b6cb792d73e4bb569a36dbfcc45290a5  303524.pdf
5b49d101ca9dbc4ea48da3a2f894a04bb2644db6  303524.pdf
ada2cb99da7a9ad73349b0be20092aa349fc8ec0bdf030d711d49167e03a1f25  303524.pdf

Title:           Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net
Creator:         Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:        Acrobat Distiller 10.1.5 (Windows)
CreationDate:    Tue May 28 21:43:06 2013 CEST
ModDate:         Tue May 28 21:43:58 2013 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       342950 bytes
Optimized:       yes
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
AAFGJD+AdvTTaf7f9f4f.B               Type 1C           WinAnsi          yes yes no     446  0
AAFGJE+AdvTTe45e47d2                 Type 1C           WinAnsi          yes yes no     447  0
AAFGJF+AdvTTb5929f4c                 Type 1C           WinAnsi          yes yes no     448  0
AAFGKG+AdvTT99c4c969                 Type 1C           WinAnsi          yes yes no     449  0
AAFGKH+AdvTT86d47313                 Type 1C           WinAnsi          yes yes no     450  0
AAFGLH+AdvTT8861b38f.I               Type 1C           WinAnsi          yes yes no     419  0
AAFHNC+AdvTT7329fd89.I               Type 1C           WinAnsi          yes yes no     451  0
AAFIFC+Helvetica                     Type 1C           WinAnsi          yes yes no      15  0
AAFIGC+Times-Roman                   Type 1C           WinAnsi          yes yes no      16  0
AAFIGD+AdvTTb5929f4c+20              Type 1C           WinAnsi          yes yes no     204  0
AAFIAC+AdvTT83913201.I               Type 1C           WinAnsi          yes yes no     203  0
AAFIBC+AdvTT86d47313+20              Type 1C           WinAnsi          yes yes no     205  0
AAFIIE+AdvTT99c4c969+20              Type 1C           WinAnsi          yes yes no     206  0
AAFIJE+AdvTTb5929f4c+03              Type 1C           Custom           yes yes yes     48  0
AAFIOD+AdvTT6120e2aa+27              Type 1C           Custom           yes yes yes    208  0
AAFIOE+AdvTT5843c571                 Type 1C           WinAnsi          yes yes no     209  0
AAFIOF+AdvTT5843c571+20              Type 1C           WinAnsi          yes yes no     210  0
AAFIOG+AdvTT83913201.I+20            Type 1C           WinAnsi          yes yes no      71  0
AAFIPH+AdvTT4fa15320.B               Type 1C           WinAnsi          yes yes no     207  0
AAFJBH+AdvTT86d47313+03              Type 1C           Custom           yes yes yes     94  0
AAFJEH+AdvTT43ccf47d                 Type 1C           WinAnsi          yes yes no     121  0
AAFJMF+AdvTT1b53b5fb.I               Type 1C           WinAnsi          yes yes no     211  0
AAFJNG+AdvTTe45e47d2+20              Type 1C           WinAnsi          yes yes no     175  0
AAFKOA+FrutigerLTStd-Bold            Type 1C           Custom           yes yes yes    186  0
AAFLCA+FrutigerLTStd-Roman           Type 1C           Custom           yes yes yes    187  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-11-27 02:59:13 CET
 RepresentationInformation: 303524.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-11-26 12:50:05 CET
  Size: 342950
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 464
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: sectionAbs1
     Item: 
      Title: Background, process of development and restrictions
      Destination: sectionSec1
      Children: 
       Item: 
        Title: General consideration
        Destination: sectionSec2
       Item: 
        Title: Diagnosis
        Destination: sectionSec3
       Item: 
        Title: Pretreatment clinical evaluation
        Destination: sectionSec4
        Children: 
         Item: 
          Title: Complete history
          Destination: sectionSec5
         Item: 
          Title: Complete physical examination
          Destination: sectionSec6
         Item: 
          Title: Laboratory and radiographic evaluation
          Destination: sectionSec7
       Item: 
        Title: Definition of organ involvement
        Destination: sectionSec8
        Children: 
         Item: 
          Title: Possibly involved organs
          Destination: sectionSec9
       Item: 
        Title: Risk organs (bone marrow, liver, spleen, CNS)
        Destination: sectionSec10
       Item: 
        Title: “Special Sites” and “CNS-Risk” bone involvement
        Destination: sectionSec11
       Item: 
        Title: Endocrinologic dysfunction
        Destination: sectionSec12
        Children: 
         Item: 
          Title: Dermatological involvement
          Destination: sectionSec13
         Item: 
          Title: Gastrointestinal involvement
          Destination: sectionSec14
       Item: 
        Title: Stratification
        Destination: sectionSec15
       Item: 
        Title: Treatment
        Destination: sectionSec16
        Children: 
         Item: 
          Title: Management algorithms (see Figure 1)
          Destination: sectionSec17
         Item: 
          Title: Careful observation, local or “mild systemic” therapy
          Destination: sectionSec18
         Item: 
          Title: Systemic therapy
          Destination: sectionSec19
       Item: 
        Title: Treatment options in case of reactivation
        Destination: sectionSec20
        Children: 
         Item: 
          Title: Reactivation of single system disease
          Destination: sectionSec21
         Item: 
          Title: Reactivation after systemic therapy
          Destination: sectionSec22
       Item: 
        Title: Radiotherapy
        Destination: sectionSec23
       Item: 
        Title: Treatment and hormone replacement of endocrinopathies
        Destination: sectionSec24
       Item: 
        Title: Central nervous system involvement
        Destination: sectionSec25
        Children: 
         Item: 
          Title: Tumorous lesions
          Destination: sectionSec26
         Item: 
          Title: Neurodegerative LCH
          Destination: sectionSec27
       Item: 
        Title: Primary pulmonary LCH
        Destination: sectionSec28
        Children: 
         Item: 
          Title: Epidemiology
          Destination: sectionSec29
       Item: 
        Title: Clinical features
        Destination: sectionSec30
       Item: 
        Title: Diagnosis
        Destination: sectionSec31
       Item: 
        Title: Treatment and prognosis
        Destination: sectionSec32
       Item: 
        Title: Pregnancy
        Destination: sectionSec33
       Item: 
        Title: Follow up
        Destination: sectionSec34
     Item: 
      Title: Competing interest
      Destination: ArtNote1
     Item: 
      Title: Authors’ contributions
      Destination: ArtNote2
     Item: 
      Title: Author details
      Destination: sectionaunote1
     Item: 
      Title: References
      Destination: sectionBib1
   Info: 
    Title: Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.1.5 (Windows)
    CreationDate: Tue May 28 21:43:06 CEST 2013
    ModDate: Tue May 28 21:43:58 CEST 2013
   ID: 0xb4a0749367f8bd43a084360fa0b3241b, 0xbf17d13b38d7720eec04fa040b21ba2c
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 52
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 15
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 7
      ImageHeight: 38
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 4
      ImageHeight: 45
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 13
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 50
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 16
      ImageHeight: 19
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 6
      ImageHeight: 42
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 58
      ImageHeight: 69
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 16
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 25
      ImageHeight: 66
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: AAFGJF+AdvTTb5929f4c
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: AAFGJF+AdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFGKG+AdvTT99c4c969
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: AAFGKG+AdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFGKH+AdvTT86d47313
      FontSubset: true
      FirstChar: 33
      LastChar: 122
      FontDescriptor: 
       FontName: AAFGKH+AdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFHNC+AdvTT7329fd89.I
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: AAFHNC+AdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIOG+AdvTT83913201.I+20
      FontSubset: true
      FirstChar: 147
      LastChar: 148
      FontDescriptor: 
       FontName: AAFIOG+AdvTT83913201.I+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1531, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIAC+AdvTT83913201.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: AAFIAC+AdvTT83913201.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIGD+AdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 129
      LastChar: 150
      FontDescriptor: 
       FontName: AAFIGD+AdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -218, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIBC+AdvTT86d47313+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: AAFIBC+AdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIIE+AdvTT99c4c969+20
      FontSubset: true
      FirstChar: 146
      LastChar: 148
      FontDescriptor: 
       FontName: AAFIIE+AdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIFC+Helvetica
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: AAFIFC+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIPH+AdvTT4fa15320.B
      FontSubset: true
      FirstChar: 66
      LastChar: 121
      FontDescriptor: 
       FontName: AAFIPH+AdvTT4fa15320.B
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1052, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIGC+Times-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: AAFIGC+Times-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIOD+AdvTT6120e2aa+27
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: AAFIOD+AdvTT6120e2aa+27
       Flags: Symbolic
       FontBBox: 0, -197, 1572, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AAFIOE+AdvTT5843c571
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: AAFIOE+AdvTT5843c571
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -208, 927, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIOF+AdvTT5843c571+20
      FontSubset: true
      FirstChar: 147
      LastChar: 148
      FontDescriptor: 
       FontName: AAFIOF+AdvTT5843c571+20
       Flags: Nonsymbolic
       FontBBox: -208, -208, 1000, 687
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFJMF+AdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: AAFJMF+AdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFJBH+AdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: AAFJBH+AdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -135, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AAFGLH+AdvTT8861b38f.I
      FontSubset: true
      FirstChar: 41
      LastChar: 86
      FontDescriptor: 
       FontName: AAFGLH+AdvTT8861b38f.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFJNG+AdvTTe45e47d2+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: AAFJNG+AdvTTe45e47d2+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1302, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFIJE+AdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: AAFIJE+AdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AAFJEH+AdvTT43ccf47d
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: AAFJEH+AdvTT43ccf47d
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 1010, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFKOA+FrutigerLTStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 147
      FontDescriptor: 
       FontName: AAFKOA+FrutigerLTStd-Bold
       Flags: Symbolic, ForceBold
       FontBBox: -166, -250, 1000, 935
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AAFLCA+FrutigerLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: AAFLCA+FrutigerLTStd-Roman
       Flags: Symbolic
       FontBBox: -169, -250, 1000, 935
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AAFGJD+AdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: AAFGJD+AdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAFGJE+AdvTTe45e47d2
      FontSubset: true
      FirstChar: 34
      LastChar: 122
      FontDescriptor: 
       FontName: AAFGJE+AdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/"
           x:xmptk="Adobe XMP Core 4.2.1-c043 52.372728, 2009/01/18-15:08:04">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description xmlns:xmp="http://ns.adobe.com/xap/1.0/" rdf:about="">
         <xmp:Label>Orphanet Journal of Rare Diseases 2013, 8:1. doi:10.1186/1750-1172-8-72</xmp:Label>
      </rdf:Description>
      <rdf:Description xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>http://dx.doi.org/10.1186/1750-1172-8-72</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Michael Girschikofsky</rdf:li>
               <rdf:li>Maurizio Arico</rdf:li>
               <rdf:li>Diego Castillo</rdf:li>
               <rdf:li>Anthony Chu</rdf:li>
               <rdf:li>Claus Doberauer</rdf:li>
               <rdf:li>Joachim Fichter</rdf:li>
               <rdf:li>Julien Haroche</rdf:li>
               <rdf:li>Gregory A Kaltsas</rdf:li>
               <rdf:li>Polyzois Makras</rdf:li>
               <rdf:li>Angelo V Marzano</rdf:li>
               <rdf:li>Mathilde de Menthon</rdf:li>
               <rdf:li>Oliver Micke</rdf:li>
               <rdf:li>Emanuela Passoni</rdf:li>
               <rdf:li>Heinrich M Seegenschmiedt</rdf:li>
               <rdf:li>Abdellatif Tazi</rdf:li>
               <rdf:li>Kenneth L McClain</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Orphanet Journal of Rare Diseases 2013, 8:1. doi:10.1186/1750-1172-8-72</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Orphanet Journal of Rare Diseases</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:date>
            <rdf:Seq>
               <rdf:li>2013-05-14</rdf:li>
            </rdf:Seq>
         </dc:date>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">� 2013 Girschikofsky et al.; licensee BioMed Central Ltd.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Langerhans</rdf:li>
               <rdf:li>Adult</rdf:li>
               <rdf:li>Histiocytosis</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/" rdf:about="">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" rdf:about="">
         <prism:url>Orphanet Journal of Rare Diseases</prism:url>
         <prism:doi>10.1186/1750-1172-8-72</prism:doi>
         <prism:pageRange>1</prism:pageRange>
         <prism:startingPage>1</prism:startingPage>
         <prism:endingPage>1</prism:endingPage>
         <prism:copyright>� 2013 Girschikofsky et al.; licensee BioMed Central Ltd.</prism:copyright>
         <prism:publicationName>Orphanet Journal of Rare Diseases</prism:publicationName>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:volume>8</prism:volume>
         <prism:rightsAgent>reprints@biomedcentral.com</prism:rightsAgent>
         <prism:publicationDate>2013-05-14</prism:publicationDate>
         <prism:number>1</prism:number>
         <prism:issueidentifier>1</prism:issueidentifier>
         <prism:issn>Orphanet Journal of Rare Diseases</prism:issn>
      </rdf:Description>
   <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/"><pdf:Keywords> Langerhans; Adult; Histiocytosis</pdf:Keywords></rdf:Description></rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 0
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 125, 238, 130, 248
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 117, 154, 122, 164
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 410, 238, 515, 248
      Annotation: 
       Subtype: Link
       Rect: 428, 226, 523, 236
      Annotation: 
       Subtype: Link
       Rect: 457, 167, 462, 177
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 464, 167, 469, 177
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 307, 107, 312, 117
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 314, 107, 319, 117
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 114, 128, 236, 135
      Annotation: 
       Subtype: Link
       Rect: 287, 67, 403, 74
     Thumb: true
    Page: 
     Label: 1
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 526, 243, 536
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 189, 334, 194, 344
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 149, 238, 154, 248
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 99, 106, 104, 116
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 107, 106, 117, 116
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 230, 58, 235, 68
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 241, 58, 251, 68
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 384, 197, 394, 207
       Destination: 164
     Thumb: true
    Page: 
     Label: 2
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 96, 550, 101, 560
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 77, 526, 87, 536
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 272, 358, 281, 368
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 152, 322, 156, 332
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 177, 322, 182, 332
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 488, 490, 498, 500
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 500, 490, 510, 500
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 442, 358, 452, 368
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 498, 226, 508, 236
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 510, 226, 520, 236
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 452, 214, 457, 224
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 474, 190, 484, 200
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 486, 190, 495, 200
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 470, 142, 479, 152
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 482, 142, 491, 152
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 523, 106, 533, 116
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 320, 70, 330, 80
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 462, 58, 472, 68
       Destination: 164
     Thumb: true
    Page: 
     Label: 3
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 130, 169, 140
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 414, 94, 424, 104
       Destination: 164
     Thumb: true
    Page: 
     Label: 4
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 574, 232, 584
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 233, 538, 242, 548
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 171, 382, 181, 392
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 193, 58, 203, 68
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 447, 358, 452, 367
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 307, 154, 317, 164
       Destination: 164
     Thumb: true
    Page: 
     Label: 5
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 682, 226, 692
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 249, 550, 258, 560
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 277, 514, 287, 524
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 213, 502, 222, 512
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 236, 430, 246, 440
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 252, 418, 262, 428
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 239, 346, 249, 356
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 149, 250, 158, 260
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 504, 610, 513, 620
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 483, 562, 493, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 321, 538, 331, 548
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 369, 526, 379, 536
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 523, 454, 533, 464
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 439, 430, 448, 440
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 365, 406, 370, 416
       Destination: 74
     Thumb: true
    Page: 
     Label: 6
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 646, 102, 656
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 233, 634, 242, 644
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 244, 634, 254, 644
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 116, 598, 125, 608
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 127, 598, 137, 608
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 165, 586, 175, 596
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 272, 538, 282, 548
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 249, 310, 258, 320
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 258, 106, 268, 116
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 271, 106, 281, 116
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 255, 58, 265, 68
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 511, 646, 520, 656
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 522, 646, 532, 656
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 472, 610, 477, 620
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 464, 514, 474, 524
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 392, 394, 402, 404
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 345, 226, 355, 236
       Destination: 178
     Thumb: true
    Page: 
     Label: 7
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 646, 150, 656
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 152, 646, 162, 656
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 193, 634, 202, 644
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 264, 562, 273, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 275, 562, 285, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 143, 430, 153, 440
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 227, 406, 237, 416
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 224, 346, 234, 356
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 161, 274, 171, 284
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 173, 274, 183, 284
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 227, 178, 232, 188
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 252, 178, 257, 188
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 159, 94, 169, 104
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 172, 70, 182, 80
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 448, 562, 457, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 505, 538, 515, 548
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 493, 478, 503, 488
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 420, 406, 425, 416
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 489, 202, 498, 212
       Destination: 178
     Thumb: true
    Page: 
     Label: 8
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 562, 133, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 155, 502, 165, 512
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 167, 502, 177, 512
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 363, 670, 372, 680
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 374, 670, 384, 680
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 398, 586, 408, 596
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 410, 586, 420, 596
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 453, 538, 463, 548
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 523, 490, 533, 500
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 365, 466, 370, 476
       Destination: 148
      Annotation: 
       Subtype: Link
       Rect: 293, 106, 297, 114
       Destination: 53
     Thumb: true
    Page: 
     Label: 9
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 121, 622, 131, 632
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 118, 562, 128, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 130, 562, 140, 572
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 231, 442, 236, 452
       Destination: 148
      Annotation: 
       Subtype: Link
       Rect: 381, 513, 522, 521
     Thumb: true
    Page: 
     Label: 10
     Sequence: 11
     Thumb: true
  Checksum: c8da8e37
   Type: CRC32
  Checksum: b6cb792d73e4bb569a36dbfcc45290a5
   Type: MD5
  Checksum: 5b49d101ca9dbc4ea48da3a2f894a04bb2644db6
   Type: SHA-1
  Checksum: ada2cb99da7a9ad73349b0be20092aa349fc8ec0bdf030d711d49167e03a1f25
   Type: SHA-256