9ce73af876756e0acd0704a312ddb418 pmc_22162924.pdf c55bc9cc1d465cf061e5aa83c9fecdca1939c5b0 pmc_22162924.pdf 03d84cb49a37ec31b2d1680521a07304484e6ee7838ad85578d386bb5a4e6849 pmc_22162924.pdf Title: OTT-16392-eribulin-mesylate-as-a-microtubule-inhibitor-for-the-treatme Subject: Eribulin mesylate and metastatic breast cancer Author: Cortés Creator: Adobe InDesign CS3 (5.0) Producer: Adobe PDF Library 8.0 CreationDate: Fri Nov 11 04:06:19 2011 CET ModDate: Sun Nov 13 23:22:57 2011 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 220215 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WUYVSW+Symbol CID Type 0C Identity-H yes yes yes 152 0 RUPWAG+GillSansMT TrueType WinAnsi yes yes yes 138 0 BWNEKM+GillSansMT-Bold TrueType WinAnsi yes yes yes 139 0 RUPWAG+MuseeBold Type 1C Custom yes yes yes 140 0 LTLHUS+Musee Type 1C Custom yes yes yes 141 0 WUYVSW+TimesNewRomanPS Type 1C Custom yes yes yes 151 0 RUPWAG+GillSansMT TrueType WinAnsi yes yes yes 130 0 RUPWAG+GillSansMT TrueType WinAnsi yes yes yes 136 0 WUYVSW+TimesNewRomanPS-Italic Type 1C WinAnsi yes yes yes 99 0 WUYVSW+Arial Type 1C WinAnsi yes yes no 100 0 WUYVSW+Arial Type 1C WinAnsi yes yes no 108 0 BWNEKM+GillSansMT-Bold CID TrueType Identity-H yes yes yes 107 0 WUYVSW+Arial-Italic Type 1C WinAnsi yes yes no 105 0 WUYVSW+Symbol-Bold CID Type 0C Identity-H yes yes yes 109 0 WUYVSW+MathematicalPi-One CID Type 0C Identity-H yes yes yes 110 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 14:02:08 CEST RepresentationInformation: pmc_22162924.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-25 14:29:41 CET Size: 220215 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 183 FreeObjects: 3 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Info: Title: OTT-16392-eribulin-mesylate-as-a-microtubule-inhibitor-for-the-treatme Author: Cortés Subject: Eribulin mesylate and metastatic breast cancer Creator: Adobe InDesign CS3 (5.0) Producer: Adobe PDF Library 8.0 CreationDate: Fri Nov 11 04:36:19 CET 2011 ModDate: Sun Nov 13 23:22:57 CET 2011 ID: 0x46ea1abbac828e4d8c5ef748715d385c29, 0x4810ba0bbddde6408a31e48e11d2e61929 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: WUYVSW+Symbol Encoding: Identity-H ToUnicode: true Font: BaseFont: BWNEKM+GillSansMT-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: WUYVSW+Symbol-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: WUYVSW+MathematicalPi-One Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: WUYVSW+TimesNewRomanPS-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: WUYVSW+TimesNewRomanPS-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -191, -216, 1031, 868 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WUYVSW+Arial FontSubset: true FirstChar: 72 LastChar: 79 FontDescriptor: FontName: WUYVSW+Arial Flags: Nonsymbolic FontBBox: -222, -250, 1006, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WUYVSW+TimesNewRomanPS FontSubset: true FirstChar: 30 LastChar: 233 FontDescriptor: FontName: WUYVSW+TimesNewRomanPS Flags: Serif, Nonsymbolic FontBBox: -167, -216, 1009, 878 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WUYVSW+Arial-Italic FontSubset: true FirstChar: 72 LastChar: 72 FontDescriptor: FontName: WUYVSW+Arial-Italic Flags: Nonsymbolic FontBBox: -261, -250, 1059, 936 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: RUPWAG+MuseeBold FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: RUPWAG+MuseeBold Flags: Serif, Nonsymbolic FontBBox: -232, -301, 1658, 974 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WUYVSW+Arial FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: WUYVSW+Arial Flags: Nonsymbolic FontBBox: -222, -250, 1006, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LTLHUS+Musee FontSubset: true FirstChar: 31 LastChar: 116 FontDescriptor: FontName: LTLHUS+Musee Flags: Serif, Nonsymbolic FontBBox: -221, -301, 1653, 974 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: RUPWAG+GillSansMT FontSubset: true FirstChar: 32 LastChar: 242 FontDescriptor: FontName: RUPWAG+GillSansMT Flags: Nonsymbolic FontBBox: -162, -282, 1041, 918 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BWNEKM+GillSansMT-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BWNEKM+GillSansMT-Bold Flags: Nonsymbolic FontBBox: -177, -319, 1167, 939 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType0: Font: BaseFont: WUYVSW+MathematicalPi-One CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WUYVSW+MathematicalPi-One Flags: Serif, Symbolic FontBBox: -30, -210, 1000, 779 FontFile3: true Font: BaseFont: WUYVSW+Symbol CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WUYVSW+Symbol Flags: Serif, Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true Font: BaseFont: WUYVSW+Symbol-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WUYVSW+Symbol-Bold Flags: Serif, Symbolic FontBBox: -196, -317, 1090, 1030 FontFile3: true CIDFontType2: Font: BaseFont: BWNEKM+GillSansMT-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BWNEKM+GillSansMT-Bold Flags: Symbolic FontBBox: -177, -319, 1167, 939 FontFile2: true XMP: 2011-11-11T08:36:19+05:30 2011-11-11T08:36:20+05:30 2011-11-11T08:36:20+05:30 Adobe InDesign CS3 (5.0) JPEG 256 256 /9j/4AAQSkZJRgABAgEASABIAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABAASAAAAAEA AQBIAAAAAQAB/+4AE0Fkb2JlAGQAAAAAAQUAAm5A/9sAhAAMCAgICAgMCAgMEAsLCxAUDg0NDhQY EhMTExIYFBIUFBQUEhQUGx4eHhsUJCcnJyckMjU1NTI7Ozs7Ozs7Ozs7AQ0LCxAOECIYGCIyKCEo MjsyMjIyOzs7Ozs7Ozs7Ozs7Ozs7OztAQEBAQDtAQEBAQEBAQEBAQEBAQEBAQEBAQED/wAARCAEA AMYDAREAAhEBAxEB/8QBQgAAAQUBAQEBAQEAAAAAAAAAAwABAgQFBgcICQoLAQABBQEBAQEBAQAA AAAAAAABAAIDBAUGBwgJCgsQAAEEAQMCBAIFBwYIBQMMMwEAAhEDBCESMQVBUWETInGBMgYUkaGx QiMkFVLBYjM0coLRQwclklPw4fFjczUWorKDJkSTVGRFwqN0NhfSVeJl8rOEw9N14/NGJ5SkhbSV xNTk9KW1xdXl9VZmdoaWprbG1ub2N0dXZ3eHl6e3x9fn9xEAAgIBAgQEAwQFBgcHBgI7AQACEQMh MRIEQVFhcSITBTKBkRShsUIjwVLR8DMkYuFygpJDUxVjczTxJQYWorKDByY1wtJEk1SjF2RFVTZ0 ZeLys4TD03Xj80aUpIW0lcTU5PSltcXV5fVWZnaGlqa2xtbm9ic3R1dnd4eXp7fH1+f3/9oADAMB AAIRAxEAPwDrfqx9WPq3kfVvpN9/ScG223Bxn2WPxqnOc51TC5znFkkkpKdL/mn9Vf8Aym6f/wCw tP8A6TSUr/mn9Vf/ACm6f/7C0/8ApNJSv+af1V/8pun/APsLT/6TSUr/AJp/VX/ym6f/AOwtP/pN JSv+af1V/wDKbp//ALC0/wDpNJSv+af1V/8AKbp//sLT/wCk0lK/5p/VX/ym6f8A+wtP/pNJSv8A mn9Vf/Kbp/8A7C0/+k0lK/5p/VX/AMpun/8AsLT/AOk0lK/5p/VX/wApun/+wtP/AKTSUr/mn9Vf /Kbp/wD7C0/+k0lK/wCaf1V/8pun/wDsLT/6TSUr/mn9Vf8Aym6f/wCwtP8A6TSUr/mn9Vf/ACm6 f/7C0/8ApNJSv+af1V/8pun/APsLT/6TSUr/AJp/VX/ym6f/AOwtP/pNJSv+af1V/wDKbp//ALC0 /wDpNJSv+af1V/8AKbp//sLT/wCk0lK/5p/VX/ym6f8A+wtP/pNJSv8Amn9Vf/Kbp/8A7C0/+k0l K/5p/VX/AMpun/8AsLT/AOk0lK/5p/VX/wApun/+wtP/AKTSUr/mn9Vf/Kbp/wD7C0/+k0lOb1b6 sfVuvP6KyvpOCxt2c9ljW41QD2jDzX7XAM1G5gPxCSnS+qf/AIlejf8Apvxf/PNaSnWSUjvuqx6X 33O2V1tLnuPYDkpKc3/nV9X/APuaz7nf+RSUr/nV9X/+5rPud/5FJSv+dX1f/wC5rPud/wCRSUr/ AJ1fV/8A7ms+53/kUlK/51fV/wD7ms+53/kUlLt+tHQHODW5jCSYAh3J/spKdVJSklKSUpJSklKS UpJSklKSUpJSklOW/wCs/Qa3urfmMDmEtcIdoRofzUlLf86egD/tYzXyd/5FJTZwer9N6k5zMG9t zqwC4NBEA/EBJTcSU5PWf+Uehf8Apws/9sc9JSvqn/4lejf+m/F/881pKdZJTC6qu+p9NzQ+uwFr 2ngg8hJTQ/5t9C/7g0/5qSlf82+hf9waf81JSv8Am30L/uDT/mpKV/zb6F/3Bp/zUlK/5t9C/wC4 NP8AmpKUPq50NpDm4VQIMgwkp0klKSUpJSklKSUpJSklKSU5ttv1hFrxTj4rqw47C614cWzoSBWd YSUw9b6y/wDcbD/7ef8A+k0lK9b6y/8AcbD/AO3n/wDpNJTnP6JlWPc9/SenOc4kuJsfqT/1tJS3 7Cyf/Knp2n/CP/8ASaSnR6N063CssdZhYuJvaADjOc4ug8O3Nakp1klOT1n/AJR6F/6cLP8A2xz0 lK+qf/iV6N/6b8X/AM81pKdZJTGzf6bvT+nB2z49vFA3WiY1erStZ10kehZitbtbIsre526Pdq2x g58khdaqlVmtmGz6x/6bB/7at/8ASyKFbPrH/psH/tq3/wBLJKb1IuFTRkFptj3msENnyDiSkpIk pSSlJKUkpSSlJKUkpSSlJKUkpSSlJKUkpq9Rd1BuMT0ttT8iRAunZHf6JCSnK9b67f6DA+9//pRJ Te6XZ1577P2xXj1sAHpnH3ST3nc5ySnRSU5PWf8AlHoX/pws/wDbHPSUr6p/+JXo3/pvxf8AzzWk p1klIspjrMa6tglz63NaPEkEBJTyvTOl9fp6f9nZjjp1df2c/ZcWrHxW2u9b9O53pZGSf5oCf0g3 eHZJSun0/XDH6djYb6bDXsZQWWOxd9bWnFDtxrdtLNouDIJdEbtdUlNrpeL9aMfPY297m4FbaQKi anhxJyBb7tbBtAqgAx+KSmNlX11/WLaLvf6mQcaq0UeltNuQ2gPLG79vpem7nd49wkpq0Zf12poZ fnVvps9Ha2q52LZW685GytllmO0PL7KzyxjWt51OgSmTsP624xsxsU5Jpi977a34YL7H5LrWuqa9 kh7q5nc7Z7gNvJCU3cOz62kdXZn0uaGn/Jr6bccvfJf9DdVtZDdn84Haz2gBKZdMf9ZxRmHqjLza MWk0NYcUA3io+q2gjdr6n51sN8BAkpSnt+tdnRcXY51PUWNsN8Gh+57J9NriWBkPIElob/ZSU1qq vrhXc31n5FlYvcwvqOLvfWy29tL7G2QwMdXsNnptD/3RykpfNx/rkKHUYmRbZe/FfttcMVtTbnVv MOhgsDm2FoZtlsfSJOqSkOfV9a8hlTW05ZGK/e2wHB9d7iIY4AuFW5ocQ6QBzE6JKZZNf1zvbXNL XZGI+yxjy+ltb3mvJDDXG5wgWNaNzeeQRqkptbfrVf0npznB2P1AEjLAfS8taZaC+A2p7tsE7WxP ASU0cbpf1qpvzX2OsezKyqnv91LTYypmBX6s17CC5tVgc3QeWoSUt07C+t1OJi12faqm0Cqv09+L vDWGgOaQwurLAQ/+Vs77klOj0mv60WZNX7SsuqoaHuu3jFLnWD0vY30Wu/RH3bfz4+lrCSnoElKS UpJSklOT1n/lHoX/AKcLP/bHPSUr6p/+JXo3/pvxf/PNaSnWSUgzzkDByDiEC8VPNRLS/wB+07fa C0nXtKSnmul9Q+tQ2dNdSGurApN9+PkuFew7GWPtsv8A0/qtG/2v9n0XGdUlOnmZfXGdYGJiNZ9n sFQD349j2tluQ6xxtZY1vLGDafFJTjY31m+tmTWwP6XbjXGy+p9b8Owtbsra5jhaMgt2tsdtDoPq cgNgwlNh3WvrW0tNOG3JZ6YeJxrqXWFgw5b77D6ZsOQ+Nw9uwzOsJTHp3XvrXn1iyzAOKGktc2/F sY9xJc0FrfXeGhpidTuAnSdEptZvV+vY+D06zFoORZfUX3uOLdLrR6e2j0WuDqPU3O/SPlrNuvKS kB6h13pWD02k/rGZl2XPva6jIsLz6m4VtHrPNIh8bnEsb4RokpgzrX1myLtv2eymtmQagThWsNrB ZiEP91loYPTteJPO08HQJSum9f8ArXnMbZb044oZd6drL8exj3BzqmTXFzgGs9Rx3SdwZMNn2pTc 6P1PruW3IqyWD1qsWp9Tn4l+M03OZL2vdc8A+7SGcePYJTUy+sfW59FdtGCcUue87fSdc7Y7Gyr6 97Gu0LHCprtdXyB2SUy6dn/WTH6X1W22l+TbS3NycEWU3Ne94vyvRqLHvLi1zWs2NEENICSkfU+v fW3p1D7mdP8AtsWFkY2Na57WtdY3f6ZvG8PhgEH2yXe4CElMXdf+tNTjW/Ec5zrMxv8AQcgspZX6 rsZz7K7XepuFY0YzXcBII1Skx659Y6zWfsz7Tdk0VmsYNzdlVrKd9jrPtBa3a95J+lEEHxCUk6X1 T6wWX49ee1za7nN32OwrhqKccmsNDh6Uvc/3vlukeCSnpUlKSUpJSklKSU5PWf8AlHoX/pws/wDb HPSUr6p/+JXo3/pvxf8AzzWkp1klNfqNtlHT8q6k7bK6bHsMTDmtJGh80lPNM+vFo6bkZ5xKr6sO tj7r6b3WVuFj3VB7DXjuJY0tmwhvth0AxqlKp+v1F762sqxw204mxz8hzDGU3dBa/HEvAgtYzcSC CdqSm+z6yWDpeHnWsxmPy7zQ4uyC2iogvEPuNJh/s27dv0vbPdJTTo+u7sikZFOGy+pr3MtfRc52 m9lVZpD6KzZvNjTw3TgnSUpGfr9W2/GxTj0325dD76ziZDrqnFnqe1l32djDHpw+SCHECDykp6qk 3OpY7IY2u0tBsZW4vaHdw17mVkjz2hJTI11ue21zWl7AQ1xAkB0TB84SUySUpJSklKSUpJSklKSU pJSklKSUpJSklKSUpJTk9Z/5R6F/6cLP/bHPSUr6p/8AiV6N/wCm/F/881pKdZJSklKSUpJSklKS UpJSxIAk6AclJSL7bh/6er/Pb/ekpX23D/09X+e3+9JSvtuH/p6v89v96SlfbcP/AE9X+e3+9JSv tuH/AKer/Pb/AHpKV9tw/wDT1f57f70lK+24f+nq/wA9v96SkoIcA5pkHUEJKXSUpJSklKSUpJSk lKSU5PWf+Uehf+nCz/2xz0lK+qf/AIlejf8Apvxf/PNaSnWSUpJSklKSUpJSklKSUjyP5iyBPsdo G7p0/dPPwSU8P6d//cG7/wBw1P8A6VSUr07/APuDd/7hqf8A0qkp18L6u2XspybDjNY6HOpt6dVW +J1a73naUlOx+xOjf9wMX/tln/kUlK/YnRv+4GL/ANss/wDIpKV+xOjf9wMX/tln/kUlK/YnRv8A uBi/9ss/8ikpuNa1jQxgDWtADWgQAB2CSl0lKSUpJSklKSUpJSklOT1n/lHoX/pws/8AbHPSUr6p /wDiV6N/6b8X/wA81pKdZJSklKSUpJSklKSUpJTGxrXscx43NcCCPEHskpx/+a/Qf/K7/pn/ANKp KV/zX6D/AOV3/TP/AKVSUr/mv0H/AMrv+mf/AEqkpX/NfoP/AJXf9M/+lUlK/wCa/Qf/ACu/6Z/9 KpKdOhjcalmPRS5ldbQ1jZaYA4Gr0lJPUf8A6N33t/8AJJKV6j/9G772/wDkklK9R/8Ao3fe3/yS Sleo/wD0bvvb/wCSSUr1H/6N33t/8kkpXqP/ANG772/+SSUr1H/6N33t/wDJJKXa4u5aW/GP4EpK ZJKcnrP/ACj0L/04Wf8AtjnpKV9U/wDxK9G/9N+L/wCea0lOskpq9UNY6dkm42CsVO3GmPUiPzJ/ O8ElPEev0T/Sdc/zq0lK9fon+k65/nVpKV6/RP8ASdc/zq0lO79XumYN5Z1XFyOoRW9zRVlvbBMR q1rePd4pKekSUiyYONbu3gbHSa/p8H6Pn4JKeQ9LC/03X/uP/kElLtbiN+jf9YBPhuH/AHxJS/6v /wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgk pX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/ AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkpX6v/wByfrD/ANL/AMgkp1vq/wCl6t3p 29Ss9okdRnaNfzJA1SU7iSnJ6z/yj0L/ANOFn/tjnpKV9U//ABK9G/8ATfi/+ea0lOskpDmMssxb WVW+g9zCG2/uEjR3ySU89+zes/8Azwt/zW/+TSUr9m9Z/wDnhb/mt/8AJpKdLpLbsJlg6h1NmaXk FhO1u0CZH0ikpv8A2vF/01f+eP70lLjKxSYF1ZJ4G4f3pKVlENxrXFzmAMcS5mrhodW+aSnjvt2N /wCW/U/+2z/ckpX27G/8t+p/9tn+5JSvt2N/5b9T/wC2z/ckpX27G/8ALfqf/bZ/uSUr7djf+W/U /wDts/3JKV9uxv8Ay36n/wBtn+5JSvt2N/5b9T/7bP8AckpX27G/8t+p/wDbZ/uSUr7djf8Alv1P /ts/3JKV9uxv/Lfqf/bZ/uSUr7djf+W/U/8Ats/3JKV9uxv/AC36n/22f7klK+3Y3/lv1P8A7bP9 ySnY+rmRVddcK83Ly4aJblNLQ3XlspKd5JTk9Z/5R6F/6cLP/bHPSUr6p/8AiV6N/wCm/F/881pK dZJTV6pt/Z2Tv2hvpOnc0vER3a3U/BJTw+3A/fxf/YG5JStuB+/i/wDsDckpW3A/fxf/AGBuSUrb gfv4v/sDckpvdM6V+0Hufguw91BaSXYljIJnbG8j91JT1LftVPTn/bb2+u1jy++th2t+kQ4M14CS nlP2w3/56Hf+wLv7klK/bDf/AJ6Hf+wLv7klK/bDf/nod/7Au/uSUr9sN/8Anod/7Au/uSUr9sN/ +eh3/sC7+5JSv2w3/wCeh3/sC7+5JSv2w3/56Hf+wLv7klK/bDf/AJ6Hf+wLv7klK/bDf/nod/7A u/uSUr9sN/8Anod/7Au/uSUr9sN/+eh3/sC7+5JSv2w3/wCeh3/sC7+5JSv2w3/56Hf+wLv7klOx 9XM0Zd1zR1Y9T2tB2HHNGyTzJ5lJTvJKcnrP/KPQv/ThZ/7Y56SlfVP/AMSvRv8A034v/nmtJTrJ Ka+fXZbhX10gusdW4NDXemSSNIf+b8UlOBgdCz7ri3P+141YaSHtzTYS6RpAaO0pKb//ADZx/wDu Znf+xDklK/5s4/8A3Mzv/YhySlf82cf/ALmZ3/sQ5JSv+bOP/wBzM7/2Ickp0XNGLhFjbC0U1QLb PeRtb9N3jxJSU8z+27f/AJ4cf/2FKSlftu3/AOeHH/8AYUpKV+27f/nhx/8A2FKSlftu3/54cf8A 9hSkpX7bt/8Anhx//YUpKV+27f8A54cf/wBhSkpX7bt/+eHH/wDYUpKV+27f/nhx/wD2FKSlftu3 /wCeHH/9hSkpX7bt/wDnhx//AGFKSlftu3/54cf/ANhSkpX7bt/+eHH/APYUpKV+27f/AJ4cf/2F KSnU6DnvzLbWu6lX1Da0HbXV6W2TyT3SU7KSnJ6z/wAo9C/9OFn/ALY56SlfVP8A8SvRv/Tfi/8A nmtJTrJKUkpSSlJKUkpSSlJKR5JIx7SHNaQxxDn/AERodXeSSnk/tmT/AOWfR/8ANCSlfbMn/wAs +j/5oSUr7Zk/+WfR/wDNCSlfbMn/AMs+j/5oSUr7Zk/+WfR/80JKV9syf/LPo/8AmhJSvtmT/wCW fR/80JKV9syf/LPo/wDmhJSvtmT/AOWfR/8ANCSlfbMn/wAs+j/5oSUr7Zk/+WfR/wDNCSlfbMn/ AMs+j/5oSUr7Zk/+WfR/80JKdXoF1tttosysLJhogYYAI1/OSU7aSnJ6z/yj0L/04Wf+2OekpX1T /wDEr0b/ANN+L/55rSU6ySlJKUkpSSlJKUkpSSkWT/R7fofQd/O/zfB+n/J8UlPI/wD1spKXa1zz tYPq04ngDUpKZ/Zsj/RfVz/NP9ySlfZsj/RfVz/NP9ySlfZsj/RfVz/NP9ySlfZsj/RfVz/NP9yS lfZsj/RfVz/NP9ySlfZsj/RfVz/NP9ySlfZsj/RfVz/NP9ySlfZsj/RfVz/NP9ySnTw8boX2Zn7Q q6V9o13+g2v0+Tt27xPEJKTfZvqr/oun/wCbT/ckpX2b6q/6Lp/+bT/ckptYNXSK3O/ZrMZriBv+ zhgMdp2JKbiSnJ6z/wAo9C/9OFn/ALY56SlfVP8A8SvRv/Tfi/8AnmtJTrJKUkpSSlJKUkpSSlJK R5DXPosY1rXucxwDH/RcSOHeRSU85R0fNN9YyOj9NbUXtFjmiXBs+4jzhJTr/sDon/cHH/7bb/ck pX7A6J/3Bx/+22/3JKV+wOif9wcf/ttv9ySlfsDon/cHH/7bb/ckpX7A6J/3Bx/+22/3JKV+wOif 9wcf/ttv9ySlfsDon/cHH/7bb/ckpX7A6J/3Bx/+22/3JKV+wOif9wcf/ttv9ySlfsDon/cHH/7b b/ckpX7A6J/3Bx/+22/3JKV+wOif9wcf/ttv9ySk+L07AwXOdh49dBeIca2hsgeMJKbKSnJ6z/yj 0L/04Wf+2OekpX1T/wDEr0b/ANN+L/55rSU6ySlJKUkpSSlJKUkpSSkeRYace20NLzWxzg0GCYEw kp5T/nhmf+U+R/29Z/6SSUr/AJ4Zn/lPkf8Ab1n/AKSSUr/nhmf+U+R/29Z/6SSU9D0rIPUcCrMt qsxnWbpqc95LdrnN5O3mJ4SU2/RZ4u/z3f3pKV6LPF3+e7+9JSvRZ4u/z3f3pKV6LPF3+e7+9JSv RZ4u/wA9396Sleizxd/nu/vSUr0WeLv89396Sleizxd/nu/vSUr0WeLv89396Sl2sDeJ+ZJ/KSkp kkpyes/8o9C/9OFn/tjnpKV9U/8AxK9G/wDTfi/+ea0lOskpSSlJKUkpSSlJKUkpFlO241zi/wBK K3H1AJ2QD7o7wkp4v9p1/wDz02f+wj0lK/adf/z02f8AsI9JSv2nX/8APTZ/7CPSUr9p1/8Az02f +wj0lK/adf8A89Nn/sI9JSv2nX/89Nn/ALCPSUr9p1//AD02f+wj0lK/adf/AM9Nn/sI9JSv2nX/ APPTZ/7CPSUuOpNIJb9Z7SGiXEYj9BMT95SUt+06/wD56bP/AGEekpX7Tr/+emz/ANhHpKV+06// AJ6bP/YR6Sna+rWW3IuvDerO6ntaDsdS6rZrzLuZSU76SnJ6z/yj0L/04Wf+2OekpX1T/wDEr0b/ ANN+L/55rSU6ySlJKUkpSSlJKUkpSSkWSXDHtLS1pDHQ6z6AMHV3l4pKeT+09T/8sOhf54/8gkpX 2nqf/lh0L/PH/kElK+09T/8ALDoX+eP/ACCSlfaep/8Alh0L/PH/AJBJSvtPU/8Ayw6F/nj/AMgk pX2nqf8A5YdC/wA8f+QSUr7T1P8A8sOhf54/8gkpX2nqf/lh0L/PH/kElK+09T/8sOhf54/8gkpX 2rqg46j0PXn3j/yKSlfaep/+WHQv88f+QSUr7T1P/wAsOhf54/8AIJKV9p6n/wCWHQv88f8AkElO t9X7cqy277Rk9PyAGiBgkFw1/PgDRJTtpKcnrP8Ayj0L/wBOFn/tjnpKV9U//Er0b/034v8A55rS U6ySlJKUkpSSlJKUkpSSkWS0ux7WtYLSWOArOgcSD7T8UlPJ/s3qH/ztYv8A28z/AMmkpX7N6h/8 7WL/ANvM/wDJpKV+zeof/O1i/wDbzP8AyaSmd3Sc2twDPq/h3AtDpZaBBP5p3luo8tElMP2b1D/5 2sX/ALeZ/wCTSUr9m9Q/+drF/wC3mf8Ak0lK/ZvUP/naxf8At5n/AJNJSv2b1D/52sX/ALeZ/wCT SUr9m9Q/+drF/wC3mf8Ak0lK/ZvUP/naxf8At5n/AJNJSv2b1D/52sX/ALeZ/wCTSUr9m9Q/+drF /wC3mf8Ak0lK/ZvUP/naxf8At5n/AJNJTrfV/Fyce2439Lq6aC0AOqe15frwdrjwkp20lOT1n/lH oX/pws/9sc9JSvqn/wCJXo3/AKb8X/zzWkp1klKSUpJSklKSUpJSklIsoNONcHNc8Gt0tZ9IiDo3 zSU8b9n6b/5U9Y+5/wD5JJSvs/Tf/KnrH3P/APJJKV9n6b/5U9Y+5/8A5JJSvs/Tf/KnrH3P/wDJ JKV9n6b/AOVPWPuf/wCSSUr7P03/AMqesfc//wAkkpX2fpv/AJU9Y+5//kklK+z9N/8AKnrH3P8A /JJKV9n6b/5U9Y+5/wD5JJSvs/Tf/KnrH3P/APJJKV9n6b/5U9Y+5/8A5JJSvs/Tf/KnrH3P/wDJ JKV9n6b/AOVPWPuf/wCSSU7v1cxcStluRj42XiucfTLMzduIHulocTpqkp2klOT1n/lHoX/pws/9 sc9JSvqn/wCJXo3/AKb8X/zzWkp1klKSUpJSklKSUpJSklMLbGU1PusMMraXuPOjRJSU8x1L6ydF z/T9HqmRh+nun0a3jduj6Ut7QkppftTpn/zwZ3+Y7/yCSlftTpn/AM8Gd/mO/wDIJKV+1Omf/PBn f5jv/IJKV+1Omf8AzwZ3+Y7/AMgkpX7U6Z/88Gd/mO/8gkpX7U6Z/wDPBnf5jv8AyCSlftTpn/zw Z3+Y7/yCSlftTpn/AM8Gd/mO/wDIJKV+1Omf/PBnf5jv/IJKV+1Omf8AzwZ3+Y7/AMgkpX7U6Z/8 8Gd/mO/8gkpX7U6Z/wDPBnf5jv8AyCSnY+reXiZN1wxupZGeWtBLb2kBuvIkBJTvpKcnrP8Ayj0L /wBOFn/tjnpKV9U//Er0b/034v8A55rSU6ySlJKUkpSSlJKUkpSSkeQ5zce1zHCtwY4h7votIHJ8 gkp5b9p9W/8AL3p3/R/8ikpX7T6t/wCXvTv+j/5FJSv2n1b/AMvenf8AR/8AIpKV+0+rf+XvTv8A o/8AkUlK/afVv/L3p3/R/wDIpKV+0+rf+XvTv+j/AORSUr9p9W/8venf9H/yKSlftPq3/l707/o/ +RSUr9p9W/8AL3p3/R/8ikpX7T6t/wCXvTv+j/5FJSv2n1b/AMvenf8AR/8AIpKV+0+rf+XvTv8A o/8AkUlK/afVv/L3p3/R/wDIpKdToOXmZFtoyuoYucGtBa3GiWmeXQAkp2UlOT1n/lHoX/pws/8A bHPSUr6p/wDiV6N/6b8X/wA81pKdZJSklKSUpJSklKSUpJSPJBdj2hrWvJY4Bj/ouMHR3kUlPJ/Y eo/+UnTP85v/AJJJSvsPUf8Ayk6Z/nN/8kkpX2HqP/lJ0z/Ob/5JJSvsPUf/ACk6Z/nN/wDJJKV9 h6j/AOUnTP8AOb/5JJSvsPUf/KTpn+c3/wAkkpX2HqP/AJSdM/zm/wDkklLtwOoOMHo/S2CCZJae BMaP78JKW+w9R/8AKTpn+c3/AMkkpX2HqP8A5SdM/wA5v/kklK+w9R/8pemf5zf/ACSSlfYeo/8A lL0z/Ob/AOSSUr7D1H/yk6Z/nN/8kkp1egUZNNtpvwcTCBaIdikEu14dBKSnbSU5PWf+Uehf+nCz /wBsc9JSvqn/AOJXo3/pvxf/ADzWkp1klMbHtrY57iGhoklxgCPEpKav7TxP+5GN/wBvD+5JSv2n if8AcjG/7eH9ySlftPE/7kY3/bw/uSUuOpYziGtvxyToALhr+CSmxN37rf8AOP8A5BJTDIBfiXNs r3yxwNbCZcI+iDA1KSni/wBm4X/zuZf/AG69JSv2bhf/ADuZf/br0lJsjomHjhhPQL7A+SPTyHPI iPpRxykpD+zcL/53Mv8A7dekpX7Nwv8A53Mv/t16Sk7ehYjsc5H7BuAEnYckh+n8jlJSD9m4X/zu Zf8A269JSv2bhf8AzuZf/br0lK/ZuF/87mX/ANuvSUr9m4X/AM7mX/269JTOnCw6LBa36t5Li2dL Hue3URq1wISUxd07Dc4uP1cy5Jk/pX90lLfs3C/+dzL/AO3XpKd76usqY57K+lP6dsYB6lmrnieC 6JMJKdxJTk9Z/wCUehf+nCz/ANsc9JSvqn/4lejf+m/F/wDPNaSnWSU1epx+zsmQD+ido5nqA6d2 D6XwSU8X+j/0OP8A+456Slfo/wDQ4/8A7jnpKV+j/wBDj/8AuOekpdrmscHsqoa5pBBHTnyCElOj T1rrN9zKGZIDrHBgLsOwCXGNSTokp6Bjcurp9o6jcHWBjy62hpYQ2Dq0a6hJTyn2jpv/AJbdY+9/ /kUlK+0dN/8ALbrH3v8A/IpKV9o6b/5bdY+9/wD5FJSvtHTf/LbrH3v/APIpKS15nRG1Obbm9Vts dO21zrg5mmkbYGnOoSUi+0dN/wDLbrH3v/8AIpKV9o6b/wCW3WPvf/5FJSvtHTf/AC26x97/APyK SlfaOm/+W3WPvf8A+RSUr7R03/y26x97/wDyKSlfaOm/+W3WPvf/AORSUr7R03/y26x97/8AyKSm VmV0lzy6rqXV6WHitjrCB8N0lJTrfVu3FsuuGPmZuWQ0SMwuIbry3cBqkp30lOT1n/lHoX/pws/9 sc9JSvqn/wCJXo3/AKb8X/zzWkp1klNXqcfs7Jkgfonauf6YGnd4+j8UlPF/o/8ATY//ALkXpKV+ j/02P/7kXpKUAxxDW20EnQAdRekpv/sDq/8A3G/9nbf7klNzp+N9YOmte2jEqcLCCfVyX2ceG5qS nXqtznYNtmcK8S4B8OYfUa0AaP1A4SU87+0cv/556P8A2Hr/ALklK/aOX/8APPR/7D1/3JKV+0cv /wCeej/2Hr/uSUr9o5f/AM89H/sPX/ckpX7Ry/8A556P/Yev+5JSv2jl/wDzz0f+w9f9ySlftHL/ APnno/8AYev+5JSv2jl//PPR/wCw9f8AckpX7Ry//nno/wDYev8AuSUr9o5f/wA89H/sPX/ckpX7 Ry//AJ56P/Yev+5JSv2jl/8Azz0f+w9f9ySlftHL/wDnno/9h6/7klOp0HJuvttFvVq+pgNBDa62 17NeTt8UlO0kpyes/wDKPQv/AE4Wf+2OekpX1T/8SvRv/Tfi/wDnmtJTrJKa3UQ52BkNYHOca3AB jQ9xMdmu0J8ikp4wYfUxe54x8zaWAE/ZaSSQTxWfaNO4KSmf2XqP+gzf/YLG/vSU7H1fxd5tZnYt hI2uY/Jxqqo8m+nKSnoUlKSUjyN3oWbA0u2OgWfQmPzvLxSU8z6fWf8AQdD+5396Slen1n/QdD+5 396Slen1n/QdD+5396Slen1n/QdD+5396Slen1n/AEHQ/ud/ekpXp9Z/0HQ/ud/ekpXp9Z/0HQ/u d/ekpXp9Z/0HQ/ud/ekpXp9Z/wBB0P7nf3pKV6fWf9B0P7nf3pKV6fWf9B0P7nf3pKV6fWf9B0P7 nf3pKV6fWf8AQdD+5396SnS6G3ObZb9rrwGDaNpwQQ46/nyeElOwkpyes/8AKPQv/ThZ/wC2Oekp X1T/APEr0b/034v/AJ5rSU6ySkeRRVlUWY17d9VrSx7ZIkHQiRBSU5P/ADO+rn/cT/wW3/0okpX/ ADO+rn/cT/wW3/0okpX/ADO+rn/cT/wW3/0okptdP6B0npVzsjAo9KxzTWXb3u9pIMQ9zhy1JToJ KY2VsurfVYJZY0tcOJBEHhJTj/8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP /Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76u f9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8A M76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSlf8AM76uf9xP/Bbf/SiSm507onS+kve/Ap9J1gAe d73SB/Xc5JTeSU5PWf8AlHoX/pws/wDbHPSUr6p/+JXo3/pvxf8AzzWkp1klIcy30MW27e2v02F2 94Ja2ByQElPPf85W/wDlpif9t2f+RSU6WO/rGVSzIx8nGfVYNzHBjtR80lJPS69/p8f/ADHJKV6X Xv8AT4/+Y5JTe9N/+kd9zf8AyKSkeR6lVFlrbSCxjnAv2hsgT7obwkp5n/nL1H/uX07/ALcd/wCk 0lK/5y9R/wC5fTv+3Hf+k0lK/wCcvUf+5fTv+3Hf+k0lK/5y9R/7l9O/7cd/6TSUr/nL1H/uX07/ ALcd/wCk0lNzp/1jqd6n7Uz8VkbfT9B+6ed27eweSSm3/wA4Oif+WTPvb/5BJSv+cHRP/LJn3t/8 gkpX/ODon/lkz72/+QSUr/nB0T/yyZ97f/IJKV/zg6J/5ZM+9v8A5BJSv+cHRP8AyyZ97f8AyCSm GR9YulNosdj9QrfcGONbXOaAXge0E7fFJSTouT1nKBt6jXUyl7GvpfU4O3btZ08klOqkpyes/wDK PQv/AE4Wf+2Oekpzfqx9Z/q3j/VvpNF/VsGq2rBxmWVvyamua5tTA5rml8ggpKdL/nZ9Vf8Ay56f /wCxVP8A6USUxt+tX1YfW5jOuYFbnAgPbk0EtPiA5xH4JKaX7c6J/wDPZjf9vYX/AJBJSv250X/5 7cf/ALewv/IJKV+3Oi//AD24/wD29hf+QSU2cX6zfVyhhbf9YcLJJMh1mRjNIHh+jLAkpN/zs+qv /lz0/wD9iqf/AEokpjb9afqvZU+tvW+ntL2lod9ppMEiJgvSU4n2ron/AM9mB9+H/wCSSUr7V0T/ AOezA+/D/wDJJKV9q6J/89mB9+H/AOSSUr7V0T/57MD78P8A8kkpX2ron/z2YH34f/kklK+1dE/+ ezA+/D/8kkpX2ron/wA9mB9+H/5JJSvtXRP/AJ7MD78P/wAkkpX2ron/AM9mB9+H/wCSSUr7V0T/ AOezA+/D/wDJJKV9q6J/89mB9+H/AOSSUr7V0T/57MD78P8A8kkpnVmdCZax7/rTgWNa4FzC7EAc AdWyHd0lO0PrX9VGgNb1jp4A0AGVTAH+ekpX/Oz6q/8Alz0//wBiqf8A0okpzerfWf6t2Z/RX19W wXtpznvsc3JqIY04eazc4h+g3PA+JSU//9k= uuid:bc9d7c36-6f84-4658-8a69-7ed6daa2dad3 adobe:docid:indd:09fd099a-3bce-11df-a0e0-816edfed9e66 proof:pdf 17b3b378-f380-11dd-a2ee-9265e11cd0a0 adobe:docid:indd:264a317f-e48a-11dd-b97b-aaf2f9c05b20 ReferenceStream 72.00 72.00 Inches uuid:0EF9059756F6E0119945929D4025CCCE uuid:0AF9059756F6E0119945929D4025CCCE ReferenceStream 72.00 72.00 Inches uuid:4755C53E5BF6E0119945929D4025CCCE uuid:0FF9059756F6E0119945929D4025CCCE application/pdf OTT-16392-eribulin-mesylate-as-a-microtubule-inhibitor-for-the-treatme Eribulin mesylate and metastatic breast cancer metastatic breast cancer eribulin mesylate halichondrin B tubulin-targeted agents Cortés published by Dove Press Print Adobe PDF Library 8.0 False Pages: Page: Label: 185 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 494, 736, 560, 749 Annotation: Subtype: Link Rect: 130, 34, 172, 40 Annotation: Subtype: Link Rect: 70, 23, 103, 31 Annotation: Subtype: Link Rect: 70, 13, 157, 19 Annotation: Subtype: Link Rect: 90, 66, 163, 76 Annotation: Subtype: Widget Rect: 221, 559, 353, 568 AppearanceDictionary: true Annotation: Subtype: Widget Rect: 221, 571, 558, 595 AppearanceDictionary: true Page: Label: 186 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 149, 34, 191, 40 Annotation: Subtype: Link Rect: 87, 21, 125, 31 Annotation: Subtype: Link Rect: 494, 751, 543, 763 Page: Label: 187 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 480, 34, 522, 40 Annotation: Subtype: Link Rect: 486, 21, 524, 31 Annotation: Subtype: Link Rect: 68, 751, 117, 763 Page: Label: 188 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 149, 34, 191, 40 Annotation: Subtype: Link Rect: 87, 21, 125, 31 Annotation: Subtype: Link Rect: 494, 751, 543, 763 Page: Label: 189 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 480, 34, 522, 40 Annotation: Subtype: Link Rect: 486, 21, 524, 31 Annotation: Subtype: Link Rect: 68, 751, 117, 763 Page: Label: 190 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 149, 34, 191, 40 Annotation: Subtype: Link Rect: 87, 21, 125, 31 Annotation: Subtype: Link Rect: 494, 751, 543, 763 Page: Label: 191 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 480, 34, 522, 40 Annotation: Subtype: Link Rect: 486, 21, 524, 31 Annotation: Subtype: Link Rect: 68, 751, 117, 763 Page: Label: 192 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 154, 68, 299, 75 Annotation: Subtype: Link Rect: 304, 88, 444, 96 Annotation: Subtype: Link Rect: 149, 34, 191, 40 Annotation: Subtype: Link Rect: 87, 21, 125, 31 Annotation: Subtype: Link Rect: 494, 751, 543, 763 Annotation: Subtype: Link Rect: 464, 138, 525, 153 Annotation: Subtype: Link Rect: 429, 230, 541, 238 Annotation: Subtype: Link Rect: 318, 220, 366, 228 Checksum: 0cded290 Type: CRC32 Checksum: 9ce73af876756e0acd0704a312ddb418 Type: MD5 Checksum: c55bc9cc1d465cf061e5aa83c9fecdca1939c5b0 Type: SHA-1