e76a342bff3c10f73c5047d8619d33b8  302248.pdf
93f183c3e9babf872279032c2aff895a2aacb217  302248.pdf
e9caedae57933c86b7ec097bb11ac589cf0f1d98772d2baefd59833b36791e6b  302248.pdf

Title:           Src, a potential target for overcoming trastuzumab resistance in HER2-positive breast carcinoma
Subject:         British Journal of Cancer 111, 689 (2014). doi:10.1038/bjc.2014.327
Author:          G Peiró
Creator:         Arbortext Advanced Print Publisher 9.0.226/W
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Fri Jul 25 12:26:47 2014 CEST
ModDate:         Wed Jul 30 09:09:35 2014 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           7
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       470561 bytes
Optimized:       yes
PDF version:     1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MKFOPI+AdvOTa851a675.B               Type 1C           WinAnsi          yes yes no     275  0
MKFPAJ+AdvOTb0d2661a                 Type 1C           Custom           yes yes no     276  0
MKFPAK+AdvOTf1c06d06.I               Type 1C           MacRoman         yes yes no     277  0
MKFPBL+AdvOTdadbfad7.B               Type 1C           WinAnsi          yes yes no     283  0
MKFPBM+AdvOT0906c96e                 Type 1C           WinAnsi          yes yes no     284  0
MKFPBN+AdvP4C4E74                    Type 1C           Custom           yes yes yes    285  0
MKFPCN+AdvOT1ef757c0                 Type 1C           Custom           yes yes yes    293  0
MKFPCO+AdvOT7d6df7ab.I               Type 1C           Custom           yes yes yes    294  0
MKFPCP+AdvTA42                       Type 1C           Custom           yes yes yes    305  0
MKFPDA+AdvOTfe809cc4                 Type 1C           WinAnsi          yes yes no     306  0
MKFPLO+AdvOT3b9b4d35                 Type 1C           WinAnsi          yes yes no     309  0
MKGAGL+AdvOTb65e897d.B               Type 1C           Custom           yes yes yes    129  0
MKGAJL+AdvOT45bf69de.BI              Type 1C           Custom           yes yes yes    123  0
MKGAJM+AdvEls-ent4                   Type 1C           WinAnsi          yes yes no     124  0
MKGAJN+AdvPi2                        Type 1C           WinAnsi          yes yes no     120  0
MKGAJO+AdvEls-ent5                   Type 1C           WinAnsi          yes yes no     121  0
MKGBCL+AdvPi1                        Type 1C           WinAnsi          yes yes no     134  0
MKGBKJ+AdvOT1916b968.BI              Type 1C           WinAnsi          yes yes no     137  0
MKGDGA+AdvItcSymbol-M                Type 1C           WinAnsi          yes yes no     139  0
MKGDJA+AdvGreek_BI                   Type 1C           WinAnsi          yes yes no     142  0
MKGEAO+Helvetica                     Type 1C           WinAnsi          yes yes no     143  0
MKGEAP+Symbol                        Type 1C           Custom           yes yes yes    141  0
MKGGOO+AdvOT8f428072.I               Type 1C           WinAnsi          yes yes no     140  0
MKGJLO+Helvetica                     Type 1C           WinAnsi          yes yes no     147  0
MKGKAN+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     146  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-19 02:54:10 CEST
 RepresentationInformation: 302248.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-10-18 16:36:06 CEST
  Size: 470561
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 331
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: title_link
      Destination: title_link
      Children: 
       Item: 
        Title: MATERIALS AND METHODS
        Destination: A1
        Children: 
         Item: 
          Title: Tumour samples and patientsCloseCurlyQuote follow-up
          Destination: B1
         Item: 
          Title: Immunohistochemistry (IHC)
          Destination: B2
         Item: 
          Title: In situ hybridisation (ISH) analysis
          Destination: B3
         Item: 
          Title: Mutational analysis of PIK3CA
          Destination: B4
         Item: 
          Title: Cell culture
          Destination: B5
         Item: 
          Title: Dose-response studies
          Destination: B6
         Item: 
          Title: Western blotting analysis
          Destination: B7
         Item: 
          Title: Statistical analyses
          Destination: B8
       Item: 
        Title: RESULTS
        Destination: A2
       Item: 
        Title: Table 1 
        Destination: tab_bktbltbl1
       Item: 
        Title: DISCUSSION
        Destination: A3
       Item: 
        Title: Table 2 
        Destination: tab_bktbltbl2
       Item: 
        Title: Figure™1Representative example of the immunohistochemical expression of pSrc-Y416 (membrane±cytoplasm) (times400)
        Destination: fig_bkfigfig1
       Item: 
        Title: Table 3 
        Destination: tab_bktbltbl3
       Item: 
        Title: Figure™2Western blot results of Src and pSrc-Y416 (active) expression in BT474 parental and resistant cells.The expression of total Src did not change in resistant cells when compared with the parental cell line. In contrast, increased pSrc-Y416 was demon
        Destination: fig_bkfigfig2
       Item: 
        Title: Table 4 
        Destination: tab_bktbltbl4
       Item: 
        Title: A4
        Destination: A4
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: M1
       Item: 
        Title: A5
        Destination: A5
       Item: 
        Title: A6
        Destination: A6
       Item: 
        Title: Figure™3Kaplan-Meier plots for pSrc-Y416 results in patients under adjuvant trastuzumab therapy with HR-negative tumours: (A) overall survival, (B) disease-free survival
        Destination: fig_bkfigfig3
   Info: 
    Title: Src, a potential target for overcoming trastuzumab resistance in HER2-positive breast carcinoma
    Author: G Peiró
    Subject: British Journal of Cancer 111, 689 (2014). doi:10.1038/bjc.2014.327
    Creator: Arbortext Advanced Print Publisher 9.0.226/W
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Fri Jul 25 12:26:47 CEST 2014
    ModDate: Wed Jul 30 09:39:35 CEST 2014
   ID: 0x44a661e9a4bc46bd8a8b6ad22d57a96e, 0x6421428a67c6054089de3bd1b7485ea4
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1015
      ImageHeight: 762
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 840
      ImageHeight: 871
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1810
      ImageHeight: 1497
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1799
      ImageHeight: 1310
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MKGAGL+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 40
      LastChar: 144
      FontDescriptor: 
       FontName: MKGAGL+AdvOTb65e897d.B
       Flags: Serif, Symbolic
       FontBBox: -125, -250, 1052, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKGBCL+AdvPi1
      FontSubset: true
      FirstChar: 52
      LastChar: 97
      FontDescriptor: 
       FontName: MKGBCL+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGBKJ+AdvOT1916b968.BI
      FontSubset: true
      FirstChar: 51
      LastChar: 110
      FontDescriptor: 
       FontName: MKGBKJ+AdvOT1916b968.BI
       Flags: Nonsymbolic
       FontBBox: -156, -270, 1187, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGDGA+AdvItcSymbol-M
      FontSubset: true
      FirstChar: 177
      LastChar: 177
      FontDescriptor: 
       FontName: MKGDGA+AdvItcSymbol-M
       Flags: Nonsymbolic
       FontBBox: -62, -229, 1208, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGGOO+AdvOT8f428072.I
      FontSubset: true
      FirstChar: 51
      LastChar: 118
      FontDescriptor: 
       FontName: MKGGOO+AdvOT8f428072.I
       Flags: Nonsymbolic
       FontBBox: -166, -281, 1041, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGEAP+Symbol
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: MKGEAP+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKGDJA+AdvGreek_BI
      FontSubset: true
      FirstChar: 97
      LastChar: 97
      FontDescriptor: 
       FontName: MKGDJA+AdvGreek_BI
       Flags: Serif, Nonsymbolic
       FontBBox: -10, -229, 1062, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGEAO+Helvetica
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: MKGEAO+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGKAN+Helvetica-Oblique
      FontSubset: true
      FirstChar: 80
      LastChar: 80
      FontDescriptor: 
       FontName: MKGKAN+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKFOPI+AdvOTa851a675.B
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: MKFOPI+AdvOTa851a675.B
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1125, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGJLO+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: MKGJLO+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKFPAJ+AdvOTb0d2661a
      FontSubset: true
      FirstChar: 25
      LastChar: 180
      FontDescriptor: 
       FontName: MKFPAJ+AdvOTb0d2661a
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1000, 927
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MKFPAK+AdvOTf1c06d06.I
      FontSubset: true
      FirstChar: 44
      LastChar: 245
      FontDescriptor: 
       FontName: MKFPAK+AdvOTf1c06d06.I
       Flags: Nonsymbolic
       FontBBox: -166, -270, 1031, 927
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: MKFPBL+AdvOTdadbfad7.B
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: MKFPBL+AdvOTdadbfad7.B
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1156, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKFPBM+AdvOT0906c96e
      FontSubset: true
      FirstChar: 37
      LastChar: 180
      FontDescriptor: 
       FontName: MKFPBM+AdvOT0906c96e
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKFPBN+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 254
      FontDescriptor: 
       FontName: MKFPBN+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKFPCN+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 31
      LastChar: 180
      FontDescriptor: 
       FontName: MKFPCN+AdvOT1ef757c0
       Flags: Serif, Symbolic
       FontBBox: -135, -250, 1010, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKFPCO+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: MKFPCO+AdvOT7d6df7ab.I
       Flags: Serif, Symbolic
       FontBBox: -156, -250, 1000, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKFPCP+AdvTA42
      FontSubset: true
      FirstChar: 38
      LastChar: 38
      FontDescriptor: 
       FontName: MKFPCP+AdvTA42
       Flags: Serif, Symbolic
       FontBBox: -72, -145, 875, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKFPDA+AdvOTfe809cc4
      FontSubset: true
      FirstChar: 37
      LastChar: 150
      FontDescriptor: 
       FontName: MKFPDA+AdvOTfe809cc4
       Flags: Nonsymbolic
       FontBBox: -166, -281, 1000, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKFPLO+AdvOT3b9b4d35
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: MKFPLO+AdvOT3b9b4d35
       Flags: Nonsymbolic
       FontBBox: -156, -281, 1031, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGAJN+AdvPi2
      FontSubset: true
      FirstChar: 97
      LastChar: 109
      FontDescriptor: 
       FontName: MKGAJN+AdvPi2
       Flags: Serif, Nonsymbolic
       FontBBox: 16, -335, 981, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGAJO+AdvEls-ent5
      FontSubset: true
      FirstChar: 49
      LastChar: 88
      FontDescriptor: 
       FontName: MKGAJO+AdvEls-ent5
       Flags: Serif, Nonsymbolic
       FontBBox: 9, -343, 1166, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGAJL+AdvOT45bf69de.BI
      FontSubset: true
      FirstChar: 51
      LastChar: 117
      FontDescriptor: 
       FontName: MKGAJL+AdvOT45bf69de.BI
       Flags: Serif, Symbolic
       FontBBox: -177, -250, 1072, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKGAJM+AdvEls-ent4
      FontSubset: true
      FirstChar: 111
      LastChar: 111
      FontDescriptor: 
       FontName: MKGAJM+AdvEls-ent4
       Flags: Nonsymbolic
       FontBBox: 0, -343, 1166, 1218
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/bjc.2014.327</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>G Peir&amp;oacute;</rdf:li>
               <rdf:li>F Ortiz-Mart&amp;iacute;nez</rdf:li>
               <rdf:li>A Gallardo</rdf:li>
               <rdf:li>A P&amp;eacute;rez-Balaguer</rdf:li>
               <rdf:li>J S&amp;aacute;nchez-Pay&amp;aacute;</rdf:li>
               <rdf:li>J J Ponce</rdf:li>
               <rdf:li>A Tibau</rdf:li>
               <rdf:li>L L&amp;oacute;pez-Vilaro</rdf:li>
               <rdf:li>D Escuin</rdf:li>
               <rdf:li>E Adrover</rdf:li>
               <rdf:li>A Barnadas</rdf:li>
               <rdf:li>E Lerma</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">British Journal of Cancer 111, 689 (2014). doi:10.1038/bjc.2014.327</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© 2014 Nature Publishing Group</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Src, a potential target for overcoming trastuzumab resistance in HER2-positive breast carcinoma</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:copyright>© 2014 Cancer Research UK</prism:copyright>
         <prism:doi>10.1038/bjc.2014.327</prism:doi>
         <prism:eIssn>1532-1827</prism:eIssn>
         <prism:endingPage>695</prism:endingPage>
         <prism:issn>0007-0920</prism:issn>
         <prism:number>4</prism:number>
         <prism:publicationName>British Journal of Cancer</prism:publicationName>
         <prism:startingPage>689</prism:startingPage>
         <prism:volume>111</prism:volume>
         <prism:publicationDate>
            <rdf:Bag>
               <rdf:li>2014-06-17</rdf:li>
            </rdf:Bag>
         </prism:publicationDate>
         <prism:rightsAgent>
            <rdf:Bag>
               <rdf:li>permissions@nature.com</rdf:li>
            </rdf:Bag>
         </prism:rightsAgent>
         <prism:url>
            <rdf:Bag>
               <rdf:li>http://dx.doi.org/10.1038/bjc.2014.327</rdf:li>
            </rdf:Bag>
         </prism:url>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreateDate>2014-07-25T10:26:47Z</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher 9.0.226/W</xap:CreatorTool>
         <xap:Label>British Journal of Cancer 111, 689 (2014). doi:10.1038/bjc.2014.327</xap:Label>
         <xap:MetadataDate>2014-07-30T12:39:35+05:30</xap:MetadataDate>
         <xap:ModifyDate>2014-07-30T12:39:35+05:30</xap:ModifyDate>
         <xap:Identifier>
            <rdf:Bag>
               <rdf:li>doi:10.1038/bjc.2014.327</rdf:li>
            </rdf:Bag>
         </xap:Identifier>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/bjc.2014.327"
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:b1fc6ffa-57a4-4520-8686-36d7441637dc</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:eae9ebf5-c6c5-4f72-b247-5c73a95f49f6</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 135, 131, 188, 140
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 194, 131, 260, 140
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 46, 121, 122, 130
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 87, 110, 154, 120
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 159, 110, 224, 120
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 229, 110, 289, 120
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 303, 173, 391, 182
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 422, 131, 499, 140
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 179, 84, 241, 92
      Annotation: 
       Subtype: Link
       Rect: 43, 20, 118, 29
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 46, 734, 148, 744
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 112, 692, 173, 702
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 182, 640, 262, 649
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 76, 619, 179, 629
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 266, 619, 291, 629
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 609, 61, 618
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 145, 588, 243, 597
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 46, 556, 101, 566
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 248, 556, 291, 566
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 546, 61, 555
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 91, 536, 140, 545
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 144, 536, 206, 545
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 211, 536, 272, 545
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 109, 525, 176, 534
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 181, 525, 242, 534
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 247, 525, 291, 534
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 515, 61, 524
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 89, 180, 172, 189
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 306, 661, 380, 670
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 485, 520, 514, 529
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 434, 389, 495, 398
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 519, 342, 551, 351
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 303, 332, 342, 341
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 372, 20, 446, 29
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 314, 368, 345, 377
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 462, 358, 495, 367
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 347, 316, 375, 325
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 409, 190, 440, 200
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 314, 107, 343, 116
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 43, 20, 118, 29
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 194, 154, 203
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 229, 54, 289, 64
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 44, 123, 53
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 131, 44, 207, 53
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 215, 44, 289, 53
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 303, 504, 371, 514
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 376, 504, 444, 514
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 389, 463, 447, 472
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 494, 452, 549, 461
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 303, 442, 377, 451
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 381, 337, 457, 346
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 535, 306, 551, 315
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 303, 295, 347, 305
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 354, 295, 438, 305
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 498, 264, 548, 273
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 447, 233, 518, 242
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 337, 201, 406, 210
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 434, 117, 502, 127
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 507, 117, 551, 127
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 303, 107, 321, 116
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 502, 97, 551, 106
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 303, 86, 321, 95
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 325, 86, 395, 95
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 372, 20, 446, 29
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 128, 507, 137
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 419, 86, 482, 95
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 306, 54, 374, 64
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 20, 118, 29
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 273, 232, 291, 241
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 43, 222, 81, 231
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 86, 222, 149, 231
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 219, 222, 288, 231
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 92, 190, 169, 200
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 423, 682, 487, 691
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 397, 651, 459, 660
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 464, 651, 527, 660
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 372, 20, 446, 29
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 417, 136, 517, 145
      Annotation: 
       Subtype: Link
       Rect: 43, 20, 118, 29
     Thumb: true
  Checksum: 3e4999cc
   Type: CRC32
  Checksum: e76a342bff3c10f73c5047d8619d33b8
   Type: MD5
  Checksum: 93f183c3e9babf872279032c2aff895a2aacb217
   Type: SHA-1
  Checksum: e9caedae57933c86b7ec097bb11ac589cf0f1d98772d2baefd59833b36791e6b
   Type: SHA-256