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Title:           Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
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     Item: 
      Title: Abstract
      Destination: sectionAbs1
      Children: 
       Item: 
        Title: Background
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       Item: 
        Title: Methods/design
        Destination: sectionASec2
       Item: 
        Title: Discussion
        Destination: sectionASec3
     Item: 
      Title: Background
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      Children: 
       Item: 
        Title: Objective
        Destination: sectionSec2
     Item: 
      Title: Methods/design
      Destination: sectionSec3
      Children: 
       Item: 
        Title: Overview of methods
        Destination: sectionSec4
       Item: 
        Title: Literature search
        Destination: sectionSec5
       Item: 
        Title: Eligibility criteria
        Destination: sectionSec6
       Item: 
        Title: Study selection
        Destination: sectionSec7
       Item: 
        Title: Data collection and extraction
        Destination: sectionSec8
       Item: 
        Title: Outcomes of interest and statistical analysis
        Destination: sectionSec9
       Item: 
        Title: Risk of bias assessment
        Destination: sectionSec10
       Item: 
        Title: Optimal information size and the progression of the body of evidence
        Destination: sectionSec11
       Item: 
        Title: Sensitivity analysis
        Destination: sectionSec12
       Item: 
        Title: Author contact
        Destination: sectionSec13
       Item: 
        Title: Reporting
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     Item: 
      Title: Discussion
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      Children: 
       Item: 
        Title: Strengths and limitations of our protocol
        Destination: sectionSec16
       Item: 
        Title: Ethical and data monitoring implications
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       Item: 
        Title: Public engagement in science
        Destination: sectionSec18
     Item: 
      Title: Conclusion
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     Item: 
      Title: Trial status
      Destination: sectionSec20
     Item: 
      Title: Additional files
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     Item: 
      Title: Abbreviations
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     Item: 
      Title: Competing interests
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     Item: 
      Title: Authors’ contributions
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     Item: 
      Title: Acknowledgements
     Item: 
      Title: Funding
      Destination: sectionArt1356235573101005
     Item: 
      Title: Author details
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     Item: 
      Title: References
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