fc1edc5cb0184ea4cbf6e36ed48151d2 302431.pdf edce075746939a5bf52a915355389be55c5cb2fa 302431.pdf accb7c44ee88876f7c0f0d95f291882961b100485d1f73f23f310146723c9219 302431.pdf Title: Sepsis-associated hyperlactatemia Subject: 2014, :. doi:10.1186/s13054-014-0503-3 Author: Mercedes Garcia-Alvarez Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows) CreationDate: Sat Aug 30 12:41:20 2014 CEST ModDate: Sat Aug 30 12:44:52 2014 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1342469 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JOJLMC+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 510 0 JOJLMD+AdvTTe45e47d2 Type 1C WinAnsi yes yes no 512 0 JOJLME+AdvTTb5929f4c Type 1C WinAnsi yes yes no 514 0 JOJLMF+AdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 516 0 JOMDOP+AdvTT86d47313 Type 1C WinAnsi yes yes no 518 0 JOMEAA+AdvTT86d47313+20 Type 1C WinAnsi yes yes no 520 0 JOMECP+AdvTT7329fd89.I Type 1C WinAnsi yes yes no 522 0 JOMEFP+AdvTT99c4c969 Type 1C WinAnsi yes yes no 234 0 JOMEHA+AdvTT83913201.I Type 1C WinAnsi yes yes no 232 0 JOMEKA+AdvTT86d47313+03 Type 1C Custom yes yes yes 237 0 JONBHC+AdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 246 0 JONBHD+AdvTTb5929f4c+03 Type 1C Custom yes yes yes 243 0 JONBLD+AdvTT8861b38f.I Type 1C WinAnsi yes yes no 249 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-25 02:50:51 CEST RepresentationInformation: 302431.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-24 14:00:29 CEST Size: 1342469 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: sectionAbs1 Item: Title: Introduction Destination: sectionSec1 Item: Title: Normal lactate metabolism Destination: sectionSec2 Children: Item: Title: Production Destination: sectionSec3 Item: Title: Removal Destination: sectionSec4 Children: Item: Title: Gluconeogenesis Destination: sectionSec5 Item: Title: Oxidation Destination: sectionSec6 Item: Title: Lactate use during stress Destination: sectionSec7 Item: Title: Why has the tissue hypoxia paradigm emerged and dominated until now? Destination: sectionSec8 Item: Title: Source of lactate in sepsis Destination: sectionSec9 Children: Item: Title: Tissue hypoxia Destination: sectionSec10 Item: Title: Mitochondrial dysfunction Destination: sectionSec11 Item: Title: Pyruvate dehydrogenase Destination: sectionSec12 Item: Title: DO2-VO2 mismatch Destination: sectionSec13 Item: Title: Alternative explanations for sepsis-associated hyperlactatemia Destination: sectionSec14 Children: Item: Title: Adrenergic-driven aerobic glycolysis Destination: sectionSec15 Item: Title: Where does lactate come from in sepsis? Destination: sectionSec16 Item: Title: The concept of lactate clearance Destination: sectionSec17 Children: Item: Title: The argument in favor of tissue hypoxia as the cause of sepsis-associated hyperlactatemia Destination: sectionSec18 Item: Title: Conclusion Destination: sectionSec19 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Competing interests Destination: ArtNote1 Item: Title: Author details Destination: sectionaunote1 Item: Title: References Destination: sectionBib1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1946 ImageHeight: 1452 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1403 ImageHeight: 468 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 1001 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: JOJLMD+AdvTTe45e47d2 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: JOJLMD+AdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOJLME+AdvTTb5929f4c FontSubset: true FirstChar: 39 LastChar: 237 FontDescriptor: FontName: JOJLME+AdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOJLMF+AdvTTb5929f4c+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: JOJLMF+AdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -218, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMDOP+AdvTT86d47313 FontSubset: true FirstChar: 37 LastChar: 177 FontDescriptor: FontName: JOMDOP+AdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMEAA+AdvTT86d47313+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: JOMEAA+AdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMEHA+AdvTT83913201.I FontSubset: true FirstChar: 71 LastChar: 120 FontDescriptor: FontName: JOMEHA+AdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMECP+AdvTT7329fd89.I FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: JOMECP+AdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMEFP+AdvTT99c4c969 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JOMEFP+AdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOMEKA+AdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JOMEKA+AdvTT86d47313+03 Flags: Symbolic FontBBox: -135, -250, 906, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JONBHD+AdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JONBHD+AdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JONBHC+AdvTT1b53b5fb.I FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: JONBHC+AdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JONBLD+AdvTT8861b38f.I FontSubset: true FirstChar: 46 LastChar: 80 FontDescriptor: FontName: JONBLD+AdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JOJLMC+AdvTTaf7f9f4f.B FontSubset: true FirstChar: 39 LastChar: 121 FontDescriptor: FontName: JOJLMC+AdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding XMP: 2014, :. doi:10.1186/s13054-014-0503-3 2014-08-30T18:41:20+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2014-08-30T18:44:52+08:00 2014-08-30T18:44:52+08:00 application/pdf http://dx.doi.org/10.1186/s13054-014-0503-3 Mercedes Garcia-Alvarez Paul Marik Rinaldo Bellomo Sepsis-associated hyperlactatemia 2014, :. doi:10.1186/s13054-014-0503-3 � 2014 Garcia-Alvarez et al. licensee BioMed Central Ltd. 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