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PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f2a3793 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2ca6d51e Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cf1bb78 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@624b035d Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aca0115 Item: Title: Results and Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@340d1fa5 Children: Item: Title: Global transcriptional adaptation of recombinant Pichia pastoris to hypoxia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4998a455 Item: Title: The effect of hypoxia on the proteome of Pichia pastoris Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@444cee32 Item: Title: Multi-level analysis of the P. pastoris central carbon metabolism adaptation to hypoxia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16aa37a6 Children: Item: Title: Glycolytic and Pentose Phosphate Pathway (PPP) fluxes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12b7eea Item: Title: Fluxes around the pyruvate node, intercompartmental transport and Tricarboxylic Acids (TCA) cycle Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e99353f Item: Title: Transcriptional regulation of metabolic enzymes and fluxes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2c76e369 Item: Title: Other key cellular processes with important transcriptional changes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@314c194d Children: Item: Title: Lipid metabolism and membrane biogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b112783 Item: Title: Stress response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23394894 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5cbfe9d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13b8f864 Children: Item: Title: Yeast strains and chemostat cultivations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@54bb7759 Item: Title: Sampling for DNA microarray- and 2D-DIGE analysis from P. pastoris chemostat cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5f989f84 Item: Title: Protein analysis by 2D-DIGE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d10c424 Item: Title: DNA microarrays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37bd2664 Item: Title: Validation of microarrays by qRT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63238bd2 Children: Item: Title: cDNA generation and primer design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32b0bad7 Item: Title: Primer validation and amplicon purification for standard curve Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@70ba9340 Item: Title: qRT-PCR assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69198891 Item: Title: Data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b551d7f Item: Title: Analytical procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@10382a9 Item: Title: Biosynthetically directed fractional (BDF) 13C-labelling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@d7725c4 Item: Title: NMR spectroscopy and metabolic flux ratio (METAFoR) analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@9506dc4 Item: Title: 13C-constrained metabolic flux analysis (13C-MFA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f5663a2 Item: Title: Acknowledgements Destination: 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2010-11-11T13:12:37+05:30 2010-11-11T13:12:37+05:30 Arbortext Advanced Print Publisher 10.0.1082/W Unicode BMC Systems Biology 2010, 4:141. doi:10.1186/1752-0509-4-141 application/pdf http://dx.doi.org/10.1186/1752-0509-4-141 Kristin Baumann Marc Carnicer Martin Dragosits Alexandra B Graf Johannes Stadlmann Paula Jouhten Hannu Maaheimo Brigitte Gasser Joan Albiol Diethard Mattanovich Pau Ferrer A multi-level study of recombinant Pichia pastoris in different oxygen conditions BMC Systems Biology 2010, 4:141. doi:10.1186/1752-0509-4-141 BioMed Central Ltd 2010-10-22 © 2010 Baumann et al; licensee BioMed Central Ltd. uuid:6367c3fd-050b-4ff4-a3b2-211adbb0aa55 uuid:a036d28b-f345-4226-a461-e1406381f24b True http://www.biomedcentral.com/1752-0509/4/141 10.1186/1752-0509-4-141 141 141 © 2010 Baumann et al; licensee BioMed Central Ltd. 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