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Title:           Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen–glucose deprived cultured cortical cells
Author:          Nahuai Badiola; Cristina Malagelada; Nuria Llecha; Juan Hidalgo; Joan X. Comella; Josefa Sabriá; José Rodríguez-Alvarez
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      Title: Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activa.....
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      Children: 
       Item: 
        Title: Introduction
        Destination: section1
       Item: 
        Title: Material and methods
        Destination: sec1
        Children: 
         Item: 
          Title: Animals
          Destination: section3
         Item: 
          Title: Reagents
          Destination: section4
         Item: 
          Title: Antibodies
          Destination: section5
         Item: 
          Title: Cell cultures
          Destination: section6
         Item: 
          Title: Oxygen–glucose deprivation
          Destination: section7
         Item: 
          Title: TNF-α release determination
          Destination: section8
         Item: 
          Title: Fluorescent analysis of necrosis and apoptosis
          Destination: section9
         Item: 
          Title: Cell viability
          Destination: section10
         Item: 
          Title: RNA isolation
          Destination: section11
         Item: 
          Title: Reverse transcription-quantitative PCR
          Destination: section12
         Item: 
          Title: Caspases activity assay
          Destination: section13
         Item: 
          Title: Western blot analysis
          Destination: section14
         Item: 
          Title: Immunohistochemistry
          Destination: section15
         Item: 
          Title: Statistical analysis
          Destination: section16
       Item: 
        Title: Results
        Destination: section17
        Children: 
         Item: 
          Title: TNF-α is involved in OGD-mediated apoptotic death
          Destination: section18
         Item: 
          Title: TNF-α induces apoptosis in cultured cortical cells
          Destination: section19
         Item: 
          Title: The expression of TNF-α and TNFR1 in neurons and microglia is increased after OGD
          Destination: section20
         Item: 
          Title: OGD-mediated caspase-3 activation but not of caspase-9, is TNF-α-dependent
          Destination: section21
         Item: 
          Title: Activation of caspase-8 in OGD is mediated by tumour necrosis factor receptor 1 (TNFR1)
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         Item: 
          Title: Caspase-8 is involved in OGD-mediated activation of caspase-3
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        Title: Discussion
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: References
        Destination: section26
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