3fd85bddc907c7d963003bfdf20cd28f ploone_a2013m12v8n12p82484.pdf be4bfce554ba2242ab082636b71e425cfd1ca386 ploone_a2013m12v8n12p82484.pdf be1f6cbc9497d05ed09acb03d0ffc3db5b206b8a8c0bebe20557e68447ac033b ploone_a2013m12v8n12p82484.pdf Creator: AH XSL Formatter V6.1 MR2 for Linux64 : 6.1.6.12685 (2013/09/18 10:39JST) Producer: Antenna House PDF Output Library 6.1.425 (Linux64) CreationDate: Mon Dec 16 16:45:41 2013 CET ModDate: Mon Dec 16 16:45:41 2013 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 2477859 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NICKQX+Arial-BoldMT CID TrueType Identity-H yes yes yes 6 0 NICKQX+DejaVuSans-Bold CID TrueType Identity-H yes yes yes 7 0 NICKQX+ArialMT CID TrueType Identity-H yes yes yes 9 0 NICKQX+Arial-ItalicMT CID TrueType Identity-H yes yes yes 14 0 NICKQX+DejaVuSans CID TrueType Identity-H yes yes yes 17 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:59:21 CEST RepresentationInformation: ploone_a2013m12v8n12p82484.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-15 15:56:24 CEST Size: 2477859 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 439 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Structure-Based Analysis of A19D, a Variant of Transthyretin Involved in Familial Amyloid Cardiomyopathy Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Ethics Statement Item: Title: Patient Privacy and Informed Consent for Publication Item: Title: Enzymatic Amplification of Genomic DNA Item: Title: Cloning in the pGEM-T vector Item: Title: Direct DNA sequencing of TTR exons Item: Title: FoldX prediction Item: Title: Results Children: Item: Title: Description of a new TTR variant in Brazil encoding an alanine to aspartic acid substitution at position 19 (A19D) Item: Title: Case report of one Brazilian FAP patient with a rare mutation on the TTR gene Item: Title: Structural and thermodynamic stability prediction of the alanine to aspartic acid substitution at TTR position 19 Item: Title: Evaluating the structural modifications caused by Ala19Asp substitution and their implication for predicting decreased thermodynamic stability Item: Title: Discussion Item: Title: Supporting Information Item: Title: Author Contributions Item: Title: References Info: Creator: AH XSL Formatter V6.1 MR2 for Linux64 : 6.1.6.12685 (2013/09/18 10:39JST) Producer: Antenna House PDF Output Library 6.1.425 (Linux64) CreationDate: Mon Dec 16 08:45:41 CET 2013 ModDate: Mon Dec 16 08:45:41 CET 2013 ID: 0x8326452398baef29786b8573fdef58a8, 0x8326452398baef29786b8573fdef58a8 Filters: 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