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Title:          Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas
Subject:        British Journal of Cancer 106, 1367 (2012). doi:10.1038/bjc.2012.85
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     Item: 
      Title: Increased signalling of EGFR and IGF1R, and deregulation of PTENsolPI3KsolAkt pathway are related with trastuzumab resistance in HER2 breast carcinomas
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        Title: Patients and methods
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          Title: Tumour samples and patients’ follow-up
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         Item: 
          Title: Immunohistochemistry
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          Title: Mutational analysis of PIK3CA
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          Title: Phosphatase and tensin homologue mutation and promoter hypermethylation
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          Title: In situ hybridisation analysis
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          Title: Statistical analyses
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        Title: Results
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          Title: Clinicopathological data
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        Title: Table 1 Panel of antibodies for the immunohistochemical analysis
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          Title: Tumour molecular features
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            Title: Hormonal receptors (HR)
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            Title: Growth factor receptors
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            Title: Biomarkers associated with the PI3KsolAktsolmTOR and MAPK signalling pathways
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        Title: Table 2 Summary of the main clinicopathological data
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        Title: Table 3 Statistical correlations between clinicopathological, immunohistochemical and molecular data for all tumours
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        Title: Figure 1 Immunohistochemical expression of EGFR, alphaIGFR, p110a, pAKT, pBad, and loss of PTEN in HER2-positive breast carcinomas.
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            Title: Cell proliferation and apoptosis markers
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          Title: Relationship between biomarkers and recurrence
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          Title: Survival analyses
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            Title: Metastatic BC (group A)
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        Title: Table 5 Multivariate analysis of histological and biological factors for patients with trastuzumab treatment in the metastatic disease (group A) (Cox model)
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            Title: Early-stage BC (group B)
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        Title: Discussion
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        Title: ACKNOWLEDGEMENTS
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        Title: Conflict of interest
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        Title: REFERENCES
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   Type: CRC32
  Checksum: 5355f26e4c2d1b3ad99312561f907211
   Type: MD5
  Checksum: 9a71a02c9fde7b87442b1bd0e27fd86580e28c12
   Type: SHA-1