a8c6728b3b3518eac048e807489ced5d pmc_24790957.pdf c88cfa13a0828793f5d5f12a29e7960de790a4e9 pmc_24790957.pdf dda041663d6fa893838468e49be72b500fbdfd840e27a3b7c7ce34ff8d078809 pmc_24790957.pdf Title: Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells Subject: Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. Keywords: silver nanoparticles, fluorescence, cytotoxicity, goldfish, human hepatoma cells Author: Elisabete Oliveira and Carlos Lodeiro Creator: LaTeX with hyperref package Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Nov 28 16:23:00 2013 CET ModDate: Wed Dec 4 14:52:56 2013 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2647818 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BFLBNL+Univers-Black Type 1C WinAnsi yes yes no 460 0 BFLBNM+Univers-Light Type 1C MacRoman yes yes no 461 0 BFLCBM+Univers Type 1C MacRoman yes yes no 465 0 BFLCBN+Univers-BoldOblique Type 1C WinAnsi yes yes no 466 0 BFLCBO+Univers-LightOblique Type 1C Custom yes yes no 467 0 BFLCBP+Univers-Bold Type 1C MacRoman yes yes no 471 0 BFLCCA+Univers-CondensedBold Type 1C WinAnsi yes yes no 474 0 BFLBNK+Minion-Regular Type 1C Custom yes yes no 475 0 BFLCDB+Minion-Italic Type 1C Custom yes yes no 479 0 BFLCDC+MTGU Type 1C Custom yes yes yes 483 0 BFLCEC+Minion-Bold Type 1C Custom yes yes no 246 0 BFLCED+MTSYN Type 1C Custom yes yes yes 245 0 BFLCEE+Univers-CondensedBoldOblique Type 1C MacRoman yes yes no 237 0 BFLCFF+RMTMI Type 1C WinAnsi yes yes no 247 0 BFLCOC+ArialMT Type 1C WinAnsi yes yes no 256 0 BFLCOD+HelveticaNeue-Bold Type 1C WinAnsi yes yes no 252 0 BFLDEC+Arial-BoldMT Type 1C WinAnsi yes yes no 253 0 BFLKNB+Calibri Type 1C WinAnsi yes yes no 282 0 BFMMEA+MTGUB Type 1C WinAnsi yes yes no 286 0 BFMMHA+Minion-BoldItalic Type 1C WinAnsi yes yes no 289 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2018-06-05 04:58:14 CEST RepresentationInformation: pmc_24790957.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-01-27 08:14:07 CET Size: 2647818 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 640 FreeObjects: 7 IncrementalUpdates: 4 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Children: Item: Title: Chemicals and Starting Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Physical Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: Instruments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Particles size distribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: TEM measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: MALDI-TOF-MS studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Photophysical measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Synthesis of silver nanoparticles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Cytotoxicity of the AgNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: CLSM in vivo imaging of AgNP-Treated HEPG2 cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Flow cytometry of AgNP-treated cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: In vivo studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Results and Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Children: Item: Title: MALDI-TOF-MS Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Children: Item: Title: Cytotoxicological studies in goldfish Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: Dose-dependent cytotoxicity of AgNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: Intracellular location of AgNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: Silver nanoparticle uptake by Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e6ea0c6 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a38e57f Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5577140b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c6b6478 Info: Title: Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells Author: Elisabete Oliveira and Carlos Lodeiro Subject: Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. Keywords: silver nanoparticles, fluorescence, cytotoxicity, goldfish, human hepatoma cells Creator: LaTeX with hyperref package Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Nov 28 16:53:00 CET 2013 ModDate: Wed Dec 04 15:22:56 CET 2013 ID: 0x829dc96d69f549008d21cd3cd4bb146a, 0xc0a93c3bec2f774a9c9d1960d41c695b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: ImageWidth: 416 ImageHeight: 400 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 432 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 432 ImageHeight: 400 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 424 ImageHeight: 336 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 416 ImageHeight: 384 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 416 ImageHeight: 336 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 779 ImageHeight: 462 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 442 ImageHeight: 348 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 288 ImageHeight: 288 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: ImageWidth: 458 ImageHeight: 320 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 442 ImageHeight: 320 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 442 ImageHeight: 348 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 442 ImageHeight: 322 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 442 ImageHeight: 322 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 288 ImageHeight: 288 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 442 ImageHeight: 352 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 456 ImageHeight: 352 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 288 ImageHeight: 288 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 731 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Interpolate: true Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 1418 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Interpolate: true Fonts: Type1: Font: BaseFont: BFLCOC+ArialMT FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: BFLCOC+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFMMHA+Minion-BoldItalic FontSubset: true FirstChar: 49 LastChar: 49 FontDescriptor: FontName: BFMMHA+Minion-BoldItalic Flags: Serif, Nonsymbolic, Italic, ForceBold FontBBox: -189, -250, 1148, 821 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLCDC+MTGU FontSubset: true FirstChar: 2 LastChar: 181 FontDescriptor: FontName: BFLCDC+MTGU Flags: Symbolic FontBBox: 24, -213, 839, 683 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BFLBNL+Univers-Black FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: BFLBNL+Univers-Black Flags: Nonsymbolic, ForceBold FontBBox: -153, -250, 992, 986 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLBNM+Univers-Light FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: BFLBNM+Univers-Light Flags: Nonsymbolic FontBBox: -151, -250, 1000, 957 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BFLCEE+Univers-CondensedBoldOblique FontSubset: true FirstChar: 45 LastChar: 222 FontDescriptor: FontName: BFLCEE+Univers-CondensedBoldOblique Flags: Nonsymbolic, Italic, ForceBold FontBBox: -86, -250, 1066, 969 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BFLCBM+Univers FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: BFLCBM+Univers Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BFLCBN+Univers-BoldOblique FontSubset: true FirstChar: 42 LastChar: 237 FontDescriptor: FontName: BFLCBN+Univers-BoldOblique Flags: Nonsymbolic, Italic, ForceBold FontBBox: -173, -250, 1148, 938 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLCBO+Univers-LightOblique FontSubset: true FirstChar: 30 LastChar: 242 FontDescriptor: FontName: BFLCBO+Univers-LightOblique Flags: Nonsymbolic, Italic FontBBox: -151, -250, 1144, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BFLCED+MTSYN FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: BFLCED+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BFLCEC+Minion-Bold FontSubset: true FirstChar: 31 LastChar: 150 FontDescriptor: FontName: BFLCEC+Minion-Bold Flags: Serif, Nonsymbolic, ForceBold FontBBox: -148, -250, 1147, 830 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BFLCBP+Univers-Bold FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: BFLCBP+Univers-Bold Flags: Nonsymbolic, ForceBold FontBBox: -167, -250, 995, 938 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BFLCFF+RMTMI FontSubset: true FirstChar: 44 LastChar: 62 FontDescriptor: FontName: BFLCFF+RMTMI Flags: Nonsymbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLCCA+Univers-CondensedBold FontSubset: true FirstChar: 45 LastChar: 89 FontDescriptor: FontName: BFLCCA+Univers-CondensedBold Flags: Nonsymbolic, ForceBold FontBBox: -83, -250, 1000, 969 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLKNB+Calibri FontSubset: true FirstChar: 42 LastChar: 49 FontDescriptor: FontName: BFLKNB+Calibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLBNK+Minion-Regular FontSubset: true FirstChar: 30 LastChar: 241 FontDescriptor: FontName: BFLBNK+Minion-Regular Flags: Serif, Nonsymbolic FontBBox: -141, -250, 1104, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BFLCOD+HelveticaNeue-Bold FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: BFLCOD+HelveticaNeue-Bold Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLDEC+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: BFLDEC+Arial-BoldMT Flags: Nonsymbolic, ForceBold FontBBox: -627, -375, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFMMEA+MTGUB FontSubset: true FirstChar: 181 LastChar: 181 FontDescriptor: FontName: BFMMEA+MTGUB Flags: Nonsymbolic, ForceBold FontBBox: 0, -205, 879, 699 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFLCDB+Minion-Italic FontSubset: true FirstChar: 30 LastChar: 237 FontDescriptor: FontName: BFLCDB+Minion-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -139, -250, 1101, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: silver nanoparticles, fluorescence, cytotoxicity, goldfish, human hepatoma cells Acrobat Distiller 8.1.0 (Windows) LaTeX with hyperref package 2013-12-04T19:22:56+05:30 2013-11-28T20:53+05:30 2013-12-04T19:22:56+05:30 application/pdf Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells Elisabete Oliveira and Carlos Lodeiro Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. silver nanoparticles fluorescence cytotoxicity goldfish human hepatoma cells uuid:cfd3cf91-f930-4879-abd4-c81bec1cb96e uuid:85f74015-43bb-4c99-82ea-3d77d95f789d Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 378, 747, 512, 755 Annotation: Subtype: Link Rect: 424, 739, 512, 747 Annotation: Subtype: Link Rect: 419, 732, 512, 739 Annotation: Subtype: Link Rect: 522, 732, 551, 759 Annotation: Subtype: Link Rect: 44, 730, 123, 760 Annotation: Subtype: Link Rect: 44, 658, 550, 719 Annotation: Subtype: Link Rect: 44, 637, 128, 647 Annotation: Subtype: Link Rect: 146, 636, 225, 647 Annotation: Subtype: Link Rect: 233, 637, 327, 647 Annotation: Subtype: Link Rect: 336, 637, 392, 647 Annotation: Subtype: Link Rect: 400, 637, 465, 647 Annotation: Subtype: Link Rect: 44, 624, 175, 635 Annotation: Subtype: Link Rect: 183, 624, 254, 635 Annotation: Subtype: Link Rect: 280, 626, 350, 635 Annotation: Subtype: Link Rect: 66, 403, 88, 404 Annotation: Subtype: Link Rect: 63, 334, 155, 344 Destination: 215 Annotation: Subtype: Link Rect: 158, 334, 178, 344 Destination: 215 Annotation: Subtype: Link Rect: 181, 334, 221, 344 Destination: 215 Annotation: Subtype: Link Rect: 224, 334, 243, 344 Destination: 215 Annotation: Subtype: Link Rect: 247, 334, 289, 344 Destination: 215 Annotation: Subtype: Link Rect: 44, 322, 63, 333 Destination: 215 Annotation: Subtype: Link Rect: 66, 322, 193, 333 Destination: 215 Annotation: Subtype: Link Rect: 197, 322, 216, 333 Destination: 215 Annotation: Subtype: Link Rect: 110, 265, 180, 275 Destination: 215 Annotation: Subtype: Link Rect: 184, 265, 203, 275 Destination: 215 Annotation: Subtype: Link Rect: 66, 241, 245, 242 Destination: 215 Annotation: Subtype: Link Rect: 70, 231, 89, 241 Destination: 215 Annotation: Subtype: Link Rect: 66, 173, 117, 184 Destination: 215 Annotation: Subtype: Link Rect: 121, 173, 140, 184 Destination: 215 Annotation: Subtype: Link Rect: 143, 173, 189, 184 Destination: 215 Annotation: Subtype: Link Rect: 192, 173, 211, 184 Destination: 215 Annotation: Subtype: Link Rect: 106, 139, 193, 149 Destination: 215 Annotation: Subtype: Link Rect: 197, 139, 217, 149 Destination: 215 Annotation: Subtype: Link Rect: 194, 116, 263, 126 Destination: 221 Annotation: Subtype: Link Rect: 266, 116, 286, 126 Destination: 221 Annotation: Subtype: Link Rect: 336, 334, 363, 344 Destination: 215 Annotation: Subtype: Link Rect: 367, 334, 386, 344 Destination: 215 Annotation: Subtype: Link Rect: 350, 276, 383, 287 Destination: 215 Annotation: Subtype: Link Rect: 388, 276, 408, 287 Destination: 215 Annotation: Subtype: Link Rect: 321, 264, 518, 265 Destination: 215 Annotation: Subtype: Link Rect: 326, 253, 345, 264 Destination: 215 Annotation: Subtype: Link Rect: 327, 229, 516, 230 Destination: 215 Annotation: Subtype: Link Rect: 332, 219, 351, 229 Destination: 215 Annotation: Subtype: Link Rect: 356, 219, 400, 229 Destination: 215 Annotation: Subtype: Link Rect: 405, 219, 424, 229 Destination: 215 Annotation: Subtype: Link Rect: 382, 196, 432, 207 Destination: 215 Annotation: Subtype: Link Rect: 436, 196, 455, 207 Destination: 215 Annotation: Subtype: Link Rect: 458, 196, 510, 207 Destination: 215 Annotation: Subtype: Link Rect: 513, 196, 536, 207 Destination: 215 Annotation: Subtype: Link Rect: 538, 196, 544, 207 Destination: 215 Annotation: Subtype: Link Rect: 430, 127, 468, 138 Destination: 221 Annotation: Subtype: Link Rect: 471, 127, 491, 138 Destination: 221 Annotation: Subtype: Link Rect: 305, 93, 343, 103 Destination: 215 Annotation: Subtype: Link Rect: 348, 93, 367, 103 Destination: 215 Annotation: Subtype: Link Rect: 482, 70, 521, 81 Destination: 215 Annotation: Subtype: Link Rect: 524, 70, 544, 81 Destination: 215 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 420, 25, 541, 34 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 47, 686, 75, 697 Destination: 221 Annotation: Subtype: Link Rect: 79, 686, 98, 697 Destination: 221 Annotation: Subtype: Link Rect: 101, 686, 145, 697 Destination: 215 Annotation: Subtype: Link Rect: 149, 686, 168, 697 Destination: 215 Annotation: Subtype: Link Rect: 117, 675, 171, 685 Destination: 215 Annotation: Subtype: Link Rect: 177, 675, 196, 685 Destination: 215 Annotation: Subtype: Link Rect: 81, 549, 133, 559 Destination: 215 Annotation: Subtype: Link Rect: 139, 549, 158, 559 Destination: 215 Annotation: Subtype: Link Rect: 178, 146, 263, 156 Destination: 215 Annotation: Subtype: Link Rect: 266, 146, 285, 156 Destination: 215 Annotation: Subtype: Link Rect: 404, 329, 448, 340 Destination: 215 Annotation: Subtype: Link Rect: 454, 329, 473, 340 Destination: 215 Annotation: Subtype: Link Rect: 479, 329, 519, 340 Destination: 221 Annotation: Subtype: Link Rect: 524, 329, 543, 340 Destination: 221 Annotation: Subtype: Link Rect: 454, 226, 499, 237 Destination: 221 Annotation: Subtype: Link Rect: 504, 226, 523, 237 Destination: 221 Annotation: Subtype: Link Rect: 44, 25, 125, 34 Annotation: Subtype: Link Rect: 123, 25, 198, 34 Annotation: Subtype: Link Rect: 420, 25, 540, 34 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 199, 237, 248, 247 Destination: 215 Annotation: Subtype: Link Rect: 255, 237, 274, 247 Destination: 215 Annotation: Subtype: Link Rect: 338, 698, 356, 708 Destination: 215 Annotation: Subtype: Link Rect: 361, 698, 380, 708 Destination: 215 Annotation: Subtype: Link Rect: 394, 457, 450, 468 Destination: 215 Annotation: Subtype: Link Rect: 456, 457, 475, 468 Destination: 215 Annotation: Subtype: Link Rect: 342, 377, 377, 387 Destination: 215 Annotation: Subtype: Link Rect: 380, 377, 400, 387 Destination: 215 Annotation: Subtype: Link Rect: 439, 354, 520, 365 Destination: 215 Annotation: Subtype: Link Rect: 524, 354, 544, 365 Destination: 215 Annotation: Subtype: Link Rect: 515, 217, 547, 227 Destination: 215 Annotation: Subtype: Link Rect: 302, 205, 321, 216 Destination: 215 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 420, 25, 541, 34 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 141, 615, 175, 626 Destination: 40 Annotation: Subtype: Link Rect: 44, 512, 84, 523 Destination: 40 Annotation: Subtype: Link Rect: 145, 480, 220, 491 Destination: 215 Annotation: Subtype: Link Rect: 224, 480, 243, 491 Destination: 215 Annotation: Subtype: Link Rect: 101, 479, 248, 480 Destination: 215 Annotation: Subtype: Link Rect: 105, 469, 124, 479 Destination: 215 Annotation: Subtype: Link Rect: 179, 443, 218, 454 Destination: 40 Annotation: Subtype: Link Rect: 44, 421, 84, 431 Destination: 40 Annotation: Subtype: Link Rect: 90, 375, 130, 386 Destination: 40 Annotation: Subtype: Link Rect: 411, 661, 459, 672 Destination: 206 Annotation: Subtype: Link Rect: 425, 650, 473, 660 Destination: 206 Annotation: Subtype: Link Rect: 376, 466, 410, 477 Destination: 60 Annotation: Subtype: Link Rect: 44, 25, 125, 34 Annotation: Subtype: Link Rect: 123, 25, 198, 34 Annotation: Subtype: Link Rect: 420, 25, 540, 34 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 55, 198, 107, 209 Destination: 60 Annotation: Subtype: Link Rect: 44, 164, 78, 174 Destination: 60 Annotation: Subtype: Link Rect: 149, 129, 183, 140 Destination: 60 Annotation: Subtype: Link Rect: 155, 120, 207, 130 Destination: 215 Annotation: Subtype: Link Rect: 212, 120, 232, 130 Destination: 215 Annotation: Subtype: Link Rect: 102, 109, 147, 119 Destination: 215 Annotation: Subtype: Link Rect: 153, 109, 172, 119 Destination: 215 Annotation: Subtype: Link Rect: 177, 109, 229, 119 Destination: 215 Annotation: Subtype: Link Rect: 234, 109, 253, 119 Destination: 215 Annotation: Subtype: Link Rect: 500, 143, 547, 153 Destination: 221 Annotation: Subtype: Link Rect: 302, 131, 321, 142 Destination: 221 Annotation: Subtype: Link Rect: 326, 131, 373, 142 Destination: 221 Annotation: Subtype: Link Rect: 378, 131, 398, 142 Destination: 221 Annotation: Subtype: Link Rect: 302, 95, 336, 106 Destination: 60 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 420, 25, 541, 34 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 156, 707, 190, 718 Destination: 60 Annotation: Subtype: Link Rect: 84, 686, 133, 697 Destination: 215 Annotation: Subtype: Link Rect: 136, 686, 155, 697 Destination: 215 Annotation: Subtype: Link Rect: 158, 686, 222, 697 Destination: 215 Annotation: Subtype: Link Rect: 225, 686, 245, 697 Destination: 215 Annotation: Subtype: Link Rect: 161, 558, 198, 569 Destination: 60 Annotation: Subtype: Link Rect: 171, 317, 216, 328 Destination: 215 Annotation: Subtype: Link Rect: 221, 317, 240, 328 Destination: 215 Annotation: Subtype: Link Rect: 244, 317, 289, 328 Destination: 215 Annotation: Subtype: Link Rect: 44, 306, 63, 316 Destination: 215 Annotation: Subtype: Link Rect: 239, 292, 273, 303 Destination: 93 Annotation: Subtype: Link Rect: 188, 223, 226, 234 Destination: 93 Annotation: Subtype: Link Rect: 192, 145, 236, 156 Destination: 215 Annotation: Subtype: Link Rect: 242, 145, 261, 156 Destination: 215 Annotation: Subtype: Link Rect: 92, 77, 134, 87 Destination: 215 Annotation: Subtype: Link Rect: 138, 77, 157, 87 Destination: 215 Annotation: Subtype: Link Rect: 427, 134, 504, 144 Destination: 215 Annotation: Subtype: Link Rect: 507, 134, 527, 144 Destination: 215 Annotation: Subtype: Link Rect: 422, 77, 462, 87 Destination: 215 Annotation: Subtype: Link Rect: 465, 77, 484, 87 Destination: 215 Annotation: Subtype: Link Rect: 44, 25, 125, 34 Annotation: Subtype: Link Rect: 123, 25, 198, 34 Annotation: Subtype: Link Rect: 420, 25, 540, 34 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 68, 709, 87, 720 Destination: 221 Annotation: Subtype: Link Rect: 91, 709, 141, 720 Destination: 215 Annotation: Subtype: Link Rect: 145, 709, 164, 720 Destination: 215 Annotation: Subtype: Link Rect: 129, 686, 176, 697 Destination: 221 Annotation: Subtype: Link Rect: 180, 686, 200, 697 Destination: 221 Annotation: Subtype: Link Rect: 54, 661, 95, 672 Destination: 93 Annotation: Subtype: Link Rect: 90, 606, 151, 617 Destination: 215 Annotation: Subtype: Link Rect: 154, 606, 173, 617 Destination: 215 Annotation: Subtype: Link Rect: 228, 595, 289, 605 Destination: 215 Annotation: Subtype: Link Rect: 44, 583, 63, 594 Destination: 215 Annotation: Subtype: Link Rect: 177, 569, 221, 580 Destination: 93 Annotation: Subtype: Link Rect: 321, 674, 530, 675 Destination: 215 Annotation: Subtype: Link Rect: 324, 663, 343, 674 Destination: 215 Annotation: Subtype: Link Rect: 347, 663, 397, 674 Destination: 215 Annotation: Subtype: Link Rect: 401, 663, 420, 674 Destination: 215 Annotation: Subtype: Link Rect: 370, 535, 412, 546 Destination: 206 Annotation: Subtype: Link Rect: 336, 489, 370, 500 Destination: 123 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 420, 25, 541, 34 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 142, 569, 176, 580 Destination: 186 Annotation: Subtype: Link Rect: 218, 546, 258, 557 Destination: 186 Annotation: Subtype: Link Rect: 188, 489, 229, 500 Destination: 186 Annotation: Subtype: Link Rect: 47, 454, 87, 465 Destination: 186 Annotation: Subtype: Link Rect: 244, 386, 286, 396 Destination: 206 Annotation: Subtype: Link Rect: 157, 351, 210, 362 Destination: 206 Annotation: Subtype: Link Rect: 228, 353, 250, 362 Destination: 206 Annotation: Subtype: Link Rect: 239, 340, 286, 351 Destination: 206 Annotation: Subtype: Link Rect: 352, 695, 386, 706 Destination: 206 Annotation: Subtype: Link Rect: 403, 560, 438, 571 Destination: 221 Annotation: Subtype: Link Rect: 442, 560, 461, 571 Destination: 221 Annotation: Subtype: Link Rect: 434, 478, 476, 488 Destination: 206 Annotation: Subtype: Link Rect: 44, 25, 125, 34 Annotation: Subtype: Link Rect: 123, 25, 198, 34 Annotation: Subtype: Link Rect: 420, 25, 540, 34 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 335, 208, 550, 219 Annotation: Subtype: Link Rect: 302, 199, 360, 208 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 420, 25, 541, 34 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 44, 25, 125, 34 Annotation: Subtype: Link Rect: 123, 25, 198, 34 Annotation: Subtype: Link Rect: 416, 25, 537, 34 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 423, 576, 450, 584 Annotation: Subtype: Link Rect: 448, 575, 468, 584 Annotation: Subtype: Link Rect: 468, 577, 503, 584 Annotation: Subtype: Link Rect: 361, 529, 387, 537 Annotation: Subtype: Link Rect: 390, 529, 422, 536 Annotation: Subtype: Link Rect: 425, 529, 460, 537 Annotation: Subtype: Link Rect: 463, 529, 486, 537 Annotation: Subtype: Link Rect: 489, 528, 516, 537 Annotation: Subtype: Link Rect: 44, 25, 118, 34 Annotation: Subtype: Link Rect: 417, 25, 537, 34 Checksum: fd6ecb3a Type: CRC32 Checksum: a8c6728b3b3518eac048e807489ced5d Type: MD5 Checksum: c88cfa13a0828793f5d5f12a29e7960de790a4e9 Type: SHA-1