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Title:          Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons
Subject:        Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN).
Keywords:       motoneuron disease, spasticity, hypereflexia, KCC2 transporter, SOD1G93A mice
Author:         Xavier Navarro
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      Title: Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons
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        Title: Introduction
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        Title: Material and Methods
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         Item: 
          Title: Transgenic SOD1G93A Mice
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          Title: Surgical Procedures
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          Title: Functional Assessment
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         Item: 
          Title: Nerve Conduction Tests
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         Item: 
          Title: Histology
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          Title: Protein Extraction and Western Blot
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         Item: 
          Title: Statistical Analysis
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: SOD1G93A Animals Show Hyperreflexia and Spasticity at Late Stages of Disease Progression
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         Item: 
          Title: Spinal Cord Injury Causes Locomotor Impairment and Hyperreflexia
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          Title: KCC2 Expression is not Altered in Lumbar Spinal MNs of SOD1G93A Animals
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         Item: 
          Title: Reduced Active form of KCC2 in Lumbar Spinal MNs after SCI
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         Item: 
          Title: Reduced Active form of KCC2 is Observed in Lumbar Spinal MNs after Sciatic Nerve Crush
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         Item: 
          Title: Absence of Down-Regulation KCC2 Response to Axonal Insult in ALS MNs
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         Item: 
          Title: Microglial Reactivity is Increased in SOD1G93A and After Sciatic Nerve Crush and SCI
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          Title: Increased Serotonin Projections in SOD1G93A Lumbar Spinal Cord
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          Title: Reduced Inhibition and Renshaw Cells Degeneration in SOD1G93A Lumbar Spinal Cord
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        Title: Discussion
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          Title: Factors Contributing to Spasticity in SOD1G93A Mice
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        Title: Differential MN Response between SOD1G93A and Nerve Crushed MNs
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    Author: Xavier Navarro
    Subject: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN).
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   Type: CRC32
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   Type: MD5
  Checksum: 0e4e94ef0c274cde33eb84a74f0e6b1190369967
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