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Title:          Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep
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      Title: Introduction
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      Title: Materials and methods
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        Title: Ethics statement
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       Item: 
        Title: Animals
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       Item: 
        Title: Necropsy and tissue collection
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       Item: 
        Title: Total RNA isolation and cDNA synthesis
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       Item: 
        Title: Quantitative real-time PCR
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       Item: 
        Title: Histopathology
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       Item: 
        Title: Immunohistochemistry
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       Item: 
        Title: Protein extraction and Western/dot blot analysis
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     Item: 
      Title: Results
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      Children: 
       Item: 
        Title: Scrapie-associated neuropathology
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        Title: Gene transcription
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       Item: 
        Title: Protein distribution in central nervous system
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         Item: 
          Title: Collagen 1 alpha 2 immunolabeling
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         Item: 
          Title: Collagen 3 alpha 1 immunolabeling
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         Item: 
          Title: Galanin 1 immunolabeling
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         Item: 
          Title: Calpain 6 immunolabeling
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         Item: 
          Title: Melatonin receptor 1B immunolabeling
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         Item: 
          Title: Metallothionein 1 + 2 immunolabeling
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       Item: 
        Title: Protein quantification by blotting assay
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     Item: 
      Title: Discussion
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     Item: 
      Title: Competing interests
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     Item: 
      Title: Authors’ contributions
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      Title: Acknowledgements
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     Item: 
      Title: Author details
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     Item: 
      Title: References
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