35cc53d8d839e91fbfb15585e4ea5f77 pmc_24991965.pdf 72e288ff993b33ae201c838f4f46b6309b507b27 pmc_24991965.pdf 6e222ff4892b61072e6ff3b4c2234d5e108b42e90f5de98e10d3c14198f65540 pmc_24991965.pdf Title: Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated Subject: Journal of Investigative Dermatology 134, 2890 (2014). doi:10.1038/jid.2014.265 Author: Tzu-Kai Lin Creator: Arbortext Advanced Print Publisher 9.0.226/W Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 8 13:48:02 2014 CEST ModDate: Mon Nov 3 16:12:17 2014 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 2428153 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NAGHPM+AdvOptima-b Type 1C MacRoman yes yes no 370 0 NAGHPN+AdvOptima Type 1C Custom yes yes no 371 0 NAGHPO+AdvOpm Type 1C MacRoman yes yes no 375 0 NAGIAO+AdvOptima-i Type 1C Custom yes yes no 377 0 NAGIBP+AdvOT4a0edb87.I Type 1C WinAnsi yes yes no 382 0 NAGIEP+AdvTA42 Type 1C Custom yes yes yes 384 0 NAGILN+AdvEls-ent7 Type 1C WinAnsi yes yes no 179 0 NAGIMO+AdvPi1 Type 1C WinAnsi yes yes no 178 0 NAGIMP+AdvEls-ent4 Type 1C WinAnsi yes yes no 181 0 NAGIOA+AdvOptima-bi Type 1C WinAnsi yes yes no 175 0 NAGPFK+Helvetica-Oblique Type 1C WinAnsi yes yes no 203 0 Symbol Type 1C Custom yes no yes 192 0 NAGPGL+Helvetica-Bold Type 1C WinAnsi yes yes no 193 0 NAHCMI+AdvP4C4E74 Type 1C Custom yes yes yes 189 0 NAGPDK+Helvetica Type 1C WinAnsi yes yes no 190 0 NAKJPG+AdvItcSymbol-M Type 1C WinAnsi yes yes no 208 0 NALOOG+AdvEls-ent5 Type 1C WinAnsi yes yes no 209 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:54:50 CEST RepresentationInformation: pmc_24991965.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-29 05:47:50 CET Size: 2428153 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 404 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Stress increases endogenous GC and decreases inflammation in murine inflammatory dermatosis models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Irritant contact dermatitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Acute allergic contact dermatitis model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Atopic dermatitis model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Stress improves epidermal function in AD mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Stress-induced improvements in inflammation and epidermal function can be attributed to increased endogenous GC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Figure™1Stress reduces cutaneous inflammation in irritant and allergic contact dermatitis models.(a, b) To induce irritant contact dermatitis (ICD), both ears of one group of C57BLsolJ mice were treated topically with 20thinspmgrl of 0.03percnt phorbol 12 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Figure™2Stress reduces epidermal hyperplasia and inflammation in acute allergic contact dermatitis (ACD) mice.(a-c) Representative hematoxylin and eosin sections of normal or ACD mice, with or without superimposed stress. (d-f) Proliferating cell nuclear Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Figure™4Co-administered stress improves epidermal function in the atopic dermatitis (AD) model.(a) Stress improves barrier function and stratum corneum hydration in AD mice. (b) Coadministration of mifeprostone (Ru486) worsens barrier function, but it doe Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Table 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Figure™3Psychological stress reduces inflammation and epidermal hyperplasia in an atopic dermatitis (AD) model.(a, b) Changes in epidermal hyperplasia and inflammation in nonstressed versus stressed animals (quantitative data are in d). (c, d) Reversal of Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Experimental protocols and disease models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Serum IgE and GC measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Quantitative PCR for mRNA expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Inflammatory cell quantifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Quantification of epidermal thickness, proliferation, and inflammatory cell density Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: A5 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: A6 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: A7 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated Author: Tzu-Kai Lin Subject: Journal of Investigative Dermatology 134, 2890 (2014). doi:10.1038/jid.2014.265 Creator: Arbortext Advanced Print Publisher 9.0.226/W Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 08 13:48:02 CEST 2014 ModDate: Mon Nov 03 16:42:17 CET 2014 ID: 0xad01dacc98bd835bc6feecab9e02d278, 0x7ed5a7c746d6df408f4a45ed2e991dcb Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 826 ImageHeight: 408 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 778 ImageHeight: 494 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 726 ImageHeight: 497 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1168 ImageHeight: 584 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 957 ImageHeight: 472 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1173 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1577 ImageHeight: 695 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3024 ImageHeight: 607 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3026 ImageHeight: 702 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1070 ImageHeight: 646 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1152 ImageHeight: 799 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1139 ImageHeight: 811 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1062 ImageHeight: 644 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1139 ImageHeight: 799 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1001 ImageHeight: 392 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: NAGIEP+AdvTA42 FontSubset: true FirstChar: 38 LastChar: 38 FontDescriptor: FontName: NAGIEP+AdvTA42 Flags: Serif, Symbolic FontBBox: -72, -145, 875, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Symbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAGPGL+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 103 FontDescriptor: FontName: NAGPGL+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGPFK+Helvetica-Oblique FontSubset: true FirstChar: 80 LastChar: 110 FontDescriptor: FontName: NAGPFK+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGIOA+AdvOptima-bi FontSubset: true FirstChar: 45 LastChar: 110 FontDescriptor: FontName: NAGIOA+AdvOptima-bi Flags: Nonsymbolic FontBBox: -93, -260, 1114, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAKJPG+AdvItcSymbol-M FontSubset: true FirstChar: 177 LastChar: 177 FontDescriptor: FontName: NAKJPG+AdvItcSymbol-M Flags: Nonsymbolic FontBBox: -62, -229, 1208, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NALOOG+AdvEls-ent5 FontSubset: true FirstChar: 49 LastChar: 49 FontDescriptor: FontName: NALOOG+AdvEls-ent5 Flags: Serif, Nonsymbolic FontBBox: 9, -343, 1166, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGHPM+AdvOptima-b FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: NAGHPM+AdvOptima-b Flags: Nonsymbolic FontBBox: -93, -260, 1000, 750 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NAGIMO+AdvPi1 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: NAGIMO+AdvPi1 Flags: Serif, Nonsymbolic FontBBox: 13, -323, 958, 824 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGHPN+AdvOptima FontSubset: true FirstChar: 30 LastChar: 151 FontDescriptor: FontName: NAGHPN+AdvOptima Flags: Nonsymbolic FontBBox: -72, -260, 1000, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NAGILN+AdvEls-ent7 FontSubset: true FirstChar: 69 LastChar: 69 FontDescriptor: FontName: NAGILN+AdvEls-ent7 Flags: Nonsymbolic FontBBox: 51, -322, 1177, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGIMP+AdvEls-ent4 FontSubset: true FirstChar: 111 LastChar: 111 FontDescriptor: FontName: NAGIMP+AdvEls-ent4 Flags: Nonsymbolic FontBBox: 0, -343, 1166, 1218 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGHPO+AdvOpm FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: NAGHPO+AdvOpm Flags: Nonsymbolic FontBBox: -156, -270, 1000, 760 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NAGIAO+AdvOptima-i FontSubset: true FirstChar: 30 LastChar: 150 FontDescriptor: FontName: NAGIAO+AdvOptima-i Flags: Nonsymbolic FontBBox: -72, -260, 1114, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NAHCMI+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: NAHCMI+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAGIBP+AdvOT4a0edb87.I FontSubset: true FirstChar: 50 LastChar: 121 FontDescriptor: FontName: NAGIBP+AdvOT4a0edb87.I Flags: Serif, Nonsymbolic FontBBox: -114, -260, 1041, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAGPDK+Helvetica FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: NAGPDK+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/jid.2014.265 Tzu-Kai Lin Mao-Qiang Man Juan-Luis Santiago Tiffany C Scharschmidt Melanie Hupe Gemma Martin-Ezquerra Jong-Kyung Youm Yongjiao Zhai Carles Trullas Kenneth R Feingold Peter M Elias Journal of Investigative Dermatology 134, 2890 (2014). doi:10.1038/jid.2014.265 Nature Publishing Group © 2014 Nature Publishing Group Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated Acrobat Distiller 8.1.0 (Windows) © 2014 The Society for Investigative Dermatology, Inc 10.1038/jid.2014.265 1523-1747 2897 0022-202X 12 Journal of Investigative Dermatology 2890 134 2014-08-07 permissions@nature.com http://dx.doi.org/10.1038/jid.2014.265 2014-10-08T11:48:02Z Arbortext Advanced Print Publisher 9.0.226/W Journal of Investigative Dermatology 134, 2890 (2014). doi:10.1038/jid.2014.265 2014-11-03T20:42:17+05:30 2014-11-03T20:42:17+05:30 doi:10.1038/jid.2014.265 True uuid:184e359c-d030-46f5-a780-fa08f2abc1bf uuid:3c439e61-428b-4e43-bd82-d8622a94895a Pages: Page: Label: 2890 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 254, 360, 323, 368 Annotation: Subtype: Link Rect: 403, 262, 508, 271 Destination: 163 Annotation: Subtype: Link Rect: 515, 262, 552, 271 Destination: 163 Annotation: Subtype: Link Rect: 304, 250, 350, 260 Destination: 163 Annotation: Subtype: Link Rect: 307, 227, 390, 237 Destination: 163 Annotation: Subtype: Link Rect: 397, 227, 505, 237 Destination: 163 Annotation: Subtype: Link Rect: 435, 204, 509, 214 Destination: 163 Annotation: Subtype: Link Rect: 365, 193, 442, 202 Destination: 163 Annotation: Subtype: Link Rect: 448, 193, 529, 202 Destination: 158 Annotation: Subtype: Link Rect: 446, 170, 519, 179 Destination: 163 Annotation: Subtype: Link Rect: 528, 170, 552, 179 Destination: 163 Annotation: Subtype: Link Rect: 304, 159, 374, 168 Destination: 163 Annotation: Subtype: Link Rect: 380, 159, 482, 168 Destination: 163 Annotation: Subtype: Link Rect: 347, 113, 408, 122 Destination: 163 Annotation: Subtype: Link Rect: 443, 78, 547, 88 Destination: 163 Annotation: Subtype: Link Rect: 410, 55, 488, 65 Destination: 158 Annotation: Subtype: Link Rect: 462, 44, 547, 53 Destination: 158 Annotation: Subtype: Link Rect: 67, 134, 136, 141 Thumb: true Page: Label: 2891 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 45, 685, 145, 695 Destination: 163 Annotation: Subtype: Link Rect: 110, 651, 190, 661 Destination: 158 Annotation: Subtype: Link Rect: 196, 651, 265, 661 Destination: 163 Annotation: Subtype: Link Rect: 271, 651, 290, 661 Destination: 158 Annotation: Subtype: Link Rect: 42, 640, 92, 649 Destination: 158 Annotation: Subtype: Link Rect: 45, 582, 123, 592 Destination: 158 Annotation: Subtype: Link Rect: 129, 582, 204, 592 Destination: 158 Annotation: Subtype: Link Rect: 210, 582, 285, 592 Destination: 158 Annotation: Subtype: Link Rect: 45, 548, 113, 557 Destination: 163 Annotation: Subtype: Link Rect: 119, 548, 191, 557 Destination: 158 Annotation: Subtype: Link Rect: 197, 548, 273, 557 Destination: 158 Annotation: Subtype: Link Rect: 257, 411, 290, 420 Destination: 163 Annotation: Subtype: Link Rect: 42, 399, 122, 409 Destination: 163 Annotation: Subtype: Link Rect: 78, 376, 194, 386 Destination: 163 Annotation: Subtype: Link Rect: 95, 125, 168, 135 Destination: 163 Annotation: Subtype: Link Rect: 158, 102, 237, 112 Destination: 158 Annotation: Subtype: Link Rect: 244, 102, 290, 112 Destination: 158 Annotation: Subtype: Link Rect: 42, 91, 62, 100 Destination: 158 Annotation: Subtype: Link Rect: 482, 588, 517, 597 Destination: 37 Annotation: Subtype: Link Rect: 379, 511, 418, 520 Destination: 37 Annotation: Subtype: Link Rect: 390, 500, 426, 509 Destination: 37 Annotation: Subtype: Link Rect: 515, 489, 550, 498 Destination: 37 Annotation: Subtype: Link Rect: 307, 316, 342, 325 Destination: 37 Annotation: Subtype: Link Rect: 374, 305, 412, 314 Destination: 37 Annotation: Subtype: Link Rect: 307, 294, 377, 303 Destination: 37 Annotation: Subtype: Link Rect: 441, 283, 486, 292 Destination: 63 Annotation: Subtype: Link Rect: 414, 228, 459, 237 Destination: 63 Annotation: Subtype: Link Rect: 389, 121, 462, 130 Destination: 163 Annotation: Subtype: Link Rect: 403, 99, 457, 108 Destination: 98 Annotation: Subtype: Link Rect: 307, 77, 343, 86 Destination: 98 Annotation: Subtype: Link Rect: 490, 16, 553, 24 Thumb: true Page: Label: 2892 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 148, 125, 244, 134 Destination: 163 Annotation: Subtype: Link Rect: 249, 125, 290, 134 Destination: 163 Annotation: Subtype: Link Rect: 42, 113, 62, 123 Destination: 163 Annotation: Subtype: Link Rect: 69, 113, 138, 123 Destination: 158 Annotation: Subtype: Link Rect: 145, 113, 217, 123 Destination: 163 Annotation: Subtype: Link Rect: 45, 45, 81, 54 Destination: 98 Annotation: Subtype: Link Rect: 101, 45, 131, 54 Destination: 98 Annotation: Subtype: Link Rect: 326, 147, 401, 156 Destination: 158 Annotation: Subtype: Link Rect: 407, 147, 472, 156 Destination: 163 Annotation: Subtype: Link Rect: 478, 147, 552, 156 Destination: 158 Annotation: Subtype: Link Rect: 304, 136, 324, 145 Destination: 158 Annotation: Subtype: Link Rect: 330, 136, 401, 145 Destination: 158 Annotation: Subtype: Link Rect: 364, 206, 421, 213 Destination: 163 Thumb: true Page: Label: 2893 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 161, 273, 225, 283 Destination: 98 Annotation: Subtype: Link Rect: 158, 262, 189, 272 Destination: 98 Annotation: Subtype: Link Rect: 197, 239, 234, 249 Destination: 98 Annotation: Subtype: Link Rect: 255, 239, 285, 249 Destination: 98 Annotation: Subtype: Link Rect: 45, 136, 135, 145 Destination: 163 Annotation: Subtype: Link Rect: 144, 113, 228, 123 Destination: 163 Annotation: Subtype: Link Rect: 236, 113, 290, 123 Destination: 163 Annotation: Subtype: Link Rect: 42, 102, 89, 111 Destination: 163 Annotation: Subtype: Link Rect: 69, 79, 140, 88 Destination: 163 Annotation: Subtype: Link Rect: 146, 79, 243, 88 Destination: 163 Annotation: Subtype: Link Rect: 249, 79, 290, 88 Destination: 163 Annotation: Subtype: Link Rect: 42, 67, 99, 77 Destination: 163 Annotation: Subtype: Link Rect: 510, 331, 552, 340 Destination: 163 Annotation: Subtype: Link Rect: 304, 319, 352, 329 Destination: 163 Annotation: Subtype: Link Rect: 359, 319, 456, 329 Destination: 163 Annotation: Subtype: Link Rect: 472, 251, 550, 260 Destination: 158 Annotation: Subtype: Link Rect: 304, 239, 370, 249 Destination: 163 Annotation: Subtype: Link Rect: 376, 239, 476, 249 Destination: 158 Annotation: Subtype: Link Rect: 495, 193, 552, 203 Destination: 158 Annotation: Subtype: Link Rect: 304, 182, 325, 191 Destination: 158 Annotation: Subtype: Link Rect: 330, 182, 422, 191 Destination: 163 Annotation: Subtype: Link Rect: 341, 67, 516, 77 Destination: 158 Annotation: Subtype: Link Rect: 522, 67, 552, 77 Destination: 163 Annotation: Subtype: Link Rect: 304, 56, 373, 65 Destination: 163 Annotation: Subtype: Link Rect: 490, 16, 553, 24 Thumb: true Page: Label: 2894 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 149, 90, 285, 99 Destination: 158 Annotation: Subtype: Link Rect: 243, 67, 290, 76 Destination: 158 Annotation: Subtype: Link Rect: 42, 55, 117, 65 Destination: 158 Annotation: Subtype: Link Rect: 45, 44, 134, 53 Destination: 158 Annotation: Subtype: Link Rect: 460, 170, 550, 180 Destination: 158 Annotation: Subtype: Link Rect: 304, 159, 380, 168 Destination: 163 Annotation: Subtype: Link Rect: 439, 159, 550, 168 Destination: 158 Annotation: Subtype: Link Rect: 304, 147, 381, 157 Destination: 158 Annotation: Subtype: Link Rect: 387, 147, 464, 157 Destination: 158 Thumb: true Page: Label: 2895 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 75, 685, 183, 695 Destination: 163 Annotation: Subtype: Link Rect: 188, 685, 253, 695 Destination: 163 Annotation: Subtype: Link Rect: 258, 685, 290, 695 Destination: 158 Annotation: Subtype: Link Rect: 42, 674, 94, 684 Destination: 158 Annotation: Subtype: Link Rect: 103, 674, 245, 684 Destination: 158 Annotation: Subtype: Link Rect: 253, 674, 290, 684 Destination: 163 Annotation: Subtype: Link Rect: 42, 663, 63, 672 Destination: 163 Annotation: Subtype: Link Rect: 85, 628, 209, 638 Destination: 163 Annotation: Subtype: Link Rect: 187, 571, 288, 580 Destination: 163 Annotation: Subtype: Link Rect: 42, 559, 109, 569 Destination: 163 Annotation: Subtype: Link Rect: 115, 559, 158, 569 Destination: 163 Annotation: Subtype: Link Rect: 264, 491, 290, 500 Destination: 158 Annotation: Subtype: Link Rect: 42, 479, 142, 489 Destination: 158 Annotation: Subtype: Link Rect: 149, 479, 229, 489 Destination: 163 Annotation: Subtype: Link Rect: 149, 456, 246, 466 Destination: 158 Annotation: Subtype: Link Rect: 131, 445, 210, 454 Destination: 163 Annotation: Subtype: Link Rect: 115, 433, 204, 443 Destination: 163 Annotation: Subtype: Link Rect: 71, 204, 146, 214 Destination: 163 Annotation: Subtype: Link Rect: 535, 491, 553, 500 Destination: 163 Annotation: Subtype: Link Rect: 304, 480, 348, 488 Destination: 163 Annotation: Subtype: Link Rect: 354, 480, 425, 488 Destination: 163 Annotation: Subtype: Link Rect: 386, 228, 449, 236 Destination: 163 Annotation: Subtype: Link Rect: 455, 228, 529, 236 Destination: 163 Annotation: Subtype: Link Rect: 401, 79, 466, 87 Destination: 163 Annotation: Subtype: Link Rect: 490, 16, 553, 24 Thumb: true Page: Label: 2896 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 534, 613, 552, 621 Annotation: Subtype: Link Rect: 304, 604, 370, 612 Thumb: true Page: Label: 2897 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 526, 227, 552, 237 Annotation: Subtype: Link Rect: 304, 216, 486, 225 Annotation: Subtype: Link Rect: 490, 16, 553, 24 Thumb: true Checksum: b41f0b51 Type: CRC32 Checksum: 35cc53d8d839e91fbfb15585e4ea5f77 Type: MD5 Checksum: 72e288ff993b33ae201c838f4f46b6309b507b27 Type: SHA-1