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Sánchez-Regaña Creator: Elsevier Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Mon Nov 3 22:54:43 2014 CET ModDate: Mon Nov 3 18:09:44 2014 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.3 x 793.8 pts Page rot: 0 File size: 1117564 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OGCKEP+TrebuchetMS Type 1C Custom yes yes yes 3177 0 OGCKFP+Times-Roman Type 1C WinAnsi yes yes no 3178 0 OGCKGA+TrebuchetMS-Bold Type 1C Custom yes yes yes 3179 0 OGCLFL+NmtmibA Type 1C Custom yes yes yes 3195 0 OGCLFM+MTSYB Type 1C Custom yes yes yes 3196 0 OGCLPJ+TrebuchetMS-Italic Type 1C Custom yes yes yes 3198 0 OGCNIP+MTSY Type 1C Custom yes yes yes 3205 0 OGCPCG+TrebuchetSCR Type 1C Custom yes yes yes 2908 0 OGDKLM+MathematicalPi-One Type 1C Custom yes yes no 2921 0 OGDMGC+TrebuchetSCI Type 1C Custom yes yes yes 2917 0 OGDJGE+MathematicalPi-Four Type 1C Custom yes yes no 2913 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-11 02:52:48 CEST RepresentationInformation: 301841.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-10 16:12:48 CEST Size: 1117564 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 3267 FreeObjects: 50 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Directrices del grupo español de psoriasis (GEP) basadas en la evidencia para el uso de medicamentos biológicos en pacient... Destination: 1 Children: Item: Title: Introducción Destination: 1 Item: Title: Objetivos y metodología Destination: 1 Item: Title: Psoriasis ungueal Destination: 1 Children: Item: Title: Terapias anti-factor de necrosis tumoral α Destination: 1 Children: Item: Title: Infliximab Destination: 1 Item: Title: Etanercept Destination: 1 Item: Title: Adalimumab Destination: 1 Item: Title: Efectos adversos en las uñas durante el tratamiento con anti-factor de necrosis tumoral α Destination: 1 Item: Title: Ustekinumab Destination: 1 Item: Title: Psoriasis del cuero cabelludo Destination: 1 Children: Item: Title: Terapias anti-factor de necrosis tumoral α Destination: 1 Children: Item: Title: Infliximab Destination: 1 Item: Title: Etanercept Destination: 1 Item: Title: Adalimumab Destination: 1 Item: Title: Ustekinumab Destination: 1 Item: Title: Psoriasis palmoplantar Destination: 1 Children: Item: Title: Terapias anti-factor de necrosis tumoral α Destination: 1 Children: Item: Title: Infliximab Destination: 1 Item: Title: Etanercept Destination: 1 Item: Title: Adalimumab Destination: 1 Item: Title: Ustekinumab Destination: 1 Item: Title: Efectos adversos en el cuero cabelludo y las palmas-plantas durante la terapia biológica Destination: 1 Item: Title: Conclusiones Destination: 1 Item: Title: Conflicto de intereses Destination: 1 Item: Title: Apéndice 1 Niveles de evidencia científica (U.S. Preventive ServiceTask Force [USPSTF]) Destination: 1 Item: Title: Bibliografía Destination: 1 Info: Title: Directrices del grupo español de psoriasis (GEP) basadas en la evidencia para el uso de medicamentos biológicos en pacientes con psoriasis en localizaciones de difícil tratamiento (uñas, cuero cabelludo, palmas y plantas) Author: M. Sánchez-Regaña Subject: Actas dermosifiliogríaficas, 105 (2014) 923-934. doi:10.1016/j.ad.2014.02.015 Keywords: Creator: Elsevier Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Mon Nov 03 22:54:43 CET 2014 ModDate: Mon Nov 03 18:39:44 CET 2014 ID: 0x224635e96b90db1a99465ef190d2215f, 0x3f6ce0fe737f3b419c0f8dde0d670a71 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 272 ImageHeight: 337 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 118 ImageHeight: 118 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 295 ImageHeight: 372 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: OGDJGE+MathematicalPi-Four FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: OGDJGE+MathematicalPi-Four Flags: Symbolic FontBBox: -26, -240, 928, 773 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OGCNIP+MTSY FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: OGCNIP+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGDMGC+TrebuchetSCI FontSubset: true FirstChar: 105 LastChar: 105 FontDescriptor: FontName: OGDMGC+TrebuchetSCI Flags: Symbolic FontBBox: -60, -181, 925, 715 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGCKEP+TrebuchetMS FontSubset: true FirstChar: 31 LastChar: 252 FontDescriptor: FontName: OGCKEP+TrebuchetMS Flags: Serif, Symbolic FontBBox: -86, -262, 958, 939 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGDKLM+MathematicalPi-One FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: OGDKLM+MathematicalPi-One Flags: Symbolic FontBBox: -30, -210, 1000, 779 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OGCKFP+Times-Roman FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: OGCKFP+Times-Roman Flags: Serif, Nonsymbolic FontBBox: -168, -218, 1000, 898 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OGCKGA+TrebuchetMS-Bold FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: OGCKGA+TrebuchetMS-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -101, -270, 1010, 980 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGCLFL+NmtmibA FontSubset: true FirstChar: 44 LastChar: 44 FontDescriptor: FontName: OGCLFL+NmtmibA Flags: Symbolic, ForceBold FontBBox: -71, -209, 987, 767 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGCLFM+MTSYB FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: OGCLFM+MTSYB Flags: Symbolic, ForceBold FontBBox: -16, -935, 1043, 896 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGCPCG+TrebuchetSCR FontSubset: true FirstChar: 105 LastChar: 105 FontDescriptor: FontName: OGCPCG+TrebuchetSCR Flags: Symbolic FontBBox: -64, -183, 671, 700 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OGCLPJ+TrebuchetMS-Italic FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: OGCLPJ+TrebuchetMS-Italic Flags: Serif, Symbolic, Italic FontBBox: -86, -258, 1021, 946 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf 10.1016/j.ad.2014.02.015 Directrices del grupo español de psoriasis (GEP) basadas en la evidencia para el uso de medicamentos biológicos en pacientes con psoriasis en localizaciones de difícil tratamiento (uñas, cuero cabelludo, palmas y plantas) M. Sánchez-Regaña M.J. Aldunce Soto I. Belinchón Romero M. Ribera Pibernat R.F. Lafuente-Urrez J.M. Carrascosa Carrillo C. Ferrándiz Foraster L. Puig Sanz E. Daudén Tello D. Vidal Sarró R. Ruiz-Villaverde E. Fonseca Capdevila M.C. Rodríguez Cerdeira M.M. Alsina Gibert E. Herrera Acosta S.E. Marrón Moya en representación del Grupo Español de Psoriasis de la Academia Española de Dermatología y Venereología Psoriasis Uñas Cuero cabelludo Palmas Plantas Biológicos Psoriasis Nails Scalp Palms Soles Biologic agents Actas dermosifiliogríaficas, 105 (2014) 923-934. doi:10.1016/j.ad.2014.02.015 AEDV journal Actas dermosifiliogríaficas © 2013 Publicado por Elsevier España, S.L. y AEDV. Todos los derechos reservados. 0001-7310 105 10 December 2014 2014-12 923-934 923 934 10.1016/j.ad.2014.02.015 http://dx.doi.org/10.1016/j.ad.2014.02.015 2010-04-23 true 10.1016/j.ad.2014.02.015 elsevier.com sciencedirect.com 10.1016/j.ad.2014.02.015 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2014-11-03T21:54:43Z 2014-11-03T22:39:44+05:30 True True Acrobat Distiller 9.0.0 (Windows) uuid:7f85a2e8-e526-4a06-ad73-f5b2455cd6e8 uuid:79c166ca-8b52-45a1-93b2-0326d2f04c99 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 87, 802, 244, 808 Flags: Print Annotation: Subtype: Link Rect: 517, 631, 583, 659 Flags: Print Annotation: Subtype: Link Rect: 194, 540, 213, 547 Flags: Print Destination: 3132 Annotation: Subtype: Link Rect: 202, 540, 220, 547 Flags: Print Destination: 3132 Annotation: Subtype: Link Rect: 315, 540, 334, 547 Flags: Print Destination: 3132 Annotation: Subtype: Link Rect: 441, 540, 460, 547 Flags: Print Destination: 3132 Annotation: Subtype: 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Link Rect: 474, 568, 481, 574 Annotation: Subtype: Link Rect: 486, 567, 517, 574 Annotation: Subtype: Link Rect: 522, 568, 561, 574 Annotation: Subtype: Link Rect: 567, 567, 591, 574 Annotation: Subtype: Link Rect: 367, 558, 377, 564 Annotation: Subtype: Link Rect: 382, 558, 394, 564 Annotation: Subtype: Link Rect: 399, 557, 433, 564 Annotation: Subtype: Link Rect: 438, 557, 470, 564 Annotation: Subtype: Link Rect: 475, 558, 478, 564 Annotation: Subtype: Link Rect: 483, 558, 495, 564 Annotation: Subtype: Link Rect: 499, 558, 515, 564 Annotation: Subtype: Link Rect: 521, 558, 553, 564 Annotation: Subtype: Link Rect: 557, 558, 562, 564 Annotation: Subtype: Link Rect: 562, 558, 591, 564 Annotation: Subtype: Link Rect: 367, 547, 410, 554 Annotation: Subtype: Link Rect: 411, 550, 413, 551 Annotation: Subtype: Link Rect: 412, 550, 413, 551 Annotation: Subtype: Link Rect: 413, 550, 414, 551 Annotation: Subtype: Link Rect: 415, 548, 425, 554 Annotation: Subtype: Link Rect: 367, 537, 407, 544 Annotation: Subtype: Link Rect: 411, 537, 443, 544 Annotation: Subtype: Link Rect: 447, 537, 453, 544 Annotation: Subtype: Link Rect: 458, 538, 462, 544 Annotation: Subtype: Link Rect: 462, 538, 475, 544 Annotation: Subtype: Link Rect: 479, 537, 485, 544 Annotation: Subtype: Link Rect: 490, 538, 514, 544 Annotation: Subtype: Link Rect: 518, 537, 524, 544 Annotation: Subtype: Link Rect: 529, 538, 533, 544 Annotation: Subtype: Link Rect: 530, 537, 531, 538 Annotation: Subtype: Link Rect: 533, 537, 560, 544 Annotation: Subtype: Link Rect: 564, 538, 568, 544 Annotation: Subtype: Link Rect: 565, 537, 566, 538 Annotation: Subtype: Link Rect: 569, 537, 570, 539 Annotation: Subtype: Link Rect: 575, 538, 591, 544 Annotation: Subtype: Link Rect: 367, 528, 393, 534 Annotation: Subtype: Link Rect: 397, 527, 404, 534 Annotation: Subtype: Link Rect: 410, 527, 457, 534 Annotation: Subtype: Link Rect: 462, 527, 468, 534 Annotation: Subtype: Link Rect: 473, 528, 480, 534 Annotation: Subtype: Link Rect: 485, 528, 493, 534 Annotation: Subtype: Link Rect: 499, 528, 545, 534 Annotation: Subtype: Link Rect: 550, 528, 557, 534 Annotation: Subtype: Link Rect: 561, 527, 591, 534 Annotation: Subtype: Link Rect: 367, 518, 403, 524 Annotation: Subtype: Link Rect: 408, 517, 430, 524 Annotation: Subtype: Link Rect: 435, 518, 443, 523 Annotation: Subtype: Link Rect: 448, 517, 478, 524 Annotation: Subtype: Link Rect: 483, 518, 500, 524 Annotation: Subtype: Link Rect: 505, 518, 510, 524 Annotation: Subtype: Link Rect: 514, 517, 558, 524 Annotation: Subtype: Link Rect: 563, 517, 582, 524 Annotation: Subtype: Link Rect: 582, 518, 583, 520 Annotation: Subtype: Link Rect: 588, 518, 591, 524 Annotation: Subtype: Link Rect: 367, 507, 386, 514 Annotation: Subtype: Link Rect: 389, 508, 424, 514 Annotation: Subtype: Link Rect: 427, 507, 474, 514 Annotation: Subtype: Link Rect: 475, 510, 477, 511 Annotation: Subtype: Link Rect: 476, 510, 478, 511 Annotation: Subtype: Link Rect: 477, 510, 479, 511 Annotation: Subtype: Link Rect: 480, 508, 490, 514 Annotation: Subtype: Link Rect: 367, 498, 371, 504 Annotation: Subtype: Link Rect: 371, 498, 386, 504 Annotation: Subtype: Link Rect: 388, 497, 394, 504 Annotation: Subtype: Link Rect: 398, 498, 419, 504 Annotation: Subtype: Link Rect: 422, 497, 433, 504 Annotation: Subtype: Link Rect: 436, 498, 440, 504 Annotation: Subtype: Link Rect: 440, 497, 452, 503 Annotation: Subtype: Link Rect: 455, 497, 461, 504 Annotation: Subtype: Link Rect: 464, 498, 493, 504 Annotation: Subtype: Link Rect: 495, 498, 505, 504 Annotation: Subtype: Link Rect: 505, 497, 506, 500 Annotation: Subtype: Link Rect: 509, 498, 529, 504 Annotation: Subtype: Link Rect: 531, 497, 537, 504 Annotation: Subtype: Link Rect: 540, 498, 561, 504 Annotation: Subtype: Link Rect: 564, 497, 570, 504 Annotation: Subtype: Link Rect: 573, 498, 580, 504 Annotation: Subtype: Link Rect: 582, 498, 591, 504 Annotation: Subtype: Link Rect: 368, 488, 402, 494 Annotation: Subtype: Link Rect: 406, 488, 438, 494 Annotation: Subtype: Link Rect: 443, 488, 455, 494 Annotation: Subtype: Link Rect: 460, 488, 505, 494 Annotation: Subtype: Link Rect: 509, 487, 536, 494 Annotation: Subtype: Link Rect: 540, 488, 550, 494 Annotation: Subtype: Link Rect: 555, 488, 591, 494 Annotation: Subtype: Link Rect: 367, 478, 400, 484 Annotation: Subtype: Link Rect: 403, 477, 435, 484 Annotation: Subtype: Link Rect: 439, 479, 443, 484 Annotation: Subtype: Link Rect: 446, 477, 466, 484 Annotation: Subtype: Link Rect: 469, 479, 473, 483 Annotation: Subtype: Link Rect: 474, 477, 475, 480 Annotation: Subtype: Link Rect: 479, 477, 523, 484 Annotation: Subtype: Link Rect: 526, 478, 571, 484 Annotation: Subtype: Link Rect: 574, 478, 591, 484 Annotation: Subtype: Link Rect: 367, 469, 393, 474 Annotation: Subtype: Link Rect: 396, 467, 448, 474 Annotation: Subtype: Link Rect: 449, 471, 450, 471 Annotation: Subtype: Link Rect: 449, 471, 451, 471 Annotation: Subtype: Link Rect: 450, 471, 452, 471 Annotation: Subtype: Link Rect: 453, 469, 463, 474 Annotation: Subtype: Link Rect: 367, 459, 371, 464 Annotation: Subtype: Link Rect: 371, 459, 386, 465 Annotation: Subtype: Link Rect: 389, 457, 395, 464 Annotation: Subtype: Link Rect: 399, 459, 427, 464 Annotation: Subtype: Link Rect: 430, 459, 440, 464 Annotation: Subtype: Link Rect: 440, 457, 441, 460 Annotation: Subtype: Link Rect: 445, 459, 449, 464 Annotation: Subtype: Link Rect: 449, 459, 479, 465 Annotation: Subtype: Link Rect: 483, 457, 489, 464 Annotation: Subtype: Link Rect: 492, 459, 499, 464 Annotation: Subtype: Link Rect: 499, 457, 511, 463 Annotation: Subtype: Link Rect: 514, 459, 518, 464 Annotation: Subtype: Link Rect: 518, 457, 519, 460 Annotation: Subtype: Link Rect: 523, 459, 545, 464 Annotation: Subtype: Link Rect: 548, 457, 561, 464 Annotation: Subtype: Link Rect: 565, 459, 569, 464 Annotation: Subtype: Link Rect: 569, 457, 581, 463 Annotation: Subtype: Link Rect: 585, 457, 591, 464 Annotation: Subtype: Link Rect: 367, 449, 374, 454 Annotation: Subtype: Link Rect: 377, 449, 385, 455 Annotation: Subtype: Link Rect: 389, 449, 402, 455 Annotation: Subtype: Link Rect: 405, 449, 418, 455 Annotation: Subtype: Link Rect: 421, 449, 433, 455 Annotation: Subtype: Link Rect: 436, 447, 470, 453 Annotation: Subtype: Link Rect: 473, 449, 490, 455 Annotation: Subtype: Link Rect: 493, 449, 495, 454 Annotation: Subtype: Link Rect: 499, 447, 515, 453 Annotation: Subtype: Link Rect: 517, 449, 524, 455 Annotation: Subtype: Link Rect: 527, 449, 561, 455 Annotation: Subtype: Link Rect: 564, 447, 591, 455 Annotation: Subtype: Link Rect: 367, 439, 373, 444 Annotation: Subtype: Link Rect: 377, 437, 405, 444 Annotation: Subtype: Link Rect: 408, 439, 423, 445 Annotation: Subtype: Link Rect: 427, 439, 497, 445 Annotation: Subtype: Link Rect: 501, 437, 533, 444 Annotation: Subtype: Link Rect: 536, 439, 541, 445 Annotation: Subtype: Link Rect: 544, 437, 591, 444 Annotation: Subtype: Link Rect: 367, 427, 394, 435 Annotation: Subtype: Link Rect: 397, 429, 404, 435 Annotation: Subtype: Link Rect: 407, 429, 418, 435 Annotation: Subtype: Link Rect: 421, 429, 450, 435 Annotation: Subtype: Link Rect: 453, 429, 470, 435 Annotation: Subtype: Link Rect: 474, 427, 518, 435 Annotation: Subtype: Link Rect: 518, 429, 519, 430 Annotation: Subtype: Link Rect: 523, 427, 570, 435 Annotation: Subtype: Link Rect: 571, 431, 573, 431 Annotation: Subtype: Link Rect: 572, 431, 574, 431 Annotation: Subtype: Link Rect: 573, 431, 575, 431 Annotation: Subtype: Link Rect: 576, 429, 581, 435 Annotation: Subtype: Link Rect: 367, 419, 371, 424 Annotation: Subtype: Link Rect: 371, 419, 382, 424 Annotation: Subtype: Link Rect: 385, 417, 392, 424 Annotation: Subtype: Link Rect: 396, 419, 411, 425 Annotation: Subtype: Link Rect: 414, 417, 421, 424 Annotation: Subtype: Link Rect: 424, 419, 428, 424 Annotation: Subtype: Link Rect: 428, 419, 455, 425 Annotation: Subtype: Link Rect: 458, 419, 463, 424 Annotation: Subtype: Link Rect: 462, 417, 463, 420 Annotation: Subtype: Link Rect: 467, 417, 502, 425 Annotation: Subtype: Link Rect: 506, 419, 512, 424 Annotation: Subtype: Link Rect: 516, 419, 548, 424 Annotation: Subtype: Link Rect: 551, 417, 575, 424 Annotation: Subtype: Link Rect: 578, 419, 585, 425 Annotation: Subtype: Link Rect: 588, 419, 591, 423 Annotation: Subtype: Link Rect: 367, 409, 397, 415 Annotation: Subtype: Link Rect: 400, 409, 416, 415 Annotation: Subtype: Link Rect: 419, 409, 431, 415 Annotation: Subtype: Link Rect: 434, 407, 463, 415 Annotation: Subtype: Link Rect: 466, 409, 484, 415 Annotation: Subtype: Link Rect: 487, 409, 495, 415 Annotation: Subtype: Link Rect: 498, 407, 529, 413 Annotation: Subtype: Link Rect: 532, 409, 540, 413 Annotation: Subtype: Link Rect: 543, 409, 554, 415 Annotation: Subtype: Link Rect: 557, 407, 582, 415 Annotation: Subtype: Link Rect: 585, 409, 592, 415 Annotation: Subtype: Link Rect: 367, 399, 379, 405 Annotation: Subtype: Link Rect: 382, 399, 388, 405 Annotation: Subtype: Link Rect: 392, 397, 420, 405 Annotation: Subtype: Link Rect: 423, 399, 438, 405 Annotation: Subtype: Link Rect: 442, 397, 474, 405 Annotation: Subtype: Link Rect: 478, 399, 486, 405 Annotation: Subtype: Link Rect: 490, 397, 517, 405 Annotation: Subtype: Link Rect: 520, 399, 527, 405 Annotation: Subtype: Link Rect: 530, 397, 563, 405 Annotation: Subtype: Link Rect: 566, 399, 591, 405 Annotation: Subtype: Link Rect: 367, 389, 385, 395 Annotation: Subtype: Link Rect: 388, 389, 395, 395 Annotation: Subtype: Link Rect: 397, 389, 434, 395 Annotation: Subtype: Link Rect: 438, 389, 441, 395 Annotation: Subtype: Link Rect: 444, 389, 479, 395 Annotation: Subtype: Link Rect: 482, 387, 525, 395 Annotation: Subtype: Link Rect: 526, 391, 528, 392 Annotation: Subtype: Link Rect: 527, 391, 529, 392 Annotation: Subtype: Link Rect: 528, 391, 530, 392 Annotation: Subtype: Link Rect: 531, 389, 536, 395 Annotation: Subtype: Link Rect: 367, 379, 399, 385 Annotation: Subtype: Link Rect: 401, 377, 407, 385 Annotation: Subtype: Link Rect: 411, 379, 414, 385 Annotation: Subtype: Link Rect: 415, 379, 462, 385 Annotation: Subtype: Link Rect: 465, 377, 470, 385 Annotation: Subtype: Link Rect: 473, 379, 505, 385 Annotation: Subtype: Link Rect: 507, 377, 514, 385 Annotation: Subtype: Link Rect: 517, 377, 545, 385 Annotation: Subtype: Link Rect: 548, 377, 554, 385 Annotation: Subtype: Link Rect: 558, 379, 582, 385 Annotation: Subtype: Link Rect: 585, 377, 591, 385 Annotation: Subtype: Link Rect: 367, 369, 398, 375 Annotation: Subtype: Link Rect: 402, 369, 407, 375 Annotation: Subtype: Link Rect: 411, 369, 427, 375 Annotation: Subtype: Link Rect: 428, 369, 432, 372 Annotation: Subtype: Link Rect: 436, 367, 475, 375 Annotation: Subtype: Link Rect: 479, 369, 491, 375 Annotation: Subtype: Link Rect: 495, 369, 507, 375 Annotation: Subtype: Link Rect: 510, 367, 542, 375 Annotation: Subtype: Link Rect: 546, 369, 554, 375 Annotation: Subtype: Link Rect: 558, 367, 577, 373 Annotation: Subtype: Link Rect: 581, 369, 591, 375 Annotation: Subtype: Link Rect: 367, 358, 387, 365 Annotation: Subtype: Link Rect: 391, 357, 432, 365 Annotation: Subtype: Link Rect: 434, 359, 457, 365 Annotation: Subtype: Link Rect: 459, 357, 478, 365 Annotation: Subtype: Link Rect: 481, 359, 486, 365 Annotation: Subtype: Link Rect: 489, 359, 507, 365 Annotation: Subtype: Link Rect: 510, 357, 538, 365 Annotation: Subtype: Link Rect: 541, 359, 556, 365 Annotation: Subtype: Link Rect: 559, 357, 591, 365 Annotation: Subtype: Link Rect: 367, 347, 390, 355 Annotation: Subtype: Link Rect: 393, 347, 408, 355 Annotation: Subtype: Link Rect: 412, 349, 424, 355 Annotation: Subtype: Link Rect: 427, 349, 444, 355 Annotation: Subtype: Link Rect: 443, 349, 444, 350 Annotation: Subtype: Link Rect: 448, 348, 491, 355 Annotation: Subtype: Link Rect: 492, 351, 494, 352 Annotation: Subtype: Link Rect: 493, 351, 494, 352 Annotation: Subtype: Link Rect: 494, 351, 495, 352 Annotation: Subtype: Link Rect: 496, 349, 506, 355 Annotation: Subtype: Link Rect: 367, 337, 397, 345 Annotation: Subtype: Link Rect: 401, 338, 408, 345 Annotation: Subtype: Link Rect: 412, 339, 416, 345 Annotation: Subtype: Link Rect: 416, 339, 439, 345 Annotation: Subtype: Link Rect: 443, 338, 449, 345 Annotation: Subtype: Link Rect: 454, 339, 486, 345 Annotation: Subtype: Link Rect: 490, 339, 497, 345 Annotation: Subtype: Link Rect: 501, 339, 532, 345 Annotation: Subtype: Link Rect: 536, 337, 559, 344 Annotation: Subtype: Link Rect: 562, 339, 575, 345 Annotation: Subtype: Link Rect: 579, 339, 591, 345 Annotation: Subtype: Link Rect: 367, 327, 399, 335 Annotation: Subtype: Link Rect: 403, 329, 408, 335 Annotation: Subtype: Link Rect: 411, 327, 458, 335 Annotation: Subtype: Link Rect: 457, 328, 458, 330 Annotation: Subtype: Link Rect: 463, 327, 512, 335 Annotation: Subtype: Link Rect: 516, 327, 560, 335 Annotation: Subtype: Link Rect: 564, 327, 583, 335 Annotation: Subtype: Link Rect: 583, 329, 584, 330 Annotation: Subtype: Link Rect: 588, 329, 591, 335 Annotation: Subtype: Link Rect: 367, 318, 408, 325 Annotation: Subtype: Link Rect: 410, 319, 415, 325 Annotation: Subtype: Link Rect: 415, 319, 431, 324 Annotation: Subtype: Link Rect: 435, 318, 477, 325 Annotation: Subtype: Link Rect: 478, 321, 480, 322 Annotation: Subtype: Link Rect: 479, 321, 481, 322 Annotation: Subtype: Link Rect: 480, 321, 482, 322 Annotation: Subtype: Link Rect: 483, 319, 489, 325 Annotation: Subtype: Link Rect: 367, 308, 405, 315 Annotation: Subtype: Link Rect: 409, 308, 416, 315 Annotation: Subtype: Link Rect: 421, 308, 455, 315 Annotation: Subtype: Link Rect: 460, 308, 466, 315 Annotation: Subtype: Link Rect: 471, 308, 502, 315 Annotation: Subtype: Link Rect: 506, 308, 512, 315 Annotation: Subtype: Link Rect: 518, 309, 538, 315 Annotation: Subtype: Link Rect: 543, 308, 550, 315 Annotation: Subtype: Link Rect: 555, 309, 559, 315 Annotation: Subtype: Link Rect: 559, 309, 580, 315 Annotation: Subtype: Link Rect: 584, 308, 591, 315 Annotation: Subtype: Link Rect: 367, 299, 371, 305 Annotation: Subtype: Link Rect: 371, 298, 411, 305 Annotation: Subtype: Link Rect: 416, 298, 423, 305 Annotation: Subtype: Link Rect: 428, 299, 435, 305 Annotation: Subtype: Link Rect: 439, 299, 448, 305 Annotation: Subtype: Link Rect: 453, 299, 489, 305 Annotation: Subtype: Link Rect: 494, 299, 501, 305 Annotation: Subtype: Link Rect: 505, 299, 517, 305 Annotation: Subtype: Link Rect: 521, 298, 549, 305 Annotation: Subtype: Link Rect: 553, 299, 565, 305 Annotation: Subtype: Link Rect: 570, 298, 591, 305 Annotation: Subtype: Link Rect: 367, 289, 374, 295 Annotation: Subtype: Link Rect: 377, 289, 412, 295 Annotation: Subtype: Link Rect: 415, 289, 423, 294 Annotation: Subtype: Link Rect: 426, 288, 456, 295 Annotation: Subtype: Link Rect: 460, 289, 478, 295 Annotation: Subtype: Link Rect: 481, 289, 490, 295 Annotation: Subtype: Link Rect: 493, 288, 530, 295 Annotation: Subtype: Link Rect: 534, 288, 591, 295 Annotation: Subtype: Link Rect: 367, 278, 405, 285 Annotation: Subtype: Link Rect: 407, 278, 426, 285 Annotation: Subtype: Link Rect: 426, 279, 427, 280 Annotation: Subtype: Link Rect: 431, 279, 438, 285 Annotation: Subtype: Link Rect: 441, 279, 444, 285 Annotation: Subtype: Link Rect: 447, 279, 482, 285 Annotation: Subtype: Link Rect: 485, 278, 532, 285 Annotation: Subtype: Link Rect: 533, 281, 535, 282 Annotation: Subtype: Link Rect: 534, 281, 536, 282 Annotation: Subtype: Link Rect: 535, 281, 537, 282 Annotation: Subtype: Link Rect: 538, 279, 544, 285 Annotation: Subtype: Link Rect: 367, 269, 392, 275 Annotation: Subtype: Link Rect: 397, 268, 402, 275 Annotation: Subtype: Link Rect: 407, 268, 440, 275 Annotation: Subtype: Link Rect: 444, 268, 450, 275 Annotation: Subtype: Link Rect: 455, 269, 463, 275 Annotation: Subtype: Link Rect: 468, 269, 488, 275 Annotation: Subtype: Link Rect: 492, 268, 499, 275 Annotation: Subtype: Link Rect: 504, 268, 534, 275 Annotation: Subtype: Link Rect: 539, 268, 545, 275 Annotation: Subtype: Link Rect: 549, 269, 581, 275 Annotation: Subtype: Link Rect: 585, 269, 591, 275 Annotation: Subtype: Link Rect: 367, 259, 371, 265 Annotation: Subtype: Link Rect: 371, 259, 401, 265 Annotation: Subtype: Link Rect: 404, 259, 417, 265 Annotation: Subtype: Link Rect: 420, 259, 436, 265 Annotation: Subtype: Link Rect: 439, 259, 445, 265 Annotation: Subtype: Link Rect: 448, 259, 483, 265 Annotation: Subtype: Link Rect: 486, 259, 493, 265 Annotation: Subtype: Link Rect: 496, 259, 508, 265 Annotation: Subtype: Link Rect: 512, 258, 541, 265 Annotation: Subtype: Link Rect: 544, 258, 566, 265 Annotation: Subtype: Link Rect: 569, 259, 591, 265 Annotation: Subtype: Link Rect: 367, 249, 382, 255 Annotation: Subtype: Link Rect: 385, 248, 412, 255 Annotation: Subtype: Link Rect: 412, 249, 413, 251 Annotation: Subtype: Link Rect: 416, 249, 420, 255 Annotation: Subtype: Link Rect: 423, 249, 433, 255 Annotation: Subtype: Link Rect: 436, 249, 453, 255 Annotation: Subtype: Link Rect: 456, 249, 491, 255 Annotation: Subtype: Link Rect: 494, 248, 537, 255 Annotation: Subtype: Link Rect: 538, 251, 540, 252 Annotation: Subtype: Link Rect: 539, 251, 541, 252 Annotation: Subtype: Link Rect: 540, 251, 542, 252 Annotation: Subtype: Link Rect: 543, 249, 549, 255 Annotation: Subtype: Link Rect: 367, 239, 393, 245 Annotation: Subtype: Link Rect: 396, 238, 403, 245 Annotation: Subtype: Link Rect: 406, 239, 420, 245 Annotation: Subtype: Link Rect: 423, 238, 429, 245 Annotation: Subtype: Link Rect: 433, 239, 437, 245 Annotation: Subtype: Link Rect: 437, 239, 458, 245 Annotation: Subtype: Link Rect: 461, 238, 468, 245 Annotation: Subtype: Link Rect: 472, 239, 476, 245 Annotation: Subtype: Link Rect: 476, 238, 502, 245 Annotation: Subtype: Link Rect: 505, 239, 508, 245 Annotation: Subtype: Link Rect: 508, 238, 509, 241 Annotation: Subtype: Link Rect: 513, 239, 528, 245 Annotation: Subtype: Link Rect: 531, 239, 536, 245 Annotation: Subtype: Link Rect: 535, 239, 536, 241 Annotation: Subtype: Link Rect: 540, 239, 574, 245 Annotation: Subtype: Link Rect: 577, 239, 591, 245 Annotation: Subtype: Link Rect: 367, 228, 383, 234 Annotation: Subtype: Link Rect: 385, 230, 391, 235 Annotation: Subtype: Link Rect: 394, 229, 406, 235 Annotation: Subtype: Link Rect: 409, 228, 441, 235 Annotation: Subtype: Link Rect: 444, 230, 448, 235 Annotation: Subtype: Link Rect: 451, 228, 498, 235 Annotation: Subtype: Link Rect: 500, 228, 519, 235 Annotation: Subtype: Link Rect: 521, 230, 527, 235 Annotation: Subtype: Link Rect: 530, 229, 538, 235 Annotation: Subtype: Link Rect: 540, 228, 571, 235 Annotation: Subtype: Link Rect: 574, 229, 577, 235 Annotation: Subtype: Link Rect: 580, 229, 592, 235 Annotation: Subtype: Link Rect: 367, 219, 384, 225 Annotation: Subtype: Link Rect: 387, 219, 419, 225 Annotation: Subtype: Link Rect: 422, 219, 426, 225 Annotation: Subtype: Link Rect: 426, 219, 455, 225 Annotation: Subtype: Link Rect: 459, 218, 501, 225 Annotation: Subtype: Link Rect: 502, 222, 504, 222 Annotation: Subtype: Link Rect: 503, 222, 505, 222 Annotation: Subtype: Link Rect: 504, 222, 506, 222 Annotation: Subtype: Link Rect: 507, 219, 517, 225 Annotation: Subtype: Link Rect: 367, 209, 393, 215 Annotation: Subtype: Link Rect: 396, 210, 400, 215 Annotation: Subtype: Link Rect: 399, 208, 401, 211 Annotation: Subtype: Link Rect: 404, 210, 427, 215 Annotation: Subtype: Link Rect: 431, 208, 438, 215 Annotation: Subtype: Link Rect: 441, 208, 464, 216 Annotation: Subtype: Link Rect: 467, 210, 474, 215 Annotation: Subtype: Link Rect: 478, 210, 491, 215 Annotation: Subtype: Link Rect: 494, 208, 524, 215 Annotation: Subtype: Link Rect: 528, 208, 553, 215 Annotation: Subtype: Link Rect: 556, 208, 578, 215 Annotation: Subtype: Link Rect: 581, 210, 592, 215 Annotation: Subtype: Link Rect: 367, 200, 404, 206 Annotation: Subtype: Link Rect: 408, 200, 419, 205 Annotation: Subtype: Link Rect: 422, 200, 426, 205 Annotation: Subtype: Link Rect: 426, 200, 434, 204 Annotation: Subtype: Link Rect: 436, 200, 450, 206 Annotation: Subtype: Link Rect: 454, 200, 457, 205 Annotation: Subtype: Link Rect: 458, 200, 490, 206 Annotation: Subtype: Link Rect: 493, 200, 505, 205 Annotation: Subtype: Link Rect: 508, 198, 555, 205 Annotation: Subtype: Link Rect: 556, 202, 558, 202 Annotation: Subtype: Link Rect: 557, 202, 559, 202 Annotation: Subtype: Link Rect: 558, 202, 560, 202 Annotation: Subtype: Link Rect: 561, 200, 571, 205 Annotation: Subtype: Link Rect: 367, 188, 387, 195 Annotation: Subtype: Link Rect: 391, 190, 395, 195 Annotation: Subtype: Link Rect: 395, 188, 401, 195 Annotation: Subtype: Link Rect: 407, 190, 430, 195 Annotation: Subtype: Link Rect: 434, 188, 439, 195 Annotation: Subtype: Link Rect: 445, 190, 474, 195 Annotation: Subtype: Link Rect: 479, 188, 484, 195 Annotation: Subtype: Link Rect: 489, 190, 494, 195 Annotation: Subtype: Link Rect: 493, 188, 505, 194 Annotation: Subtype: Link Rect: 510, 188, 515, 195 Annotation: Subtype: Link Rect: 521, 190, 525, 195 Annotation: Subtype: Link Rect: 525, 190, 555, 195 Annotation: Subtype: Link Rect: 561, 188, 567, 195 Annotation: Subtype: Link Rect: 573, 190, 591, 195 Annotation: Subtype: Link Rect: 367, 178, 373, 185 Annotation: Subtype: Link Rect: 380, 180, 387, 185 Annotation: Subtype: Link Rect: 393, 180, 402, 186 Annotation: Subtype: Link Rect: 409, 180, 442, 186 Annotation: Subtype: Link Rect: 449, 178, 496, 185 Annotation: Subtype: Link Rect: 503, 180, 508, 185 Annotation: Subtype: Link Rect: 515, 178, 532, 185 Annotation: Subtype: Link Rect: 539, 178, 553, 185 Annotation: Subtype: Link Rect: 560, 180, 572, 186 Annotation: Subtype: Link Rect: 579, 180, 591, 186 Annotation: Subtype: Link Rect: 367, 168, 402, 175 Annotation: Subtype: Link Rect: 405, 170, 420, 176 Annotation: Subtype: Link Rect: 423, 168, 462, 175 Annotation: Subtype: Link Rect: 465, 168, 492, 176 Annotation: Subtype: Link Rect: 495, 170, 501, 175 Annotation: Subtype: Link Rect: 505, 168, 533, 175 Annotation: Subtype: Link Rect: 536, 170, 551, 176 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 442, 369, 467, 375 Annotation: Subtype: Link Rect: 471, 367, 502, 375 Annotation: Subtype: Link Rect: 506, 369, 509, 375 Annotation: Subtype: Link Rect: 513, 369, 524, 375 Annotation: Subtype: Link Rect: 527, 369, 544, 375 Annotation: Subtype: Link Rect: 548, 369, 582, 375 Annotation: Subtype: Link Rect: 359, 358, 400, 365 Annotation: Subtype: Link Rect: 402, 361, 404, 362 Annotation: Subtype: Link Rect: 403, 361, 405, 362 Annotation: Subtype: Link Rect: 404, 361, 406, 362 Annotation: Subtype: Link Rect: 407, 359, 413, 365 Annotation: Subtype: Link Rect: 359, 349, 382, 355 Annotation: Subtype: Link Rect: 386, 348, 397, 355 Annotation: Subtype: Link Rect: 402, 349, 415, 355 Annotation: Subtype: Link Rect: 419, 349, 424, 355 Annotation: Subtype: Link Rect: 429, 347, 472, 355 Annotation: Subtype: Link Rect: 475, 347, 523, 355 Annotation: Subtype: Link Rect: 526, 347, 558, 355 Annotation: Subtype: Link Rect: 563, 349, 582, 355 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 408, 259, 415, 265 Annotation: Subtype: Link Rect: 418, 258, 466, 265 Annotation: Subtype: Link Rect: 469, 258, 498, 265 Annotation: Subtype: Link Rect: 502, 259, 517, 265 Annotation: Subtype: Link Rect: 520, 259, 557, 265 Annotation: Subtype: Link Rect: 561, 259, 566, 265 Annotation: Subtype: Link Rect: 569, 259, 582, 264 Annotation: Subtype: Link Rect: 359, 248, 391, 255 Annotation: Subtype: Link Rect: 396, 249, 440, 255 Annotation: Subtype: Link Rect: 445, 248, 512, 255 Annotation: Subtype: Link Rect: 517, 248, 536, 255 Annotation: Subtype: Link Rect: 536, 249, 537, 251 Annotation: Subtype: Link Rect: 542, 249, 545, 255 Annotation: Subtype: Link Rect: 550, 249, 562, 255 Annotation: Subtype: Link Rect: 566, 249, 583, 255 Annotation: Subtype: Link Rect: 359, 239, 391, 245 Annotation: Subtype: Link Rect: 394, 239, 398, 245 Annotation: Subtype: Link Rect: 398, 239, 427, 245 Annotation: Subtype: Link Rect: 431, 238, 477, 245 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 434, 130, 439, 136 Annotation: Subtype: Link Rect: 438, 128, 439, 131 Annotation: Subtype: Link Rect: 443, 130, 466, 136 Annotation: Subtype: Link Rect: 468, 128, 475, 136 Annotation: Subtype: Link Rect: 477, 130, 496, 136 Annotation: Subtype: Link Rect: 499, 128, 505, 136 Annotation: Subtype: Link Rect: 509, 130, 512, 136 Annotation: Subtype: Link Rect: 513, 130, 534, 135 Annotation: Subtype: Link Rect: 536, 128, 543, 136 Annotation: Subtype: Link Rect: 546, 128, 575, 136 Annotation: Subtype: Link Rect: 577, 128, 582, 136 Annotation: Subtype: Link Rect: 359, 120, 366, 125 Annotation: Subtype: Link Rect: 369, 120, 377, 126 Annotation: Subtype: Link Rect: 381, 118, 420, 126 Annotation: Subtype: Link Rect: 423, 120, 429, 126 Annotation: Subtype: Link Rect: 432, 120, 443, 126 Annotation: Subtype: Link Rect: 446, 120, 482, 125 Annotation: Subtype: Link Rect: 485, 120, 492, 126 Annotation: Subtype: Link Rect: 496, 118, 543, 126 Annotation: Subtype: Link Rect: 546, 118, 582, 126 Annotation: Subtype: Link Rect: 359, 110, 362, 116 Annotation: Subtype: Link Rect: 365, 108, 384, 116 Annotation: Subtype: Link Rect: 387, 110, 421, 116 Annotation: Subtype: Link Rect: 425, 109, 464, 116 Annotation: Subtype: Link Rect: 465, 112, 466, 113 Annotation: Subtype: Link Rect: 466, 112, 467, 113 Annotation: Subtype: Link Rect: 467, 112, 468, 113 Annotation: Subtype: Link Rect: 469, 110, 475, 116 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 110, 778, 140, 784 Annotation: Subtype: Link Rect: 143, 777, 150, 784 Annotation: Subtype: Link Rect: 153, 778, 174, 784 Annotation: Subtype: Link Rect: 177, 777, 183, 784 Annotation: Subtype: Link Rect: 187, 778, 215, 785 Annotation: Subtype: Link Rect: 217, 778, 221, 784 Annotation: Subtype: Link Rect: 220, 777, 222, 780 Annotation: Subtype: Link Rect: 225, 778, 248, 784 Annotation: Subtype: Link Rect: 250, 777, 261, 784 Annotation: Subtype: Link Rect: 265, 778, 273, 784 Annotation: Subtype: Link Rect: 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