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Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@375e9756 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2321ab80 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77827284 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@152c7568 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@19d009b4 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@292d15a9 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4ee91f5d Children: Item: Title: Assessment of tumor biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2b0a3b24 Item: Title: Isolation and enumeration of circulating tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2cb0ce8f Item: Title: Cell cultures and molecular biomarker assay feasibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@bc92535 Item: Title: Characterization of ER, PR, and EGFR in circulating tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42a9c09e Item: Title: Characterization of HER2 and TOP2A amplification in circulating tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16a4e743 Item: Title: Statistical methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@244aeb52 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@329f671b Children: Item: Title: Detection of circulating tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f2a3793 Item: Title: Clinical-pathological characteristics and circulating tumor cell status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2ca6d51e Item: Title: Hormonal status of circulating tumor cells and corresponding primary tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cf1bb78 Item: Title: EGFR expression in circulating tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@624b035d Item: Title: HER2 and TOPO2A status of circulating tumor cells and corresponding primary tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aca0115 Item: Title: Circulating tumor cell characterization after a systemic treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@340d1fa5 Item: Title: Breast cancer subtypes and circulating tumor cell biomarker profile Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4998a455 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@444cee32 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16aa37a6 Item: Title: Acknowledgements Destination: 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Rect: 319, 455, 364, 462 Annotation: Subtype: Link Rect: 403, 437, 522, 444 Annotation: Subtype: Link Rect: 319, 428, 523, 435 Annotation: Subtype: Link Rect: 319, 419, 468, 426 Annotation: Subtype: Link Rect: 319, 410, 389, 417 Annotation: Subtype: Link Rect: 481, 392, 521, 399 Annotation: Subtype: Link Rect: 319, 383, 532, 390 Annotation: Subtype: Link Rect: 319, 374, 492, 381 Annotation: Subtype: Link Rect: 493, 338, 527, 345 Annotation: Subtype: Link Rect: 319, 329, 478, 337 Annotation: Subtype: Link Rect: 391, 302, 507, 310 Annotation: Subtype: Link Rect: 319, 293, 530, 301 Annotation: Subtype: Link Rect: 319, 284, 366, 292 Annotation: Subtype: Link Rect: 430, 266, 535, 274 Annotation: Subtype: Link Rect: 319, 257, 516, 265 Annotation: Subtype: Link Rect: 374, 230, 527, 238 Annotation: Subtype: Link Rect: 319, 221, 438, 229 Annotation: Subtype: Link Rect: 439, 204, 530, 211 Annotation: Subtype: Link Rect: 319, 195, 406, 202 Annotation: Subtype: Link Rect: 451, 177, 510, 184 Annotation: Subtype: Link Rect: 319, 168, 533, 175 Annotation: Subtype: Link Rect: 319, 159, 333, 166 Annotation: Subtype: Link Rect: 381, 150, 505, 157 Annotation: Subtype: Link Rect: 319, 141, 470, 148 Annotation: Subtype: Link Rect: 319, 114, 528, 121 Annotation: Subtype: Link Rect: 319, 105, 498, 112 Annotation: Subtype: Link Rect: 440, 78, 531, 85 Annotation: Subtype: Link Rect: 319, 69, 526, 76 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 71, 697, 287, 704 Annotation: Subtype: Link Rect: 71, 688, 172, 695 Annotation: Subtype: Link Rect: 71, 670, 288, 677 Annotation: Subtype: Link Rect: 71, 661, 217, 668 Annotation: Subtype: Link Rect: 131, 643, 276, 650 Annotation: Subtype: Link Rect: 71, 634, 273, 641 Annotation: Subtype: Link Rect: 146, 616, 285, 623 Annotation: Subtype: Link Rect: 71, 607, 195, 614 Annotation: Subtype: Link Rect: 184, 589, 275, 597 Annotation: Subtype: Link Rect: 71, 580, 286, 588 Annotation: Subtype: Link Rect: 71, 571, 180, 579 Annotation: Subtype: Link Rect: 112, 535, 271, 543 Annotation: Subtype: Link Rect: 71, 526, 126, 534 Annotation: Subtype: Link Rect: 243, 517, 265, 525 Annotation: Subtype: Link Rect: 71, 508, 246, 516 Annotation: Subtype: Link Rect: 71, 499, 263, 507 Annotation: Subtype: Link Rect: 71, 472, 242, 480 Annotation: Subtype: Link Rect: 135, 428, 276, 435 Annotation: Subtype: Link Rect: 71, 419, 281, 426 Annotation: Subtype: Link Rect: 71, 410, 290, 417 Annotation: Subtype: Link Rect: 71, 401, 275, 408 Annotation: Subtype: Link Rect: 71, 392, 137, 399 Annotation: Subtype: Link Rect: 218, 347, 275, 354 Annotation: Subtype: Link Rect: 71, 338, 238, 345 Annotation: Subtype: Link Rect: 137, 320, 273, 328 Annotation: Subtype: Link Rect: 71, 311, 218, 319 Annotation: Subtype: Link Rect: 104, 284, 270, 292 Annotation: Subtype: Link Rect: 71, 275, 271, 283 Annotation: Subtype: Link Rect: 228, 221, 275, 229 Annotation: Subtype: Link Rect: 71, 212, 283, 220 Annotation: Subtype: Link Rect: 71, 204, 222, 211 Annotation: Subtype: Link Rect: 71, 141, 282, 148 Annotation: Subtype: Link Rect: 71, 132, 269, 139 Annotation: Subtype: Link Rect: 71, 123, 260, 130 Annotation: Subtype: Link Rect: 71, 78, 281, 85 Annotation: Subtype: Link Rect: 319, 697, 510, 704 Annotation: Subtype: Link Rect: 319, 688, 347, 695 Checksum: 0af44525 Type: CRC32 Checksum: f1e55f094bcbc9dcb6ed60e1960abb40 Type: MD5 Checksum: 70245d82c511800b1600b64700aaee21dbbed0f1 Type: SHA-1