924a86b2e1c9e3b0a3c56697b1cd8d77 pmc_24885036.pdf c7947115210c75e2083dcdd29f15e73494c98cc0 pmc_24885036.pdf 2ae5aa17bbc7771b6160eaeccd55fce9029889be205155613dd8f88a07763cca pmc_24885036.pdf Title: Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity? Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows) CreationDate: Mon May 26 22:00:07 2014 CEST ModDate: Mon May 26 22:00:46 2014 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1287872 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NFNFFI+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 507 0 NFNFGI+AdvTTe45e47d2 Type 1C WinAnsi yes yes no 508 0 NFNFGJ+AdvTTb5929f4c Type 1C WinAnsi yes yes no 509 0 NFNFGK+AdvTT99c4c969 Type 1C WinAnsi yes yes no 510 0 NFNFGL+AdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 511 0 NFNFHM+AdvTT81389ce9+20 Type 1C Custom yes yes yes 471 0 NFNGIG+AdvTT7329fd89.I Type 1C WinAnsi yes yes no 512 0 NFNGMI+AdvTT8861b38f.I Type 1C WinAnsi yes yes no 202 0 NFNGKH+AdvTT86d47313 Type 1C WinAnsi yes yes no 201 0 NFNGLH+AdvTT86d47313+20 Type 1C WinAnsi yes yes no 203 0 NFNGOI+AdvTT86d47313+03 Type 1C Custom yes yes yes 205 0 NFNOPI+AdvTTb5929f4c+03 Type 1C Custom yes yes yes 206 0 NFPMLC+AdvTT99c4c969+20 Type 1C WinAnsi yes yes no 160 0 NFPMLD+AdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 207 0 NFPMOD+AdvTTe45e47d2+03 Type 1C Custom yes yes yes 208 0 NFPMOE+AdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 168 0 NFPNMP+FrutigerLTStd-Bold Type 1C Custom yes yes yes 182 0 NFPOAP+FrutigerLTStd-Roman Type 1C Custom yes yes yes 181 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-05 04:49:28 CET RepresentationInformation: pmc_24885036.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-01-29 05:49:19 CET Size: 1287872 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 525 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Material and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: Transgenic mice and drug administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Nerve conduction tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Locomotion tests and clinical disease onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Histology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Protein extraction and western blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Children: Item: Title: Combined resveratrol and PRE-084 reduces locomotor impairments and delays clinical disease onset in SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Combined resveratrol and PRE-084 preserves spinal motoneuron function in SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Combined resveratrol and PRE-084 extends survival of SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Combined resveratrol and PRE-084 administration reduces spinal motoneuron degeneration and reduces microglial reactivity in SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Combined resveratrol and PRE-084 increases Sirt1 and AMPK activation, and promotes specific PKC-depended phosphorylation of NMDA-NR1 subunits Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Children: Item: Title: Mechanisms of neuroprotection and possible overlapping effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Does the SOD1G93A mouse model present a limited therapeutic capacity? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Additional file Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: Author’s contribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: Acknowledgment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Item: Title: Reference Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62 Info: Title: Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity? 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864 FontFile3: true Encoding: WinAnsiEncoding XMP: 2014, 9:1. doi:10.1186/1750-1172-9-78 application/pdf http://dx.doi.org/10.1186/1750-1172-9-78 Renzo Mancuso Jaume del Valle Marta Morell Merc� Pall�s Rosario Osta Xavier Navarro Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity? 2014, 9:1. doi:10.1186/1750-1172-9-78 2014-05-21 � 2014 Mancuso et al.; licensee BioMed Central Ltd. 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