3bfa11dca6ed43a44452fb0bbeace286  bmcmedgen_a2012m10v15n44.pdf
76079b99bba2c7d738b7fffe70b57dcbc640661d  bmcmedgen_a2012m10v15n44.pdf
40fdc47ecb72ad89d9c5fa053dec6c64bf4cac37def723c0fece5abe1c83681b  bmcmedgen_a2012m10v15n44.pdf

Title:          PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
Creator:        Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Fri Nov  2 06:08:41 2012
ModDate:        Fri Nov  2 06:09:28 2012
Tagged:         no
Pages:          12
Encrypted:      no
Page size:      595.276 x 793.701 pts
File size:      937620 bytes
Optimized:      yes
PDF version:    1.3

name                                 type              emb sub uni object ID
------------------------------------ ----------------- --- --- --- ---------
JBFBOA+AdvTTaf7f9f4f.B               Type 1C           yes yes no     403  0
JBFBOB+AdvTTe45e47d2                 Type 1C           yes yes no     404  0
JBFBOC+AdvTTb5929f4c                 Type 1C           yes yes no     405  0
JBFBPC+AdvTTb5929f4c+20              Type 1C           yes yes no     406  0
JBFBPD+AdvTT99c4c969                 Type 1C           yes yes no     407  0
JBFBPE+AdvTT1b53b5fb.I               Type 1C           yes yes no     408  0
JBFCAF+AdvTTb5929f4c+22              Type 1C           yes yes yes    409  0
JBFCNB+AdvTT7329fd89.I               Type 1C           yes yes no     410  0
JBFDAC+AdvTT86d47313+20              Type 1C           yes yes no     218  0
JBFDAD+AdvP80516                     Type 1C           yes yes no     219  0
JBFDAE+AdvTT86d47313+21              Type 1C           yes yes no      44  0
JBFDBE+AdvTT8861b38f.I               Type 1C           yes yes no     220  0
JBFDCF+AdvTT86d47313+03              Type 1C           yes yes yes    221  0
JBFCPB+AdvTT86d47313                 Type 1C           yes yes no     222  0
JBFDNC+Times-Bold                    Type 1C           yes yes no     223  0
JBFFEK+AdvPi2                        Type 1C           yes yes no      78  0
JBFFEL+AdvPi1                        Type 1C           yes yes no      79  0
JBFFEM+AdvTTe45e47d2+20              Type 1C           yes yes no      77  0
JBFHEB+AdvTT83913201.I               Type 1C           yes yes no     225  0
JBFHIA+Times-Roman                   Type 1C           yes yes no     226  0
JBFHIB+Helvetica                     Type 1C           yes yes no     224  0
JBFHLB+Times-Italic                  Type 1C           yes yes no      99  0
JBFLGL+AdvTT99c4c969+20              Type 1C           yes yes no     227  0
JBFOAM+Helvetica-Bold                Type 1C           yes yes no     174  0
JBFOBN+Helvetica-Oblique             Type 1C           yes yes no     175  0
JBGAKO+FrutigerLTStd-Bold            Type 1C           yes yes yes    201  0
JBGANO+FrutigerLTStd-Roman           Type 1C           yes yes yes    202  0

Jhove (Rel. 1.4, 2009-07-30)
 Date: 2013-10-25 22:52:50 GMT+01:00
 RepresentationInformation: bmcmedgen_a2012m10v15n44.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2013-10-25 12:48:11 GMT+01:00
  Size: 937620
  Format: PDF
  Version: 1.3
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid destination object
   Offset: 920728
  ErrorMessage: Invalid destination object
   Offset: 920728
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 432
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@27431340
      Children: 
       Item: 
        Title: Background
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24a4e2e3
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@452bb7e0
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3934f69a
       Item: 
        Title: Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@442a15cd
     Item: 
      Title: Background
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@26fd68b1
     Item: 
      Title: Methods
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46e45076
      Children: 
       Item: 
        Title: Samples and clinical data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@375e9756
       Item: 
        Title: Measurement of PCR efficiency, limits of detection, and limits of quantification
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2321ab80
       Item: 
        Title: Selection of prototype samples for the RT-qPCR training set
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77827284
       Item: 
        Title: 10-Fold cross validation to determine stability of selected prototypes
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@152c7568
       Item: 
        Title: Measurements of assay reproducibility
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@19d009b4
       Item: 
        Title: Scaling single and Meta-Gene scores
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@292d15a9
     Item: 
      Title: Results
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4ee91f5d
      Children: 
       Item: 
        Title: Training set, subtype stability, and classification accuracy
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2b0a3b24
       Item: 
        Title: Interference from normal breast tissue contamination
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2cb0ce8f
       Item: 
        Title: Subtype, immunohistochemistry, and RT-qPCR gene scores
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@bc92535
       Item: 
        Title: Prognostic significance of gene expression versus standard methods for ER and HER2 status
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42a9c09e
     Item: 
      Title: Discussion
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16a4e743
     Item: 
      Title: Conclusions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@244aeb52
     Item: 
      Title: Additional files
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@329f671b
     Item: 
      Title: Competing interests
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f2a3793
     Item: 
      Title: Authors’ contributions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2ca6d51e
     Item: 
      Title: Acknowledgements
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cf1bb78
     Item: 
      Title: Author details
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@624b035d
     Item: 
      Title: References
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aca0115
   Info: 
    Title: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Thu Nov 01 23:08:41 GMT+01:00 2012
    ModDate: Thu Nov 01 23:09:28 GMT+01:00 2012
   ID: 0xbaef16ae653ebb02461b846a4497f7a0, 0xf4c1dfecd9692ae1ecd2f6b5cf25821f
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      MIMEType: application/pdf
      CompressionScheme: JPEG
      ColorSpace: RGB
      ImageWidth: 1420
      ImageLength: 367
      BitsPerSample: 8
   Fonts: 
    Type1: 
     Font: 
      BaseFont: JBFCPB+AdvTT86d47313
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: JBFCPB+AdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFLGL+AdvTT99c4c969+20
      FontSubset: true
      FirstChar: 146
      LastChar: 148
      FontDescriptor: 
       FontName: JBFLGL+AdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFFEL+AdvPi1
      FontSubset: true
      FirstChar: 125
      LastChar: 125
      FontDescriptor: 
       FontName: JBFFEL+AdvPi1
       Flags: Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBOC+AdvTTb5929f4c
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: JBFBOC+AdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFHLB+Times-Italic
      FontSubset: true
      FirstChar: 49
      LastChar: 83
      FontDescriptor: 
       FontName: JBFHLB+Times-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -169, -217, 1010, 883
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFDNC+Times-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 89
      FontDescriptor: 
       FontName: JBFDNC+Times-Bold
       Flags: Serif, Nonsymbolic, ForceBold
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBPC+AdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 134
      LastChar: 150
      FontDescriptor: 
       FontName: JBFBPC+AdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -218, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFHEB+AdvTT83913201.I
      FontSubset: true
      FirstChar: 49
      LastChar: 83
      FontDescriptor: 
       FontName: JBFHEB+AdvTT83913201.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBOA+AdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: JBFBOA+AdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFHIB+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JBFHIB+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBGAKO+FrutigerLTStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 147
      FontDescriptor: 
       FontName: JBGAKO+FrutigerLTStd-Bold
       Flags: Symbolic, ForceBold
       FontBBox: -166, -250, 1000, 935
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JBFDCF+AdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JBFDCF+AdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -135, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JBFFEK+AdvPi2
      FontSubset: true
      FirstChar: 123
      LastChar: 123
      FontDescriptor: 
       FontName: JBFFEK+AdvPi2
       Flags: Nonsymbolic
       FontBBox: 16, -335, 981, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBPE+AdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: JBFBPE+AdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFCNB+AdvTT7329fd89.I
      FontSubset: true
      FirstChar: 46
      LastChar: 116
      FontDescriptor: 
       FontName: JBFCNB+AdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFDAC+AdvTT86d47313+20
      FontSubset: true
      FirstChar: 147
      LastChar: 150
      FontDescriptor: 
       FontName: JBFDAC+AdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFOBN+Helvetica-Oblique
      FontSubset: true
      FirstChar: 43
      LastChar: 83
      FontDescriptor: 
       FontName: JBFOBN+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFCAF+AdvTTb5929f4c+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JBFCAF+AdvTTb5929f4c+22
       Flags: Symbolic
       FontBBox: -10, -218, 1083, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JBFHIA+Times-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JBFHIA+Times-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFDAD+AdvP80516
      FontSubset: true
      FirstChar: 87
      LastChar: 87
      FontDescriptor: 
       FontName: JBFDAD+AdvP80516
       Flags: Nonsymbolic
       FontBBox: 0, -218, 989, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFDAE+AdvTT86d47313+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: JBFDAE+AdvTT86d47313+21
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1208, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFFEM+AdvTTe45e47d2+20
      FontSubset: true
      FirstChar: 134
      LastChar: 134
      FontDescriptor: 
       FontName: JBFFEM+AdvTTe45e47d2+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1302, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBPD+AdvTT99c4c969
      FontSubset: true
      FirstChar: 37
      LastChar: 121
      FontDescriptor: 
       FontName: JBFBPD+AdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFDBE+AdvTT8861b38f.I
      FontSubset: true
      FirstChar: 44
      LastChar: 89
      FontDescriptor: 
       FontName: JBFDBE+AdvTT8861b38f.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFBOB+AdvTTe45e47d2
      FontSubset: true
      FirstChar: 35
      LastChar: 122
      FontDescriptor: 
       FontName: JBFBOB+AdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBFOAM+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: JBFOAM+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JBGANO+FrutigerLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JBGANO+FrutigerLTStd-Roman
       Flags: Symbolic
       FontBBox: -169, -250, 1000, 935
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/"
           x:xmptk="Adobe XMP Core 4.2.1-c043 52.372728, 2009/01/18-15:08:04">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description xmlns:xmp="http://ns.adobe.com/xap/1.0/" rdf:about="">
         <xmp:Label>BMC Medical Genomics 2012, 5:1. doi:10.1186/1755-8794-5-44</xmp:Label>
      </rdf:Description>
      <rdf:Description xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>http://dx.doi.org/10.1186/1755-8794-5-44</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Roy RL Bastien</rdf:li>
               <rdf:li>�lvaro Rodr�guez-Lescure</rdf:li>
               <rdf:li>Mark TW Ebbert</rdf:li>
               <rdf:li>Aleix Prat</rdf:li>
               <rdf:li>Blanca Mun�rriz</rdf:li>
               <rdf:li>Leslie Rowe</rdf:li>
               <rdf:li>Patricia Miller</rdf:li>
               <rdf:li>Manuel Ruiz-Borrego</rdf:li>
               <rdf:li>Daniel Anderson</rdf:li>
               <rdf:li>Bradley Lyons</rdf:li>
               <rdf:li>Isabel �lvarez</rdf:li>
               <rdf:li>Tracy Dowell</rdf:li>
               <rdf:li>David Wall</rdf:li>
               <rdf:li>Miguel �ngel Segu�</rdf:li>
               <rdf:li>Lee Barley</rdf:li>
               <rdf:li>Kenneth M Boucher</rdf:li>
               <rdf:li>Emilio Alba</rdf:li>
               <rdf:li>Lisa Pappas</rdf:li>
               <rdf:li>Carole A Davis</rdf:li>
               <rdf:li>Ignacio Aranda</rdf:li>
               <rdf:li>Christiane Fauron</rdf:li>
               <rdf:li>Inge J Stijleman</rdf:li>
               <rdf:li>Jos� Palacios</rdf:li>
               <rdf:li>Antonio Ant�n</rdf:li>
               <rdf:li>Eva Carrasco</rdf:li>
               <rdf:li>Rosal�a Caballero</rdf:li>
               <rdf:li>Matthew J Ellis</rdf:li>
               <rdf:li>Torsten O Nielsen</rdf:li>
               <rdf:li>Charles M Perou</rdf:li>
               <rdf:li>Mark Astill</rdf:li>
               <rdf:li>Philip S Bernard</rdf:li>
               <rdf:li>Miguel Mart�n</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Medical Genomics 2012, 5:1. doi:10.1186/1755-8794-5-44</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BMC Medical Genomics</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:date>
            <rdf:Seq>
               <rdf:li>2012-10-04</rdf:li>
            </rdf:Seq>
         </dc:date>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">� 2012 Bastien et al.; licensee BioMed Central Ltd.</rdf:li>
            </rdf:Alt>
         </dc:rights>
      </rdf:Description>
      <rdf:Description xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/" rdf:about="">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" rdf:about="">
         <prism:url>BMC Medical Genomics</prism:url>
         <prism:doi>10.1186/1755-8794-5-44</prism:doi>
         <prism:pageRange>1</prism:pageRange>
         <prism:startingPage>1</prism:startingPage>
         <prism:endingPage>1</prism:endingPage>
         <prism:copyright>� 2012 Bastien et al.; licensee BioMed Central Ltd.</prism:copyright>
         <prism:publicationName>BMC Medical Genomics</prism:publicationName>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:volume>5</prism:volume>
         <prism:rightsAgent>reprints@biomedcentral.com</prism:rightsAgent>
         <prism:publicationDate>2012-10-04</prism:publicationDate>
         <prism:number>1</prism:number>
         <prism:issueidentifier>1</prism:issueidentifier>
         <prism:issn>BMC Medical Genomics</prism:issn>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 0
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 146, 197, 153
      Annotation: 
       Subtype: Link
       Rect: 264, 67, 379, 74
     Thumb: true
    Page: 
     Label: 1
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 100, 548, 104, 558
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 108, 548, 112, 558
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 147, 512, 151, 522
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 155, 512, 159, 522
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 166, 488, 171, 498
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 173, 488, 178, 498
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 229, 464, 234, 474
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 236, 464, 241, 474
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 243, 464, 248, 474
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 250, 464, 255, 474
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 165, 452, 170, 462
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 174, 452, 183, 462
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 59, 404, 69, 414
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 75, 392, 162, 402
      Annotation: 
       Subtype: Link
       Rect: 104, 380, 114, 390
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 56, 368, 121, 378
      Annotation: 
       Subtype: Link
       Rect: 59, 356, 69, 366
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 196, 344, 267, 354
      Annotation: 
       Subtype: Link
       Rect: 206, 332, 216, 342
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 150, 320, 225, 330
      Annotation: 
       Subtype: Link
       Rect: 149, 260, 154, 270
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 158, 260, 163, 270
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 165, 260, 170, 270
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 172, 260, 182, 270
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 184, 260, 194, 270
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 59, 236, 69, 246
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 73, 236, 83, 246
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 462, 512, 467, 522
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 308, 440, 317, 450
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 463, 344, 468, 354
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 414, 320, 424, 330
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 332, 272, 342, 282
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 516, 260, 521, 270
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 368, 58, 373, 68
       Destination: 149
     Thumb: true
    Page: 
     Label: 2
     Sequence: 3
     Thumb: true
    Page: 
     Label: 3
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 162, 646, 232, 656
      Annotation: 
       Subtype: Link
       Rect: 162, 622, 167, 632
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 93, 598, 102, 608
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 396, 682, 406, 692
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 384, 274, 394, 284
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 471, 250, 476, 260
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 422, 214, 426, 224
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 522, 166, 533, 176
       Destination: 193
     Thumb: true
    Page: 
     Label: 4
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 244, 125, 254
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 93, 70, 98, 80
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 132, 70, 137, 80
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 419, 292, 424, 302
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 474, 244, 479, 254
       Destination: 90
     Thumb: true
    Page: 
     Label: 5
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 215, 312, 220, 322
       Destination: 110
      Annotation: 
       Subtype: Link
       Rect: 242, 312, 247, 322
       Destination: 110
      Annotation: 
       Subtype: Link
       Rect: 501, 312, 506, 322
       Destination: 120
     Thumb: true
    Page: 
     Label: 6
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 477, 694, 482, 704
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 383, 622, 388, 632
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 375, 610, 380, 620
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 334, 346, 339, 356
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 373, 298, 377, 308
       Destination: 149
     Thumb: true
    Page: 
     Label: 7
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 216, 526, 226, 536
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 228, 526, 237, 536
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 130, 514, 139, 524
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 511, 538, 521, 548
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 351, 466, 361, 476
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 510, 346, 520, 356
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 449, 166, 458, 176
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 490, 106, 500, 116
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 458, 58, 468, 68
       Destination: 193
     Thumb: true
    Page: 
     Label: 8
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 402, 478, 412, 488
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 330, 430, 339, 440
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 484, 250, 493, 260
       Destination: 193
     Thumb: true
    Page: 
     Label: 9
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 310, 285, 320
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 121, 202, 131, 212
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 133, 202, 143, 212
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 309, 388, 366, 396
      Annotation: 
       Subtype: Link
       Rect: 309, 358, 366, 366
      Annotation: 
       Subtype: Link
       Rect: 309, 319, 366, 327
      Annotation: 
       Subtype: Link
       Rect: 358, 292, 362, 300
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 378, 292, 381, 300
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 309, 280, 366, 288
      Annotation: 
       Subtype: Link
       Rect: 309, 223, 366, 231
      Annotation: 
       Subtype: Link
       Rect: 309, 166, 366, 174
      Annotation: 
       Subtype: Link
       Rect: 309, 82, 366, 90
     Thumb: true
    Page: 
     Label: 10
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 691, 118, 699
      Annotation: 
       Subtype: Link
       Rect: 61, 643, 118, 651
     Thumb: true
    Page: 
     Label: 11
     Sequence: 12
     Thumb: true
  Checksum: c512d03d
   Type: CRC32
  Checksum: 3bfa11dca6ed43a44452fb0bbeace286
   Type: MD5
  Checksum: 76079b99bba2c7d738b7fffe70b57dcbc640661d
   Type: SHA-1