ed3e8abfad1fb47b562d23741148a7d2 intjoumolsci_a2012v13p11869.pdf 186c91a3298f8ea02cae6a2528f40f696939fa3a intjoumolsci_a2012v13p11869.pdf d2dd3f54921eca51586bb7dd01789f38fe264ec917cedb7281146f212a74c7df intjoumolsci_a2012v13p11869.pdf Title: Is DNA Damage Response Ready for Action Anywhere? Subject: Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. Keywords: micronuclei; DSB repair; NER pathway; chromosome instability Author: Mariona Terradas, Marta Martín, Laia Hernández, Laura Tusell, Anna Genescà Creator: PScript5.dll Version 5.2.2 Producer: Acrobat Distiller 9.5.0 (Windows) CreationDate: Fri Sep 14 15:49:18 2012 ModDate: Mon Feb 29 14:56:17 2016 Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.22 x 842 pts (A4) Page rot: 0 File size: 1285012 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JOMLIC+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes no 78 0 JOMLJD+TimesNewRomanPS-BoldMT TrueType WinAnsi yes yes no 79 0 JOMLJF+TimesNewRomanPSMT TrueType WinAnsi yes yes no 80 0 JOMLJE+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 59 0 JOMMAE+Wingdings-Regular CID TrueType Identity-H yes yes yes 61 0 JOMMBF+TimesNewRomanPS-BoldItalicMT TrueType WinAnsi yes yes no 62 0 JONANK+ArialMT TrueType WinAnsi yes yes no 65 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2016-03-04 04:12:34 CET RepresentationInformation: intjoumolsci_a2012v13p11869.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2016-02-29 14:56:31 CET Size: 1285012 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, ISO PDF/A-1, Level B PDFMetadata: Objects: 90 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Info: Title: Is DNA Damage Response Ready for Action Anywhere? Author: Mariona Terradas, Marta Martín, Laia Hernández, Laura Tusell, Anna Genescà Subject: Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. Keywords: micronuclei; DSB repair; NER pathway; chromosome instability Creator: PScript5.dll Version 5.2.2 Producer: Acrobat Distiller 9.5.0 (Windows) CreationDate: Fri Sep 14 09:49:18 CEST 2012 ModDate: Mon Feb 29 14:56:17 CET 2016 ID: 0x6eef7b187ae91238c99be65a91a48f0f, 0x5f4ac09981b7904896d5303101a679eb Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1181 ImageHeight: 1536 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1181 ImageHeight: 767 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 970 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 483 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1927 ImageHeight: 1240 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: JOMLJE+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: JOMMAE+Wingdings-Regular Encoding: Identity-H ToUnicode: true TrueType: Font: BaseFont: JONANK+ArialMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: JONANK+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: JOMLJF+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 242 FontDescriptor: FontName: JOMLJF+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: JOMLIC+TimesNewRomanPS-ItalicMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JOMLIC+TimesNewRomanPS-ItalicMT Flags: Serif, Nonsymbolic, Italic FontBBox: -498, -307, 1120, 1023 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: JOMLJD+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 32 LastChar: 237 FontDescriptor: FontName: JOMLJD+TimesNewRomanPS-BoldMT Flags: Serif, Nonsymbolic FontBBox: -558, -307, 2000, 1026 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: JOMMBF+TimesNewRomanPS-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: JOMMBF+TimesNewRomanPS-BoldItalicMT Flags: Serif, Nonsymbolic, Italic FontBBox: -547, -307, 1206, 1032 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: JOMMAE+Wingdings-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JOMMAE+Wingdings-Regular Flags: Symbolic FontBBox: 0, -211, 1359, 899 FontFile2: true Font: BaseFont: JOMLJE+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JOMLJE+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true XMP: Acrobat Distiller 9.5.0 (Windows) micronuclei; DSB repair; NER pathway; chromosome instability PScript5.dll Version 5.2.2 2016-02-29T14:56:17+01:00 2012-09-14T15:49:18+08:00 2016-02-29T14:56:17+01:00 application/pdf Is DNA Damage Response Ready for Action Anywhere? Mariona Terradas, Marta Martín, Laia Hernández, Laura Tusell, Anna Genescà Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. micronuclei DSB repair NER pathway chromosome instability uuid:84c73e51-e01b-4f83-9407-0ed839610a57 uuid:7a2fd2f5-6ad2-4c68-9115-3ede2037e442 Pages: Page: Label: 1 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Page: Label: 8 Page: Label: 9 Page: Label: 10 Page: Label: 11 Page: Label: 12 Page: Label: 13 Page: Label: 14 Page: Label: 15 Checksum: 73d436df Type: CRC32 Checksum: ed3e8abfad1fb47b562d23741148a7d2 Type: MD5 Checksum: 186c91a3298f8ea02cae6a2528f40f696939fa3a Type: SHA-1