82ce1d2c39586ab645a2fac967b9cdbf Pers121.pdf cf087e7eb904434cf4813811e7933a1d41975cc0 Pers121.pdf cf156455bba58ba2a2e7f17c0f556b5a83b403c9ccf5a5d31a4b1a41a5488723 Pers121.pdf Title: An experimental and theoretical study of the structure of Lamotrigine in its neutral and protonated forms: evidence of Lamotrigine enantiomers Subject: Tetrahedron, 70 (2014) 2784-2795. doi:10.1016/j.tet.2014.02.075 Author: Ibon Alkorta Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: 25th March 2014 ModDate: Tue Mar 25 03:52:31 2014 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1661558 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FFFHLJ+AdvPS3F4C13 Type 1C WinAnsi yes yes no 858 0 FFFICH+AdvPSA35D Type 1C WinAnsi yes yes no 900 0 FFFHIP+AdvOT863180fb Type 1C WinAnsi yes yes no 864 0 FFFHJA+AdvMathPi6 Type 1C WinAnsi yes yes no 867 0 FFFHJB+AdvP4C4E59 Type 1C Custom yes yes yes 872 0 FFFHJC+AdvOTb92eb7df.I Type 1C WinAnsi yes yes no 875 0 FFFHKC+AdvOTc4d0b532 Type 1C WinAnsi yes yes no 878 0 FFFHKD+AdvP4C4E74 Type 1C Custom yes yes yes 883 0 FFFHKE+AdvOT863180fb+fb Type 1C Custom yes yes yes 888 0 FFFHKF+AdvPSSym Type 1C Custom yes yes no 892 0 FFFHKG+AdvOTb83ee1dd.B Type 1C WinAnsi yes yes no 859 0 FFFHKH+AdvPS44A44B Type 1C WinAnsi yes yes no 861 0 FFFHKI+AdvOT863180fb+20 Type 1C WinAnsi yes yes no 865 0 FFFIIG+AdvOT404f8e91.BI Type 1C WinAnsi yes yes no 576 0 FFFIJH+ArialMT Type 1C WinAnsi yes yes no 574 0 FFFIKH+Arial-BoldMT Type 1C WinAnsi yes yes no 566 0 FFFIKI+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 569 0 FFFIMJ+AdvPS3FDD77 Type 1C WinAnsi yes yes no 580 0 FFFIMK+AdvP4C4E51 Type 1C WinAnsi yes yes no 583 0 FFFJHH+SymbolMT Type 1C Custom yes yes yes 586 0 FFFNCB+AdvPS4721B4 Type 1C WinAnsi yes yes no 594 0 FFHLFI+AdvP4C4E46 Type 1C WinAnsi yes yes no 605 0 FFHLGJ+AdvOTb92eb7df.I+20 Type 1C WinAnsi yes yes no 603 0 FFHLGK+AdvOTb92eb7df.I+fb Type 1C Custom yes yes yes 607 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-11 06:26:03 CET RepresentationInformation: Pers121.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2015-04-27 15:50:53 CEST Size: 1661558 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date Offset: 1645985 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig10' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig11' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig12' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fnb' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fnc' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4fnd' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig13' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig14' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl6fna' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib57' cannot be found Offset: 1630745 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib58' cannot be found Offset: 1630745 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 966 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2 Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: 2.1 Computational chemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 2.1.1 Energies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: 2.1.1.1 Neutral Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.1.1.2 Protonated Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.1.1.3 Geometry of Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.1.1.4 Geometry of protonated Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.1.2 NMR chemical shifts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 2.1.2.1 Neutral Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.1.2.2 Protonated Lamotrigine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.1.3 Determination of the enantiomerization barrier Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.1.4 Aromaticity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3 Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 4 Experimental section Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: 4.1 General Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 4.2 Computational methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 4.3 X-ray structure determination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 4.4 Static and dynamic NMR (DNMR) experiments and experiments of enantiodifferentiation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References and notes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: An experimental and theoretical study of the structure of Lamotrigine in its neutral and protonated forms: evidence of Lamotrigine enantiomers Author: Ibon Alkorta Subject: Tetrahedron, 70 (2014) 2784-2795. doi:10.1016/j.tet.2014.02.075 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) ID: 0xf760e2b06f44b6a89e5e704471d382d1, 0x539547c269f38b4489010d9af7a1a961 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 107 ImageHeight: 107 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 253 ImageHeight: 277 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 785 ImageHeight: 504 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1385 ImageHeight: 566 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1316 ImageHeight: 947 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 995 ImageHeight: 765 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1009 ImageHeight: 858 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1446 ImageHeight: 352 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1579 ImageHeight: 2195 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: FFFHIP+AdvOT863180fb FontSubset: true FirstChar: 36 LastChar: 237 FontDescriptor: FontName: FFFHIP+AdvOT863180fb Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFIIG+AdvOT404f8e91.BI FontSubset: true FirstChar: 69 LastChar: 90 FontDescriptor: FontName: FFFIIG+AdvOT404f8e91.BI Flags: Nonsymbolic FontBBox: -166, -239, 1114, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKI+AdvOT863180fb+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: FFFHKI+AdvOT863180fb+20 Flags: Nonsymbolic FontBBox: 9, -208, 947, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHJA+AdvMathPi6 FontSubset: true FirstChar: 113 LastChar: 113 FontDescriptor: FontName: FFFHJA+AdvMathPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFICH+AdvPSA35D FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: FFFICH+AdvPSA35D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFIMJ+AdvPS3FDD77 FontSubset: true FirstChar: 47 LastChar: 122 FontDescriptor: FontName: FFFIMJ+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFIMK+AdvP4C4E51 FontSubset: true FirstChar: 58 LastChar: 62 FontDescriptor: FontName: FFFIMK+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHJB+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 160 FontDescriptor: FontName: FFFHJB+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FFFJHH+SymbolMT FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: FFFJHH+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FFFHJC+AdvOTb92eb7df.I FontSubset: true FirstChar: 38 LastChar: 237 FontDescriptor: FontName: FFFHJC+AdvOTb92eb7df.I Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKC+AdvOTc4d0b532 FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: FFFHKC+AdvOTc4d0b532 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFNCB+AdvPS4721B4 FontSubset: true FirstChar: 97 LastChar: 115 FontDescriptor: FontName: FFFNCB+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKD+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: FFFHKD+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FFFIKH+Arial-BoldMT FontSubset: true FirstChar: 43 LastChar: 104 FontDescriptor: FontName: FFFIKH+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKE+AdvOT863180fb+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FFFHKE+AdvOT863180fb+fb Flags: Symbolic FontBBox: 40, 0, 895, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FFFIKI+Arial-BoldItalicMT FontSubset: true FirstChar: 69 LastChar: 90 FontDescriptor: FontName: FFFIKI+Arial-BoldItalicMT Flags: Nonsymbolic, Italic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHLJ+AdvPS3F4C13 FontSubset: true FirstChar: 68 LastChar: 115 FontDescriptor: FontName: FFFHLJ+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKG+AdvOTb83ee1dd.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: FFFHKG+AdvOTb83ee1dd.B Flags: Nonsymbolic FontBBox: -93, -250, 1041, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFHLGJ+AdvOTb92eb7df.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FFHLGJ+AdvOTb92eb7df.I+20 Flags: Nonsymbolic FontBBox: -41, -208, 885, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFHKF+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FFFHKF+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FFFHKH+AdvPS44A44B FontSubset: true FirstChar: 100 LastChar: 101 FontDescriptor: FontName: FFFHKH+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFHLFI+AdvP4C4E46 FontSubset: true FirstChar: 104 LastChar: 105 FontDescriptor: FontName: FFHLFI+AdvP4C4E46 Flags: Nonsymbolic FontBBox: 17, -1759, 453, 40 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFFIJH+ArialMT FontSubset: true FirstChar: 32 LastChar: 197 FontDescriptor: FontName: FFFIJH+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FFHLGK+AdvOTb92eb7df.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FFHLGK+AdvOTb92eb7df.I+fb Flags: Symbolic FontBBox: -114, -208, 833, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.tet.2014.02.075 An experimental and theoretical study of the structure of Lamotrigine in its neutral and protonated forms: evidence of Lamotrigine enantiomers Ibon Alkorta José Elguero Anna Font Judit Galcera Ignasi Mata Elies Molins Albert Virgili Lamotrigine X-ray crystallography Dynamic NMR Tautomerism Axial chirality GIAO calculations Tetrahedron, 70 (2014) 2784-2795. doi:10.1016/j.tet.2014.02.075 Elsevier Ltd journal Tetrahedron Copyright © 2014 Elsevier Ltd. All rights reserved 0040-4020 70 17 29 April 2014 2014-04-29 2784-2795 2784 2795 10.1016/j.tet.2014.02.075 http://dx.doi.org/10.1016/j.tet.2014.02.075 2010-04-23 true 10.1016/j.tet.2014.02.075 elsevier.com sciencedirect.com 6.4 10.1016/j.tet.2014.02.075 noindex 2010-04-23 true 25th March 2014 sciencedirect.com elsevier.com Elsevier 2014-03-25T08:22:31+05:30 2014-03-25T08:22:31+05:30 True 25th March 2014 Acrobat Distiller 8.0.0 (Windows) uuid:2e681ef6-204b-4ddd-b292-5370e1a255df uuid:764c792e-9b34-4148-9750-33ec4bbe2827 Pages: Page: Label: 2784 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 32, 547, 32, 549 Annotation: Subtype: Link Rect: 97, 550, 101, 560 Destination: 779 Annotation: Subtype: Link Rect: 104, 550, 108, 560 Destination: 779 Annotation: Subtype: Link Rect: 108, 545, 114, 556 Annotation: Subtype: Link Rect: 114, 547, 114, 549 Annotation: Subtype: Link Rect: 114, 545, 128, 556 Annotation: Subtype: Link Rect: 134, 545, 175, 556 Annotation: Subtype: Link Rect: 177, 550, 181, 560 Destination: 779 Annotation: Subtype: Link Rect: 187, 547, 187, 549 Annotation: Subtype: Link Rect: 241, 550, 246, 560 Destination: 779 Annotation: Subtype: Link Rect: 252, 547, 252, 549 Annotation: Subtype: Link Rect: 318, 550, 322, 560 Destination: 779 Annotation: Subtype: Link Rect: 328, 547, 328, 549 Annotation: Subtype: Link Rect: 388, 550, 392, 560 Destination: 779 Annotation: Subtype: Link Rect: 398, 547, 398, 549 Annotation: Subtype: Link Rect: 460, 550, 464, 560 Destination: 779 Annotation: Subtype: Link Rect: 32, 534, 32, 536 Annotation: Subtype: Link Rect: 99, 537, 104, 547 Destination: 779 Annotation: Subtype: Link Rect: 241, 260, 245, 268 Destination: 213 Annotation: Subtype: Link Rect: 249, 260, 253, 268 Destination: 213 Annotation: Subtype: Link Rect: 87, 250, 90, 258 Destination: 213 Annotation: Subtype: Link Rect: 95, 250, 98, 258 Destination: 213 Annotation: Subtype: Link Rect: 149, 229, 152, 237 Destination: 213 Annotation: Subtype: Link Rect: 383, 302, 386, 310 Destination: 213 Annotation: Subtype: Link Rect: 401, 94, 407, 102 Destination: null Annotation: Subtype: Link Rect: 338, 73, 344, 81 Destination: null Annotation: Subtype: Link Rect: 60, 75, 111, 82 Annotation: Subtype: Link Rect: 60, 66, 142, 73 Annotation: Subtype: Link Rect: 493, 591, 552, 617 Annotation: Subtype: Link Rect: 319, 711, 372, 719 Annotation: Subtype: Link Rect: 273, 655, 408, 663 Annotation: Subtype: Link Rect: 32, 39, 159, 45 Annotation: Subtype: Link Rect: 242, 739, 324, 745 Annotation: Subtype: Link Rect: 329, 739, 343, 745 Page: Label: 2785 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 224, 670, 231, 678 Destination: null Annotation: Subtype: Link Rect: 279, 252, 286, 260 Destination: null Annotation: Subtype: Link Rect: 428, 722, 442, 730 Destination: null Annotation: Subtype: Link Rect: 556, 691, 562, 699 Destination: null Annotation: Subtype: Link Rect: 481, 645, 502, 653 Destination: 1 Annotation: Subtype: Link Rect: 311, 259, 338, 267 Destination: 1 Annotation: Subtype: Link Rect: 492, 50, 513, 58 Destination: 19 Annotation: Subtype: Link Rect: 492, 40, 519, 48 Destination: 19 Annotation: Subtype: Link Rect: 311, 169, 327, 176 Destination: 1 Page: Label: 2786 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 225, 105, 231, 113 Destination: null Annotation: Subtype: Link Rect: 127, 81, 148, 89 Destination: 19 Annotation: Subtype: Link Rect: 277, 42, 283, 50 Destination: null Annotation: Subtype: Link Rect: 344, 101, 424, 109 Destination: null Annotation: Subtype: Link Rect: 527, 91, 552, 99 Destination: null Annotation: Subtype: Link Rect: 490, 81, 523, 88 Destination: null Annotation: Subtype: Link Rect: 490, 60, 511, 68 Destination: 1 Annotation: Subtype: Link Rect: 304, 39, 324, 47 Destination: 39 Annotation: Subtype: Link Rect: 172, 273, 188, 279 Destination: 19 Page: Label: 2787 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 144, 488, 151, 496 Destination: null Annotation: Subtype: Link Rect: 45, 411, 65, 419 Destination: 39 Annotation: Subtype: Link Rect: 217, 411, 236, 419 Destination: 39 Annotation: Subtype: Link Rect: 519, 442, 541, 450 Destination: 39 Page: Label: 2788 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 252, 687, 283, 695 Destination: null Annotation: Subtype: Link Rect: 215, 447, 235, 455 Destination: 39 Annotation: Subtype: Link Rect: 114, 405, 191, 413 Destination: null Annotation: Subtype: Link Rect: 246, 394, 266, 402 Destination: 58 Annotation: Subtype: Link Rect: 511, 645, 532, 653 Destination: 58 Annotation: Subtype: Link Rect: 404, 583, 436, 591 Destination: null Annotation: Subtype: Link Rect: 521, 551, 541, 559 Destination: 58 Annotation: Subtype: Link Rect: 449, 520, 468, 528 Destination: 39 Annotation: Subtype: Link Rect: 461, 499, 481, 507 Destination: 58 Annotation: Subtype: Link Rect: 505, 426, 528, 434 Destination: 39 Annotation: Subtype: Link Rect: 546, 426, 550, 434 Destination: 58 Page: Label: 2789 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 247, 656, 267, 664 Destination: 39 Annotation: Subtype: Link Rect: 159, 645, 191, 653 Destination: null Annotation: Subtype: Link Rect: 161, 604, 181, 612 Destination: 82 Annotation: Subtype: Link Rect: 349, 719, 406, 727 Destination: null Annotation: Subtype: Link Rect: 421, 677, 430, 685 Destination: null Annotation: Subtype: Link Rect: 435, 680, 441, 688 Destination: null Annotation: Subtype: Link Rect: 446, 624, 470, 632 Destination: null Annotation: Subtype: Link Rect: 409, 534, 415, 542 Destination: null Annotation: Subtype: Link Rect: 472, 513, 478, 521 Destination: null Annotation: Subtype: Link Rect: 518, 415, 541, 423 Destination: null Annotation: Subtype: Link Rect: 534, 342, 557, 350 Destination: null Page: Label: 2790 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 75, 191, 82, 199 Destination: null Annotation: Subtype: Link Rect: 32, 143, 60, 151 Destination: 127 Annotation: Subtype: Link Rect: 145, 126, 156, 134 Destination: 213 Annotation: Subtype: Link Rect: 161, 126, 168, 134 Destination: 213 Annotation: Subtype: Link Rect: 124, 49, 128, 57 Destination: 213 Annotation: Subtype: Link Rect: 492, 586, 499, 594 Destination: null Annotation: Subtype: Link Rect: 533, 426, 537, 434 Destination: 213 Annotation: Subtype: Link Rect: 470, 356, 477, 364 Destination: null Annotation: Subtype: Link Rect: 494, 335, 501, 343 Destination: null Annotation: Subtype: Link Rect: 426, 311, 454, 319 Destination: 127 Annotation: Subtype: Link Rect: 420, 251, 436, 259 Destination: null Annotation: Subtype: Link Rect: 504, 210, 519, 218 Destination: null Annotation: Subtype: Link Rect: 323, 196, 350, 204 Destination: 127 Annotation: Subtype: Link Rect: 463, 136, 470, 144 Destination: null Annotation: Subtype: Link Rect: 304, 122, 332, 130 Destination: 127 Annotation: Subtype: Link Rect: 462, 70, 490, 78 Destination: 19 Page: Label: 2791 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 395, 686, 399, 692 Destination: 213 Annotation: Subtype: Link Rect: 458, 686, 465, 692 Destination: null Annotation: Subtype: Link Rect: 520, 686, 527, 692 Destination: null Annotation: Subtype: Link Rect: 355, 449, 358, 455 Destination: null Annotation: Subtype: Link Rect: 380, 355, 385, 361 Destination: null Annotation: Subtype: Link Rect: 398, 355, 403, 361 Destination: null Annotation: Subtype: Link Rect: 491, 309, 508, 316 Destination: null Annotation: Subtype: Link Rect: 535, 309, 542, 316 Destination: null Annotation: Subtype: Link Rect: 504, 304, 507, 310 Destination: null Annotation: Subtype: Link Rect: 504, 252, 507, 259 Destination: null Annotation: Subtype: Link Rect: 425, 226, 428, 233 Destination: null Annotation: Subtype: Link Rect: 504, 218, 507, 224 Destination: null Annotation: Subtype: Link Rect: 504, 201, 507, 207 Destination: null Annotation: Subtype: Link Rect: 447, 89, 449, 96 Destination: null Annotation: Subtype: Link Rect: 447, 81, 450, 87 Destination: null Page: Label: 2792 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 183, 659, 190, 667 Destination: null Annotation: Subtype: Link Rect: 135, 572, 162, 580 Destination: 127 Annotation: Subtype: Link Rect: 58, 555, 65, 563 Destination: null Annotation: Subtype: Link Rect: 179, 541, 257, 549 Destination: null Annotation: Subtype: Link Rect: 244, 520, 272, 528 Destination: 19 Annotation: Subtype: Link Rect: 79, 373, 106, 381 Destination: 127 Annotation: Subtype: Link Rect: 88, 332, 115, 340 Destination: 127 Annotation: Subtype: Link Rect: 169, 311, 195, 319 Destination: 127 Annotation: Subtype: Link Rect: 253, 248, 283, 256 Destination: 127 Annotation: Subtype: Link Rect: 49, 237, 54, 245 Destination: 127 Annotation: Subtype: Link Rect: 56, 241, 63, 249 Destination: null Annotation: Subtype: Link Rect: 348, 712, 355, 720 Destination: null Annotation: Subtype: Link Rect: 360, 712, 367, 720 Destination: null Annotation: Subtype: Link Rect: 416, 656, 497, 664 Destination: 181 Annotation: Subtype: Link Rect: 517, 607, 523, 615 Destination: null Annotation: Subtype: Link Rect: 446, 565, 452, 573 Destination: null Annotation: Subtype: Link Rect: 326, 440, 342, 448 Destination: null Annotation: Subtype: Link Rect: 457, 440, 464, 448 Destination: null Annotation: Subtype: Link Rect: 413, 398, 420, 406 Destination: null Annotation: Subtype: Link Rect: 332, 387, 339, 395 Destination: null Annotation: Subtype: Link Rect: 455, 384, 474, 392 Destination: 39 Annotation: Subtype: Link Rect: 529, 384, 549, 392 Destination: 58 Annotation: Subtype: Link Rect: 503, 352, 523, 360 Destination: 58 Annotation: Subtype: Link Rect: 436, 342, 462, 350 Destination: 146 Annotation: Subtype: Link Rect: 331, 95, 338, 102 Destination: null Annotation: Subtype: Link Rect: 407, 283, 413, 290 Destination: null Page: Label: 2793 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 191, 573, 197, 581 Destination: null Annotation: Subtype: Link Rect: 127, 518, 142, 526 Destination: null Annotation: Subtype: Link Rect: 202, 518, 209, 526 Destination: null Annotation: Subtype: Link Rect: 185, 486, 200, 494 Destination: null Annotation: Subtype: Link Rect: 64, 476, 71, 484 Destination: null Annotation: Subtype: Link Rect: 76, 455, 83, 463 Destination: null Annotation: Subtype: Link Rect: 209, 434, 225, 442 Destination: null Annotation: Subtype: Link Rect: 207, 423, 214, 431 Destination: null Annotation: Subtype: Link Rect: 286, 230, 293, 238 Destination: null Annotation: Subtype: Link Rect: 286, 220, 293, 228 Destination: null Annotation: Subtype: Link Rect: 100, 210, 107, 218 Destination: null Annotation: Subtype: Link Rect: 104, 115, 111, 123 Destination: null Annotation: Subtype: Link Rect: 98, 105, 105, 113 Destination: null Annotation: Subtype: Link Rect: 103, 95, 110, 102 Destination: null Annotation: Subtype: Link Rect: 74, 74, 81, 82 Destination: null Annotation: Subtype: Link Rect: 555, 670, 562, 678 Destination: null Annotation: Subtype: Link Rect: 413, 659, 421, 667 Destination: null Annotation: Subtype: Link Rect: 437, 635, 464, 643 Destination: 181 Annotation: Subtype: Link Rect: 534, 133, 562, 141 Destination: null Annotation: Subtype: Link Rect: 330, 122, 339, 130 Destination: null Annotation: Subtype: Link Rect: 513, 426, 516, 432 Destination: null Page: Label: 2794 Sequence: 11 Page: Label: 2795 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 233, 691, 240, 699 Destination: null Annotation: Subtype: Link Rect: 74, 666, 78, 674 Destination: 213 Annotation: Subtype: Link Rect: 191, 666, 196, 674 Destination: 213 Annotation: Subtype: Link Rect: 199, 670, 206, 678 Destination: null Annotation: Subtype: Link Rect: 87, 283, 229, 291 Annotation: Subtype: Link Rect: 197, 273, 293, 281 Annotation: Subtype: Link Rect: 42, 262, 104, 270 Annotation: Subtype: Link Rect: 54, 222, 293, 229 Annotation: Subtype: Link Rect: 54, 214, 183, 221 Annotation: Subtype: Link Rect: 55, 206, 293, 213 Annotation: Subtype: Link Rect: 55, 198, 293, 205 Annotation: Subtype: Link Rect: 55, 190, 108, 197 Annotation: Subtype: Link Rect: 194, 183, 234, 189 Annotation: Subtype: Link Rect: 55, 175, 101, 181 Annotation: Subtype: Link Rect: 104, 175, 128, 181 Annotation: Subtype: Link Rect: 132, 175, 255, 181 Annotation: Subtype: Link Rect: 257, 175, 277, 181 Annotation: Subtype: Link Rect: 279, 175, 293, 181 Annotation: Subtype: Link Rect: 59, 167, 148, 173 Annotation: Subtype: Link Rect: 153, 167, 164, 173 Annotation: Subtype: Link Rect: 55, 159, 194, 165 Annotation: Subtype: Link Rect: 199, 159, 209, 165 Annotation: Subtype: Link Rect: 55, 151, 293, 157 Annotation: Subtype: Link Rect: 55, 143, 293, 149 Annotation: Subtype: Link Rect: 55, 135, 108, 141 Annotation: Subtype: Link Rect: 54, 127, 293, 133 Annotation: Subtype: Link Rect: 54, 119, 293, 125 Annotation: Subtype: Link Rect: 54, 111, 66, 117 Annotation: Subtype: Link Rect: 71, 111, 82, 117 Annotation: Subtype: Link Rect: 55, 103, 293, 109 Annotation: Subtype: Link Rect: 55, 95, 292, 101 Annotation: Subtype: Link Rect: 55, 87, 293, 93 Annotation: Subtype: Link Rect: 55, 79, 223, 85 Annotation: Subtype: Link Rect: 228, 79, 239, 85 Annotation: Subtype: Link Rect: 55, 71, 198, 77 Annotation: Subtype: Link Rect: 203, 71, 213, 77 Annotation: Subtype: Link Rect: 54, 63, 293, 69 Annotation: Subtype: Link Rect: 54, 55, 65, 61 Annotation: Subtype: Link Rect: 70, 55, 81, 61 Annotation: Subtype: Link Rect: 55, 47, 293, 53 Annotation: Subtype: Link Rect: 55, 39, 91, 45 Annotation: Subtype: Link Rect: 95, 39, 106, 45 Annotation: Subtype: Link Rect: 324, 720, 529, 727 Annotation: Subtype: Link Rect: 324, 712, 562, 719 Annotation: Subtype: Link Rect: 324, 704, 439, 711 Annotation: Subtype: Link Rect: 324, 696, 562, 703 Annotation: Subtype: Link Rect: 324, 688, 356, 695 Annotation: Subtype: Link Rect: 361, 688, 372, 695 Annotation: Subtype: Link Rect: 324, 680, 562, 687 Annotation: Subtype: Link Rect: 324, 672, 346, 679 Annotation: Subtype: Link Rect: 351, 672, 562, 679 Annotation: Subtype: Link Rect: 324, 664, 335, 671 Annotation: Subtype: Link Rect: 340, 664, 351, 671 Annotation: Subtype: Link Rect: 323, 656, 562, 663 Annotation: Subtype: Link Rect: 323, 648, 540, 655 Annotation: Subtype: Link Rect: 545, 648, 556, 655 Annotation: Subtype: Link Rect: 324, 640, 365, 647 Annotation: Subtype: Link Rect: 371, 640, 373, 647 Annotation: Subtype: Link Rect: 376, 640, 436, 647 Annotation: Subtype: Link Rect: 439, 640, 445, 647 Annotation: Subtype: Link Rect: 448, 640, 562, 647 Annotation: Subtype: Link Rect: 324, 632, 454, 639 Annotation: Subtype: Link Rect: 459, 632, 474, 639 Annotation: Subtype: Link Rect: 324, 625, 521, 631 Annotation: Subtype: Link Rect: 526, 625, 541, 631 Annotation: Subtype: Link Rect: 324, 617, 471, 623 Annotation: Subtype: Link Rect: 476, 617, 488, 623 Annotation: Subtype: Link Rect: 323, 609, 562, 615 Annotation: Subtype: Link Rect: 323, 601, 335, 607 Annotation: Subtype: Link Rect: 340, 601, 351, 607 Annotation: Subtype: Link Rect: 324, 593, 562, 599 Annotation: Subtype: Link Rect: 324, 585, 364, 591 Annotation: Subtype: Link Rect: 369, 585, 380, 591 Annotation: Subtype: Link Rect: 324, 577, 562, 583 Annotation: Subtype: Link Rect: 324, 569, 467, 575 Annotation: Subtype: Link Rect: 472, 569, 483, 575 Annotation: Subtype: Link Rect: 324, 561, 562, 567 Annotation: Subtype: Link Rect: 324, 553, 562, 559 Annotation: Subtype: Link Rect: 324, 545, 335, 551 Annotation: Subtype: Link Rect: 340, 545, 352, 551 Annotation: Subtype: Link Rect: 324, 537, 413, 543 Annotation: Subtype: Link Rect: 415, 537, 562, 543 Annotation: Subtype: Link Rect: 324, 529, 407, 535 Annotation: Subtype: Link Rect: 411, 529, 423, 535 Annotation: Subtype: Link Rect: 324, 521, 449, 527 Annotation: Subtype: Link Rect: 451, 521, 562, 527 Annotation: Subtype: Link Rect: 324, 513, 338, 519 Annotation: Subtype: Link Rect: 341, 513, 494, 519 Annotation: Subtype: Link Rect: 499, 513, 513, 519 Annotation: Subtype: Link Rect: 323, 505, 355, 511 Annotation: Subtype: Link Rect: 356, 505, 562, 511 Annotation: Subtype: Link Rect: 323, 497, 389, 503 Annotation: Subtype: Link Rect: 394, 497, 406, 503 Annotation: Subtype: Link Rect: 324, 489, 562, 495 Annotation: Subtype: Link Rect: 324, 481, 524, 487 Annotation: Subtype: Link Rect: 324, 473, 369, 479 Annotation: Subtype: Link Rect: 372, 473, 562, 479 Annotation: Subtype: Link Rect: 324, 465, 399, 472 Annotation: Subtype: Link Rect: 404, 465, 415, 472 Annotation: Subtype: Link Rect: 324, 457, 431, 464 Annotation: Subtype: Link Rect: 435, 457, 562, 464 Annotation: Subtype: Link Rect: 324, 449, 371, 456 Annotation: Subtype: Link Rect: 376, 449, 394, 456 Annotation: Subtype: Link Rect: 323, 441, 562, 448 Annotation: Subtype: Link Rect: 323, 433, 368, 440 Annotation: Subtype: Link Rect: 373, 433, 388, 440 Annotation: Subtype: Link Rect: 324, 425, 518, 432 Annotation: Subtype: Link Rect: 522, 425, 538, 432 Annotation: Subtype: Link Rect: 324, 417, 488, 424 Annotation: Subtype: Link Rect: 493, 417, 500, 424 Annotation: Subtype: Link Rect: 324, 409, 562, 416 Annotation: Subtype: Link Rect: 324, 401, 430, 408 Annotation: Subtype: Link Rect: 435, 401, 449, 408 Annotation: Subtype: Link Rect: 324, 393, 562, 400 Annotation: Subtype: Link Rect: 324, 385, 335, 392 Annotation: Subtype: Link Rect: 340, 385, 350, 392 Annotation: Subtype: Link Rect: 323, 362, 448, 368 Annotation: Subtype: Link Rect: 453, 362, 468, 368 Annotation: Subtype: Link Rect: 324, 354, 502, 360 Annotation: Subtype: Link Rect: 507, 354, 518, 360 Annotation: Subtype: Link Rect: 324, 346, 526, 352 Annotation: Subtype: Link Rect: 531, 346, 546, 352 Annotation: Subtype: Link Rect: 324, 338, 516, 344 Annotation: Subtype: Link Rect: 521, 338, 533, 344 Annotation: Subtype: Link Rect: 323, 330, 498, 336 Annotation: Subtype: Link Rect: 503, 330, 517, 336 Annotation: Subtype: Link Rect: 324, 322, 562, 328 Annotation: Subtype: Link Rect: 324, 314, 562, 320 Annotation: Subtype: Link Rect: 324, 306, 381, 312 Annotation: Subtype: Link Rect: 324, 298, 562, 304 Annotation: Subtype: Link Rect: 324, 290, 562, 296 Annotation: Subtype: Link Rect: 324, 282, 562, 288 Annotation: Subtype: Link Rect: 324, 274, 562, 280 Annotation: Subtype: Link Rect: 324, 266, 562, 272 Annotation: Subtype: Link Rect: 324, 258, 562, 264 Annotation: Subtype: Link Rect: 324, 250, 562, 256 Annotation: Subtype: Link Rect: 324, 242, 562, 248 Annotation: Subtype: Link Rect: 324, 234, 562, 240 Annotation: Subtype: Link Rect: 324, 226, 562, 232 Annotation: Subtype: Link Rect: 324, 218, 562, 224 Annotation: Subtype: Link Rect: 324, 210, 472, 216 Annotation: Subtype: Link Rect: 477, 210, 562, 216 Annotation: Subtype: Link Rect: 324, 202, 562, 208 Annotation: Subtype: Link Rect: 324, 194, 339, 201 Annotation: Subtype: Link Rect: 324, 186, 436, 193 Annotation: Subtype: Link Rect: 441, 186, 453, 193 Annotation: Subtype: Link Rect: 324, 178, 441, 185 Annotation: Subtype: Link Rect: 446, 178, 457, 185 Annotation: Subtype: Link Rect: 324, 170, 515, 177 Annotation: Subtype: Link Rect: 520, 170, 536, 177 Annotation: Subtype: Link Rect: 323, 162, 562, 169 Annotation: Subtype: Link Rect: 323, 154, 426, 161 Annotation: Subtype: Link Rect: 431, 154, 442, 161 Annotation: Subtype: Link Rect: 324, 146, 525, 153 Annotation: Subtype: Link Rect: 530, 146, 542, 153 Annotation: Subtype: Link Rect: 324, 138, 562, 145 Annotation: Subtype: Link Rect: 324, 130, 370, 137 Annotation: Subtype: Link Rect: 324, 122, 487, 129 Annotation: Subtype: Link Rect: 492, 122, 503, 129 Annotation: Subtype: Link Rect: 323, 114, 502, 121 Annotation: Subtype: Link Rect: 507, 114, 518, 121 Annotation: Subtype: Link Rect: 324, 106, 540, 113 Annotation: Subtype: Link Rect: 544, 106, 556, 113 Annotation: Subtype: Link Rect: 324, 98, 478, 105 Annotation: Subtype: Link Rect: 483, 98, 490, 105 Annotation: Subtype: Link Rect: 324, 91, 499, 97 Annotation: Subtype: Link Rect: 504, 91, 515, 97 Annotation: Subtype: Link Rect: 324, 83, 463, 89 Annotation: Subtype: Link Rect: 468, 83, 479, 89 Annotation: Subtype: Link Rect: 324, 75, 562, 81 Annotation: Subtype: Link Rect: 324, 67, 562, 73 Annotation: Subtype: Link Rect: 324, 59, 387, 65 Annotation: Subtype: Link Rect: 392, 59, 403, 65 Annotation: Subtype: Link Rect: 323, 51, 458, 57 Annotation: Subtype: Link Rect: 324, 43, 347, 49 Annotation: Subtype: Link Rect: 350, 43, 540, 49 Checksum: 4a69edd9 Type: CRC32 Checksum: 82ce1d2c39586ab645a2fac967b9cdbf Type: MD5 Checksum: cf087e7eb904434cf4813811e7933a1d41975cc0 Type: SHA-1