cancer patients treated with durvalumab and carboplatin-etoposide (NCT04712903 Trial)
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Piedra, Aida (Universitat Autònoma de Barcelona) ;
Guinart Cuadra, Albert (Institut de Recerca Sant Pau) ;
Martinez-Recio, Sergio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mulet Gual, Maria (Institut de Recerca Sant Pau) ;
Zamora, Carlos (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Osuna Gómez, Rubén (Institut de Recerca Sant Pau) ;
Cantó, Elisabet (Institut de Recerca Sant Pau) ;
Ortiz, M. Àngels (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alejandre, Jose (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Barba Joaquin, Andrés (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sanz-Beltran, Judit (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Serra, Jorgina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
Paz-Ares, Luis (Hospital Universitario 12 de Octubre (Madrid)) ;
Diz Taín, Pilar (Complejo Asistencial Universitario de León) ;
Moreno Vega, Alberto Luis (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Callejo, A. (Astrazeneca Farmacéutica Spain S.A.) ;
Vidal, Silvia (Institut de Recerca Sant Pau) ;
Majem, Margarita (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Introduction: Despite improved efficacy with first-line immune checkpoint inhibitors plus platinum250 based chemotherapy for extensive-stage small cell lung cancer (ES-SCLC), long-term survival remains limited. [...]
2026
Journal of translational medicine, 2026
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2026-02-26
14:12 |
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20 p, 1.0 MB |
Magnesium Balance in Chronic Kidney Disease : Mineral Metabolism, Immunosuppressive Therapies and Sodium-Glucose Cotransporter 2 Inhibitors
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Lloret, Maria Jesus (Institut de Recerca Sant Pau) ;
Fayos de Arizon, Leonor (Institut de Recerca Sant Pau) ;
Massó, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valdivielso, José Manuel (Instituto de Salud Carlos III) ;
Díaz Tocados, Juan Miguel (Instituto de Salud Carlos III) ;
Domínguez-Coral, Juan Diego (Instituto de Salud Carlos III) ;
Tinoco Aranda, Adria Patricia (Fundació Puigvert) ;
Rodríguez Ortiz, María Encarnación (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
It is now widely recognized that maintaining magnesium (Mg) homeostasis is critical for health, especially in the context of chronic kidney disease (CKD). Patients with CKD commonly develop hyperphosphatemia and secondary hyperparathyroidism, which are controlled by therapies targeting intestinal phosphate absorption and circulating calcium levels or by modulating parathyroid calcium sensing. [...]
2025 - 10.3390/ijms26125657
International journal of molecular sciences, Vol. 26, Num. 12 (June 2025) , art. 5657
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2026-02-26
10:36 |
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10 p, 480.1 KB |
Epidemiological changes in Chlamydia pneumoniae molecular detections before, during and after the COVID-19 pandemic in 27 European sites and Taiwan, 2018 to 2023
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Berengua, Carla (Institut de Recerca Sant Pau) ;
Flipse, Jacky (Rijnstate Hospital) ;
Keše, Darja (Laboratory for diagnostics of atypical bacterial infections. Institute of Microbiology and Immunology. Faculty of Medicine) ;
Greub, Gilbert (Lausanne University Hospital) ;
Tagini, Florian (Lausanne University Hospital) ;
Uldum, Søren Anker (Statens Serum Institut) ;
Ivan, Branislav (University Hospital Basel (Basilea, Suïssa)) ;
Capaul, Riccarda (Zentrallabor. Kantonspital Graubünden) ;
Edouard, Sophie (IHU-Méditerranée Infection) ;
Fischer, Adrien (Geneva University Hospitals) ;
de Artola, Diego García Martínez (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Goldenberger, Daniel (University Hospital Basel (Basilea, Suïssa)) ;
Heddema, Edou (Zuyderland Medical Centre. Glims) ;
Hermans, Mirjam (Jeroen Bosch Hospital) ;
Imkamp, Frank (University of Zurich) ;
Lejarraga, Clara (Microbiology laboratory. HUC) ;
Lienhard, Reto (ADMED Microbiologie) ;
Maffioli, Carola (MCL Laboratories) ;
Matheeussen, Veerle (University Hospital Antwerp) ;
Meyer Sauteur, Patrick M. (University Children's Hospital Zurich (Zúric, Suïssa)) ;
Mitrovic, Irena (Luzerner Kantonsspital (Suïssa)) ;
Opota, Onya (Lausanne University Hospital) ;
Orasch, Christina (MEDISYN SA) ;
Drevinek, Pavel (Motol University Hospital) ;
Peuchant, Olivia (Bordeaux University Hospital) ;
Po-Yu, Liu (Taichung Veterans General Hospital) ;
Puolakkainen, Mirja (University of Helsinki) ;
Remy, Melissa (MEDISYN SA) ;
Thai, Khoa T.D. (Star-shl) ;
Wohlwend, Nadia (Laboratory Dr. Risch) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, lockdowns and enhanced hygiene led to a decrease in respiratory pathogens. However, as NPIs were relaxed, a resurgence in several respiratory pathogens was observed including one local Chlamydia pneumoniae outbreak in Switzerland, prompting the need for a better understanding of C. [...]
2025 - 10.2807/1560-7917.ES.2025.30.23.2400682
Eurosurveillance, Vol. 30, Num. 23 (December 2025) , art. 2400682
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2026-02-26
09:16 |
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2026-02-25
14:12 |
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13 p, 580.5 KB |
Effect of DAPAgliflozin on Myocardial Fibrosis and Ventricular Function in Patients with ST-Segment Elevation Myocardial Infarction-DAPA-STEMI Trial
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Ortega-Paz, Luis (University of Florida) ;
Sionis, Alessandro (Institut de Recerca Sant Pau) ;
Arevalos, Victor (Universidad Nacional de Asunción) ;
Andrea-Riba, Rut (Hospital Clínic i Provincial de Barcelona) ;
De Diego, Oriol (Universidad Nacional de Asunción) ;
Ortega, Emilio (Hospital Clínic i Provincial de Barcelona) ;
Dantas, Ana Paula (Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Angiolillo, Dominick J. (University of Florida) ;
Sabaté, Manel (Hospital Clínic i Provincial de Barcelona) ;
Ortiz Pérez, José Tomás (Hospital Clínic i Provincial de Barcelona) ;
Brugaletta, Salvatore (Hospital Clínic i Provincial de Barcelona) ;
Laudani, Claudio (University of Catania) ;
Vidal-Calés, Pablo (Hospital Clínic i Provincial de Barcelona) ;
Morr, Carlos Igor (Hospital Clínic i Provincial de Barcelona) ;
Jimenez Trinidad, Francisco Rafael (Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Background: Myocardial fibrosis leads to ventricular dysfunction and worsened prognosis, especially after ST-segment elevation myocardial infarction (STEMI). Sodium-glucose cotransporter 2 inhibitors (SGLT2is) offer cardiovascular benefits by reducing markers of myocardial fibrosis and fibroblast activity. [...]
2025 - 10.3390/jcdd12060220
Journal of Cardiovascular Development and Disease, Vol. 12, Num. 6 (June 2025) , p. 220
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2026-02-25
14:12 |
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18 p, 1.4 MB |
Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation : STIMIT ACTIVATOR 1 pivotal trial
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Subirà, Carles (Institut de Recerca Sant Pau) ;
Watson, David (University of Virgina) ;
Ranieri, Marco (University of Turin) ;
Goligher, Ewan C. (University Health Network) ;
Brochard, Laurent (University of Toronto) ;
Schreiber, Annia F. (University of Toronto) ;
Sklar, Michael (Unity Health Toronto (St. Michael's Hospital)) ;
Santos, Marlene (University of Toronto) ;
Ko, Matthew (University of Toronto) ;
Panelli, Alessandro (Charité-Universitätsmedizin Berlin) ;
Schaller, Stefan J. (Technical University of Munich) ;
Theodore, Danny (University of Virgina) ;
Rowley, Daniel D. (University of Virgina) ;
Bonde, Pramod (Yale School of Medicine) ;
Baedorf Kassis, Elias N. (Harvard Medical School) ;
Talmor, Daniel S. (Harvard Medical School) ;
Slutsky, Arthur S. (University of Toronto) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background : Ventilator-induced diaphragmatic dysfunction (VIDD) occurs in up to 60% of mechanically ventilated patients and prolongs ventilatory dependance. The consequences of VIDD are muscle atrophy, reduction of strength, and injury of muscle fibers. [...]
2025 - 10.1186/s13063-025-08838-2
Trials, Vol. 26, Num. 1 (December 2025) , p. 202
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2026-02-25
13:12 |
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15 p, 1.7 MB |
Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk : The Di@bet.es Study
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Llauradó, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Cedó, Lídia (Institut d'Investigació Sanitària Pere Virgili (IISPV) - Hospital Universitari de Tarragona Joan XXIII) ;
Climent, Elisenda (Hospital del Mar (Barcelona, Catalunya)) ;
Badia, Joan (Institut d'Investigació Sanitària Pere Virgili) ;
Rojo-Martínez, G. (Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA-Plataforma Bionand)) ;
Yanes, Oscar (Institut d'Investigació Sanitària Pere Virgili) ;
Vinaixa, Maria (Institut d'Investigació Sanitària Pere Virgili) ;
Granado-Casas, Minerva (Instituto de Salud Carlos III) ;
Mauricio Puente, Dídac (Institut de Recerca Sant Pau) ;
Fernández-Veledo, Sonia (Universitat Rovira i Virgili) ;
Vendrell, Joan (Institut d'Investigació Sanitària Pere Virgili (IISPV) - Hospital Universitari de Tarragona Joan XXIII) ;
Flores-Le Roux, Juana (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Identifying nutritional patterns associated with developing type 2 diabetes (T2D) can facilitate more effective and personalized dietary interventions. Short-chain fatty acids (SCFAs), key metabolites derived from gut microbiota, are produced through the anaerobic fermentation of dietary fibers. [...]
2025 - 10.1186/s12916-025-04186-9
BMC Medicine, Vol. 23, Num. 1 (December 2025) , p. 337
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2026-02-24
14:12 |
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9 p, 800.0 KB |
A comparison of open, laparoscopic, and robotic radical nephrectomy with tumor thrombectomy from the intercontinental collaboration on renal cell carcinoma
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Cannoletta, Donato (Instituto Alexander Fleming) ;
Spiess, Philippe E. (H. Lee Moffitt Cancer Center & Research Institute) ;
Abreu, Diego (Hospital Pasteur) ;
Rodríguez, Alejandro (Atrium Health Wake Forest Baptist Medical Center) ;
Sandberg, Maxwell (Atrium Health Wake Forest Baptist Medical Center) ;
Russell, Gregory (Wake Forest University School of Medicine) ;
Malakismail, Jacob (Rosalind Franklin University of Medicine and Science) ;
Hayes, Mitchell (H. Lee Moffitt Cancer Center & Research Institute) ;
David, Reuben Ben (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Miller, Justin (University of South Florida Health Morsani College of Medicine) ;
Patel, Kartik (University of Alabama Birmingham Medical Center) ;
Aljabi, Brejjette (University of Alabama Birmingham Medical Center) ;
Byun, Seok Soon (Seoul National University Bundang Medical Center) ;
Rodríguez Faba, Óscar (Institut de Recerca Sant Pau) ;
Letowski, Tatiana (Instituto Alexander Fleming) ;
Villoldo, Gustavo (Instituto Alexander Fleming) ;
Marchinena, Patricio Garcia (Hospital Italiano) ;
Mourao, Thiago (A.C. Camargo Cancer Institute) ;
Ciancio, Gaetano (University of Miami Miller School of Medicine) ;
Peyton, Charles C. (University of Alabama Birmingham Medical Center) ;
Zanotti, Rafael (A.C. Camargo Cancer Institute) ;
Mehrazin, Reza (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Zequi, Stênio de Cássio (A.C. Camargo Cancer Institute) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The gold standard treatment for renal cell carcinoma with a tumor thrombus (RCC-TT) is radical nephrectomy with tumor thrombectomy (RN-TT). Operative approaches to this can be done open (ORN-TT), laparoscopic (LRN-TT), or robotic (RRN-TT). [...]
2025 - 10.1007/s11701-025-02424-z
Journal of robotic surgery, Vol. 19, Num. 1 (December 2025) , p. 269
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2026-02-24
14:12 |
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8 p, 776.7 KB |
Daratumumab for PRCA after HCT : study and practical considerations from the EBMT Transplant Complications Working Party
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Gagelmann, N. (University Medical Center Hamburg-Eppendorf) ;
Peczynski, Christophe (Hôpital Saint Antoine) ;
Boreland, William (Hôpital Saint Antoine) ;
Kulagin, Alexander (Pavlov University) ;
Esquirol, Albert (Institut de Recerca Sant Pau) ;
Kuball, Jürgen (University Medical Center Utrecht) ;
Bethge, Wolfgang (Universitaet Tuebingen) ;
Maertens, Johan (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Stölzel, Friedrich (University Medical Center Schleswig-Holstein) ;
Forcade, Edouard (Hopital Haut-Leveque) ;
Collin, Matthew (RVI Newcastle) ;
Kroeger, Nicolaus (University Medical Center Hamburg-Eppendorf) ;
López Corral, Lucia (Hospital Clínico Universitario (Salamanca)) ;
Mussetti, Alberto (Hospital Duran i Reynals (Hospitalet del Llobregat, Catalunya)) ;
Bloor, Adrian (Christie Hospital Manchester) ;
Ladetto, Marco (H SS. Antonio e Biagio) ;
Schoemans, Hélène (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Penack, Olaf (University Medicine Berlin) ;
Moiseev, Ivan (Pavlov University) ;
Peric, Zinaida (University of Rijeka) ;
Witte, Moniek de (University Medical Center Utrecht) ;
Broers, Annoek E.C. (Erasmus MC Cancer Institute) ;
Jost, Edgar (University Hospital Aachen (Alemanya)) ;
Sica, Simona (Universita Cattolica S. Cuore) ;
Errico, Gerardo (Nottingham City Hospital) ;
Parma, Matteo (Ospedale San Gerardo (Itàlia)) ;
Choi, Goda (University Medical Center Groningen) ;
Di Chio, Maria Chiara (University of Milano) ;
Finazzi, Maria Chiara (Secretary and Italian National BMT Registry - GITMO) ;
Rifon, Jose (Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Pure red cell aplasia (PRCA) is a relevant complication after ABO-mismatched allogeneic hematopoietic cell transplantation (HCT). No standard treatment exists, and practice is heterogenous. In this study, we took advantage of an international collaboration to describe characteristics and outcomes of patients receiving daratumumab for PRCA following first allogeneic HCT. [...]
2025 - 10.1038/s41408-025-01315-8
Blood Cancer Journal, Vol. 15, Num. 1 (December 2025) , p. 106
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