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     Item: 
      Title: Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Cell culture and treatment with Roscovitine
         Item: 
          Title: Cdk5-wt and Cdk5 kinase mutant stable transfections
         Item: 
          Title: CIP cloning and stable transfections
         Item: 
          Title: In vitro capillary tubule-like structure formation on MatrigeTM
         Item: 
          Title: Spheroid based in vitro angiogenesis assay
         Item: 
          Title: Colorimetric adhesion assay
         Item: 
          Title: Spreading assay
         Item: 
          Title: In vitro angiogenesis assay with continuous live cell imaging
         Item: 
          Title: Western Blotting
         Item: 
          Title: Confocal and fluorescence microscopical analysis.
         Item: 
          Title: Cdk5 kinase activity
         Item: 
          Title: MEF2C siRNAs
         Item: 
          Title: Affymetrix Microarray
         Item: 
          Title: Calpain activity
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: R-roscovitine is a selective inhibitor of Cdk5 activity in hBMECs
         Item: 
          Title: Cdk5 overexpression supports in vitro hBMEC angiogenesis during hypoxia
         Item: 
          Title: pTyr(15)Cdk5 and p35 mobilization are essential for in vitro brain endothelial cell migration through association with integrin beta-1 and talin proteins
         Item: 
          Title: Cdk5 and MEF2C promote proper spatial organization of brain endothelial cells
         Item: 
          Title: Modulation of Cdk5/p25 signalling rescued in vitro angiogenesis in acute hypoxia
       Item: 
        Title: Discussion
       Item: 
        Title: Supporting Information
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Author Contributions
       Item: 
        Title: References
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