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      Title: Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial
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       Item: 
        Title: Abstract
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        Title: Background
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          Title: Primary question
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          Title: Secondary questions
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          Title: Other questions
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        Title: POISE-2 data collection and analytic plan
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          Title: POISE-2 AKI substudy data collection
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            Title: Longer term kidney function measurement
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          Title: Patient selection
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          Title: Intention to treat
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          Title: Primary definition of acute kidney injury
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          Title: Alternate definitions of AKI
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          Title: Subgroup analyses: presence of preoperative CKD and chronic aspirin use
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          Title: Additional analyses
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            Title: Longer term kidney function loss after surgery
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            Title: Postoperative cardiac events
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            Title: A higher risk of AKI with aspirin
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           Item: 
            Title: Exclusion of major urological surgeries
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            Title: Effects of clonidine on AKI
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        Title: Recognised limitations
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          Title: Errors with serum creatinine as a measure of kidney function
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         Item: 
          Title: Limited statistical power for the most clinically important kidney outcomes
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        Title: Conclusions
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     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 568, 268, 576
      Annotation: 
       Subtype: Link
       Rect: 61, 560, 105, 567
      Annotation: 
       Subtype: Link
       Rect: 61, 560, 137, 567
      Annotation: 
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     Thumb: true
  Checksum: 77e74bf7
   Type: CRC32
  Checksum: 5060115102934e9cb2caf3ce240dd859
   Type: MD5
  Checksum: df90f3dd99f606d5ce457d3decb04b8e5f5385db
   Type: SHA-1
  Checksum: 36ed770467edaa7b7e98b5ea726ed595e80e9fbf7b41cd26db05ab7b40252b66
   Type: SHA-256