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MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 644 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42a9c09e Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16a4e743 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@244aeb52 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@329f671b Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f2a3793 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2ca6d51e Children: Item: Title: Analysis of recombinant HpCdMT and HpCuMT metal complexes reveals sequence-determined specialization of metal binding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cf1bb78 Item: Title: Binding of Zn2+ and Cd2+ by HpCdMT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@624b035d Item: Title: Binding of Cu+ by HpCuMT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aca0115 Item: Title: Complexes of HpCdMT and HpCuMT with non-cognate metal partners Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@340d1fa5 Item: Title: Stability of the Cd6-HpCdMT and Cu12-HpCuMT complexes is documented by their metal exchange inertness Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4998a455 Item: Title: Transformation of HpCdMT and HpCuMT in yeast MT-knockout cells confirms metal-specific roles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@444cee32 Item: Title: In pulmonate snails, CdMT and CuMT isoforms are products of cell-specific expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16aa37a6 Item: Title: Pulmonate MT isoform genes display metal-specific transcription patterns Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12b7eea Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e99353f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2c76e369 Children: Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@314c194d Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b112783 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23394894 Children: Item: Title: Animals and metal exposure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5cbfe9d Item: Title: Metal analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13b8f864 Item: Title: Real-time detection PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@54bb7759 Item: Title: In situ hybridization techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5f989f84 Item: Title: Construction of the recombinant expression vectors for wild-type Roman snail MT isoforms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d10c424 Item: Title: Recombinant synthesis and purification of the metal-HpMT complexes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37bd2664 Item: Title: Analysis of recombinantly expressed and in vitro prepared metal-HpMT complexes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63238bd2 Item: Title: Metal tolerance complementation assays in transformed yeast MT-knockout cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32b0bad7 Item: Title: MT sequence alignment and phylogenetic analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@70ba9340 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69198891 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b551d7f Item: Title: Authors' contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@10382a9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@d7725c4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@9506dc4 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f5663a2 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a761fe Children: Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6d126b07 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5430d082 Item: Title: Authors' contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50c931fc Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@48f0c0d3 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2011, 9:4. doi:10.1186/1741-7007-9-4 BioMed Central Ltd 2011-01-21 © 2011 Palacios et al; licensee BioMed Central Ltd. uuid:d2880df1-9dba-4b25-8a98-b24206851e48 uuid:82873b61-bffe-4474-b979-c6e336ab0681 True http://www.biomedcentral.com/1741-7007/9/4 10.1186/1741-7007-9-4 4 4 © 2011 Palacios et al; licensee BioMed Central Ltd. 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