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Title:           Adalimumab regulates intracellular TNFa production in patients with rheumatoid arthritis
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      Title: Abstract
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        Title: Introduction
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       Item: 
        Title: Methods
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       Item: 
        Title: Results
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       Item: 
        Title: Conclusions
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     Item: 
      Title: Introduction
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     Item: 
      Title: Methods
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      Children: 
       Item: 
        Title: Samples
        Destination: sectionSec3
       Item: 
        Title: Determination of intracellular tumor necrosis factor α production in leukocytes
        Destination: sectionSec4
       Item: 
        Title: Determination of membrane tumor necrosis factor α on monocytes
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       Item: 
        Title: Determination of tumor necrosis factor α levels in cultures supernatants
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       Item: 
        Title: Determination of adalimumab levels and antiadalimumab antibodies in serum
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       Item: 
        Title: Flow cytometry analysis
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       Item: 
        Title: Statistical analysis
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     Item: 
      Title: Results
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       Item: 
        Title: Tumor necrosis factor α production in rheumatoid arthritis patients
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       Item: 
        Title: Intracellular tumor necrosis factor α production in rheumatoid arthritis patients after adalimumab treatment
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       Item: 
        Title: Intracellular tumor necrosis factor α regulation in rheumatoid arthritis patients in good to moderate responders to adalimumab
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       Item: 
        Title: Adalimumab levels and antiadalimumab antibodies in serum of rheumatoid arthritis patients
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       Item: 
        Title: Free tumor necrosis factor α levels at the membrane of monocytes and in the culture supernatants from rheumatoid arthritis patients
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       Item: 
        Title: Regulation of intracellular tumor necrosis factor α production by tumor necrosis factor α signaling
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      Title: Discussion
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     Item: 
      Title: Conclusions
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      Title: Abbreviations
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      Title: Competing interests
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     Item: 
      Title: Authors’ contributions
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      Title: Acknowledgements
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