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Keywords: exercise, aging, Alzheimer, SAMP8, microRNAs Author: Perla Kaliman Creator: LaTeX with hyperref package Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Mar 15 11:34:04 2014 ModDate: Sat Mar 15 13:33:30 2014 Tagged: yes Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts File size: 1105569 bytes Optimized: no PDF version: 1.4 name type emb sub uni object ID ------------------------------------ ----------------- --- --- --- --------- LODDHJ+Univers-Black Type 1C yes yes no 419 0 BGJFCM+Univers-Light Type 1C yes yes no 420 0 BGJFGN+Univers Type 1C yes yes no 424 0 BGJFGO+Univers-BoldOblique Type 1C yes yes no 425 0 BGJFGP+Univers-LightOblique Type 1C yes yes no 426 0 BGJFHP+Univers-Bold Type 1C yes yes no 432 0 BGJFIA+Univers-CondensedBold Type 1C yes yes no 433 0 BGJFCK+Minion-Regular Type 1C yes yes no 434 0 LODDHJ+Univers-Black Type 1C yes yes yes 456 0 BGJFKC+MTGU Type 1C yes yes yes 197 0 BGJFKA+MTSYN Type 1C yes yes yes 204 0 BGJFKB+Minion-Italic Type 1C yes yes no 203 0 BGJFLD+RMTMI Type 1C yes yes no 209 0 BGJFLE+Minion-Bold Type 1C yes yes no 207 0 BGPLAM+RMTMIB Type 1C yes yes no 215 0 BHDPOJ+MSAM5 Type 1C yes yes no 217 0 BHJMCN+Minion-BoldItalic Type 1C yes yes no 218 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2014-09-18 22:44:43 GMT+01:00 RepresentationInformation: froagineu_a2014m3v6n51p1.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2014-09-16 12:31:32 GMT+01:00 Size: 1105569 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 547 FreeObjects: 1 IncrementalUpdates: 3 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77827284 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@152c7568 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@19d009b4 Children: Item: Title: Animal Care and Voluntary Exercise Paradigm Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@292d15a9 Item: Title: Plasma Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4ee91f5d Item: Title: Total RNA Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2b0a3b24 Item: Title: Real-Time Quantitative PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2cb0ce8f Item: Title: Western Blots Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@bc92535 Item: Title: microRNA Expression Array Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42a9c09e Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16a4e743 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@244aeb52 Children: Item: Title: Positive Effects of 8 Weeks of Voluntary Wheel Running in Hippocampal Gene Expression and IGF1 Plasma Levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@329f671b Item: Title: microRNA Expression Profile is Altered in SAMP8 Hippocampus and Modulated by Physical Exercise Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7f2a3793 Item: Title: Animal Care and Voluntary Exercise Paradigm Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2ca6d51e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cf1bb78 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@624b035d Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aca0115 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@340d1fa5 Info: Title: Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise Author: Perla Kaliman Subject: The senescence-accelerated SAMP8 mouse model displays features of cognitive decline and Alzheimer's disease. 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