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Title:           Dasatinib worsens the effect of cetuximab in combination with fractionated radiotherapy in FaDu- and A431-derived xenografted tumours
Subject:         British Journal of Cancer 111, 1310 (2014). doi:10.1038/bjc.2014.432
Author:          M Baro
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        Title: MATERIALS AND METHODS
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          Title: Cell lines and pharmacological inhibitors
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         Item: 
          Title: Xenografted tumours and in™vivo treatments
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          Title: BrdU incorporation assay
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          Title: CD31solPECAM immunostaining and VEGF determination
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          Title: Western blot analysis and RAS-GTP assay
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          Title: Statistical analysis
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       Item: 
        Title: RESULTS
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          Title: Dasatinib worsens the effect of cetuximab on cell proliferation in FaDu and A431 cell lines
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       Item: 
        Title: Figure™1Differential effect of dasatinib on cell proliferation.The SCC5, SCC25, SCC29, FaDu and A431 cells were plated (ap12thinsp000 cells per cm2 in 60thinspmm dishes) in complete medium and incubated for 5 days before drug treatment. For in™vitro cell 
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          Title: Dasatinib worsens the effect of radiotherapy combined with cetuximab in FaDu and A431 xenografted tumours
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        Title: Figure™2Dasatinib (DST) worsens the effect of radiotherapy (XRT) combined with cetuximab (C225) in FaDu and A431 xenografted tumours.The FaDu- and A431-derived tumours were established by subcutaneous injection of 1times106 cells into the right hind limb 
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          Title: Dasatinib increases DNA synthesis and tumour-associated angiogenesis in FaDu and A431 xenografted tumours treated with radiotherapy and cetuximab
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         Item: 
          Title: Dasatinib increases secretion of VEGF in FaDu and A431 cell lines treated with radiotherapy and cetuximab
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         Item: 
          Title: Dasatinib inhibits SRC tyrosine kinase in FaDu and A431 cells
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       Item: 
        Title: Figure™3Dasatinib (DST) increases DNA synthesis and tumour-associated angiogenesis in FaDu and A431 xenografted tumours treated with cetuximab (C225) and radiotherapy (XRT).Xenografted tumours were treated in parallel as described in Figure™2 and sampled 
        Destination: fig_bkfigfig3
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        Title: Figure™4Dasatinib (DST) increases VEGF secretion in FaDu and A431 cell cultures treated with cetuximab (C225) and radiotherapy (XRT).(A) The FaDu cells and (B) A431 cells were plated (ap45thinsp000 cells per cm2 in 60thinspmm dishes) and cultured for 24th
        Destination: fig_bkfigfig4
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        Title: Figure™5The SRC inhibitor PP2 recapitulated the effects of dasatinib on cell signalling.(A) Dasatinib and (B) PP2 drugs were used to treat FaDu and A431 cells. Cultures (ap12thinsp000 cells per cm2 in 60thinspmm dishes) were incubated for 5 days and then 
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         Item: 
          Title: Dasatinib increases the activity of RAS in FaDu and A431 cells
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        Title: DISCUSSION
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        Title: Figure™6Effect of dasatinib on RAS activity in cell cultures treated with cetuximab.(A) The FaDu cells and (B) A431 cells (ap12thinsp000 cells per cm2 in 60thinspmm dishes) were incubated for 5 days and then treated in FBS-free medium with: (1) vehicles (
        Destination: fig_bkfigfig6
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        Title: ACKNOWLEDGEMENTS
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        Title: A5
        Destination: A5
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