9ddd9df0993cb26ddb91fc0cee5178ae pmc_18797464.pdf eacc059578078aa0d0f5fee2b05d29abbc754238 pmc_18797464.pdf fb341123d04d7e87d6f70ecf0abe9753226761a72a37dc9215f1f53de7bca8ca pmc_18797464.pdf Creator: 3B2 Total Publishing System 8.07f/W Producer: Acrobat Distiller 4.05 for Windows CreationDate: Wed Sep 17 10:38:32 2008 CEST ModDate: Wed Sep 17 05:08:33 2008 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595 x 794 pts Page rot: 0 File size: 130188 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IGNIOL+AdvGillSan-L Type 1C WinAnsi yes yes no 196 0 IGNION+AdvGillSan-B Type 1C Custom yes yes no 192 0 IGNIPP+AdvGillSan-LI Type 1C WinAnsi yes yes no 194 0 IGNJAB+AdvP4C4E74 Type 1C Custom yes yes yes 203 0 IGNJBC+AdvTA42 Type 1C Custom yes yes yes 215 0 IGNJBE+AdvP4C4E46 Type 1C Custom yes yes no 213 0 IGNJBG+AdvMinionTB-R Type 1C WinAnsi yes yes no 219 0 IGNJCI+AdvMinionTB-I Type 1C WinAnsi yes yes no 220 0 IGNJCK+AdvPi1 Type 1C WinAnsi yes yes no 225 0 IGNJIK+AdvPi2 Type 1C WinAnsi yes yes no 53 0 IGNJJL+AdvMinionTB-B Type 1C WinAnsi yes yes no 54 0 IGNJKN+AdvEls-ent5 Type 1C WinAnsi yes yes no 55 0 IGNJOO+AdvEls-ent4 Type 1C WinAnsi yes yes no 56 0 IGNKAP+AdvGillSan-BI Type 1C WinAnsi yes yes no 57 0 IGNKEA+AdvMinionTB-BI Type 1C WinAnsi yes yes no 58 0 IGNKKP+Helvetica Type 1C WinAnsi yes yes no 59 0 IGNKMB+Helvetica-Oblique Type 1C WinAnsi yes yes no 60 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2018-07-28 04:42:36 CEST RepresentationInformation: pmc_18797464.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2017-12-20 13:44:49 CET Size: 130188 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 245 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatinsol5-fluorouracil as first-line chemotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77556fd Children: Item: Title: MATERIALS AND METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@368239c8 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@9e89d68 Item: Title: Chemotherapy regimen description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3b192d32 Item: Title: Clinical parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Item: Title: Genetic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Item: Title: RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Table 1 Genetic markers evaluated in this study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Children: Item: Title: Genetic determinants and response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Genetic determinants and survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Genetic determinants and neurotoxicity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Genetic determinants and resectability of liver metastases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: Table 2 Baseline characteristics of the 126 patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Table 3 Positive relationships between response and molecular determinants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Children: Item: Title: ERCC1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Figure 1 Progression-free survival according to the genotype of (A) ERCC1-118 and (B) XPD 751. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Figure 2 Overall survival according to the genotype of (A) ERCC1-118 and (B) XPD 751. 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