e3067278857b2631a55dbf9be6232537  JouBioChe_a2002v277n34.pdf
d3c7066fe0f2e677aaa949bf288c2b250277da41  JouBioChe_a2002v277n34.pdf
9e01a083826b47e9245df5a5ed87579adfc392187b87c5b1d81de07a8b569744  JouBioChe_a2002v277n34.pdf

Title:           Specific Cleavage of Hepatitis C Virus RNA Genome by Human RNase P*
Subject:         
Keywords:        
Author:          Anna Nadal
Creator:         Elsevier
Producer:        ; modified using iTextSharp™ 5.5.13.1 ©2000-2019 iText Group NV (AGPL-version)
CreationDate:    Wed Aug  7 14:14:02 2002 CEST
ModDate:         Sun Oct 11 14:42:42 2020 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           8
Encrypted:       no
Page size:       605 x 786 pts
Page rot:        0
File size:       1242978 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
YZSUHQ+NewCenturySchlbk-Bold         Type 1C           Custom           yes yes no      61  0
UJWTNT+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     88  0
AENWGD+NewCenturySchlbk-Roman        Type 1C           Custom           yes yes no      62  0
VHFTDB+HelveticaNeue-Bold            Type 1C           WinAnsi          yes yes no      63  0
RZDMBC+NewCenturySchlbk-Italic       Type 1C           MacRoman         yes yes no      64  0
BKVKTJ+NewCenturySchlbk-BoldItalic   Type 1C           WinAnsi          yes yes no      65  0
YYTUEF+Universal-NewswithCommPi      Type 1C           Custom           yes yes no      66  0
GTAJTZ+Universal-GreekwithMathPi     Type 1C           Custom           yes yes no      79  0
FESSYH+HelveticaNeue-Roman           Type 1C           WinAnsi          yes yes no      86  0
OSFDIE+Optima-Bold                   Type 1C           WinAnsi          yes yes no      89  0
DYJXHE+NewCenturySchlbk-Roman        Type 1C           WinAnsi          yes yes no      33  0
ZCRVVK+NewCenturySchlbk-Italic       Type 1C           WinAnsi          yes yes no      37  0
CKSXXI+MathematicalPi-One            Type 1C           Custom           yes yes no      35  0
ASEUJT+NewCenturySchlbk-Bold         Type 1C           WinAnsi          yes yes no      43  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-01-11 03:02:32 CET
 RepresentationInformation: JouBioChe_a2002v277n34.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-01-10 10:38:51 CET
  Size: 1242978
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 131
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Specific Cleavage of Hepatitis C Virus RNA Genome by  Human RNase P*
      Children: 
       Item: 
        Title: EXPERIMENTAL PROCEDURES
       Item: 
        Title: RESULTS
        Destination: 1
        Children: 
         Item: 
          Title: Cleavage of HCV RNA Transcripts
          Destination: 1
         Item: 
          Title: RNase P Is Responsible for the HCV RNA Cleavages
         Item: 
          Title: Direct Method: End Group Determination and Cleavage
Precision by RNA Fingerprinting
         Item: 
          Title: RNase P Cleaves HCV Variants
         Item: 
          Title: HCV RNA Competes with RNase P Cleavage of Pre-tRNA
       Item: 
        Title: DISCUSSION
        Destination: 1
       Item: 
        Title: ACKNOWLEDGEMENTS
       Item: 
        Title: REFERENCES
   Info: 
    Title: Specific Cleavage of Hepatitis C Virus RNA Genome by Human RNase P*
    Author: Anna Nadal
    Subject: 
    Keywords: 
    Creator: Elsevier
    Producer: ; modified using iTextSharp™ 5.5.13.1 ©2000-2019 iText Group NV (AGPL-version)
    CreationDate: Wed Aug 07 14:14:02 CEST 2002
    ModDate: Sun Oct 11 15:12:42 CEST 2020
   ID: 0xe96eb5498bfa6e11eeb883ef4865c36c, 0xf10b638a8868294893e49a156e1f0a2f
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1251
      ImageHeight: 1283
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1027
      ImageHeight: 675
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 997
      ImageHeight: 1704
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 646
      ImageHeight: 1613
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1027
      ImageHeight: 2646
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1276
      ImageHeight: 871
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 742
      ImageHeight: 1708
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2092
      ImageHeight: 1517
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: UJWTNT+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: RZDMBC+NewCenturySchlbk-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 245
      FontDescriptor: 
       FontName: RZDMBC+NewCenturySchlbk-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -166, -250, 994, 958
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: BKVKTJ+NewCenturySchlbk-BoldItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: BKVKTJ+NewCenturySchlbk-BoldItalic
       Flags: Serif, Nonsymbolic, Italic, ForceBold
       FontBBox: -205, -250, 1147, 991
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DYJXHE+NewCenturySchlbk-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: DYJXHE+NewCenturySchlbk-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -195, -250, 1000, 965
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: YYTUEF+Universal-NewswithCommPi
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: YYTUEF+Universal-NewswithCommPi
       Flags: Symbolic
       FontBBox: -7, -227, 989, 764
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: CKSXXI+MathematicalPi-One
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: CKSXXI+MathematicalPi-One
       Flags: Symbolic
       FontBBox: -30, -210, 1000, 779
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: ZCRVVK+NewCenturySchlbk-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ZCRVVK+NewCenturySchlbk-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -166, -250, 994, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ASEUJT+NewCenturySchlbk-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ASEUJT+NewCenturySchlbk-Bold
       Flags: Serif, Nonsymbolic, ForceBold
       FontBBox: -165, -250, 1000, 988
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GTAJTZ+Universal-GreekwithMathPi
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: GTAJTZ+Universal-GreekwithMathPi
       Flags: Symbolic
       FontBBox: -30, -240, 1012, 815
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: FESSYH+HelveticaNeue-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 255
      FontDescriptor: 
       FontName: FESSYH+HelveticaNeue-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1076, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OSFDIE+Optima-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: OSFDIE+Optima-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -97, -271, 1000, 921
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: YZSUHQ+NewCenturySchlbk-Bold
      FontSubset: true
      FirstChar: 25
      LastChar: 181
      FontDescriptor: 
       FontName: YZSUHQ+NewCenturySchlbk-Bold
       Flags: Serif, Nonsymbolic, ForceBold
       FontBBox: -165, -250, 1000, 988
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: AENWGD+NewCenturySchlbk-Roman
      FontSubset: true
      FirstChar: 22
      LastChar: 181
      FontDescriptor: 
       FontName: AENWGD+NewCenturySchlbk-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -195, -250, 1000, 965
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: VHFTDB+HelveticaNeue-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 255
      FontDescriptor: 
       FontName: VHFTDB+HelveticaNeue-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: UJWTNT+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: UJWTNT+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -306, 2000, 1006
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1074/jbc.M203595200</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Specific Cleavage of Hepatitis C Virus RNA Genome by Human RNase P*</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Anna Nadal</rdf:li>
               <rdf:li>Marı�a Martell</rdf:li>
               <rdf:li>J. Robin Lytle</rdf:li>
               <rdf:li>Alita J. Lyons</rdf:li>
               <rdf:li>Hugh D. Robertson</rdf:li>
               <rdf:li>Beatriz Cabot</rdf:li>
               <rdf:li>Juan I. Esteban</rdf:li>
               <rdf:li>Rafael Esteban</rdf:li>
               <rdf:li>Jaime Guardia</rdf:li>
               <rdf:li>Jordi Go�mez</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default"/>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>© 2002 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Biological Chemistry</prism:publicationName>
         <prism:copyright>Copyright © 2002 © 2002 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.. All rights reserved.</prism:copyright>
         <prism:issn>0021-9258</prism:issn>
         <prism:volume>277</prism:volume>
         <prism:number>34</prism:number>
         <prism:coverDisplayDate>23 August 2002</prism:coverDisplayDate>
         <prism:coverDate>2002-08-23</prism:coverDate>
         <prism:pageRange>30606-30613</prism:pageRange>
         <prism:startingPage>30606</prism:startingPage>
         <prism:endingPage>30613</prism:endingPage>
         <prism:doi>10.1074/jbc.M203595200</prism:doi>
         <prism:url>http://dx.doi.org/10.1074/jbc.M203595200</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1074/jbc.M203595200</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1074/jbc.M203595200</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2002-08-07T12:14:02Z</xap:CreateDate>
         <xap:ModifyDate>2020-10-11T18:12:42+05:30</xap:ModifyDate>
         <xap:MetadataDate>2020-10-11T18:12:42+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords/>
         <pdf:Producer>; modified using iTextSharp™ 5.5.13.1 ©2000-2019 iText Group NV (AGPL-version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:166dfd9a-732c-4af2-a0d3-032ea1d6a180</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:464b1822-c8e7-4757-8313-7df3af20770f</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 30606
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 183, 13, 206, 20
    Page: 
     Label: 30607
     Sequence: 2
    Page: 
     Label: 30608
     Sequence: 3
    Page: 
     Label: 30609
     Sequence: 4
    Page: 
     Label: 30610
     Sequence: 5
    Page: 
     Label: 30611
     Sequence: 6
    Page: 
     Label: 30612
     Sequence: 7
    Page: 
     Label: 30613
     Sequence: 8
  Checksum: f9f73d2c
   Type: CRC32
  Checksum: e3067278857b2631a55dbf9be6232537
   Type: MD5
  Checksum: d3c7066fe0f2e677aaa949bf288c2b250277da41
   Type: SHA-1
  Checksum: 9e01a083826b47e9245df5a5ed87579adfc392187b87c5b1d81de07a8b569744
   Type: SHA-256