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Keywords: critical drug evaluation, dabigatran, demand-side measures, managed introduction new medicines, registries Author: Brian Godman Creator: LaTeX with hyperref package Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jun 5 16:37:36 2014 CEST ModDate: Mon Jun 9 09:40:36 2014 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1191610 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OMPPPK+Univers-Black Type 1C WinAnsi yes yes no 520 0 OMPPPL+Univers-Light Type 1C Custom yes yes no 521 0 ONAADL+Univers Type 1C WinAnsi yes yes no 526 0 ONAADM+Univers-BoldOblique Type 1C Custom yes yes no 527 0 ONAAEN+Univers-LightOblique Type 1C Custom yes yes no 531 0 ONAAEO+Minion-BoldItalic Type 1C WinAnsi yes yes no 535 0 ONAAEP+Minion-Italic Type 1C Custom yes yes no 536 0 ONAAGP+Univers-Bold Type 1C MacRoman yes yes no 541 0 ONAAIA+Univers-CondensedBold Type 1C WinAnsi yes yes no 367 0 OMPPPJ+Minion-Regular Type 1C Custom yes yes no 365 0 ONAAIB+Minion-Bold Type 1C MacRoman yes yes no 360 0 ONAAKB+MTSYN Type 1C Custom yes yes yes 371 0 ONAAKC+RMTMI Type 1C WinAnsi yes yes no 370 0 ONAAMC+Univers-CondensedBoldOblique Type 1C MacRoman yes yes no 378 0 ONAGGO+MTSYB Type 1C WinAnsi yes yes no 379 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:54:52 CEST RepresentationInformation: pmc_24959145.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-29 05:48:13 CET Size: 1191610 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 644 FreeObjects: 1 IncrementalUpdates: 4 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Methodology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Health Authority and Health Insurance Company Activities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Proposed Model and Associated Activities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Post Launch Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Italy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: New Zealand Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Ireland Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Scotland Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Slovenia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Spain (Catalonia) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Sweden (Stockholm County Council) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Summary of the findings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Info: Title: Dabigatran - a continuing exemplar case history demonstrating the need for comprehensive models to optimize the utilization of new drugs Author: Brian Godman Subject: Background: There are potential conflicts between authorities and companies to fund new premium priced drugs especially where there are effectiveness, safety and/or budget concerns. 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