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Title:          Learning improvement after PI3K activation correlates with de novo formation of functional small spines
Subject:        PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes.
Keywords:       dendritic spines, structural plasticity, PI3K, hippocampus
Author:         Miguel Morales
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     Item: 
      Title: Learning improvement after pi3k activation correlates with de novo formation of functional small spines
      Children: 
       Item: 
        Title: Introduction
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       Item: 
        Title: Materials and methods
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        Children: 
         Item: 
          Title: Animals
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         Item: 
          Title: Behavioral experiments
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         Item: 
          Title: Elevated plus maze
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         Item: 
          Title: Contextual fear conditioning
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         Item: 
          Title: PI3K-activating peptides
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         Item: 
          Title: Golgi staining and spine density quantification
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         Item: 
          Title: Spine morphology analysis
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         Item: 
          Title: In vivo electrophysiology and pharmacology
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         Item: 
          Title: Local field potential analysis
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         Item: 
          Title: Hippocampal cell cultures
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         Item: 
          Title: Transfection
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         Item: 
          Title: Rna extraction, reverse transcription, and real-time rt-pcr
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         Item: 
          Title: Immunocytochemistry and image analysis of spines in cultures
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         Item: 
          Title: Time-lapse analysis
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         Item: 
          Title: Transgenic mice colony and stereotaxis
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         Item: 
          Title: Biolistic labeling
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         Item: 
          Title: Statistics
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: PI3K overactivation improves learning abilities in rats
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         Item: 
          Title: Spine density in the hippocampus is upregulated by CFC and PI3K activation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612
         Item: 
          Title: PI3K favors the formation of small head spines
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         Item: 
          Title: In vivo PI3K activation induces changes in schaffer-ca1 input
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         Item: 
          Title: PI3K spine formation is independent of neuronal activity
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         Item: 
          Title: Spine stability partially depends on PI3K activity
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         Item: 
          Title: Activation of nmda is required for the PI3K spine formation process
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         Item: 
          Title: Newborn spines in culture are associated with presynaptic terminals
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         Item: 
          Title: PI3K activation upregulates glutamate receptors and the early gene arc expression
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         Item: 
          Title: PI3K overexpression induces small spine formation in cultured neurons
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         Item: 
          Title: PI3K overexpression increases spine density in the Tg2576 mice model of alzheimer's disease
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       Item: 
        Title: Discussion
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        Children: 
         Item: 
          Title: Structural remodeling after PI3K overactivation
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         Item: 
          Title: Spine size as a key element linked to functional attributes
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         Item: 
          Title: NMDA activity correlates with the formation of new spines
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         Item: 
          Title: Electrophysiology recordings suggest that new spines are functional
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         Item: 
          Title: PI3K spinogenic effect in Tg2576 mice
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       Item: 
        Title: Author contributions
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        Title: Acknowledgments
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       Item: 
        Title: References
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    Title: Learning improvement after PI3K activation correlates with de novo formation of functional small spines
    Author: Miguel Morales
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    Keywords: dendritic spines, structural plasticity, PI3K, hippocampus
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               <rdf:li xml:lang="x-default">Learning improvement after PI3K activation correlates with de novo formation of functional small spines</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Miguel Morales</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes.</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>dendritic spines</rdf:li>
               <rdf:li>structural plasticity</rdf:li>
               <rdf:li>PI3K</rdf:li>
               <rdf:li>hippocampus</rdf:li>
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   Type: MD5
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