d63d96c705acb3fba38f786de921ebdf brasci_a2013m9v3n3p1395.pdf a0e5a392bbe1358ad182f48be3f1a55a22de1149 brasci_a2013m9v3n3p1395.pdf 016d309ce23024141e754e4c77fb5aec3e1da8445638ed344f82203de629d934 brasci_a2013m9v3n3p1395.pdf Title: The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke Subject: Advances in acute stroke therapy resulting from thrombolytic treatment, endovascular procedures, and stroke units have improved significantly stroke survival and prognosis; however, for the large majority of patients lacking access to advanced therapies stroke mortality and residual morbidity remain high and many patients become incapacitated by motor and cognitive deficits, with loss of independence in activities of daily living. Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). Citicoline has therapeutic effects at several stages of the ischemic cascade in acute ischemic stroke and has demonstrated efficiency in a multiplicity of animal models of acute stroke. Long-term treatment with citicoline is safe and effective, improving post-stroke cognitive decline and enhancing patients’ functional recovery. Prolonged citicoline administration at optimal doses has been demonstrated to be remarkably well tolerated and to enhance endogenous mechanisms of neurogenesis and neurorepair contributing to physical therapy and rehabilitation. Keywords: citicoline; neuroprotection; neurorepair; ischemic stroke; hemorrhagic stroke; vascular dementia; vascular cognitive disorders; neurogenesis; synaptogenesis; neuronal plasticity Author: José Álvarez-Sabín Creator: PScript5.dll Version 5.2.2 Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Sun Sep 22 23:39:00 2013 ModDate: Sun Sep 22 23:55:08 2013 Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.22 x 842 pts (A4) Page rot: 0 File size: 1077396 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MFJMNA+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes no 159 0 MFJNAA+TimesNewRomanPS-BoldMT TrueType WinAnsi yes yes no 160 0 MFJNCC+TimesNewRomanPSMT TrueType WinAnsi yes yes no 161 0 MFJNDD+TimesNewRomanPS-BoldItalicMT TrueType WinAnsi yes yes no 162 0 MFKAKO+ArialMT TrueType WinAnsi yes yes no 117 0 MFJNBB+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 120 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2017-03-29 11:28:44 CEST RepresentationInformation: brasci_a2013m9v3n3p1395.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2016-12-09 10:51:29 CET Size: 1077396 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 176 FreeObjects: 2 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Info: Title: The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke Author: José Álvarez-Sabín Subject: Advances in acute stroke therapy resulting from thrombolytic treatment, endovascular procedures, and stroke units have improved significantly stroke survival and prognosis; however, for the large majority of patients lacking access to advanced therapies stroke mortality and residual morbidity remain high and many patients become incapacitated by motor and cognitive deficits, with loss of independence in activities of daily living. Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). Citicoline has therapeutic effects at several stages of the ischemic cascade in acute ischemic stroke and has demonstrated efficiency in a multiplicity of animal models of acute stroke. Long-term treatment with citicoline is safe and effective, improving post-stroke cognitive decline and enhancing patients’ functional recovery. Prolonged citicoline administration at optimal doses has been demonstrated to be remarkably well tolerated and to enhance endogenous mechanisms of neurogenesis and neurorepair contributing to physical therapy and rehabilitation. Keywords: citicoline; neuroprotection; neurorepair; ischemic stroke; hemorrhagic stroke; vascular dementia; vascular cognitive disorders; neurogenesis; synaptogenesis; neuronal plasticity Creator: PScript5.dll Version 5.2.2 Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Sun Sep 22 17:39:00 CEST 2013 ModDate: Sun Sep 22 17:55:08 CEST 2013 ID: 0x865e491631f18fd9e29f9fa6d70f7a71, 0xe6694de8c8a55044a56a2646bcffde89 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: ImageWidth: 270 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 112 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 112 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 86 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: 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Román Advances in acute stroke therapy resulting from thrombolytic treatment, endovascular procedures, and stroke units have improved significantly stroke survival and prognosis; however, for the large majority of patients lacking access to advanced therapies stroke mortality and residual morbidity remain high and many patients become incapacitated by motor and cognitive deficits, with loss of independence in activities of daily living. Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). Citicoline has therapeutic effects at several stages of the ischemic cascade in acute ischemic stroke and has demonstrated efficiency in a multiplicity of animal models of acute stroke. Long-term treatment with citicoline is safe and effective, improving post-stroke cognitive decline and enhancing patients’ functional recovery. Prolonged citicoline administration at optimal doses has been demonstrated to be remarkably well tolerated and to enhance endogenous mechanisms of neurogenesis and neurorepair contributing to physical therapy and rehabilitation. citicoline neuroprotection neurorepair ischemic stroke hemorrhagic stroke vascular dementia vascular cognitive disorders neurogenesis synaptogenesis neuronal plasticity 2013-09-22T23:39+08:00 PScript5.dll Version 5.2.2 2013-09-22T23:55:08+08:00 2013-09-22T23:55:08+08:00 Acrobat Distiller 9.0.0 (Windows) citicoline; neuroprotection; neurorepair; ischemic stroke; hemorrhagic stroke; vascular dementia; vascular cognitive disorders; neurogenesis; synaptogenesis; neuronal plasticity uuid:01035ad2-4916-4d17-a07d-6adab1506741 uuid:ee2628e4-0418-46b2-b761-e8ed93e2b98e Pages: Page: Label: 1 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Page: Label: 8 Page: Label: 9 Page: Label: 10 Page: Label: 11 Page: Label: 12 Page: Label: 13 Page: Label: 14 Page: Label: 15 Page: Label: 16 Page: Label: 17 Page: Label: 18 Page: Label: 19 Page: Label: 20 Checksum: 4f55865a Type: CRC32 Checksum: d63d96c705acb3fba38f786de921ebdf Type: MD5 Checksum: a0e5a392bbe1358ad182f48be3f1a55a22de1149 Type: SHA-1