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Title:          Detecting un-authorized genetically modified organisms (GMOs) and derived materials
Subject:        Biotechnology Advances, 30 (2012) 1318-1335. doi:10.1016/j.biotechadv.2012.01.024
Keywords:       Un-approved GMO;  Unknown GMO;  GMO screening;  Matrix approach;  Genetically engineered organism;  GEM;  Un-approved GEM
Author:         Arne Holst-Jensen
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      Title: Detecting un-authorized genetically modified organisms (GMOs) and derived materials
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        Title: 1. Introduction
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          Title: 1.1. Significance of GMOs
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          Title: 1.2. Genetic and phenotypic detection of GMOs
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        Title: 2. The “modular approach” in GMO analysis
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          Title: 2.1. The concept of modularity
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          Title: 2.2. Modules for GMO detection
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            Title: 2.2.1. Taxon specific modules
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            Title: 2.2.2. Element specific modules
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            Title: 2.2.3. Construct specific modules
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            Title: 2.2.4. Event specific modules
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            Title: 2.2.5. Validation and other modules
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        Title: 3. Classification of GMOs
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          Title: 3.1. Classification based on origin of the inserted genetic elements—four generations of GMOs
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            Title: 3.1.1. The first generation—single trait transgenes
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            Title: 3.1.2. Second generation—stacked trait GMOs
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            Title: 3.1.3. Third generation—near-intragenics
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            Title: 3.1.4. Fourth generation—intragenics and cisgenics
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          Title: 3.2. Classification based on DNA sequence information knowledge
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            Title: 3.2.1. Fully characterized GMOs (ISK-class 1)
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            Title: 3.2.2. GMOs not fully characterized but transformed with known construct(s) (ISK-class 2)
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           Item: 
            Title: section21
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            Title: 3.2.4. GMOs transformed only with genetic elements not used in GMOs of other ISK-classes (ISK-class 4)
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          Title: 3.3. Legal classification of GMOs
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        Title: 4. Where do un-authorized GMOs come from?
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        Title: 5. The matrix approach—the testing paradigm of today
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        Title: 6. Qualitative screening
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        Title: 7. Exploiting quantitative information
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        Title: 8. Exploiting traceability data and publicly available information
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        Title: 9. Reference materials
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        Title: 10. Analytical detection of un-authorized GMOs in practice
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          Title: 10.1. Direct detection of a registered, un-authorized GMO
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          Title: 10.2. Limited screening-based GMO testing of products consisting of a single or a low number of ingredients
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          Title: 10.3. Complex screening-based GMO testing of products containingmultipleingredients and/or where DNA quantity and/or integrity are significantlyaffected by processing
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        Title: 11. Alternative and advanced technologies for routine and ad hoc application
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          Title: 11.3. Next generation sequencing technologies
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        Title: Acknowledgments
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        Title: References
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    Keywords: Un-approved GMO;  Unknown GMO;  GMO screening;  Matrix approach;  Genetically engineered organism;  GEM;  Un-approved GEM
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