5fd3381a4fb792529ab9b227163d42ca pmc_24099525.pdf 79f6ef56f6605c477ebff07ecaeeeed886f6c3dc pmc_24099525.pdf b54b05d42baa512a1d8ab4597af2bd170254a80cdbb963bb034766d51515ddb3 pmc_24099525.pdf Title: Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows) CreationDate: Thu Oct 10 14:30:37 2013 CEST ModDate: Thu Oct 10 14:31:26 2013 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 3683510 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KECDPF+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 420 0 KECDPG+AdvTTe45e47d2 Type 1C WinAnsi yes yes no 421 0 KECDPH+AdvTT7329fd89.I Type 1C WinAnsi yes yes no 422 0 KECDPI+AdvTTb5929f4c Type 1C WinAnsi yes yes no 423 0 KECDPJ+AdvTT99c4c969 Type 1C WinAnsi yes yes no 424 0 KECEAJ+AdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 425 0 KECEAK+AdvTT86d47313 Type 1C WinAnsi yes yes no 426 0 KECEBL+AdvTT8861b38f.I Type 1C WinAnsi yes yes no 427 0 KECEPI+AdvTT86d47313+20 Type 1C Custom yes yes yes 230 0 KECEPH+AdvTT86d47313+03 Type 1C Custom yes yes yes 231 0 KECFDH+AdvTTb5929f4c+03 Type 1C Custom yes yes yes 232 0 KECFDI+AdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 233 0 KECKKI+Helvetica-Bold Type 1C WinAnsi yes yes no 234 0 KEDCMH+AdvTT99c4c969+20 Type 1C WinAnsi yes yes no 235 0 KEGKHC+AdvTT43ccf47d Type 1C WinAnsi yes yes no 186 0 KEGKID+AdvTT5fa5645c.I Type 1C WinAnsi yes yes no 187 0 KEGKIE+AdvTT43ccf47d+03 Type 1C Custom yes yes yes 188 0 KEGLHP+FrutigerLTStd-Bold Type 1C Custom yes yes yes 210 0 KEGLLO+FrutigerLTStd-Roman Type 1C Custom yes yes yes 211 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-01-29 02:40:19 CET RepresentationInformation: pmc_24099525.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-10 03:57:26 CEST Size: 3683510 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 447 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Overall structure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Similarities with other SLR and TPR proteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Structural analysis of inter- and intra-SLR interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Metal-ion binding site between SLRs 3 and 4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Crystal contacts between the C-terminal super-helical groove of one molecule and the C-terminal tail of the molecule belonging to the adjacent asymmetric unit Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Epitope mapping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Cloning, expression and purification of c5321 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Expression and purification of selenomethionine-labelled c5321 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Crystallisation and data collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Structure solution and refinement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Production of monoclonal antibodies against c5321 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Epitope mapping of monoclonal antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Availability of supporting data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows) CreationDate: Thu Oct 10 14:30:37 CEST 2013 ModDate: Thu Oct 10 14:31:26 CEST 2013 ID: 0xd230fc0b62464b2a296f72375b873fd1, 0xcff046acb6a84d6d701e0f6214e11696 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 1051 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1381 ImageHeight: 887 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1419 ImageHeight: 914 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1946 ImageHeight: 821 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 712 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1394 ImageHeight: 657 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1932 ImageHeight: 1050 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1949 ImageHeight: 1270 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: KECDPF+AdvTTaf7f9f4f.B FontSubset: true FirstChar: 45 LastChar: 117 FontDescriptor: FontName: KECDPF+AdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECDPG+AdvTTe45e47d2 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: KECDPG+AdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECDPH+AdvTT7329fd89.I FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: KECDPH+AdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECEPI+AdvTT86d47313+20 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: KECEPI+AdvTT86d47313+20 Flags: Symbolic FontBBox: -218, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KECDPI+AdvTTb5929f4c FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: KECDPI+AdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECEPH+AdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: KECEPH+AdvTT86d47313+03 Flags: Symbolic FontBBox: -135, -250, 906, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KECDPJ+AdvTT99c4c969 FontSubset: true FirstChar: 35 LastChar: 197 FontDescriptor: FontName: KECDPJ+AdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECFDH+AdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: KECFDH+AdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KECEAJ+AdvTT1b53b5fb.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: KECEAJ+AdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECFDI+AdvTTb5929f4c+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: KECFDI+AdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -218, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECEAK+AdvTT86d47313 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: KECEAK+AdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECKKI+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 66 FontDescriptor: FontName: KECKKI+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KECEBL+AdvTT8861b38f.I FontSubset: true FirstChar: 41 LastChar: 121 FontDescriptor: FontName: KECEBL+AdvTT8861b38f.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEDCMH+AdvTT99c4c969+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: KEDCMH+AdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -218, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEGLHP+FrutigerLTStd-Bold FontSubset: true FirstChar: 32 LastChar: 147 FontDescriptor: FontName: KEGLHP+FrutigerLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -166, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEGLLO+FrutigerLTStd-Roman FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: KEGLLO+FrutigerLTStd-Roman Flags: Symbolic FontBBox: -169, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEGKHC+AdvTT43ccf47d FontSubset: true FirstChar: 37 LastChar: 176 FontDescriptor: FontName: KEGKHC+AdvTT43ccf47d Flags: Serif, Nonsymbolic FontBBox: -20, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEGKID+AdvTT5fa5645c.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: KEGKID+AdvTT5fa5645c.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1052, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEGKIE+AdvTT43ccf47d+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KEGKIE+AdvTT43ccf47d+03 Flags: Symbolic FontBBox: -125, -250, 895, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: BMC Structural Biology 2013, 13:1. doi:10.1186/1472-6807-13-19 application/pdf http://dx.doi.org/10.1186/1472-6807-13-19 Dunja Urosev Mario Ferrer-Navarro Ilaria Pastorello Elena Cartocci Lionel Costenaro Dmitrijs Zhulenkovs Jean-Didier Mar�chal Ainars Leonchiks David Reverter Laura Serino Marco Soriani Xavier Daura Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold BMC Structural Biology 2013, 13:1. doi:10.1186/1472-6807-13-19 BMC Structural Biology 2013-10-07 � 2013 Urosev et al.; licensee BioMed Central Ltd. c5321 Sel1-like repeat Crystal structure Super-helical fold Antigen Uropathogenic Escherichia coli True BMC Structural Biology 10.1186/1472-6807-13-19 1 1 1 � 2013 Urosev et al.; licensee BioMed Central Ltd. BMC Structural Biology journal 13 reprints@biomedcentral.com 2013-10-07 1 1 BMC Structural Biology c5321; Sel1-like repeat; Crystal structure; Super-helical fold; Antigen; Uropathogenic Escherichia coli Pages: Page: Label: 0 Annotations: Annotation: Subtype: Link Rect: 213, 174, 218, 184 Destination: 197 Annotation: Subtype: Link Rect: 528, 210, 533, 220 Destination: 197 Annotation: Subtype: Link Rect: 487, 150, 492, 160 Destination: 197 Annotation: Subtype: Link Rect: 114, 137, 176, 144 Annotation: Subtype: Link Rect: 264, 67, 379, 74 Thumb: true Page: Label: 1 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 175, 646, 180, 656 Destination: 197 Annotation: Subtype: Link Rect: 146, 598, 150, 608 Destination: 197 Annotation: Subtype: Link Rect: 92, 502, 97, 512 Destination: 197 Annotation: Subtype: Link Rect: 282, 490, 287, 500 Destination: 197 Annotation: Subtype: Link Rect: 108, 478, 113, 488 Destination: 197 Annotation: Subtype: Link Rect: 226, 430, 231, 440 Destination: 197 Annotation: Subtype: Link Rect: 257, 382, 262, 392 Destination: 197 Annotation: Subtype: Link Rect: 224, 130, 229, 140 Destination: 197 Annotation: Subtype: Link Rect: 148, 82, 153, 92 Destination: 197 Annotation: Subtype: Link Rect: 156, 82, 165, 92 Destination: 197 Annotation: Subtype: Link Rect: 307, 694, 317, 704 Destination: 197 Annotation: Subtype: Link Rect: 462, 598, 472, 608 Destination: 197 Annotation: Subtype: Link Rect: 474, 598, 484, 608 Destination: 197 Annotation: Subtype: Link Rect: 378, 574, 388, 584 Destination: 197 Annotation: Subtype: Link Rect: 390, 574, 400, 584 Destination: 197 Annotation: Subtype: Link Rect: 443, 406, 452, 416 Destination: 197 Annotation: Subtype: Link Rect: 352, 82, 361, 92 Destination: 197 Thumb: true Page: Label: 2 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 103, 658, 108, 668 Destination: 20 Annotation: Subtype: Link Rect: 256, 622, 261, 632 Destination: 33 Annotation: Subtype: Link Rect: 397, 694, 402, 704 Destination: 33 Annotation: Subtype: Link Rect: 429, 466, 434, 476 Destination: 33 Annotation: Subtype: Link Rect: 377, 358, 387, 368 Destination: 197 Annotation: Subtype: Link Rect: 503, 262, 508, 272 Destination: 197 Annotation: Subtype: Link Rect: 390, 70, 400, 80 Destination: 197 Annotation: Subtype: Link Rect: 216, 84, 223, 91 Destination: 202 Thumb: true Page: Label: 3 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 59, 322, 69, 332 Destination: 197 Annotation: Subtype: Link Rect: 336, 250, 341, 260 Destination: 53 Annotation: Subtype: Link Rect: 489, 214, 494, 224 Destination: 33 Annotation: Subtype: Link Rect: 500, 214, 505, 224 Destination: 53 Annotation: Subtype: Link Rect: 528, 214, 533, 224 Destination: 73 Annotation: Subtype: Link Rect: 462, 166, 467, 176 Destination: 197 Annotation: Subtype: Link Rect: 469, 166, 479, 176 Destination: 197 Annotation: Subtype: Link Rect: 533, 70, 538, 80 Destination: 53 Thumb: true Page: Label: 4 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 488, 510, 492, 518 Destination: 197 Annotation: Subtype: Link Rect: 122, 95, 126, 103 Destination: 53 Annotation: Subtype: Link Rect: 128, 85, 132, 93 Destination: 53 Annotation: Subtype: Link Rect: 452, 85, 455, 93 Destination: 53 Thumb: true Page: Label: 5 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 144, 370, 149, 380 Destination: 53 Annotation: Subtype: Link Rect: 280, 310, 285, 320 Destination: 53 Annotation: Subtype: Link Rect: 280, 262, 285, 272 Destination: 53 Annotation: Subtype: Link Rect: 91, 226, 96, 236 Destination: 73 Annotation: Subtype: Link Rect: 280, 202, 285, 212 Destination: 53 Annotation: Subtype: Link Rect: 269, 70, 273, 80 Destination: 53 Annotation: Subtype: Link Rect: 491, 370, 496, 380 Destination: 53 Annotation: Subtype: Link Rect: 438, 310, 443, 320 Destination: 53 Annotation: Subtype: Link Rect: 401, 154, 406, 164 Destination: 53 Annotation: Subtype: Link Rect: 113, 440, 117, 448 Destination: 53 Annotation: Subtype: Link Rect: 273, 440, 277, 448 Destination: 53 Annotation: Subtype: Link Rect: 504, 440, 507, 448 Destination: 53 Thumb: true Page: Label: 6 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 88, 694, 93, 704 Destination: 197 Annotation: Subtype: Link Rect: 95, 694, 105, 704 Destination: 197 Annotation: Subtype: Link Rect: 138, 562, 143, 572 Destination: 97 Annotation: Subtype: Link Rect: 173, 466, 178, 476 Destination: 97 Annotation: Subtype: Link Rect: 226, 454, 236, 464 Destination: 197 Annotation: Subtype: Link Rect: 386, 346, 391, 356 Destination: 115 Thumb: true Page: Label: 7 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 273, 262, 283, 272 Destination: 197 Annotation: Subtype: Link Rect: 375, 430, 379, 440 Destination: 132 Annotation: Subtype: Link Rect: 417, 406, 422, 416 Destination: 132 Annotation: Subtype: Link Rect: 441, 310, 445, 320 Destination: 132 Annotation: Subtype: Link Rect: 422, 118, 427, 128 Destination: 132 Thumb: true Page: Label: 8 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 150, 346, 155, 356 Destination: 132 Annotation: Subtype: Link Rect: 307, 358, 317, 368 Destination: 197 Annotation: Subtype: Link Rect: 319, 358, 329, 368 Destination: 197 Annotation: Subtype: Link Rect: 332, 358, 342, 368 Destination: 197 Annotation: Subtype: Link Rect: 381, 322, 391, 332 Destination: 197 Annotation: Subtype: Link Rect: 433, 322, 438, 332 Destination: 132 Thumb: true Page: Label: 9 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 190, 598, 199, 608 Destination: 197 Annotation: Subtype: Link Rect: 201, 598, 211, 608 Destination: 197 Annotation: Subtype: Link Rect: 101, 562, 111, 572 Destination: 197 Annotation: Subtype: Link Rect: 138, 526, 148, 536 Destination: 197 Annotation: Subtype: Link Rect: 92, 490, 102, 500 Destination: 197 Annotation: Subtype: Link Rect: 245, 310, 255, 320 Destination: 197 Annotation: Subtype: Link Rect: 121, 166, 157, 176 Destination: 155 Annotation: Subtype: Link Rect: 174, 106, 178, 116 Destination: 168 Annotation: Subtype: Link Rect: 231, 58, 236, 68 Destination: 168 Annotation: Subtype: Link Rect: 307, 58, 317, 68 Destination: 197 Annotation: Subtype: Link Rect: 319, 58, 329, 68 Destination: 197 Thumb: true Page: Label: 10 Sequence: 11 Thumb: true Page: Label: 11 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 195, 622, 205, 632 Destination: 197 Annotation: Subtype: Link Rect: 141, 586, 150, 596 Destination: 197 Annotation: Subtype: Link Rect: 275, 490, 285, 500 Destination: 202 Annotation: Subtype: Link Rect: 239, 442, 244, 452 Destination: 20 Annotation: Subtype: Link Rect: 147, 118, 157, 128 Destination: 202 Annotation: Subtype: Link Rect: 180, 106, 190, 116 Destination: 202 Thumb: true Page: Label: 12 Sequence: 13 Thumb: true Page: Label: 13 Sequence: 14 Thumb: true Checksum: 8d93c9bc Type: CRC32 Checksum: 5fd3381a4fb792529ab9b227163d42ca Type: MD5 Checksum: 79f6ef56f6605c477ebff07ecaeeeed886f6c3dc Type: SHA-1