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Title:           Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution
Subject:         CellReports, 8 (2014) 1832-1844. doi:10.1016/j.celrep.2014.07.055
Author:          Robin van der Lee
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      Title: Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Long N-Terminal Disordered Segments Contribute to Short Protein Half-Life In Vivo
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         Item: 
          Title: Internal Disordered Segments Also Contribute to Short Protein Half-Life
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         Item: 
          Title: Terminal and Internal Disordered Segments Have Combined Effects on Half-Life
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         Item: 
          Title: The Effects of Disordered Segments on Half-Life Are Independent of the Overall Disorder Degree
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         Item: 
          Title: Disordered Segments Have Direct Effects on Half-Life Rather than Acting Indirectly by Embedding Destruction Signals
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         Item: 
          Title: Disordered Segments Have Similar Effects on Protein Turnover in Mouse and Human
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         Item: 
          Title: Divergence in Disordered Segments during Evolution Can Impact Protein Half-Life
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         Item: 
          Title: Functional Analysis and Literature Evidence Support the Role of Disordered Segments in Governing Protein Half-Life and Phen ...
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        Title: Discussion
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         Item: 
          Title: The Structure and Composition of the Proteasome Suggest Molecular Mechanisms to Explain the Observations
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         Item: 
          Title: Disordered Segments Influence Half-Life as an Intrinsic Feature that Can Be Modulated by Other Mechanisms
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         Item: 
          Title: Disordered Segments Could Influence the Dynamics and Regulation of Signaling Pathways
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         Item: 
          Title: Divergence in Disordered Segments Provides a Means for Tuning Protein Half-Life during Evolution and Could Generate Phenoty ...
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        Title: Experimental Procedures
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          Title: Protein Half-Life Data and Calculation of Disordered Segments
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          Title: Paralog Data and Calculations
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        Title: Acknowledgments
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        Title: References
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    Author: Robin van der Lee
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