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Title:          MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness
Subject:        Cell Death and Disease 5, e1401 (2014). doi:10.1038/cddis.2014.356
Author:         L Planells-Ferrer
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        Title: Results
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          Title: The DR antagonist LFG is downregulated in high-risk NBL
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          Title: LFG is associated with NBL differentiation
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          Title: Reduction of LFG levels modulates proliferation, adhesion and migration of NBL cells
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        Title: Table 1 
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        Title: Figure™1LFG is downregulated in high-risk NBL. (a) mRNA expression of the DR antagonists FLIP (1868gat), PEA15 (32260at) and LFG (33293at) in different NBL stages obtained from GSE3960 data set. Data were analyzed by one-way ANOVA; astPlt0.05, astastPlt0
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          Title: LFG knockdown alters cell adhesion programs
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        Title: Figure™2LFG levels are associated with NBL differentiation. (a) Relative LFG expression in histologically favorable (n=30) versus unfavorable (n=8) primary tumors. mRNA levels were measured by qPCR. astastPlt0.01, unpaired t-test. (b) All-trans RA (10thin
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        Title: Figure™3LFG knockdown favors the metastatic potential of NBL cell lines. (a) Western blot showing LFG downregulation after infection with shScr or shLFG lentiviruses using anti-FAIM2 (H-21) antibody (Santa Cruz Biotechnology Inc). Bands were quantified an
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          Title: LFG expression is directly modulated by MYCN
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        Title: Figure™4LFG knockdown increases the metastatic potential of SH-SY5Y cells. (a) Xenograft formation assay with shScr and shLFG SH-SY5Y cells injected into the flank of NMRI nude mice. (b) Tumor volume measured at different days postinjection using a digita
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        Title: Figure™5LFG knockdown alters the expression of cell adhesion molecules. (a) KEGG pathway enrichment analysis of differentially expressed genes between shScr and shLFG-transduced SH-SY5Y cells. (b) Gene set enrichment analysis performed on genes differenti
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        Title: Figure™6MYCN represses directly LFG transcription. (a) Representative images of MYCN-Tet-off-inducible Tet21N cells treated with or without doxycycline (100thinspngsolml). Scale bar, 100thinspmgrm. (b) Tet21N cell line treated with doxycycline (100thinspn
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        Title: Discussion
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        Title: Materials and Methods
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          Title: Reagents
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          Title: Analysis of mRNA NBL data sets
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          Title: Human samples
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          Title: Gene expression analysis by qPCR
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          Title: Western blot
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          Title: Cell lines
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          Title: RA differentiation
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          Title: Sphere formation
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          Title: LFG knockdown
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          Title: Cell proliferation and adhesion assays
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          Title: Migration assays
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          Title: Xenografts
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          Title: mRNA microarray analysis
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          Title: ChIP assays
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          Title: Statistical analysis
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        Title: ACKNOWLEDGEMENTS
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    Title: MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness
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